Search Results - "DESAI, Rooma"

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer by Laverty, Duncan, Desai, Rooma, Uchański, Tomasz, Masiulis, Simonas, Stec, Wojciech J., Malinauskas, Tomas, Zivanov, Jasenko, Pardon, Els, Steyaert, Jan, Miller, Keith W., Aricescu, A. Radu

“…Type A γ-aminobutyric acid (GABA A ) receptors are pentameric ligand-gated ion channels and the main drivers of fast inhibitory neurotransmission in the…”
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High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing α4β3δ subunits by Zhou, Xiaojuan, Desai, Rooma, Zhang, Yinghui, Stec, Wojciech J, Miller, Keith W, Jounaidi, Youssef

“…The inhibitory γ-aminobutyric acid type A receptors are implicated in numerous physiological processes, including cognition and inhibition of…”
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Human α1β3γ2L gamma‐aminobutyric acid type A receptors: High‐level production and purification in a functional state by Dostalova, Zuzana, Zhou, Xiaojuan, Liu, Aiping, Zhang, Xi, Zhang, Yinghui, Desai, Rooma, Forman, Stuart A., Miller, Keith W.

“…Gamma‐aminobutyric acid type A receptors (GABAARs) are the most important inhibitory chloride ion channels in the central nervous system and are major targets…”
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Protein Kinase C Modulates Inactivation of Kv3.3 Channels by Desai, Rooma, Kronengold, Jack, Mei, Jianfeng, Forman, Stuart A., Kaczmarek, Leonard K.

“…Modulation of some Kv3 family potassium channels by protein kinase C (PKC) regulates their amplitude and kinetics and adjusts firing patterns of auditory…”
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GABAA receptor signalling mechanisms revealed by structural pharmacology by Masiulis, Simonas, Desai, Rooma, Uchański, Tomasz, Serna Martin, Itziar, Laverty, Duncan, Karia, Dimple, Malinauskas, Tomas, Zivanov, Jasenko, Pardon, Els, Kotecha, Abhay, Steyaert, Jan, Miller, Keith W., Aricescu, A. Radu

“…Type-A γ-aminobutyric (GABA A ) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines…”
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GABA A receptor signalling mechanisms revealed by structural pharmacology by Masiulis, Simonas, Desai, Rooma, Uchański, Tomasz, Serna Martin, Itziar, Laverty, Duncan, Karia, Dimple, Malinauskas, Tomas, Zivanov, Jasenko, Pardon, Els, Kotecha, Abhay, Steyaert, Jan, Miller, Keith W, Aricescu, A Radu

“…Type-A γ-aminobutyric (GABA ) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines…”
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Differential assembly diversifies GABA A receptor structures and signalling by Sente, Andrija, Desai, Rooma, Naydenova, Katerina, Malinauskas, Tomas, Jounaidi, Youssef, Miehling, Jonas, Zhou, Xiaojuan, Masiulis, Simonas, Hardwick, Steven W, Chirgadze, Dimitri Y, Miller, Keith W, Aricescu, A Radu

“…Type A γ-aminobutyric acid receptors (GABA Rs) are pentameric ligand-gated chloride channels that mediate fast inhibitory signalling in neural circuits and can…”
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Differential assembly diversifies GABAA receptor structures and signalling by Sente, Andrija, Desai, Rooma, Naydenova, Katerina, Malinauskas, Tomas, Jounaidi, Youssef, Miehling, Jonas, Zhou, Xiaojuan, Masiulis, Simonas, Hardwick, Steven W., Chirgadze, Dimitri Y., Miller, Keith W., Aricescu, A. Radu

“…Type A γ-aminobutyric acid receptors (GABA A Rs) are pentameric ligand-gated chloride channels that mediate fast inhibitory signalling in neural circuits 1 , 2…”
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Slack and Slick K Na Channels Regulate the Accuracy of Timing of Auditory Neurons by Yang, Bo, Desai, Rooma, Kaczmarek, Leonard K.

“…The Slack (sequence like a calcium-activated K channel) and Slick (sequence like an intermediate conductance K channel) genes, which encode sodium-activated K…”
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Author Correction: GABA.sub.A receptor signalling mechanisms revealed by structural pharmacology by Masiulis, Simonas, Desai, Rooma, Uchanski, Tomasz, Martin, Itziar Serna, Laverty, Duncan, Karia, Dimple, Malinauskas, Tomas

“…In Fig. 5b, d, the arrows showing transmembrane domain rotations were inadvertently pointing clockwise instead of anticlockwise. Similarly, 'anticlockwise'…”
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Cryo-EM structure of the human [alpha]1[beta]3[gamma]2 GABA.sub.A receptor in a lipid bilayer by Laverty, Duncan, Desai, Rooma, Uchanski, Tomasz, Masiulis, Simonas, Stec, Wojciech J, Malinauskas, Tomas, Zivanov, Jasenko

“…Type A [gamma]-aminobutyric acid (GABA.sub.A) receptors are pentameric ligand-gated ion channels and the main drivers of fast inhibitory neurotransmission in…”
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Cryo-EM structure of the human 132 GABA.sub.A receptor in a lipid bilayer by Laverty, Duncan, Desai, Rooma, Uchanski, Tomasz, Masiulis, Simonas, Stec, Wojciech J, Malinauskas, Tomas, Zivanov, Jasenko

“…Type A [gamma]-aminobutyric acid (GABA.sub.A) receptors are pentameric ligand-gated ion channels and the main drivers of fast inhibitory neurotransmission in…”
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Slack and Slick KNa Channels Regulate the Accuracy of Timing of Auditory Neurons by Yang, Bo, Desai, Rooma, Kaczmarek, Leonard K

“…The Slack (sequence like a calcium-activated K channel) and Slick (sequence like an intermediate conductance K channel) genes, which encode sodium-activated K…”
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Ca2+-activated K+ Channels in Human Leukemic Jurkat T Cells by Desai, Rooma, Peretz, Asher, Idelson, Hirsh, Lazarovici, Philip, Attali, Bernard

“…Previous studies have demonstrated the presence of apamin-sensitive, small-conductance Ca2+-activated K+ currents in human leukemic Jurkat T cells. Using a…”
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High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing [alpha]4[beta]3[delta] subunits by Zhou, Xiaojuan, Desai, Rooma, Zhang, Yinghui, Stec, Wojciech J, Miller, Keith W, Jounaidi, Youssef

“…The inhibitory [gamma]-aminobutyric acid type A receptors are implicated in numerous physiological processes, including cognition and inhibition of…”
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GABA.sub.A receptor signalling mechanisms revealed by structural pharmacology by Masiulis, Simonas, Desai, Rooma, Uchanski, Tomasz, Serna Martin, Itziar, Laverty, Duncan, Karia, Dimple, Malinauskas, Tomas

“…Type-A [gamma]-aminobutyric (GABA.sub.A) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including…”
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Cryo-EM structure of the human α1β3γ2 GABA^sub A^ receptor in a lipid bilayer by Laverty, Duncan, Desai, Rooma, Uchański, Tomasz, Masiulis, Simonas, Stec, Wojciech J, Malinauskas, Tomas, Zivanov, Jasenko, Pardon, Els, Steyaert, Jan, Miller, Keith W, Aricescu, A Radu

“…Type A Y-aminobutyric acid (GABAa) receptors are pentameric ligand-gated ion channels and the main drivers of fast inhibitory neurotransmission in the…”
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Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating by Zhang, Yalan, Zhang, Xiao-Feng, Fleming, Matthew R., Amiri, Anahita, El-Hassar, Lynda, Surguchev, Alexei A., Hyland, Callen, Jenkins, David P., Desai, Rooma, Brown, Maile R., Gazula, Valeswara-Rao, Waters, Michael F., Large, Charles H., Horvath, Tamas L., Navaratnam, Dhasakumar, Vaccarino, Flora M., Forscher, Paul, Kaczmarek, Leonard K.

“…Mutations in the Kv3.3 potassium channel (KCNC3) cause cerebellar neurodegeneration and impair auditory processing. The cytoplasmic C terminus of Kv3.3…”
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γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity by DESAI, Rooma, RUESCH, Dirk, FORMAN, Stuart A

“…Background Etomidate acts at gamma-Aminobutyric acid type A (GABAA) receptors containing beta2 or beta3, but not beta1 subunits. Mutations at beta residue 265…”
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State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor by Stewart, Deirdre S, Hotta, Mayo, Desai, Rooma, Forman, Stuart A

“…A central axiom of ligand-receptor theory is that agonists bind more tightly to active than to inactive receptors. However, measuring agonist affinity in…”
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