Search Results - "DESANTE, Karl A"

Disposition and Metabolic Fate of Atomoxetine Hydrochloride: The Role of CYP2D6 in Human Disposition and Metabolism by SAUER, John-Michael, PONSLER, G. Douglas, MATTIUZ, Edward L, LONG, Amanda J, WITCHER, Jennifer W, THOMASSON, Holly R, DESANTE, Karl A

“…The role of the polymorphic cytochrome P450 2D6 (CYP2D6) in the pharmacokinetics of atomoxetine hydrochloride [(−)- N…”
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Atomoxetine hydrochloride: clinical drug-drug interaction prediction and outcome by Sauer, John-Michael, Long, Amanda J, Ring, Barbara, Gillespie, Jennifer S, Sanburn, Nathan P, DeSante, Karl A, Petullo, David, VandenBranden, Mark R, Jensen, Charles B, Wrighton, Steven A, Smith, Brian P, Read, Holly A, Witcher, Jennifer W

“…In the studies reported here, the ability of atomoxetine hydrochloride (Strattera) to inhibit or induce the metabolic capabilities of selected human isoforms…”
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Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites by Chalon, Stephan A., Desager, Jean‐Pierre, DeSante, Karl A., Frye, Reginald F., Witcher, Jennifer, Long, Amanda J., Sauer, John‐Michael, Golnez, Jean‐Luc, Smith, Brian P., Thomasson, Holly R., Horsmans, Yves

“…Background and Objectives Atomoxetine is a treatment for attention‐deficit/hyperactivity disorder and is primarily eliminated via cytochrome P4502D6 (CYP2D6)…”
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Why rate of absorption inferences in single dose bioequivalence studies are often inappropriate by BASSON, R. P, GHOSH, A, CERIMELE, B. J, DESANTE, K. A, HOWEY, D. C

“…Peak drug concentration (Cmax) measures the extremity of drug exposure and is a secondary indicator of the extent of absorption after area under the…”
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Pharmacokinetic profile of loracarbef by DeSante, K A, Zeckel, M L

“…Loracarbef, the first beta-lactam antibiotic of the carbacephem class to undergo clinical evaluation, has been the subject of extensive clinical pharmacology…”
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Confidence interval criteria for assessment of dose proportionality by SMITH, Brian P, VANDENHENDE, Francois R, DESANTE, Karl A, FARID, Nagy A, WELCH, Pamela A, CALLAGHAN, John T, FORGUE, S. Thomas

“…The aim of this work was a pragmatic, statistically sound and clinically relevant approach to dose-proportionality analyses that is compatible with common…”
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Effects of renal dysfunction on the pharmacokinetics of loracarbef by Therasse, D G, Farlow, D S, Davidson, R L, Quadracci, L J, Hatcher, B L, Cerimele, B J, DeSante, K A

“…Loracarbef, the first carbacephem antibiotic to undergo clinical development, is excreted primarily unchanged in the urine (> 90%). Data analyzed from subjects…”
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Benoxaprofen kinetics in renal impairment by Aronoff, G R, Ozawa, T, DeSante, K A, Nash, J F, Ridolfo, A S

“…To establish therapeutic guidelines, benoxaprofen kinetics were examined in 26 adult subjects with normal and decreased renal function. Mean peak plasma…”
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Antibiotic Batch Certification and Bioequivalence by DeSante, Karl A, DiSanto, Anthony R, Chodos, Dale J, Stoll, Roger G

“…All antibiotics marketed in the United States must undergo batch certification by the Food and Drug Administration. It is often assumed that the different…”
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Pharmacokinetics of dirithromycin by Sides, G D, Cerimele, B J, Black, H R, Busch, U, DeSante, K A

“…Dirithromycin is a new member of the macrolide class of antibiotics and has been developed for oral administration. Dirithromycin is a 14-membered lactone ring…”
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Tmax : an unconfounded metric for rate of absorption in single dose bioequivalence studies by BASSON, R. P, CERIMELE, B. J, DESANTE, K. A, HOWEY, D. C

“…While peak drug concentration (Cmax) is recognized to be contaminated by the extent of absorption, it has long served as the indicator of change in absorption…”
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The penetration of dirithromycin into bronchoalveolar lavage fluid and alveolar macrophages by Baughman, R P, DeSante, K A, Lanier, T L, Conforti, P M, Sides, G D

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Sensitive, specific radioimmunoassay for quantifying pergolide in plasma by Bowsher, R R, Apathy, J M, Compton, J A, Wolen, R L, Carlson, K H, DeSante, K A

“…Pergolide, a synthetic ergoline with potent dopaminergic activity, is used to treat Parkinson disease. The low plasma concentrations of pergolide achieved…”
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Clinical pharmacokinetics of pinacidil, a potassium channel opener, in hypertension by Goldberg, M R, Rockhold, F W, Thompson, W L, DeSante, K A

“…Pinacidil is a potassium channel opener that decreases blood pressure by reducing peripheral arterial resistance. In two multicenter trials, we studied the…”
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Comparative bioavailability of erythromycin-sulfisoxazole combinations by Desante, K A, Ryan, C F, Wallen, S, Heath, E C

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Chlorphenesin carbamate serum levels during subchronic administration to human (normal) volunteers by Stoll, R G, DeSante, K A, Novak, E, Monovich, R E, DiSanto, A R

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