Search Results - "DESMEULES, Jules"

Influence of Inflammation on Cytochromes P450 Activity in Adults: A Systematic Review of the Literature by Lenoir, Camille, Rollason, Victoria, Desmeules, Jules A., Samer, Caroline F.

“…Background: Available in-vitro and animal studies indicate that inflammation impacts cytochromes P450 (CYP) activity via multiple and complex transcriptional…”
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Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine by Marsousi, Niloufar, Desmeules, Jules A, Rudaz, Serge, Daali, Youssef

“…Personalized medicine aims to determine the most adequate treatment and dose regimen to obtain the maximum efficacy and minimum side effect by taking into…”
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Gender Differences in Cardiovascular Pharmacotherapy-the Example of Hypertension: A Mini Review by Kalibala, Jacklean, Pechère-Bertschi, Antoinette, Desmeules, Jules

“…Cardiovascular disease (CVD) is the leading cause of mortality worldwide in both sexes. Despite considerable progress in better understanding the patterns of…”
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Impact of Inflammation on Cytochromes P450 Activity in Pediatrics: A Systematic Review by Lenoir, Camille, Rodieux, Frédérique, Desmeules, Jules A., Rollason, Victoria, Samer, Caroline F.

“…Background and Objective Cytochromes P450 (CYP) are the major enzymes involved in hepatic metabolism of drugs. Personalization of treatment in pediatrics is a…”
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Reviewing Data Integrated for PBPK Model Development to Predict Metabolic Drug-Drug Interactions: Shifting Perspectives and Emerging Trends by Abouir, Kenza, Samer, Caroline F, Gloor, Yvonne, Desmeules, Jules A, Daali, Youssef

“…Physiologically-based pharmacokinetics (PBPK) modeling is a robust tool that supports drug development and the pharmaceutical industry and regulatory…”
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Is massage a legitimate part of nursing care? A qualitative study by Da Rocha Rodrigues, Gora, Anex, Adrien, Boegli, Monique, Bollondi Pauly, Catherine, Curtin, François, Luthy, Christophe, Desmeules, Jules, Cedraschi, Christine

“…The use of massage therapy has received increased attention in the treatment of chronic pain. However, barriers can hinder its use in nursing care. This study…”
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The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial by Huttner, Angela, MD, Dayer, Julie-Anne, MD, Yerly, Sabine, MSc, Combescure, Christophe, PhD, Auderset, Floriane, PhD, Desmeules, Jules, Prof, Eickmann, Markus, PhD, Finckh, Axel, Prof, Goncalves, Ana Rita, PhD, Hooper, Jay W, PhD, Kaya, Gürkan, MD, Krähling, Verena, PhD, Kwilas, Steve, PhD, Lemaître, Barbara, MSc, Matthey, Alain, MD, Silvera, Peter, PhD, Becker, Stephan, Prof, Fast, Patricia E, MD, Moorthy, Vasee, MD, Kieny, Marie Paule, PhD, Kaiser, Laurent, Prof, Siegrist, Claire-Anne, Prof

“…Summary Background Safe and effective vaccines against Ebola could prevent or control outbreaks. The safe use of replication-competent vaccines requires a…”
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Prediction of drug‐drug interactions using physiologically‐based pharmacokinetic models of CYP450 modulators included in Simcyp software by Marsousi, Niloufar, Desmeules, Jules A., Rudaz, Serge, Daali, Youssef

“…In recent years, physiologically based PharmacoKinetic (PBPK) modeling has received growing interest as a useful tool for the assessment of drug…”
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Prediction by pharmacogenetics of safety and efficacy of non-steroidal anti- inflammatory drugs: a review by Rollason, Victoria, Samer, Caroline Flora, Daali, Youssef, Desmeules, Jules Alexandre

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently used drugs, either on prescription or over-thecounter (OTC). Their daily dosage is based…”
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Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modeling by Magliocco, Gaëlle, Rodieux, Frédérique, Desmeules, Jules, Samer, Caroline Flora, Daali, Youssef

“…The activity of drug-metabolizing enzymes (DME) shows high inter- and intra-individual variability. Genetic polymorphisms, exposure to drugs, and environmental…”
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Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect by Ing Lorenzini, Kuntheavy, Daali, Youssef, Fontana, Pierre, Desmeules, Jules, Samer, Caroline

“…We report a patient who presented a non-ST segment elevation myocardial infarction in the context of severe normocytic hypochromic anemia related to…”
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Physiologically‐Based Pharmacokinetic Modeling for the Prediction of CYP2D6‐Mediated Gene–Drug–Drug Interactions by Storelli, Flavia, Desmeules, Jules, Daali, Youssef

“…The aim of this work was to predict the extent of Cytochrome P450 2D6 (CYP2D6)‐mediated drug–drug interactions (DDIs) in different CYP2D6 genotypes using…”
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Cannabinoids for behavioral symptoms in severe dementia: Safety and feasibility in a long-term pilot observational study in nineteen patients by Pautex, Sophie, Bianchi, Federica, Daali, Youssef, Augsburger, Marc, de Saussure, Christian, Wampfler, James, Curtin, François, Desmeules, Jules, Broers, Barbara

“…The management of behavioral symptoms and rigidity in patients with dementia constitutes a significant challenge. Short-term studies suggest an interest in the…”
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Development of a predictive score for potentially avoidable hospital readmissions for general internal medicine patients by Blanc, Anne-Laure, Fumeaux, Thierry, Stirnemann, Jérôme, Dupuis Lozeron, Elise, Ourhamoune, Aimad, Desmeules, Jules, Chopard, Pierre, Perrier, Arnaud, Schaad, Nicolas, Bonnabry, Pascal

“…Identifying patients at high risk of hospital preventable readmission is an essential step towards selecting those who might benefit from specific transitional…”
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Comparing Dried Blood Spots and Plasma Concentrations for Busulfan Therapeutic Drug Monitoring in Children by Dilo, Ana, Daali, Youssef, Desmeules, Jules, Chalandon, Yves, Uppugunduri, Chakradhara R. S., Ansari, Marc

“…Busulfan (Bu) is one of the conditioning regimen components for pediatric hematopoietic stem cell transplantation. Bu therapeutic drug monitoring (TDM) is…”
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Uncovering a Genetic Polymorphism Located in Huntingtin Associated Protein 1 in Modulation of Central Pain Sensitization Signaling Pathways by Gloor, Yvonne, Matthey, Alain, Sobo, Komla, Mouterde, Médéric, Kosek, Eva, Pickering, Gisèle, Poloni, Estella S., Cedraschi, Christine, Ehret, Georg, Desmeules, Jules A.

“…Fibromyalgia syndrome (FMS) is characterized by widespread pain and increased sensitivity to nociceptive stimulus or tenderness. While familial aggregation…”
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Outcomes of drug exposition during pregnancy: Analysis from a teratology information service by Lenoir, Camille, Boumaïza, Sabrina, Ing Lorenzini, Kuntheavy R, Boulvain, Michel, Desmeules, Jules A, Rollason, Victoria

“…We aimed to characterize drug exposures during pregnancy where the outcome was known that had benefited from counselling through our Teratology Information…”
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CYP450 Genotype—Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting by Ing Lorenzini, Kuntheavy, Desmeules, Jules, Rollason, Victoria, Bertin, Stéphane, Besson, Marie, Daali, Youssef, Samer, Caroline F.

“…Pharmacokinetic variability is a major source of differences in drug response and can be due to genetic variants and/or drug-drug interactions. Cytochromes…”
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Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cells by Marsousi, Niloufar, Doffey-Lazeyras, Fabienne, Rudaz, Serge, Desmeules, Jules A., Daali, Youssef

“…Ticagrelor is the unique reversible oral antiplatelet drug commercialized today. During this study, the intestinal permeability of ticagrelor and its potential…”
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When the Safe Alternative Is Not That Safe: Tramadol Prescribing in Children by Rodieux, Frédérique, Vutskits, Laszlo, Posfay-Barbe, Klara M, Habre, Walid, Piguet, Valérie, Desmeules, Jules A, Samer, Caroline F

“…Children represent a vulnerable population in which management of nociceptive pain is complex. Drug responses in children differ from adults due to age-related…”
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