Search Results - "DESOYE, GERNOT"

The Human Placenta in Diabetes and Obesity: Friend or Foe? The 2017 Norbert Freinkel Award Lecture by Desoye, Gernot

“…The placenta plays a key role in sustaining fetal growth and development. Due to its position between mother and fetus, it is exposed to changes in the…”
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The influence of placental metabolism on fatty acid transfer to the fetus by Perazzolo, Simone, Hirschmugl, Birgit, Wadsack, Christian, Desoye, Gernot, Lewis, Rohan M., Sengers, Bram G.

“…The factors determining fatty acid transfer across the placenta are not fully understood. This study used a combined experimental and computational modeling…”
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Epigenetic regulation of human placental function and pregnancy outcome: considerations for causal inference by Januar, Vania, BBmed (Hons), Desoye, Gernot, PhD, Novakovic, Boris, PhD, Cvitic, Silvija, PhD, Saffery, Richard, PhD

“…Epigenetic mechanisms, often defined as regulating gene activity independently of underlying DNA sequence, are crucial for healthy development. The sum total…”
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The Human Placenta in Gestational Diabetes Mellitus by Desoye, Gernot, Hauguel-de Mouzon, Sylvie

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The role of oxidative stress in the pathophysiology of gestational diabetes mellitus by Lappas, Martha, Hiden, Ursula, Desoye, Gernot, Froehlich, Julia, Hauguel-de Mouzon, Sylvie, Jawerbaum, Alicia

“…Normal human pregnancy is considered a state of enhanced oxidative stress. In pregnancy, it plays important roles in embryo development, implantation,…”
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Insulin and the IGF system in the human placenta of normal and diabetic pregnancies by Hiden, Ursula, Glitzner, Elisabeth, Hartmann, Michaele, Desoye, Gernot

“…The insulin/insulin‐like growth factor (IGF) system regulates fetal and placental growth and development. In maternal diabetes, components of this system…”
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Placental mobilization of free fatty acids contributes to altered materno-fetal transfer in obesity by Hirschmugl, Birgit, Perazzolo, Simone, Sengers, Bram G., Lewis, Rohan M., Gruber, Michael, Desoye, Gernot, Wadsack, Christian

“…Background Metabolic changes in obese pregnant women, such as changes of plasma lipids beyond physiological levels, may subsequently affect fetal development…”
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In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta by Granitzer, Sebastian, Ellinger, Isabella, Khan, Rumsha, Gelles, Katharina, Widhalm, Raimund, Hengstschläger, Markus, Zeisler, Harald, Desoye, Gernot, Tupova, Lenka, Ceckova, Martina, Salzer, Hans, Gundacker, Claudia

“…Methyl mercury (MeHg) is an organic highly toxic compound that is transported efficiently via the human placenta. Our previous data suggest that MeHg is taken…”
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Placental DNA methylation in pregnancies complicated by maternal diabetes and/or obesity: State of the art and research gaps by Hjort, Line, Novakovic, Boris, Cvitic, Silvija, Saffery, Richard, Damm, Peter, Desoye, Gernot

“…Maternal diabetes and/or obesity in pregnancy are undoubtedly associated with later disease-risk in the offspring. The placenta, interposed between the mother…”
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Human Placental Hofbauer Cells Maintain an Anti-inflammatory M2 Phenotype despite the Presence of Gestational Diabetes Mellitus by Schliefsteiner, Carolin, Peinhaupt, Miriam, Kopp, Susanne, Lögl, Jelena, Lang-Olip, Ingrid, Hiden, Ursula, Heinemann, Akos, Desoye, Gernot, Wadsack, Christian

“…Hofbauer cells (HBCs) are macrophages of the feto-placental unit. Despite the general view that these cells have an anti-inflammatory M2 phenotype, recent…”
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Evidence of human milk oligosaccharides in maternal circulation already during pregnancy: a pilot study by Jantscher-Krenn, Evelyn, Aigner, Johanna, Reiter, Birgit, Köfeler, Harald, Csapo, Bence, Desoye, Gernot, Bode, Lars, van Poppel, Mireille N M

“…Human milk oligosaccharides (HMOs) are bioactive glycans linked with health benefits to both the breast-fed infant and lactating mother. We hypothesized that…”
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Epigenetic adaptation of the placental serotonin transporter gene (SLC6A4) to gestational diabetes mellitus by Blazevic, Sofia, Horvaticek, Marina, Kesic, Maja, Zill, Peter, Hranilovic, Dubravka, Ivanisevic, Marina, Desoye, Gernot, Stefulj, Jasminka

“…We tested the hypothesis that gestational diabetes mellitus (GDM) alters the DNA methylation pattern of the fetal serotonin transporter gene (SLC6A4), and…”
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Amino Acid Transporter LAT1 (SLC7A5) Mediates MeHg-Induced Oxidative Stress Defense in the Human Placental Cell Line HTR-8/SVneo by Granitzer, Sebastian, Widhalm, Raimund, Forsthuber, Martin, Ellinger, Isabella, Desoye, Gernot, Hengstschläger, Markus, Zeisler, Harald, Salzer, Hans, Gundacker, Claudia

“…The placental barrier can protect the fetus from contact with harmful substances. The potent neurotoxin methylmercury (MeHg), however, is very efficiently…”
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Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus by Colomiere, Michelle, Permezel, Michael, Riley, Clyde, Desoye, Gernot, Lappas, Martha

“…ObjectiveStudies in adipose tissue and skeletal muscle suggest that impaired insulin action is due to defects in the insulin signaling pathway and may play a…”
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The Feto-placental Dialogue and Diabesity by Desoye, Gernot, PhD, van Poppel, Mireille, PhD

“…Recent studies have established that the neonate born to a pregnancy with maternal diabetes or obesity (‘diabesity’) is characterized by increased fat…”
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The human placental sexome differs between trophoblast epithelium and villous vessel endothelium by Cvitic, Silvija, Longtine, Mark S, Hackl, Hubert, Wagner, Karin, Nelson, Michael D, Desoye, Gernot, Hiden, Ursula

“…Molecular mechanisms underlying sexual dimorphism in mammals, fetal sex influences on intrauterine development, and the sex-biased susceptibility for selected…”
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Downregulation of p53 drives autophagy during human trophoblast differentiation by Gauster, Martin, Maninger, Sabine, Siwetz, Monika, Deutsch, Alexander, El-Heliebi, Amin, Kolb-Lenz, Dagmar, Hiden, Ursula, Desoye, Gernot, Herse, Florian, Prokesch, Andreas

“…The placental barrier is crucial for the supply of nutrients and oxygen to the developing fetus and is maintained by differentiation and fusion of…”
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Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1 by Troncoso, Felipe, Acurio, Jesenia, Herlitz, Kurt, Aguayo, Claudio, Bertoglia, Patricio, Guzman-Gutierrez, Enrique, Loyola, Marco, Gonzalez, Marcelo, Rezgaoui, Meriem, Desoye, Gernot, Escudero, Carlos

“…Placentas from gestational diabetes mellitus (GDM) are often hypervascularized; however, participation of vascular endothelial growth factor (VEGF) and its…”
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Results From a European Multicenter Randomized Trial of Physical Activity and/or Healthy Eating to Reduce the Risk of Gestational Diabetes Mellitus: The DALI Lifestyle Pilot by Simmons, David, Jelsma, Judith G M, Galjaard, Sander, Devlieger, Roland, van Assche, Andre, Jans, Goele, Corcoy, Rosa, Adelantado, Juan M, Dunne, Fidelma, Desoye, Gernot, Harreiter, Jürgen, Kautzky-Willer, Alexandra, Damm, Peter, Mathiesen, Elisabeth R, Jensen, Dorte M, Andersen, Lise Lotte, Lapolla, Annunziata, Dalfra, Maria, Bertolotto, Alessandra, Wender-Ozegowska, Ewa, Zawiejska, Agnieszka, Hill, David, Rebollo, Pablo, Snoek, Frank J, van Poppel, Mireille N M

“…Ways to prevent gestational diabetes mellitus (GDM) remain unproven. We compared the impact of three lifestyle interventions (healthy eating [HE], physical…”
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Serotonin system in the human placenta - the knowns and unknowns by Perić, Maja, Bečeheli, Ivona, Čičin-Šain, Lipa, Desoye, Gernot, Štefulj, Jasminka

“…The biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT) is a chemical messenger widely distributed in the brain and various other organs. Its homeostasis…”
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