Search Results - "DESMOND, Julian"

Long-Term Use of Cardiovascular Drugs: Challenges for Research and for Patient Care by Rossello, Xavier, Pocock, Stuart J, Julian, Desmond G

“…Little is known about the benefits and risks of the long-term use of cardiovascular drugs. Evidence from randomized clinical trials (RCTs) rarely goes beyond a…”
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Achievements and Limitations of Evidence-Based Medicine by Sheridan, Desmond J., MD, PhD, Julian, Desmond G., MD

“…Abstract Evidence-based medicine (EBM) has a long history, but was revived in the early 1990s by a campaign mounted by a movement that took its name. The EBM…”
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Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells by MORI, Akio, LEHMANN, Sören, O'KELLY, James, KUMAGAI, Takashi, DESMOND, Julian C, PERVAN, Milena, MCBRIDE, William H, KIZAKI, Masahiro, KOEFFLER, H. Phillip

“…Capsaicin is the major pungent ingredient in red peppers. Here, we report that it has a profound antiproliferative effect on prostate cancer cells, inducing…”
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Reply: The Efficacy of Exercise-Based Cardiac Rehabilitation: The Changing Face of Usual Care by Sheridan, Desmond J., Julian, Desmond G.

“…In our paper (1) we argued that the inclusion of clinical trials of rehabilitation carried out when survival of patients with coronary heart disease improved…”
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Effects of long-term use of cardiovascular drugs by Julian, Desmond G, Pocock, Stuart J

“…Some publications have questioned the effectiveness of beta-blockers in preventing death and recurrent infarction.1,2 Meta-analyses suggest no beneficial…”
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Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor: Effects on Gene Expression and Growth of Glioma Cells In vitro and In vivo by DONG YIN, ONG, John M, JINWEI HU, DESMOND, Julian C, KAWAMATA, Norihiko, KONDA, Bindu M, BLACK, Keith L, KOEFFLER, H. Phillip

“…Purpose: Histone acetylation is one of the main mechanisms involved in regulation of gene expression. During carcinogenesis, tumor-suppressor genes can be…”
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Gender differences in the management and clinical outcome of stable angina by DALY, Caroline, CLEMENS, Felicity, RUZYLLO, Witold, THYGESEN, Kristian, VERHEUGT, Freek, FOX, Kim M, LOPEZ SENDON, Jose L, TAVAZZI, Luigi, BOERSMA, Eric, DANCHIN, Nicholas, DELAHAYE, Francois, GITT, Anselm, JULIAN, Desmond, MULCAHY, David

“…We sought to examine the impact of gender on the investigation and subsequent management of stable angina and to assess gender differences in clinical outcome…”
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Seven-year outcome in the RITA-2 trial: coronary angioplasty versus medical therapy by Henderson, Robert A., Pocock, Stuart J., Clayton, Tim C., Knight, Rosemary, Fox, Keith A.A., Julian, Desmond G., Chamberlain, Douglas A.

“…This study was designed to compare the long-term consequences of percutaneous transluminal coronary angioplasty (PTCA) and continued medical treatment. The…”
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Long-Term Use of Cardiovascular Drugs by Rossello, Xavier, MD, Pocock, Stuart J., PhD, Julian, Desmond G., MD

“…Abstract Little is known about the benefits and risks of the long-term use of cardiovascular drugs. Evidence from randomized clinical trials (RCTs) rarely goes…”
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Histone Deacetylase Inhibitors Have a Profound Antigrowth Activity in Endometrial Cancer Cells by TAKAI, Noriyuki, DESMOND, Julian C, KUMAGAI, Takashi, GUI, Dorina, SAID, Jonathan W, WHITTAKER, Sadie, MIYAKAWA, Isao, KOEFFLER, H. Phillip

“…Purpose: HDAC inhibitors (HDACIs) have been shown to inhibit cancer cell proliferation, stimulate apoptosis, and induce cell cycle arrest. Our purpose was to…”
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Case definitions for acute coronary heart disease in epidemiology and clinical research studies a statement from the AHA council on epidemiology and prevention; AHA statistics committee; World heart federation council on epidemiology and prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the National Heart, Lung, and Blood Institute by LUEPKER, Russell V, APPLE, Fred S, LEVY, Daniel, MANOLIO, Ten, MENDIS, Shanthi, MENSAH, George, PAJAK, Andrzej, PRINEAS, Ronald J, SRINATH REDDY, K, ROGER, Veronique L, ROSAMOND, Wayne D, SHAHAR, Eyal, CHRISTENSON, Robert H, SHARRETT, A. Richey, SORLIE, Paul, TUNSTALL-PEDOE, Hugh, CROW, Richard S, FORTMANN, Stephen P, GOFF, David, GOLDBERG, Robert J, HAND, Mary M, JAFFE, Allan S, JULIAN, Desmond G

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Predicting prognosis in stable angina—results from the Euro heart survey of stable angina: prospective observational study by Daly, Caroline A, De Stavola, Bianca, Sendon, Jose L Lopez, Tavazzi, Luigi, Boersma, Eric, Clemens, Felicity, Danchin, Nicholas, Delahaye, Francois, Gitt, Anselm, Julian, Desmond, Mulcahy, David, Ruzyllo, Witold, Thygesen, Kristian, Verheugt, Freek, Fox, Kim M

“…Abstract Objectives To investigate the prognosis associated with stable angina in a contemporary population as seen in clinical practice, to identify the key…”
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Epigenetic Silencing of the Candidate Tumor Suppressor Gene Per1 in Non–Small Cell Lung Cancer by GERY, Sigal, KOMATSU, Naoki, KAWAMATA, Norihiko, MILLER, Carl W, DESMOND, Julian, VIRK, Renu K, MARCHEVSKY, Alberto, MCKENNA, Robert, TAGUCHI, Hirokuni, KOEFFLER, H. Phillip

“…Purpose: Epigenetic events are a critical factor contributing to cancer development. The purpose of this study was to identify tumor suppressor genes silenced…”
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Scutellaria baicalensis, a herbal medicine: Anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines by Kumagai, Takashi, Müller, Claudia I, Desmond, Julian C, Imai, Yasufumi, Heber, David, Koeffler, H. Phillip

“…Abstract Scutellaria baicalensis (S.B.) is a widely used Chinese herbal medicine. We initially investigated its in vitro anti-tumor activities. S.B inhibited…”
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Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer by Wolf, Ido, Bose, Shikha, Desmond, Julian C, Lin, Bryan T, Williamson, Elizabeth A, Karlan, Beth Y, Koeffler, H Phillip

“…A pharmacological-based global screen for epigenetically silenced tumor suppressor genes was performed in MCF-7 and MDA-MB-231 breast cancer cells. Eighty-one…”
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Epigenetic regulation and molecular characterization of C/EBPα in pancreatic cancer cells by Kumagai, Takashi, Akagi, Tadayuki, Desmond, Julian C., Kawamata, Norihiko, Gery, Sigal, Imai, Yasufumi, Song, Jee Hoon, Gui, Dorina, Said, Jonathan, Koeffler, H. Phillip

“…Molecular‐targeted therapy is a hopeful approach for pancreatic cancer. Silencing of tumor suppressor genes can occur by histone deacetylation and/or DNA…”
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The clinical characteristics and investigations planned in patients with stable angina presenting to cardiologists in Europe: from the Euro Heart Survey of Stable Angina by Daly, Caroline A., Clemens, Felicity, Sendon, Jose L. Lopez, Tavazzi, Luigi, Boersma, Eric, Danchin, Nicholas, Delahaye, Francois, Gitt, Anselm, Julian, Desmond, Mulcahy, David, Ruzyllo, Witold, Thygesen, Kristian, Verheugt, Freek, Fox, Kim M.

“…Aims The Euro Heart Survey of Stable Angina set out to prospectively study the presentation and management of patients with stable angina as first seen by a…”
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Crystal structures of prostaglandin D2 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin by LEVERING, Andrew L, RIDE, Jon P, BUNCE, Christopher M, DESMOND, Julian C, CUMMINGS, Stephen M, WHITE, Scott A

“…Abstract It is becoming increasingly well established that nonsteroidal anti-inflammatory drugs (NSAID) protect against tumors of the gastrointestinal tract…”
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Randomized, controlled, phase 3 study to evaluate the safety and efficacy of fibrin sealant VH S/D 4 s-apr (Artiss) to improve tissue adherence in subjects undergoing rhytidectomy by Hester, Jr, T Roderick, Shire, James R, Nguyen, Davis B, Gerut, Zachary E, Chen, Achih H, Diamond, Jason, Desmond, Julian C, Silvati-Fidell, Laura, Abrams, Steve Zvi, Rohrich, Rod J

“…Suction drains are commonly placed after rhytidectomy to avoid seroma formation that may result from dead spaces between skin layers. Fibrin sealants promote…”
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The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs by DESMOND, Julian C, MOUNTFORD, Joanne C, DRAYSON, Mark T, WALKER, Elizabeth A, HEWISON, Martin, RIDE, Jonathan P, LUONG, Quang T, HAYDEN, Rachel E, VANIN, Elio F, BUNCE, Christopher M

“…We and others have demonstrated expression of the aldo-keto reductase AKR1C3 in myeloid leukemia cell lines and that inhibitors of the enzyme, including…”
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