Search Results - "DEWALD, W"

Anthracycline Dose Intensification in Acute Myeloid Leukemia by Fernandez, Hugo F, Sun, Zhuoxin, Yao, Xiaopan, Litzow, Mark R, Luger, Selina M, Paietta, Elisabeth M, Racevskis, Janis, Dewald, Gordon W, Ketterling, Rhett P, Bennett, John M, Rowe, Jacob M, Lazarus, Hillard M, Tallman, Martin S

“…Patients with AML who were between 17 and 60 years of age were randomly assigned to receive induction therapy with the standard dose of daunorubicin or twice…”
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The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both “atypical” myeloproliferative disorders and myelodysplastic syndromes by Steensma, David P., Dewald, Gordon W., Lasho, Terra L., Powell, Heather L., McClure, Rebecca F., Levine, Ross L., Gilliland, D. Gary, Tefferi, Ayalew

“…A somatic mutation in the JH2 autoinhibitory domain of the Janus kinase 2 (JAK2) tyrosine kinase was recently described in polycythemia vera, essential…”
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Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial by Moorman, Anthony V., Harrison, Christine J., Buck, Georgina A.N., Richards, Sue M., Secker-Walker, Lorna M., Martineau, Mary, Vance, Gail H., Cherry, Athena M., Higgins, Rodney R., Fielding, Adele K., Foroni, Letizia, Paietta, Elisabeth, Tallman, Martin S., Litzow, Mark R., Wiernik, Peter H., Rowe, Jacob M., Goldstone, Anthony H., Dewald, Gordon W.

“…Pretreatment cytogenetics is a known predictor of outcome in hematologic malignancies. However, its usefulness in adult acute lymphoblastic leukemia (ALL) is…”
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Phase III Trial of Fludarabine Plus Cyclophosphamide Compared With Fludarabine for Patients With Previously Untreated Chronic Lymphocytic Leukemia: US Intergroup Trial E2997 by FLINN, Ian W, NEUBERG, Donna S, TALLMAN, Martin S, GREVER, Michael R, DEWALD, Gordon W, BENNETT, John M, PAIETTA, Elisabeth M, HUSSEIN, Mohamad A, APPELBAUM, Frederick R, LARSON, Richard A, MOORE, Dennis F

“…The combination of fludarabine and cyclophosphamide is an effective regimen for patients with chronic lymphocytic leukemia (CLL). However, it may be…”
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Comprehensive Assessment of Genetic and Molecular Features Predicting Outcome in Patients With Chronic Lymphocytic Leukemia: Results From the US Intergroup Phase III Trial E2997 by GREVER, Michael R, LUCAS, David M, PAIETTA, Elisabeth, JELINEK, Diane F, GRIBBEN, John G, BYRD, John C, DEWALD, Gordon W, NEUBERG, Donna S, REED, John C, KITADA, Shinichi, FLINN, Ian W, TALLMAN, Martin S, APPELBAUM, Frederick R, LARSON, Richard A

“…Genomic features including unmutated immunoglobulin variable region heavy chain (IgVH) genes, del(11q22.3), del(17p13.1), and p53 mutations have been reported…”
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Clinical and biologic implications of recurrent genomic aberrations in myeloma by Fonseca, Rafael, Blood, Emily, Rue, Montserrat, Harrington, David, Oken, Martin M., Kyle, Robert A., Dewald, Gordon W., Van Ness, Brian, Van Wier, Scott A., Henderson, Kimberly J., Bailey, Richard J., Greipp, Philip R.

“…Nonrandom recurrent chromosomal abnormalities are ubiquitous in multiple myeloma (MM) and include, among others, translocations of the immunoglobulin heavy…”
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The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America by REMSTEIN, Ellen D, DOGAN, Ahmet, EINERSON, Richard R, PATERNOSTER, Sarah F, FINK, Stephanie R, LAW, Mark, DEWALD, Gordon W, KURTIN, Paul J

“…Several balanced translocations have been identified in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) but there…”
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Prospective Evaluation of Clonal Evolution During Long-Term Follow-Up of Patients With Untreated Early-Stage Chronic Lymphocytic Leukemia by SHANAFELT, Tait D, WITZIG, Thomas E, GEYER, Susan, ZENT, Clive S, CALL, Tim G, JELINEK, Diane F, KAY, Neil E, DEWALD, Gordon W, FINK, Stephanie R, JENKINS, Robert B, PATERNOSTER, Sarah F, SMOLEY, Stephanie A, STOCKERO, Kimberly J, NAST, Danielle M, FLYNN, Heather C, TSCHUMPER, Renee C

“…Retrospective studies suggest cytogenetic abnormalities detected by interphase fluorescent in situ hybridization (FISH) can identify patients with chronic…”
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Extramedullary acute myeloid leukemia presenting in young adults demonstrates sensitivity to high-dose anthracycline: a subset analysis from ECOG-ACRIN 1900 by Fernandez, Hugo F, Sun, Zhuoxin, Litzow, Mark R, Luger, Selina M, Paietta, Elisabeth, Racevskis, Janis, Levine, Ross L, Patel, Jay P, Abdel-Wahab, Omar, Ketterling, Rhett P, Dewald, Gordon W, Bennett, John M, Rowe, Jacob M, Lazarus, Hillard M, Tallman, Martin S

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JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained by STEENSMA, D. P, MCCLURE, R. F, KARP, J. E, TEFFERI, A, LASHO, T. L, POWELL, H. L, DEWALD, G. W, KAUFMANN, S. H

“…Signal transducer and activator of transcription (STAT) proteins are phosphorylated and activated by Janus kinases (JAKs). Recently, several groups identified…”
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Relationship of patient survival and chromosome anomalies detected in metaphase and/or interphase cells at diagnosis of myeloma by Dewald, Gordon W., Therneau, Terry, Larson, Dirk, Lee, You Kyoung, Fink, Stephanie, Smoley, Stephanie, Paternoster, Sarah, Adeyinka, Adewale, Ketterling, Rhett, Van Dyke, Daniel L., Fonseca, Rafael, Kyle, Robert

“…The clinical efficacy of evaluating genetic anomalies in metaphase cells versus interphase nuclei for multiple myeloma (MM) is poorly understood. Therefore,…”
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Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma by DEBES-MARUN, C. S, DEWALD, G. W, DISPENZIERI, A, LACY, M. Q, RAJKUMAR, S. V, LUST, J. A, GREIPP, P. R, FONSECA, R, BRYANT, S, PICKEN, E, SANTANA-DAVILA, R, GONZALEZ-PAZ, N, WINKLER, J. M, KYLE, R. A, GERTZ, M. A, WITZIG, T. E

“…The nonrandom recurrent nature of chromosome abnormalities in myeloma suggests a role for them in disease pathogenesis. We performed a careful cytogenetic…”
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Percentage of Smudge Cells on Routine Blood Smear Predicts Survival in Chronic Lymphocytic Leukemia by NOWAKOWSKI, Grzegorz S, HOYER, James D, WITZIG, Thomas E, KAY, Neil E, SHANAFELT, Tait D, ZENT, Clive S, CALL, Timothy G, BONE, Nancy D, LAPLANT, Betsy, DEWALD, Gordon W, TSCHUMPER, Renee C, JELINEK, Diane F

“…Smudge cells are ruptured chronic lymphocytic leukemia (CLL) cells appearing on the blood smears of CLL patients. Our recent findings suggest that the number…”
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Guidance for Fluorescence in Situ Hybridization Testing in Hematologic Disorders by Wolff, Daynna J, Bagg, Adam, Cooley, Linda D, Dewald, Gordon W, Hirsch, Betsy A, Jacky, Peter B, Rao, Kathleen W, Rao, P. Nagesh

“…Fluorescence in situ hybridization (FISH) provides an important adjunct to conventional cytogenetics and molecular studies in the evaluation of chromosome…”
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FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia by Pardanani, Animesh, Brockman, Stephanie R., Paternoster, Sarah F., Flynn, Heather C., Ketterling, Rhett P., Lasho, Terra L., Ho, Ching-Liang, Li, Chin-Yang, Dewald, Gordon W., Tefferi, Ayalew

“…A novel oncogenic mutation (FIP1L1-PDGFRA), which results in a constitutively activated platelet-derived growth factor receptor-α (PDGFRA), has been invariably…”
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CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy by Pardanani, Animesh, Ketterling, Rhett P., Brockman, Stephanie R., Flynn, Heather C., Paternoster, Sarah F., Shearer, Brandon M., Reeder, Terra L., Li, Chin-Yang, Cross, Nicholas C.P., Cools, Jan, Gilliland, D. Gary, Dewald, Gordon W., Tefferi, Ayalew

“…Imatinib mesylate is effective in the treatment of hematologic malignancies that are characterized by either abl- or PDGFRβ- activating mutations. The drug is…”
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Impact of cytogenetics on outcome of matched unrelated donor hematopoietic stem cell transplantation for acute myeloid leukemia in first or second complete remission by Tallman, Martin S., Dewald, Gordon W., Gandham, Sharavi, Logan, Brent R., Keating, Armand, Lazarus, Hillard M., Litzow, Mark R., Mehta, Jayesh, Pedersen, Tanya, Pérez, Waleska S., Rowe, Jacob M., Wetzler, Meir, Weisdorf, Daniel J.

“…We compared the treatment-related mortality, relapse rate, disease-free survival (DFS), and overall survival (OS) by cytogenetic risk group of 261 patients…”
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Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia by Tefferi, Ayalew, Mesa, Ruben A., Schroeder, Georgene, Hanson, Curtis A., Li, Chin‐Yang, Dewald, Gordon W.

“…The prognostic significance of bone marrow cytogenetic lesions in myelofibrosis with myeloid metaplasia (MMM) was investigated in a retrospective series of 165…”
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Rotatable serial co-sputtering of doped titania by Sittinger, V., Pflug, A., Dewald, W., Jung, S., Britze, C., Kaiser, A., Werner, W., Szyszka, B., Bräuer, G.

“…Serial co-sputtering is an extension of conventional magnetron sputtering: it utilizes cylindrical primary rotating sputter sources within a metallic or…”
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Analysis of clonal B‐cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B‐chronic lymphocytic leukaemia by Jelinek, Diane F., Tschumper, Renee C., Geyer, Susan M., Bone, Nancy D., Dewald, Gordon W., Hanson, Curtis A., Stenson, Mary J., Witzig, Thomas E., Tefferi, Ayalew, Kay, Neil E.

“…Recent reports suggest that the expression of germline (GL) Ig variable region heavy‐chain genes (VH) is a negative prognostic factor for B‐cell chronic…”
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