Search Results - "DEZIEL, Mark R"

Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin by Gumbo, Tawanda, Louie, Arnold, Deziel, Mark R, Liu, Weiguo, Parsons, Linda M, Salfinger, Max, Drusano, George L

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Selection of a Moxifloxacin Dose That Suppresses Drug Resistance in Mycobacterium tuberculosis, by Use of an In Vitro Pharmacodynamic Infection Model and Mathematical Modeling by Gumbo, Tawanda, Louie, Arnold, Deziel, Mark R., Parsons, Linda M., Salfinger, Max, Drusano, George L.

“…Background. Moxifloxacin is a quinolone antimicrobial that has potent activity against Mycobacterium tuberculosis. To optimize moxifloxacin dose and dose…”
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The Relationship between Quinolone Exposures and Resistance Amplification Is Characterized by an Inverted U: a New Paradigm for Optimizing Pharmacodynamics To Counterselect Resistance by TAM, Vincent H, LOUIE, Arnold, DEZIEL, Mark R, WEIGUO LIU, DRUSANO, George L

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Bacterial-Population Responses to Drug-Selective Pressure: Examination of Garenoxacin’s Effect on Pseudomonas aeruginosa by Tam, Vincent H., Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Leary, Robert, Drusano, George L.

“…The emergence of resistance to antibiotics is a serious problem often related to suboptimal drug dosing; such suboptimal dosing results in the preferential…”
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Pharmacodynamic Evidence that Ciprofloxacin Failure against Tuberculosis Is Not Due to Poor Microbial Kill but to Rapid Emergence of Resistance by GUMBO, Tawanda, LOUIE, Arnold, DEZIEL, Mark R, DRUSANO, George L

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Anidulafungin Pharmacokinetics and Microbial Response in Neutropenic Mice with Disseminated Candidiasis by GUMBO, Tawanda, DRUSANO, George L, WEIGUO LIU, LEI MA, DEZIEL, Mark R, DRUSANO, Michael F, LOUIE, Arnold

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Impact of Resistance Selection and Mutant Growth Fitness on the Relative Efficacies of Streptomycin and Levofloxacin for Plague Therapy by Louie, Arnold, Deziel, Mark R, Liu, Weiguo, Drusano, George L

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Effective Antimicrobial Regimens for Use in Humans for Therapy of Bacillus anthracis Infections and Postexposure Prophylaxis by DEZIEL, Mark R, HEINE, Henry, LOUIE, Arnold, KAO, Mark, BYRNE, William R, BASSET, Jennifer, MILLER, Lynda, BUSH, Karen, KELLY, Michael, DRUSANO, G. L

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Pharmacodynamics of Cidofovir for Vaccinia Virus Infection in an In Vitro Hollow-Fiber Infection Model System by MCSHARRY, James J, DEZIEL, Mark R, ZAGER, Kris, QINGMEI WENG, DRUSANO, George L

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Quinolone Efflux Pumps Play a Central Role in Emergence of Fluoroquinolone Resistance in Streptococcus pneumoniae by Jumbe, Nelson L, Louie, Arnold, Miller, Michael H, Liu, Weiguo, Deziel, Mark R, Tam, Vincent H, Bachhawat, Reetu, Drusano, George L

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In Vitro Infection Model Characterizing the Effect of Efflux Pump Inhibition on Prevention of Resistance to Levofloxacin and Ciprofloxacin in Streptococcus pneumoniae by Louie, Arnold, Brown, David L, Liu, Weiguo, Kulawy, Robert W, Deziel, Mark R, Drusano, George L

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Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy by Jumbe, Nelson, Louie, Arnold, Leary, Robert, Liu, Weiguo, Deziel, Mark R, Tam, Vincent H, Bachhawat, Reetu, Freeman, Christopher, Kahn, James B, Bush, Karen, Dudley, Michael N, Miller, Michael H, Drusano, George L

“…The worldwide increase in the prevalence of multi-antibiotic-resistant bacteria has threatened the physician's ability to provide appropriate therapy for…”
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Quinolone efflux pumps play a central role in emergence of fluoroquinolone resistance in Streptococcus pneumoniae by JUMBE, Nelson L, LOUIE, Arnold, MILLER, Michael H, WEIGUO LIU, DEZIEL, Mark R, TARN, Vincent H, BACHHAWAT, Reetu, DRUSANO, George L

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Myofibrillar protein structure and assembly during idiopathic dilated cardiomyopathy by Levine, R J, Caulfield, J B, Norton, P, Chantler, P D, Deziel, M R, Slayter, H S, Margossian, S S

“…A neutral protease, mekratin, active in human hearts at end stage idiopathic dilated cardiomyopathy (IDC), mediates the breakdown of cardiac myosin LC2. Myosin…”
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Retinoic acid inhibition of thyroxine binding to human transthyretin by Smith, T J, Davis, F B, Deziel, M R, Davis, P J, Ramsden, D B, Schoenl, M

“…All-trans retinoic acid is a potent inhibitor of [125I]-thyroxine (T4) binding to human erythrocyte membranes and can block the activation by thyroid hormone…”
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Phosphorylation of the human erythrocyte glucose transporter by protein kinase C: localization of the site of in vivo and in vitro phosphorylation by Deziel, M R, Lippes, H A, Rampal, A L, Jung, C Y

“…1. The human erythrocyte glucose transporter was phosphorylated in vitro by protein kinase C. 2. Tryptic cleavage of phosphorylated native transporter produced…”
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Purification of a high molecular weight follicle-stimulating hormone receptor-binding inhibitor from human follicular fluid by Lee, D W, Grasso, P, Dattatreyamurty, B, Deziel, M R, Reichert, Jr, L E

“…In a previous study we reported the presence in human follicular fluid (hFF) of a FSH receptor-binding inhibitor (hFSH-BI) with FSH agonist activity, which was…”
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Synthetic peptides corresponding to residues 551 to 555 and 650 to 653 of the rat testicular follicle-stimulating hormone (FSH) receptor are sufficient for post-receptor modulation of Sertoli cell responsiveness to FSH stimulation by Grasso, Patricia, Deziel, Mark R., Reichert, Leo E.

“…We have recently demonstrated that synthetic peptides corresponding to the third cytoplasmic (3i) loop (residues 533 to 555) and a region in the…”
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Increased plasma IGF-1 levels but lack of changes in adipocyte glucose transport in weanling rats with dorsomedial hypothalamic nucleus lesions 1 year after lesion production by Bernardis, Lee L., Benedict, Mark R., Deziel, Mark R., Davis, Faith B., Davis, Paul J.

“…Experimental destruction of the dorsomedial hypothalamic nuclei (DMN) in weanling rats exerts an antiaging effect by preventing microalbuminuria and kidney…”
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Biotin-conjugated reagents as site-specific probes of membrane protein structure: application to the study of the human erythrocyte hexose transporter by Deziel, M R, Mau, M M

“…A novel labeling procedure using biotin-conjugated protein-modifying reagents has been employed to study the structure and function of the human erythrocyte…”
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