Search Results - "DHAKSHINAMOORTHY, SARAVANAKUMAR"

Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders by Kannt, Aimo, Rajagopal, Sridharan, Hallur, Mahanandeesha S, Swamy, Indu, Kristam, Rajendra, Dhakshinamoorthy, Saravanakumar, Czech, Joerg, Zech, Gernot, Schreuder, Herman, Ruf, Sven

“…Nicotinamide- -methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from -adenosyl-methionine (SAM) to nicotinamide (Nam)…”
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A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders by Kannt, Aimo, Rajagopal, Sridharan, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Swaminathan, Srinivasan, Hallur, Mahanandeesha Siddappa, Kristam, Rajendra, Elvert, Ralf, Czech, Jörg, Pfenninger, Anja, Rudolph, Christine, Schreuder, Herman, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Birudukota, Swarnakumari, Shaik, Shama, Zope, Bharat Ravindra, Burri, Raghunadha Reddy, Anand, Niranjan Naranapura, Thakur, Manish Kumar, Singh, Manvi, Parveen, Reejuana, Kandan, Saravanan, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Ruf, Sven, Dhakshinamoorthy, Saravanakumar

“…Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the transfer of a methyl group from the co-factor S-adenosyl-L-methionine (SAM)…”
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Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene by Dhakshinamoorthy, S, Jaiswal, A K

“…Antioxidant response element (ARE) and nuclear transcription factor Nrf2 are known to regulate expression and coordinated induction of NQO1 and other…”
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Bach1 Competes with Nrf2 Leading to Negative Regulation of the Antioxidant Response Element (ARE)-mediated NAD(P)H:Quinone Oxidoreductase 1 Gene Expression and Induction in Response to Antioxidants by Dhakshinamoorthy, Saravanakumar, Jain, Abhinav K., Bloom, David A., Jaiswal, Anil K.

“…The antioxidant response element (ARE) and Nrf2 are known to regulate the expression and coordinated induction of genes encoding detoxifying enzymes including…”
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Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders by Ruf, Sven, Rajagopal, Sridharan, Kadnur, Sanjay Venkatachalapathi, Hallur, Mahanandeesha S., Rani, Shilpa, Kristam, Rajendra, Swaminathan, Srinivasan, Zope, Bharat Ravindra, Gondrala, Pavan Kumar, Swamy, Indu, Putta, V. P. Rama Kishore, Kandan, Saravanan, Zech, Gernot, Schreuder, Herman, Rudolph, Christine, Elvert, Ralf, Czech, Joerg, Birudukota, Swarnakumari, Siddiqui, M. Amir, Anand, Niranjan Naranapura, Mane, Vishal Subhash, Dittakavi, Sreekanth, Suresh, Juluri, Gosu, Ramachandraiah, Ramesh, Mullangi, Yura, Takeshi, Dhakshinamoorthy, Saravanakumar, Kannt, Aimo

“…Nicotinamide N-methyltransferase (NNMT) is a metabolic regulator that catalyzes the methylation of nicotinamide (Nam) using the co-factor…”
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Reoxygenation‐specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia‐reperfusion injury by Leonard, Martin O., Kieran, Niamh E., Howell, Katherine, Burne, Melissa J., Varadarajan, Raghu, Dhakshinamoorthy, Saravanakumar, Porter, Alan G., O'Farrelly, Cliona, Rabb, Hamid, Taylor, Cormac T.

“…Tissue reoxygenation following hypoxia is associated with ischemia‐reperfusion injury (IRI) and may signal the development of ischemic preconditioning, an…”
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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase by Ruf, Sven, Hallur, Mahanandeesha Siddappa, Anchan, Nisha K., Swamy, Indu N., Murugesan, Karthikai Raj, Sarkar, Sayantani, Narasimhulu, Lokesh Kananti, Putta, V.P. Rama Kishore, Shaik, Shama, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Singh, Manvi, Burri, Raghunadha Reddy, Kristam, Rajendra, Schreuder, Herman, Czech, Joerg, Rudolph, Christine, Marker, Alexander, Langer, Thomas, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Kannt, Aimo, Dhakshinamoorthy, Saravanakumar, Rajagopal, Sridharan

“…Compound 12 Human/mouse NNMT enzymatic inhibition (IC50): 0.58/4.5 µM. Inhibition of MNA in U2OS/3T3L1 cell based assay: 0.3/2.1 µM. Human/mouse metabolic…”
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Nitric Oxide-induced Transcriptional Up-regulation of Protective Genes by Nrf2 via the Antioxidant Response Element Counteracts Apoptosis of Neuroblastoma Cells by Dhakshinamoorthy, Saravanakumar, Porter, Alan G

“…Nitric oxide (NO) is a signaling molecule that in excess causes cell death. Here we report a mechanism of NO-induced transcriptional up-regulation of genes…”
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ATP citrate lyase inhibitor Bempedoic Acid alleviate long term HFD induced NASH through improvement in glycemic control, reduction of hepatic triglycerides & total cholesterol, modulation of inflammatory & fibrotic genes and improvement in NAS score by Sanjay, K.V., Vishwakarma, Santosh, Zope, Bharat Ravindra, Mane, Vishal Subhash, Mohire, Sunil, Dhakshinamoorthy, Saravanakumar

“…Non-alcoholic fatty liver disease (NAFLD) and Non-alcoholic steatohepatitis (NASH) are chronic liver disorders, the prevalence of which is increasing…”
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Small Maf (MafG and MafK) Proteins Negatively Regulate Antioxidant Response Element-mediated Expression and Antioxidant Induction of the NAD(P)H:Quinone Oxidoreductase1 Gene by Dhakshinamoorthy, Saravanakumar, Jaiswal, Anil K.

“…The antioxidant response element (ARE) is known to regulate expression and induction of NQO1, GST Ya, and other detoxifying enzyme genes in response to…”
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c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction by DHAKSHINAMOORTHY, Saravanakumar, JAISWAL, Anil K

“…Anti-oxidant response element (ARE) and nuclear factors including Nrf2 and small Maf (MafG and MafK) proteins are known to regulate expression and induction of…”
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Apoptosis initiated by dependence receptors: a new paradigm for cell death? by Porter, Alan G., Dhakshinamoorthy, Saravanakumar

“…A distinct group of receptors including DCC, UNC5, RET and Ptc1 is known to function in ligand‐dependent neuronal growth and differentiation or axon guidance…”
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Site-directed mutagenesis of cysteine to serine in the DNA binding regionof Nrf2 decreases its capacity to upregulate antioxidant responseelement-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene by Bloom, David, Dhakshinamoorthy, Saravanakumar, Jaiswal, Anil K

“…NF-E2 related factor 2 (Nrf2) is a CNC/b-zip protein that regulates antioxidant response element (ARE)-mediated expression, and antioxidant induction, of…”
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High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N‑Methyltransferase (NNMT) by Policarpo, Rocco L, Decultot, Ludovic, May, Elizabeth, Kuzmič, Petr, Carlson, Samuel, Huang, Danny, Chu, Vincent, Wright, Brandon A, Dhakshinamoorthy, Saravanakumar, Kannt, Aimo, Rani, Shilpa, Dittakavi, Sreekanth, Panarese, Joseph D, Gaudet, Rachelle, Shair, Matthew D

“…Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). NNMT overexpression…”
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High‐throughput screening assay for the quantification of Cer d18:1/16:0, d18:1/24:0, d18:1/24:1, d18:1/18:0, d18:1/14:0, d18:1/20:0, and d18:1/22:0 in HepG2 cells using RapidFire mass spectrometry by Dittakavi, Sreekanth, Mahadevan, Lavanya, Chandrashekar, Devaraj V., Bhamidipati, Ravi Kanth, Suresh, Juluri, Dhakshinamoorthy, Saravanakumar, Li, Ziyu, Baerenz, Felix, Tennagels, Norbert, Mullangi, Ramesh

“…Ceramides are known to be involved in various biological processes with their physiological levels elevated in various disease conditions such as diabetes,…”
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Cover Image by Dittakavi, Sreekanth, Mahadevan, Lavanya, Chandrashekar, Devaraj V., Bhamidipati, Ravi Kanth, Suresh, Juluri, Dhakshinamoorthy, Saravanakumar, Li, Ziyu, Baerenz, Felix, Tennagels, Norbert, Mullangi, Ramesh

“…The cover image is based on the Short Communication High throughput screening assay for quantification of Cer d18:1/16:0, d18:1/24:0, d18:1/24:1, d18:1/18:0,…”
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Cover Image by Dittakavi, Sreekanth, Mahadevan, Lavanya, Chandrashekar, Devaraj V., Bhamidipati, Ravi Kanth, Suresh, Juluri, Dhakshinamoorthy, Saravanakumar, Li, Ziyu, Baerenz, Felix, Tennagels, Norbert, Mullangi, Ramesh

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Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis by Suckling, Colin J., Mukherjee, Sambuddho, Khalaf, Abedawn I., Narayan, Ashwini, Scott, Fraser J., Khare, Sonal, Dhakshinamoorthy, Saravanakumar, Harnett, Margaret M., Harnett, William

“…Parasitic worms are receiving much attention as a potential new therapeutic approach to treating autoimmune and allergic conditions but concerns remain…”
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Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide by Swaminathan, Srinivasan, Birudukota, Swarnakumari, Thakur, Manish Kumar, Parveen, Reejuana, Kandan, Saravanan, Juluri, Suresh, Shaik, Shama, Anand, Niranjan Naranapura, Burri, Raghunadha Reddy, Kristam, Rajendra, Hallur, Mahanandeesha Siddappa, Rajagopal, Sridharan, Schreuder, Herman, Langer, Thomas, Rudolph, Christine, Ruf, Sven, Dhakshinamoorthy, Saravanakumar, Gosu, Ramachandraiah, Kannt, Aimo

“…Nicotinamide N-methyltransferase (NNMT) is a S-adenosyl-l-methionine (SAM)-dependent enzyme that catalyzes N-methylation of nicotinamide (NA) and other…”
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2134-P: Protection of Beta-Cell Mass from Diabetogenic Condition-Induced Apoptosis by the Inhibition of Mammalian STE20-Like Protein Kinase 1 (MST1) by SAMEERMAHMOOD, ZAHEERBASHA, SIVANANDHAN, DHANALAKSHMI, KALITA, BISWAJIT, RAMAIAH, SOWMYA, SIDDIQUI, AMIR, ZOPE, BHARAT R., KADNUR, SANJAY V., KANAVALLI, MADHURI, KRISHNAKUMAR, V., SWAMINATHAN, SRINIVASAN, RUDRESH, G., MOHIRE, SUNIL, BURRI, RAGHUNADHA R., KRISTAM, RAJENDRA, JEYARAJ, D.A, RAJAGOPAL, SRIRAM, DHAKSHINAMOORTHY, SARAVANAKUMAR

“…Impaired insulin secretion, a characteristic of type 2 diabetes (T2D) is partly attributed to decreased β-cell mass due to apoptotic cell death under…”
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