Search Results - "DHAENE, Karl"

Claudin-18 Splice Variant 2 Is a Pan-Cancer Target Suitable for Therapeutic Antibody Development by SAHIN, Ugur, KOSLOWSKI, Michael, DHAENE, Karl, USENER, Dirk, BRANDENBURG, Gunda, SEITZ, Gerhard, HUBER, Christoph, TÜRECI, Ozlem

“…Purpose: Antibody-based cancer therapies have emerged as the most promising therapeutics in oncology. The purpose of this study was to discover novel targets…”
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Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms by Wöll, Stefan, Schlitter, Anna Melissa, Dhaene, Karl, Roller, Marc, Esposito, Irene, Sahin, Ugur, Türeci, Özlem

“…The majority of pancreatic neoplasms are characterized by a generally lethal progress within a short period of time after primary diagnosis and the mortality…”
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MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes by Koslowski, Michael, Sahin, Ugur, Dhaene, Karl, Huber, Christoph, Türeci, Ozlem

“…Using a data mining approach for the discovery of new targets for antibody therapy of colon cancer, we identified MS4A12, a sequence homologue of CD20. We show…”
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Prostatic Leiomyoma: A Case Report by Ringoir, Annelies, Rappe, Bernard, Dhaene, Karl, Schallier, Denis

“…A pure leiomyoma of the prostate is a rare tumor. Less than 30 cases about prostatic leiomyoma have been reported. Pathologic anatomy examination is the only…”
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Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer by Grunwald, Carolin, Koslowski, Michael, Arsiray, Tülin, Dhaene, Karl, Praet, Marleen, Victor, Anja, Morresi‐Hauf, Alicia, Lindner, Michael, Passlick, Bernward, Lehr, Hans‐Anton, Schäfer, Stephan C., Seitz, Gerhard, Huber, Christoph, Sahin, Ugur, Türeci, Özlem

“…Cancer/germline (CG) antigens represent promising targets for widely applicable mono‐ and multiantigen cancer vaccines for nonsmall cell lung cancer (NSCLC)…”
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Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues by Klamp, Thorsten, Sahin, Ugur, Kyewski, Bruno, Schwendemann, Jochen, Dhaene, Karl, Türeci, Özlem

“…Defects in the autoimmune regulator (AIRE) gene cause the monogenic autoimmune disease autoimmune polyendocrinopathy syndrome type 1 (APS-1), which is…”
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A phase I dose-escalation study of IMAB362 (Zolbetuximab) in patients with advanced gastric and gastro-oesophageal junction cancer by Sahin, Ugur, Schuler, Martin, Richly, Heike, Bauer, Stefan, Krilova, Anna, Dechow, Tobias, Jerling, Markus, Utsch, Magdalena, Rohde, Christoph, Dhaene, Karl, Huber, Christoph, Türeci, Özlem

“…IMAB362 (Zolbetuximab) is a chimeric monoclonal antibody that binds to Claudin-18.2, a target antigen specific to cancer cells. In vitro, IMAB362 mediates cell…”
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Spreading Pattern and Tissue Response to Hyaluronic Acid Gel Injections in the Subcutis: Ultrasound Videos, Ultrasound Measurements, and Histology by Vandeputte, Joan, Leemans, Gaëlle, Dhaene, Karl, Forsyth, Ramses, Vanslembrouck, Jurgen, Hatem, Frank, Micheels, Patrick

“…Abstract Background Despite the popularity of hyaluronic acid (HA) filler treatments, few publications focus on their effects on adipose tissue. Objectives The…”
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Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals by Türeci, Özlem, Koslowski, Michael, Helftenbein, Gerd, Castle, John, Rohde, Christoph, Dhaene, Karl, Seitz, Gerhard, Sahin, Ugur

“…Claudin-18 isoform 2 (CLDN18.2) is one of the few members of the human claudin family of tight junction molecules with strict restriction to one cell lineage…”
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Zolbetuximab combined with EOX as first-line therapy in advanced CLDN18.2+ gastric (G) and gastroesophageal junction (GEJ) adenocarcinoma: Updated results from the FAST trial by Sahin, Ugur, Tureci, Özlem, Manikhas, Georgy M., Lordick, Florian, Rusyn, Andriy, Vynnychenko, Ihor, Dudov, Assen, Bazin, Igor, Bondarenko, Igor, Melichar, Bohuslav, Dhaene, Karl, Wiechen, Kai, Maurus, Daniel, Schuler, Martin H., Al-Batran, Salah-Eddin

“…Abstract only 16 Background: Physiologically, the tight junction protein CLDN18.2 is present only in the gastric mucosa. Upon malignant transformation,…”
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Expression of Claudin 18.2 and HER2 in gastric, gastroesophageal junction, and esophageal cancers: Results from the FAST study by Schuler, Martin H., Al-Batran, Salah-Eddin, Zvirbule, Zanete, Manikhas, Georgy, Lordick, Florian, Rusyn, Andriy V., Vynnychenko, Ihor, Dudov, Assen, Bazin, Igor, Melichar, Bohuslav, Dhaene, Karl, Wiechen, Kai, Maurus, Daniel, Tureci, Özlem, Sahin, Ugur

“…Abstract only 4038 Background: Claudin 18.2 (CLDN18.2), a gastric mucosa tight junction protein, is aberrantly expressed in various cancers. In the FAST Phase…”
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Standard Versus Extended Lymphadenectomy Associated With Pancreatoduodenectomy in the Surgical Treatment of Adenocarcinoma of the Head of the Pancreas: A Multicenter, Prospective, Randomized Study by Pedrazzoli, Sergio, DiCarlo, Valerio, Dionigi, Renzo, Mosca, Franco, Pederzoli, Paolo, Pasquali, Claudio, Klöppel, Günter, Dhaene, Karl, Michelassi, Fabrizio

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Functional TCR retrieval from single antigen-specific human T cells reveals multiple novel epitopes by Simon, Petra, Omokoko, Tana A, Breitkreuz, Andrea, Hebich, Lisa, Kreiter, Sebastian, Attig, Sebastian, Konur, Abdo, Britten, Cedrik M, Paret, Claudia, Dhaene, Karl, Türeci, Özlem, Sahin, Ugur

“…The determination of the epitope specificity of disease-associated T-cell responses is relevant for the development of biomarkers and targeted immunotherapies…”
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Telomeres, telomerase and cancer : an up-date by DHAENE, K, VAN MARCK, E, PARWARESCH, R

“…In the mid 1990s, the hypothesis emerged that the upregulation or re-expression of a telomere-synthesising ribonucleoprotein, called telomerase, is a critical…”
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In silico strategy for detection of target candidates for antibody therapy of solid tumors by Helftenbein, Gerd, Koslowski, Michael, Dhaene, Karl, Seitz, Gerhard, Sahin, Ugur, Türeci, Özlem

“…In contrast to earlier attempts for the identification of target candidates suitable for monoclonal antibody (mAb) based cancer therapies we concentrated on…”
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Syndecan-1 expression in malignant mesothelioma: correlation with cell differentiation, WT1 expression, and clinical outcome by Kumar-singh, Samir, Jacobs, Werner, Dhaene, Karl, Weyn, Barbara, Bogers, Johannes, Weyler, Joost, Marck, Eric Van

“…Syndecan‐1 binds basic fibroblast growth factor (bFGF), modulates neovascularization, plays a role in epithelial differentiation and is up‐regulated by WT1…”
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Neonatal pulmonary interstitial glycogen accumulation disorder by SMETS, Koenraad, DHAENE, Karl, SCHELSTRAETE, Petra, MEERSSCHAUT, Valérie, VANHAESEBROUCK, Piet

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SV40 large T-antigen and human pleural mesothelioma : Screening by polymerase chain reaction and tyramine-amplified immunohistochemistry by DHAENE, K, VERHULST, A, VAN MARCK, E

“…DNA-like sequences of the p53 and pRB-inactivating simian virus 40 large T-antigen (SV40 LTag) have recently been found in mesotheliomas in the United States…”
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Expression profile of telomerase subunits in human pleural mesothelioma by Dhaene, Karl, Wauters, Jan, Weyn, Barbara, Timmermans, Jean-Pierre, van Marck, Eric

“…Using the TRAP assay, telomerase activity was previously detected in over 90% of human pleural mesotheliomas (MMs), but not in mesothelial cell cultures…”
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SV40 large T-antigen and human pleural mesothelioma by Dhaene, Karl, Verhulst, Anja, Van Marck, E.

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