Search Results - "DI MAJO, Vincenzo"

High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice by Pazzaglia, Simonetta, Mancuso, Mariateresa, Atkinson, Michael J, Tanori, Mirella, Rebessi, Simonetta, Majo, Vincenzo Di, Covelli, Vincenzo, Hahn, Heidi, Saran, Anna

“…Individuals affected with the Gorlin syndrome inherit a germ-line mutation of the patched (Ptc1) developmental gene and, analogously to Ptc1 heterozygous mice,…”
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Physical, Heritable and Age-Related Factors as Modifiers of Radiation Cancer Risk in Patched Heterozygous Mice by Pazzaglia, Simonetta, Ph.D, Pasquali, Emanuela, M.Sc, Tanori, Mirella, Ph.D, Mancuso, Mariateresa, Ph.D, Leonardi, Simona, Ph.D, di Majo, Vincenzo, Ph.D, Rebessi, Simonetta, Ph.D, Saran, Anna, Ph.D

“…Purpose To address the tumorigenic potential of exposure to low/intermediate doses of ionizing radiation and to identify biological factors influencing tumor…”
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Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum by Mancuso, Mariateresa, Pasquali, Emanuela, Leonardi, Simona, Tanori, Mirella, Rebessi, Simonetta, Di Majo, Vincenzo, Pazzaglia, Simonetta, Toni, Maria Pia, Pimpinella, Maria, Covelli, Vincenzo, Saran, Anna

“…The central dogma of radiation biology, that biological effects of ionizing radiation are a direct consequence of DNA damage occurring in irradiated cells, has…”
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The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways by Mancuso, Mariateresa, Leonardi, Simona, Giardullo, Paola, Pasquali, Emanuela, Borra, Fabiana, Stefano, Ilaria De, Prisco, Maria Grazia, Tanori, Mirella, Scambia, Giovanni, Majo, Vincenzo Di, Pazzaglia, Simonetta, Saran, Anna, Gallo, Daniela

“…Abstract Gender-related differences in medulloblastoma (MB) development have been reported with a higher incidence in males (slightly above 60%) than in…”
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Protective role of 17β‐estradiol on medulloblastoma development in Patched1 heterozygous mice by Mancuso, Mariateresa, Leonardi, Simona, Ceccarelli, Manuela, Pasquali, Emanuela, Stefano, Ilaria De, Prisco, Maria Grazia, Rebessi, Simonetta, Tanori, Mirella, Scambia, Giovanni, Majo, Vincenzo Di, Pazzaglia, Simonetta, Saran, Anna, Gallo, Daniela

“…Medulloblastoma (MB) is the most common pediatric tumor of the CNS, representing ∼20% of all childhood CNS tumors. Although in recent years many molecular…”
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PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma by Tanori, Mirella, Mancuso, Mariateresa, Pasquali, Emanuela, Leonardi, Simona, Rebessi, Simonetta, Di Majo, Vincenzo, Guilly, Marie-Noëlle, Giangaspero, Felice, Covelli, Vincenzo, Pazzaglia, Simonetta, Saran, Anna

“…The patched (Ptc1) protein is a negative regulator of sonic hedgehog signaling, a genetic pathway whose perturbation causes developmental defects and…”
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Developmental and oncogenic effects of insulin-like growth factor-I in Ptc1+/- mouse cerebellum by Tanori, Mirella, Santone, Melissa, Mancuso, Mariateresa, Pasquali, Emanuela, Leonardi, Simona, Di Majo, Vincenzo, Rebessi, Simonetta, Saran, Anna, Pazzaglia, Simonetta

“…Medulloblastoma is amongst the most common malignant brain tumors in childhood, arising from neoplastic transformation of granule neuron precursors (GNPs) of…”
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The Influence of Sex on Life Shortening and Tumor Induction in CBA/Cne Mice Exposed to X Rays or Fission Neutrons by Di Majo, Vincenzo, Coppola, Mario, Rebessi, Simonetta, Saran, Anna, Pazzaglia, Simonetta, Pariset, Lorraine, Covelli, Vincenzo

“…An experimental study of male and female CBA/Cne mice was set up at Casaccia primarily to investigate the influence of sex on long-term survival and tumor…”
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Modulation of Patched-associated susceptibility to radiation induced tumorigenesis by genetic background by PAZZAGLIA, Simonetta, MANCUSO, Mariateresa, TANORI, Mirella, ATKINSON, Michael J, MEROLA, Paola, REBESSI, Simonetta, DI MAJO, Vincenzo, COVELLI, Vincenzo, HAHN, Heidi, SARAN, Anna

“…We described previously a basal cell carcinoma (BCC) and medulloblastoma (MB) phenotype for CD1Ptch1(neo67/+) mice exposed to ionizing radiation. Ptch1…”
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Hair cycle-dependent basal cell carcinoma tumorigenesis in Ptc1neo67/+ mice exposed to radiation by Mancuso, Mariateresa, Leonardi, Simona, Tanori, Mirella, Pasquali, Emanuela, Pierdomenico, Maria, Rebessi, Simonetta, Di Majo, Vincenzo, Covelli, Vincenzo, Pazzaglia, Simonetta, Saran, Anna

“…We examined the effects of hair cycle phase on basal cell carcinoma (BCC) tumorigenesis induced by radiation in mice lacking one Patched allele…”
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Basal Cell Carcinoma and Its Development by Mancuso, Mariateresa, Pazzaglia, Simonetta, Tanori, Mirella, Hahn, Heidi, Merola, Paola, Rebessi, Simonetta, Atkinson, Michael J., Di Majo, Vincenzo, Covelli, Vincenzo, Saran, Anna

“…Loss-of-function mutations in Patched (Ptch1) are implicated in constitutive activation of the Sonic hedgehog pathway in human basal cell carcinomas (BCCs),…”
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Comparative Effects of Fission Neutron and X Irradiation on 7.5-Day Mouse Embryos by Di Majo, Vincenzo, Ballardin, Elda, Metalli, Pietro

“…Fission spectrum neutrons (0-46.5 rad) were compared with 250-kV X rays (0-200 rad) for reduction of fetal weight and for embryolethal and teratogenic effects…”
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Basal cell carcinoma and its development: Insights from radiation-induced tumors in Ptch1-deficient mice by MANCUSO, Mariateresa, PAZZAGLIA, Simonetta, TANORI, Mirella, HAHN, Heidi, MEROLA, Paola, REBESSI, Simonetta, ATKINSON, Michael J, DI MAJO, Vincenzo, COVELLI, Vincenzo, SARAN, Anna

“…Loss-of-function mutations in Patched (Ptch1) are implicated in constitutive activation of the Sonic hedgehog pathway in human basal cell carcinomas (BCCs),…”
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Neoplastic Transformation of C3H 10T1/2 Cells: A Study with Fractionated Doses of Monoenergetic Neutrons by Saran, Anna, Pazzaglia, Simonetta, Pariset, Lorraine, Rebessi, Simonetta, Broerse, Johan J., Zoetelief, Johannes, Di Majo, Vincenzo, Coppola, Mario, Covelli, Vincenzo

“…As most occupational and environmental exposures to ionizing radiation are at low dose rates or in small dose fractions, risk estimation requires that the…”
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Protective role of 17 Delta b-estradiol on medulloblastoma development in Patched1 heterozygous mice by Mancuso, Mariateresa, Leonardi, Simona, Ceccarelli, Manuela, Pasquali, Emanuela, De Stefano, Ilaria, Prisco, Maria Grazia, Rebessi, Simonetta, Tanori, Mirella, Scambia, Giovanni, Di Majo, Vincenzo, Pazzaglia, Simonetta, Saran, Anna, Gallo, Daniela

“…Medulloblastoma (MB) is the most common pediatric tumor of the CNS, representing ~20% of all childhood CNS tumors. Although in recent years many molecular…”
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Developmental and oncogenic effects of Insulin-like Growth Factor-I in Ptc1.sup.+/- .sup.mouse cerebellum by Tanori, Mirella, Santone, Melissa, Mancuso, Mariateresa, Pasquali, Emanuela, Leonardi, Simona, Di Majo, Vincenzo, Rebessi, Simonetta, Saran, Anna, Pazzaglia, Simonetta

“…Background Medulloblastoma is amongst the most common malignant brain tumors in childhood, arising from neoplastic transformation of granule neuron precursors…”
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Life-span, tumor incidence, and natural killer cell activity in mice selected for high or low antibody responsiveness by Covelli, V, Marini, S, Di Majo, V, Bassani, B, Mancini, C, Adorini, L, Doria, G

“…Biozzi mice selected for high (H) or low (L) antibody responsiveness to natural antigens have been followed for their entire life-span to examine their…”
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Late Somatic Effects in Mice after Total Lymphoid Irradiation by Covelli, Vincenzo, Di Majo, Vincenzo, Coppola, Mario, Rebessi, Simonetta, Bangrazi, Caterina, Doria, Gino

“…Late somatic effects of total lymphoid irradiation have been investigated in ${\rm BC}3{\rm F}_{1}$ mice. A total X-ray dose of 34 Gy was distributed in 17…”
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Hair Cycle-Dependent Basal Cell Carcinoma Tumorigenesis in Ptc1 super(neo67/+) Mice Exposed to Radiation by Mancuso, Mariateresa, Leonardi, Simona, Tanori, Mirella, Pasquali, Emanuela, Pierdomenico, Maria, Rebessi, Simonetta, Di Majo, Vincenzo, Covelli, Vincenzo, Pazzaglia, Simonetta, Saran, Anna

“…We examined the effects of hair cycle phase on basal cell carcinoma (BCC) tumorigenesis induced by radiation in mice lacking one Patched allele (Ptc1…”
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Carcinogenesis in Laboratory Mice after Low Doses of Ionizing Radiation by Di Majo, Vincenzo, Rebessi, Simonetta, Pazzaglia, Simonetta, Saran, Anna, Covelli, Vincenzo

“…Di Majo, V., Rebessi, S., Pazzaglia, S., Saran, A. and Covelli, V. Carcinogenesis in Laboratory Mice after Low Doses of Ionizing Radiation. Radiat. Res. 159,…”
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