Search Results - "DI BERNARDO, Giovanni"

Clinical Trials Based on Mesenchymal Stromal Cells are Exponentially Increasing: Where are We in Recent Years? by Galderisi, Umberto, Peluso, Gianfranco, Di Bernardo, Giovanni

“…Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues, include multipotent stem cells, progenitors, and differentiated cells…”
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Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence by Alessio, Nicola, Squillaro, Tiziana, Di Bernardo, Giovanni, Galano, Giovanni, De Rosa, Roberto, Melone, Mariarosa Ab, Peluso, Gianfranco, Galderisi, Umberto

“…Senescent cells secrete several molecules, collectively named (SASP). In the SASP of cells that became senescent following several in vitro chemical and…”
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Correction: Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence by Alessio, Nicola, Squillaro, Tiziana, Di Bernardo, Giovanni, Galano, Giovanni, De Rosa, Roberto, Melone, Mariarosa AB, Peluso, Gianfranco, Galderisi, Umberto

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Long non-coding RNAs in regulation of adipogenesis and adipose tissue function by Squillaro, Tiziana, Peluso, Gianfranco, Galderisi, Umberto, Di Bernardo, Giovanni

“…Complex interaction between genetics, epigenetics, environment, and nutrition affect the physiological activities of adipose tissues and their dysfunctions,…”
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Different Stages of Quiescence, Senescence, and Cell Stress Identified by Molecular Algorithm Based on the Expression of Ki67, RPS6, and Beta-Galactosidase Activity by Alessio, Nicola, Aprile, Domenico, Cappabianca, Salvatore, Peluso, Gianfranco, Di Bernardo, Giovanni, Galderisi, Umberto

“…During their life span, cells have two possible states: a non-cycling, quiescent state (G0) and a cycling, activated state. Cells may enter a reversible G0…”
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Role of glycosphingolipid SSEA‐3 and FGF2 in the stemness and lineage commitment of multilineage differentiating stress enduring (MUSE) cells by Aprile, Domenico, Alessio, Nicola, Squillaro, Tiziana, Di Bernardo, Giovanni, Peluso, Gianfranco, Galderisi, Umberto

“…Objectives Multilineage differentiating Stress Enduring (MUSE) cells are endogenous, stress‐resistant stem cells, expressing pluripotency master genes and able…”
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Germicidal lamps using UV-C radiation may pose health safety issues: a biomolecular analysis of their effects on apoptosis and senescence by Alessio, Nicola, Ambrosino, Alessia, Boggi, Andrea, Aprile, Domenico, Pinto, Iole, Galano, Giovanni, Galderisi, Umberto, Di Bernardo, Giovanni

“…The battle against the COVID-19 pandemic has spurred a heightened state of vigilance in global healthcare, leading to the proliferation of diverse sanitization…”
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Irisin influences the in vitro differentiation of human mesenchymal stromal cells, promoting a tendency toward beiging adipogenesis by Di Maio, Girolamo, Alessio, Nicola, Ambrosino, Alessia, Al Sammarraie, Sura H. A., Monda, Marcellino, Di Bernardo, Giovanni

“…Mammals exhibit two distinct types of adipose depots: white adipose tissue (WAT) and brown adipose tissue (BAT). While WAT primarily functions as a site for…”
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Molecular and Physiological Effects of Browning Agents on White Adipocytes from Bone Marrow Mesenchymal Stromal Cells by Di Maio, Girolamo, Alessio, Nicola, Peluso, Gianfranco, Perrotta, Silverio, Monda, Marcellino, Di Bernardo, Giovanni

“…Two different types of adipose depots can be observed in mammals: white adipose tissue (WAT) and brown adipose tissue (BAT). The primary role of WAT is to…”
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Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process by Alessio, Nicola, Del Gaudio, Stefania, Capasso, Stefania, Di Bernardo, Giovanni, Cappabianca, Salvatore, Cipollaro, Marilena, Peluso, Gianfranco, Galderisi, Umberto

“…Low doses of radiation may have profound effects on cellular function. Individuals may be exposed to low doses of radiation either intentionally for medical…”
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IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways by Siraj, Yesuf, Aprile, Domenico, Alessio, Nicola, Peluso, Gianfranco, Di Bernardo, Giovanni, Galderisi, Umberto

“…Senescent cells exert their effects through the release of various factors, collectively referred to as the senescence-associated secretory phenotype (SASP)…”
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Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells by Capasso, Stefania, Alessio, Nicola, Squillaro, Tiziana, Di Bernardo, Giovanni, Melone, Mariarosa A, Cipollaro, Marilena, Peluso, Gianfranco, Galderisi, Umberto

“…A sharp definition of what a senescent cell is still lacking since we do not have in depth understanding of mechanisms that induce cellular senescence. In…”
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Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice by Alessio, Nicola, Acar, Mustafa B, Demirsoy, Ibrahim H, Squillaro, Tiziana, Siniscalco, Dario, Di Bernardo, Giovanni, Peluso, Gianfranco, Özcan, Servet, Galderisi, Umberto

“…White adipose tissue (WAT) is distributed in several depots with distinct metabolic and inflammatory functions. In our body there are subcutaneous (sWAT),…”
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Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti‐tumour properties by Alessio, Nicola, Acar, Mustafa Burak, Squillaro, Tiziana, Aprile, Domenico, Ayaz‐Güner, Şerife, Di Bernardo, Giovanni, Peluso, Gianfranco, Özcan, Servet, Galderisi, Umberto

“…Genotoxic injuries converge on senescence‐executive program that promotes production of a senescence‐specific secretome (SASP). The study of SASP is…”
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Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence by Alessio, Nicola, Capasso, Stefania, Ferone, Angela, Di Bernardo, Giovanni, Cipollaro, Marilena, Casale, Fiorina, Peluso, Gianfranco, Giordano, Antonio, Galderisi, Umberto

“…Although mice models rank among the most widely used tools for understanding human genetics, biology, and diseases, differences between orthologous genes among…”
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Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for developing new senotherapeutics by Oguma, Yo, Alessio, Nicola, Aprile, Domenico, Dezawa, Mari, Peluso, Gianfranco, Di Bernardo, Giovanni, Galderisi, Umberto

“…DNA damage resulting from genotoxic injury can initiate cellular senescence, a state characterized by alterations in cellular metabolism, lysosomal activity,…”
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Biomolecular Evaluation of Piceatannol's Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics? by Alessio, Nicola, Squillaro, Tiziana, Lettiero, Ida, Galano, Giovanni, De Rosa, Roberto, Peluso, Gianfranco, Galderisi, Umberto, Di Bernardo, Giovanni

“…Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing…”
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IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors by Alessio, Nicola, Aprile, Domenico, Peluso, Gianfranco, Mazzone, Valeria, Patrone, Deanira, Di Bernardo, Giovanni, Galderisi, Umberto

“…Cells that are exposed to harmful genetic damage, either from internal or external sources, may undergo senescence if they are unable to repair their DNA…”
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Methods to Investigate the Secretome of Senescent Cells by Samiminemati, Afshin, Aprile, Domenico, Siniscalco, Dario, Di Bernardo, Giovanni

“…The word "secretome" was first used to describe the proteins that cells secrete under different circumstances; however, recent studies have proven the…”
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Obesity induced by high-fat diet is associated with critical changes in biological and molecular functions of mesenchymal stromal cells present in visceral adipose tissue by Acar, Mustafa Burak, Ayaz-Güner, Şerife, Di Bernardo, Giovanni, Güner, Hüseyin, Murat, Ayşegül, Peluso, Gianfranco, Özcan, Servet, Galderisi, Umberto

“…The mesenchymal stromal cells (MSCs) residing within the stromal component of visceral adipose tissue appear to be greatly affected by obesity, with impairment…”
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