Search Results - "DEVINCENZO, John"

Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants by Griffin, M. Pamela, Yuan, Yuan, Takas, Therese, Domachowske, Joseph B, Madhi, Shabir A, Manzoni, Paolo, Simões, Eric A.F, Esser, Mark T, Khan, Anis A, Dubovsky, Filip, Villafana, Tonya, DeVincenzo, John P

“…Nirsevimab, a monoclonal antibody with an extended half-life, is designed to protect infants from respiratory syncytial virus disease after a single…”
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Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33 by Saravia, Jordy, You, Dahui, Shrestha, Bishwas, Jaligama, Sridhar, Siefker, David, Lee, Greg I, Harding, Jeffrey N, Jones, Tamekia L, Rovnaghi, Cynthia, Bagga, Bindiya, DeVincenzo, John P, Cormier, Stephania A

“…Respiratory syncytial virus (RSV) is the most common cause of infant hospitalizations and severe RSV infections are a significant risk factor for childhood…”
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Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis by Pickles, Raymond J, DeVincenzo, John P

“…Infants and young children with acute onset of wheezing and reduced respiratory airflows are often diagnosed with obstruction and inflammation of the small…”
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Oral GS-5806 Activity in a Respiratory Syncytial Virus Challenge Study by DeVincenzo, John P, Whitley, Richard J, Mackman, Richard L, Scaglioni-Weinlich, Cecilia, Harrison, Lisa, Farrell, Eric, McBride, Stephen, Lambkin-Williams, Robert, Jordan, Robert, Xin, Yan, Ramanathan, Srini, O’Riordan, Thomas, Lewis, Sandra A, Li, Xiaoming, Toback, Seth L, Lin, Shao-Lee, Chien, Jason W

“…Respiratory syncytial virus is a common cause of illness and hospitalization, especially among infants and immunocompromised persons, but there are no accepted…”
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Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study by DeVincenzo, John P, McClure, Matthew W, Symons, Julian A, Fathi, Hosnieh, Westland, Christopher, Chanda, Sushmita, Lambkin-Williams, Rob, Smith, Patrick, Zhang, Qingling, Beigelman, Leo, Blatt, Lawrence M, Fry, John

“…There are limited treatment options for infection with the respiratory syncytial virus. In this human challenge model, a new oral nucleoside analogue,…”
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Comparison of antiviral resistance across acute and chronic viral infections by Mason, Stephen, Devincenzo, John P., Toovey, Stephen, Wu, Jim Z., Whitley, Richard J.

“…Antiviral therapy can lead to drug resistance, but multiple factors determine the frequency of drug resistance mutations and the clinical consequences. When…”
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Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus by Habibi, Maximillian S, Jozwik, Agnieszka, Makris, Spyridon, Dunning, Jake, Paras, Allan, DeVincenzo, John P, de Haan, Cornelis A M, Wrammert, Jens, Openshaw, Peter J M, Chiu, Christopher

“…Despite relative antigenic stability, respiratory syncytial virus (RSV) reinfects throughout life. After more than 40 years of research, no effective human…”
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Uncovering critical properties of the human respiratory syncytial virus by combining in vitro assays and in silico analyses by Beauchemin, Catherine A A, Kim, Young-In, Yu, Qin, Ciaramella, Giuseppe, DeVincenzo, John P

“…Many aspects of the respiratory syncytial virus (RSV) are still poorly understood. Yet these knowledge gaps have had and could continue to have adverse,…”
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randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus by DeVincenzo, John, Lambkin-Williams, Robert, Wilkinson, Tom, Cehelsky, Jeffrey, Nochur, Sara, Walsh, Edward, Meyers, Rachel, Gollob, Jared, Vaishnaw, Akshay

“…RNA interference (RNAi) is a natural mechanism regulating protein expression that is mediated by small interfering RNAs (siRNA). Harnessing RNAi has potential…”
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Respiratory Mucosal Proteome Quantification in Human Influenza Infections by Marion, Tony, Elbahesh, Husni, Thomas, Paul G, DeVincenzo, John P, Webby, Richard, Schughart, Klaus

“…Respiratory influenza virus infections represent a serious threat to human health. Underlying medical conditions and genetic make-up predispose some influenza…”
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Respiratory Syncytial Virus Load, Viral Dynamics, and Disease Severity in Previously Healthy Naturally Infected Children by Saleeby, Chadi M. El, Bush, Andy J., Harrison, Lisa M., Aitken, Jody A., DeVincenzo, John P.

“…Background. Respiratory syncytial virus (RSV) disease severity was thought to be a result of host immunopathology but alternatively may be driven by high-level…”
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Viral Load Drives Disease in Humans Experimentally Infected with Respiratory Syncytial Virus by DEVINCENZO, John P, WILKINSON, Tom, OXFORD, John, PAREEK, Rajat, MOORE, Ryves, WALSH, Ed, STUDHOLME, Robert, DORSETT, Preston, ALVAREZ, Rene, LAMBKIN-WILLIAMS, Robert, VAISHNAW, Akshay, CEHELSKY, Jeff, MEYERS, Rachel, NOCHUR, Saraswathy, HARRISON, Lisa, MEEKING, Patricia, MANN, Alex, MOANE, Elizabeth

“…Respiratory syncytial virus (RSV) is the leading cause of childhood lower respiratory infection, yet viable therapies are lacking. Two major challenges have…”
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Vaccination strategies against respiratory syncytial virus by Yamin, Dan, Jones, Forrest K., DeVincenzo, John P., Gertler, Shai, Kobiler, Oren, Townsend, Jeffrey P., Galvani, Alison P.

“…Respiratory syncytial virus (RSV) is the most common cause of US infant hospitalization. Additionally, RSV is responsible for 10,000 deaths annually among the…”
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ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients by Gottlieb, Jens, MD, Zamora, Martin R., MD, Hodges, Tony, MD, Musk, A.W., MD, Sommerwerk, Urte, MD, Dilling, Daniel, MD, FACP, Arcasoy, Selim, MD, DeVincenzo, John, MD, Karsten, Verena, PhD, Shah, Shaily, Bettencourt, Brian R., PhD, Cehelsky, Jeffrey, MBA, Nochur, Sara, PhD, Gollob, Jared, MD, Vaishnaw, Akshay, MD, Simon, Amy R., MD, Glanville, Allan R., MD, MBBS

“…Background Respiratory syncytial virus (RSV) infection in lung transplant (LTx) patients is associated with an increased incidence of bronchiolitis obliterans…”
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Human Genetic Factors and Respiratory Syncytial Virus Disease Severity by MIYAIRI, Isao, DEVINCENZO, John P

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein by DeVincenzo, John, Tait, Dereck, Efthimiou, John, Mori, Julie, Kim, Young-In, Thomas, Elaine, Wilson, Lynn, Harland, Rachel, Mathews, Neil, Cockerill, Stuart, Powell, Kenneth, Littler, Edward

“…Effective treatments for respiratory syncytial virus (RSV) infection are lacking. Here, we report a human proof-of-concept study for RV521, a small-molecule…”
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Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults by Bagga, Bindiya, Cehelsky, Jeffrey E., Vaishnaw, Akshay, Wilkinson, Tom, Meyers, Rachel, Harrison, Lisa M., Roddam, Philippa L., Walsh, Edward E., DeVincenzo, John P.

“…We studied preexisting respiratory syncytial virus (RSV)-specific serum and nasal antibodies and their correlation with infectivity, viral dynamics, and…”
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Mucosal immune responses predict clinical outcomes during influenza infection independently of age and viral load by Oshansky, Christine M, Gartland, Andrew J, Wong, Sook-San, Jeevan, Trushar, Wang, David, Roddam, Philippa L, Caniza, Miguela A, Hertz, Tomer, Devincenzo, John P, Webby, Richard J, Thomas, Paul G

“…Children are an at-risk population for developing complications following influenza infection, but immunologic correlates of disease severity are not…”
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Respiratory syncytial virus human experimental infection model: provenance, production, and sequence of low-passaged memphis-37 challenge virus by Kim, Young-In, DeVincenzo, John P, Jones, Bart G, Rudraraju, Rajeev, Harrison, Lisa, Meyers, Rachel, Cehelsky, Jeff, Alvarez, Rene, Hurwitz, Julia L

“…Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in children and is responsible for as many as 199,000 childhood…”
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Altered gut microbiota in infants is associated with respiratory syncytial virus disease severity by Harding, Jeffrey N, Siefker, David, Vu, Luan, You, Dahui, DeVincenzo, John, Pierre, JF, Cormier, Stephania A

“…Abstract Background Respiratory syncytial virus (RSV) is the number one cause of lower respiratory tract infections in infants. There are still no vaccines or…”
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