Search Results - "DHANASEKARAN, M"

The landscape of long noncoding RNAs in the human transcriptome by Iyer, Matthew K, Niknafs, Yashar S, Malik, Rohit, Singhal, Udit, Sahu, Anirban, Hosono, Yasuyuki, Barrette, Terrence R, Prensner, John R, Evans, Joseph R, Zhao, Shuang, Poliakov, Anton, Cao, Xuhong, Dhanasekaran, Saravana M, Wu, Yi-Mi, Robinson, Dan R, Beer, David G, Feng, Felix Y, Iyer, Hariharan K, Chinnaiyan, Arul M

“…Arul Chinnaiyan and colleagues report the curation of 7,256 RNA sequencing libraries from tumors, normal tissues and cell lines. They find 58,648 lncRNAs, of…”
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Repression of E-cadherin by the polycomb group protein EZH2 in cancer by Cao, Q, Yu, J, Dhanasekaran, S M, Kim, J H, Mani, R-S, Tomlins, S A, Mehra, R, Laxman, B, Cao, X, Kleer, C G, Varambally, S, Chinnaiyan, A M

“…Enhancer of zeste homolog 2 (EZH2) is a critical component of the polycomb-repressive complex 2 (PRC2), which is involved in gene silencing and histone H3…”
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Somatic Bi-allelic Loss of TSC Genes in Eosinophilic Solid and Cystic Renal Cell Carcinoma by Mehra, Rohit, Vats, Pankaj, Cao, Xuhong, Su, Fengyun, Lee, Nicole D., Lonigro, Robert, Premkumar, Kumpati, Trpkov, Kiril, McKenney, Jesse K., Dhanasekaran, Saravana M., Chinnaiyan, Arul M.

“…Renal cell carcinomas (RCC) with overlapping histomorphologic features poses diagnostic challenges. This is exemplified in RCCs with eosinophilic cytoplasm…”
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Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA by Hosono, Yasuyuki, Niknafs, Yashar S., Prensner, John R., Iyer, Matthew K., Dhanasekaran, Saravana M., Mehra, Rohit, Pitchiaya, Sethuramasundaram, Tien, Jean, Escara-Wilke, June, Poliakov, Anton, Chu, Shih-Chun, Saleh, Sahal, Sankar, Keerthana, Su, Fengyun, Guo, Shuling, Qiao, Yuanyuan, Freier, Susan M., Bui, Huynh-Hoa, Cao, Xuhong, Malik, Rohit, Johnson, Timothy M., Beer, David G., Feng, Felix Y., Zhou, Weibin, Chinnaiyan, Arul M.

“…Large-scale transcriptome sequencing efforts have vastly expanded the catalog of long non-coding RNAs (lncRNAs) with varying evolutionary conservation, lineage…”
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The mutational landscape of lethal castration-resistant prostate cancer by Grasso, Catherine S., Wu, Yi-Mi, Robinson, Dan R., Cao, Xuhong, Dhanasekaran, Saravana M., Khan, Amjad P., Quist, Michael J., Jing, Xiaojun, Lonigro, Robert J., Brenner, J. Chad, Asangani, Irfan A., Ateeq, Bushra, Chun, Sang Y., Siddiqui, Javed, Sam, Lee, Anstett, Matt, Mehra, Rohit, Prensner, John R., Palanisamy, Nallasivam, Ryslik, Gregory A., Vandin, Fabio, Raphael, Benjamin J., Kunju, Lakshmi P., Rhodes, Daniel R., Pienta, Kenneth J., Chinnaiyan, Arul M., Tomlins, Scott A.

“…Exome sequencing is used to investigate the role of mutations and copy number aberrations in metastatic castration-resistant prostate cancer, revealing…”
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Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1 , an unannotated lincRNA implicated in disease progression by Chinnaiyan, Arul M, Prensner, John R, Iyer, Matthew K, Balbin, O Alejandro, Dhanasekaran, Saravana M, Cao, Qi, Brenner, J Chad, Laxman, Bharathi, Asangani, Irfan A, Grasso, Catherine S, Kominsky, Hal D, Cao, Xuhong, Jing, Xiaojun, Wang, Xiaoju, Siddiqui, Javed, Wei, John T, Robinson, Daniel, Iyer, Hari K, Palanisamy, Nallasivam, Maher, Christopher A

“…New noncoding RNAs can be discovered by assembling transcripts from RNA-Seq data. Prensner et al . apply this approach across >100 prostate cancer samples to…”
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Next-generation RNA Sequencing–based Biomarker Characterization of Chromophobe Renal Cell Carcinoma and Related Oncocytic Neoplasms by Skala, Stephanie L., Wang, Xiaoming, Zhang, Yuping, Mannan, Rahul, Wang, Lisha, Narayanan, Sathiya P., Vats, Pankaj, Su, Fengyun, Chen, Jin, Cao, Xuhong, Siddiqui, Javed, Argani, Pedram, Cieślik, Marcin P., Giordano, Thomas J., Chinnaiyan, Arul M., Dhanasekaran, Saravana M., Mehra, Rohit

“…Renal cell carcinomas (RCCs) are a heterogeneous group of neoplasms. Recent sequencing studies revealed various molecular features associated with histologic…”
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An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression by Yu, Jindan, Yu, Jianjun, Mani, Ram-Shankar, Cao, Qi, Brenner, Chad J., Cao, Xuhong, Wang, Xiaoju, Wu, Longtao, Li, James, Hu, Ming, Gong, Yusong, Cheng, Hong, Laxman, Bharathi, Vellaichamy, Adaikkalam, Shankar, Sunita, Li, Yong, Dhanasekaran, Saravana M., Morey, Roger, Barrette, Terrence, Lonigro, Robert J., Tomlins, Scott A., Varambally, Sooryanarayana, Qin, Zhaohui S., Chinnaiyan, Arul M.

“…Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the oncogenic ETS transcription factor ERG occur in approximately 50% of prostate…”
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Experimental study on the morphology and hardness variation of TiAl alloy at different heat treatment cycles by Bhattacharyya, Anandarup, Dhanasekaran, M

“…This work aims to study the morphology of γ-TiAl alloy and its dependence on the hardness value. It was observed that there was a change in the hardness value…”
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New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites by Lee, Inhan, Ajay, Subramanian S, Yook, Jong In, Kim, Hyun Sil, Hong, Su Hyung, Kim, Nam Hee, Dhanasekaran, Saravana M, Chinnaiyan, Arul M, Athey, Brian D

“…MicroRNAs (miRNAs) are known to post-transcriptionally regulate target mRNAs through the 3'-UTR, which interacts mainly with the 5'-end of miRNA in animals…”
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Polycaprolactone scaffold engineered for sustained release of resveratrol: therapeutic enhancement in bone tissue engineering by Kamath, Manjunath Srinivas, Ahmed, Shiek S S J, Dhanasekaran, M, Santosh, S Winkins

“…Biomaterials-based three-dimensional scaffolds are being extensively investigated in bone tissue engineering. A potential scaffold should be osteoconductive,…”
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RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1 by Prensner, John R, MD, Zhao, Shuang, MSc, Erho, Nicholas, MSc, Schipper, Matthew, PhD, Iyer, Matthew K, PhD, Dhanasekaran, Saravana M, PhD, Magi-Galluzzi, Cristina, MD, Mehra, Rohit, MD, Sahu, Anirban, BSc, Siddiqui, Javed, MSc, Davicioni, Elai, PhD, Den, Robert B, MD, Dicker, Adam P, Prof, Karnes, R Jeffrey, MD, Wei, John T, Prof, Klein, Eric A, Prof, Jenkins, Robert B, Prof, Chinnaiyan, Arul M, Prof, Feng, Felix Y, Dr

“…Summary Background Improved clinical predictors for disease progression are needed for localised prostate cancer, since only a subset of patients develop…”
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Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer by Cao, Qi, Mani, Ram-Shankar, Ateeq, Bushra, Dhanasekaran, Saravana M., Asangani, Irfan A., Prensner, John R., Kim, Jung H., Brenner, J. Chad, Jing, Xiaojun, Cao, Xuhong, Wang, Rui, Li, Yong, Dahiya, Arun, Wang, Lei, Pandhi, Mithil, Lonigro, Robert J., Wu, Yi-Mi, Tomlins, Scott A., Palanisamy, Nallasivam, Qin, Zhaohui, Yu, Jindan, Maher, Christopher A., Varambally, Sooryanarayana, Chinnaiyan, Arul M.

“…Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group (PcG)…”
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The central role of EED in the orchestration of polycomb group complexes by Cao, Qi, Wang, Xiaoju, Zhao, Meng, Yang, Rendong, Malik, Rohit, Qiao, Yuanyuan, Poliakov, Anton, Yocum, Anastasia K., Li, Yong, Chen, Wei, Cao, Xuhong, Jiang, Xia, Dahiya, Arun, Harris, Clair, Feng, Felix Y., Kalantry, Sundeep, Qin, Zhaohui S., Dhanasekaran, Saravana M., Chinnaiyan, Arul M.

“…Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem…”
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Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes by Dhanasekaran, Saravana M., Alejandro Balbin, O, Chen, Guoan, Nadal, Ernest, Kalyana-Sundaram, Shanker, Pan, Jincheng, Veeneman, Brendan, Cao, Xuhong, Malik, Rohit, Vats, Pankaj, Wang, Rui, Huang, Stephanie, Zhong, Jinjie, Jing, Xiaojun, Iyer, Matthew, Wu, Yi-Mi, Harms, Paul W., Lin, Jules, Reddy, Rishindra, Brennan, Christine, Palanisamy, Nallasivam, Chang, Andrew C., Truini, Anna, Truini, Mauro, Robinson, Dan R., Beer, David G., Chinnaiyan, Arul M.

“…Lung cancer is emerging as a paradigm for disease molecular subtyping, facilitating targeted therapy based on driving somatic alterations. Here we perform…”
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The polycomb group protein EZH2 is involved in progression of prostate cancer by Chinnaiyan, Arul M, Varambally, Sooryanarayana, Dhanasekaran, Saravana M, Zhou, Ming, Barrette, Terrence R, Kumar-Sinha, Chandan, Sanda, Martin G, Ghosh, Debashis, Pienta, Kenneth J, Sewalt, Richard G. A. B, Otte, Arie P, Rubin, Mark A

“…Prostate cancer is a leading cause of cancer-related death in males and is second only to lung cancer. Although effective surgical and radiation treatments…”
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Delineation of prognostic biomarkers in prostate cancer by Chinnaiyan, Arul M, Dhanasekaran, Saravana M, Barrette, Terrence R, Ghosh, Debashis, Shah, Rajal, Varambally, Sooryanarayana, Kurachi, Kotoku, Pienta, Kenneth J, Rubin, Mark A

“…Prostate cancer is the most frequently diagnosed cancer in American men. Screening for prostate-specific antigen (PSA) has led to earlier detection of prostate…”
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Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer by Chinnaiyan, Arul M, Tomlins, Scott A, Laxman, Bharathi, Dhanasekaran, Saravana M, Helgeson, Beth E, Cao, Xuhong, Morris, David S, Menon, Anjana, Jing, Xiaojun, Cao, Qi, Han, Bo, Yu, Jindan, Wang, Lei, Montie, James E, Rubin, Mark A, Pienta, Kenneth J, Roulston, Diane, Shah, Rajal B, Varambally, Sooryanarayana, Mehra, Rohit

“…Recently, we identified recurrent gene fusions involving the 5′ untranslated region of the androgen-regulated gene TMPRSS2 and the ETS (E26…”
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The lncRNA PCAT29 inhibits oncogenic phenotypes in prostate cancer by Malik, Rohit, Patel, Lalit, Prensner, John R, Shi, Yang, Iyer, Matthew K, Subramaniyan, Shruthi, Carley, Alexander, Niknafs, Yashar S, Sahu, Anirban, Han, Sumin, Ma, Teng, Liu, Meilan, Asangani, Irfan A, Jing, Xiaojun, Cao, Xuhong, Dhanasekaran, Saravana M, Robinson, Dan R, Feng, Felix Y, Chinnaiyan, Arul M

“…Long noncoding RNAs (lncRNA) have recently been associated with the development and progression of a variety of human cancers. However, to date, the interplay…”
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Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer by Kim, Jung H, Dhanasekaran, Saravana M, Prensner, John R, Cao, Xuhong, Robinson, Daniel, Kalyana-Sundaram, Shanker, Huang, Christina, Shankar, Sunita, Jing, Xiaojun, Iyer, Matthew, Hu, Ming, Sam, Lee, Grasso, Catherine, Maher, Christopher A, Palanisamy, Nallasivam, Mehra, Rohit, Kominsky, Hal D, Siddiqui, Javed, Yu, Jindan, Qin, Zhaohui S, Chinnaiyan, Arul M

“…Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of prostate cancer progression. We mapped the global DNA methylation…”
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