Search Results - "DEUTSCHER, S. L"

Effects of Thomsen-Friedenreich antigen-specific peptide P-30 on β-galactoside-mediated homotypic aggregation and adhesion to the endothelium of MDA-MB-435 human breast carcinoma cells by GLINSKY, V. V, HUFLEJT, M. E, GLINSKY, G. V, DEUTSCHER, S. L, QUINN, T. P

“…Both the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are…”
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Molecular Analysis of the 60-kDa Human Ro Ribonucleoprotein by Deutscher, Susan L., Harley, John B., Keene, Jack D.

“…Ro, or Sjogren syndrome type A (SS-A), antigen is the most prevalent of the human systemic autoimmune specificities and exists as an inabundant…”
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Mechanism of galactosylation in the Golgi apparatus. A Chinese hamster ovary cell mutant deficient in translocation of UDP-galactose across Golgi vesicle membranes by Deutscher, S L, Hirschberg, C B

“…The biochemical defect in the mutant Chinese hamster ovary cell lines Clone 13 (Briles, E. B., Li, E., and Kornfeld, S. (1977). J. Biol. Chem. 252, 1107-1116)…”
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A Sequence-Specific Conformational Epitope on U1 RNA is Recognized by a Unique Autoantibody by Deutscher, Susan L., Keene, Jack D.

“…An autoantibody from a patient with lupus-overlap syndrome was found to bind a specific region of U1 RNA. By using RNA sequence analysis, immunoprecipitation,…”
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The role of Thomsen-Friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium by GLINSKY, Vladislav V, GLINSKY, Gennadi V, RITTENHOUSE-OLSON, Kate, HUFLEJT, Margaret E, GLINSKII, Olga V, DEUTSCHER, Susan L, QUINN, Thomas P

“…Interactions of metastatic cancer cells with vasculatory endothelium are critical during early stages of cancer metastasis. Understanding the molecular…”
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Translocation across Golgi vesicle membranes: a CHO glycosylation mutant deficient in CMP-sialic acid transport by Deutscher, S L, Nuwayhid, N, Stanley, P, Briles, E I, Hirschberg, C B

“…Golgi vesicle membranes from the Lec2 CHO glycosylation mutant translocate CMP-sialic acid at only 2% the rate of vesicles from wild-type CHO cells. The…”
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The 19-kDa glycoprotein coded by region E3 of adenovirus. Purification, characterization, and structural analysis by Wold, W S, Cladaras, C, Deutscher, S L, Kapoor, Q S

“…The 19-kDa glycoprotein (gp 19K) coded by early region E3 of adenovirus is of interest as a model for glycoprotein processing and sorting, as well as for the…”
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Crystal structure of an antigen-binding fragment bound to single-stranded DNA by Tanner, J J, Komissarov, A A, Deutscher, S L

“…Antibodies to DNA are characteristic of the autoimmune disease systemic lupus erythematosus (SLE) and they also serve as models for the study of protein-DNA…”
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Long‐term outcome in mixed connective tissue disease: Longitudinal clinical and serologic findings by Burdt, Mark A., Hoffman, Robert W., Deutscher, Susan L., Wang, Grace S., Johnson, Jane C., Sharp, Gordon C.

“…Objective To determine the long‐term clinical and immunologic outcomes in a well‐characterized cohort of 47 patients with mixed connective tissue disease…”
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Evidence for Structural Plasticity of Heavy Chain Complementarity-determining Region 3 in Antibody–ssDNA Recognition by Schuermann, Jonathan P., Prewitt, Season P., Davies, Christopher, Deutscher, Susan L., Tanner, John J.

“…Anti-DNA antibodies play important roles in the pathogenesis of autoimmune diseases. They also represent a unique and relatively unexplored class of…”
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Isolation and characterization of nucleic acid-binding antibody fragments from autoimmune mice-derived bacteriophage display libraries by Calcutt, M J, Kremer, M T, Giblin, M F, Quinn, T P, Deutscher, S L

“…The display of antibody fragments (Fab) on the surface of filamentous bacteriophage and selection of phage that bind to a particular antigen has enabled the…”
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Subfractionation of Rat Liver Golgi Apparatus: Separation of Enzyme Activities Involved in the Biosynthesis of the Phosphomannosyl Recognition Marker in Lysosomal Enzymes by Deutscher, Susan L., Creek, Kim E., Merion, Michael, Hirschberg, Carlos B.

“…A highly purified Golgi apparatus preparation from rat liver was subfractionated on a Percoll gradient into two major protein peaks of similar size that…”
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The cDNA sequence encoding human protein kinase C-zeta by Barbee, J L, Deutscher, S L, Loomis, C R, Burns, D J

“…A 1779-bp complementary DNA (cDNA) that encodes protein kinase C-zeta (PKC-zeta) has been isolated from a human frontal cortex library using traditional…”
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High-throughput fluorescence spectroscopic analysis of affinity of peptides displayed on bacteriophage by Landon, Linda A., Harden, Wesley, Illy, Cynthia, Deutscher, Susan L.

“…Fluorescence spectroscopy titrations, although widely used to analyze binding affinity, are not an efficient screening method for detecting high-affinity…”
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Characterization of peptides that bind the tumor-associated Thomsen-Friedenreich antigen selected from bacteriophage display libraries by Peletskaya, Elena N, Glinsky, Vladislav V, Glinsky, Gennadi V, Deutscher, Susan L, Quinn, Thomas P

“…Peptides with high affinities and specificities for numerous proteins and nucleic acids have been previously identified from random peptide bacteriophage…”
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Thermodynamics of Fab−ssDNA Interactions:  Contribution of Heavy Chain Complementarity Determining Region 3 by Komissarov, Andrey A, Deutscher, Susan L

“…The recombinant anti-ssDNA Fab, DNA-1, and 16 heavy chain complementarity determining region 3 (HCDR3) mutant variants were selected for thermodynamic…”
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Novel deletion mutants that enhance a distant upstream 5′ splice in the E3 transcription unit of adenovirus 2 by Deutscher, Susan L., Bhat, Bheem M., Pursley, Michael H., Cladaras, Christos, Wold, William S.M.

“…Region E3 of adenovirus is a “complex” transcription unit: i.e.different mRNAs and proteins arise by differential RNA 3′ end selection and differential…”
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Analysis of anti-U1 RNA antibodies in patients with connective tissue disease. Association with HLA and clinical manifestations of disease by Hoffman, R W, Sharp, G C, Deutscher, S L

“…To determine the prevalence of anti-U1 RNA antibodies in connective tissue disease (CTD) patients and evaluate immunogenetic and clinical features of patients…”
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Equilibrium binding studies of recombinant anti-single-stranded DNA Fab. Role of heavy chain complementarity-determining regions by Komissarov, A A, Calcutt, M J, Marchbank, M T, Peletskaya, E N, Deutsher, S L

“…We previously isolated nucleic acid-binding antibody fragments (Fab) from bacteriophage display libraries representing the immunoglobulin repertoire of…”
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In Vivo Selection of Phage for the Optical Imaging of PC-3 Human Prostate Carcinoma in Mice by Newton, Jessica R., Kelly, Kimberly A., Mahmood, Umar, Weissleder, Ralph, Deutscher, Susan L.

“…There is an increasing medical need to detect and spatially localize early and aggressive forms of prostate cancer. Affinity ligands derived from bacteriophage…”
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