Search Results - "DESAI, Ravi"

Cell mechanics control rapid transitions between blebs and lamellipodia during migration by Bergert, Martin, Chandradoss, Stanley D, Desai, Ravi A, Paluch, Ewa

“…Protrusion formation is an essential step during cell migration. Cells migrating in three-dimensional environments and in vivo can form a wide variety of…”
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Force transmission during adhesion-independent migration by Bergert, Martin, Erzberger, Anna, Desai, Ravi A., Aspalter, Irene M., Oates, Andrew C., Charras, Guillaume, Salbreux, Guillaume, Paluch, Ewa K.

“…Bergert et al. use theoretical modelling and cell-based experiments to show that adhesion-independent cell migration is powered by nonspecific substrate…”
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Mechanical regulation of cell function with geometrically modulated elastomeric substrates by Desai, Ravi A, Yang, Michael T, Chen, Christopher S, Fu, Jianping, Wang, Yang-Kao, Liu, Zhijun, Yu, Xiang

“…We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and…”
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Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning by Shaya, Oren, Binshtok, Udi, Hersch, Micha, Rivkin, Dmitri, Weinreb, Sheila, Amir-Zilberstein, Liat, Khamaisi, Bassma, Oppenheim, Olya, Desai, Ravi A., Goodyear, Richard J., Richardson, Guy P., Chen, Christopher S., Sprinzak, David

“…During development, cells undergo dramatic changes in their morphology. By affecting contact geometry, these morphological changes could influence cellular…”
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A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions by Desai, Ravi V, Chen, Xinyue, Martin, Benjamin, Chaturvedi, Sonali, Hwang, Dong Woo, Li, Weihan, Yu, Chen, Ding, Sheng, Thomson, Matt, Singer, Robert H, Coleman, Robert A, Hansen, Maike M K, Weinberger, Leor S

“…Stochastic fluctuations in gene expression ("noise") are often considered detrimental, but fluctuations can also be exploited for benefit (e.g., dither). We…”
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Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity by Chen, Christopher S, Yang, Michael T, Fu, Jianping, Wang, Yang-Kao, Desai, Ravi A

“…We describe the use of a microfabricated cell culture substrate, consisting of a uniform array of closely spaced, vertical, elastomeric microposts, to study…”
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Brahma safeguards canalization of cardiac mesoderm differentiation by Hota, Swetansu K., Rao, Kavitha S., Blair, Andrew P., Khalilimeybodi, Ali, Hu, Kevin M., Thomas, Reuben, So, Kevin, Kameswaran, Vasumathi, Xu, Jiewei, Polacco, Benjamin J., Desai, Ravi V., Chatterjee, Nilanjana, Hsu, Austin, Muncie, Jonathon M., Blotnick, Aaron M., Winchester, Sarah A. B., Weinberger, Leor S., Hüttenhain, Ruth, Kathiriya, Irfan S., Krogan, Nevan J., Saucerman, Jeffrey J., Bruneau, Benoit G.

“…Differentiation proceeds along a continuum of increasingly fate-restricted intermediates, referred to as canalization 1 , 2 . Canalization is essential for…”
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Noise-driven cellular heterogeneity in circadian periodicity by Li, Yan, Shan, Yongli, Desai, Ravi V., Cox, Kimberly H., Weinberger, Leor S., Takahashi, Joseph S.

“…Nongenetic cellular heterogeneity is associated with aging and disease. However, the origins of cell-to-cell variability are complex and the individual…”
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Cell polarity triggered by cell-cell adhesion via E-cadherin by Desai, Ravi A, Gao, Lin, Raghavan, Srivatsan, Liu, Wendy F, Chen, Christopher S

“…Cell polarity is orchestrated by numerous extracellular cues, and guides events such as chemotaxis, mitosis and wound healing. In scrape-wound assays of cell…”
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Kidney Damage and Stress Biomarkers for Early Identification of Drug-Induced Kidney Injury: A Systematic Review by Desai, Ravi J., Kazarov, Christina L., Wong, Adrian, Kane-Gill, Sandra L.

“…Introduction Acute kidney injury (AKI) resulting from nephrotoxic medication use is prominent in hospitalized patients and is attributable to overall increases…”
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Biophysical Regulations of Epigenetic State and Notch Signaling in Neural Development Using Microgroove Substrates by Hsu, Chia-Chen, Serio, Andrea, Gopal, Sahana, Gelmi, Amy, Chiappini, Ciro, Desai, Ravi A., Stevens, Molly M.

“…A number of studies have recently shown how surface topography can alter the behavior and differentiation patterns of different types of stem cells. Although…”
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Tricuspid regurgitation and right ventricular function after mitral valve surgery with or without concomitant tricuspid valve procedure by Desai, Ravi R., BE, Vargas Abello, Lina Maria, MD, Klein, Allan L., MD, Marwick, Thomas H., MD, PhD, Krasuski, Richard A., MD, Ye, Ying, BS, Nowicki, Edward R., MD, MS, Rajeswaran, Jeevanantham, MSc, Blackstone, Eugene H., MD, Pettersson, Gösta B., MD, PhD

“…Objectives To study the effect of mitral valve repair with or without concomitant tricuspid valve repair on functional tricuspid regurgitation and right…”
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Cytoplasmic Amplification of Transcriptional Noise Generates Substantial Cell-to-Cell Variability by Hansen, Maike M K, Desai, Ravi V, Simpson, Michael L, Weinberger, Leor S

“…Transcription is an episodic process characterized by probabilistic bursts, but how the transcriptional noise from these bursts is modulated by cellular…”
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Contact inhibition of locomotion probabilities drive solitary versus collective cell migration by Desai, Ravi A., Gopal, Smitha B., Chen, Sophia, Chen, Christopher S.

“…Contact inhibition of locomotion (CIL) is the process whereby cells collide, cease migrating in the direction of the collision, and repolarize their migration…”
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Diagnostic performance of cardiac stress perfusion MRI in the detection of coronary artery disease using fractional flow reserve as the reference standard: a meta-analysis by Desai, Ravi R, Jha, Saurabh

“…OBJECTIVE. This is an analysis of pooled studies for the determination of the test characteristics of stress perfusion cardiac MRI in the diagnosis of…”
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Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature by Elliott, Hunter, Fischer, Robert S., Myers, Kenneth A., Desai, Ravi A., Gao, Lin, Chen, Christopher S., Adelstein, Robert S., Waterman, Clare M., Danuser, Gaudenz

“…In many cases, cell function is intimately linked to cell shape control. We used endothelial cell branching morphogenesis as a model to understand the role of…”
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Theory of time delayed genetic oscillations with external noisy regulation by Negrete, Jose, Lengyel, Iván M, Rohde, Laurel, Desai, Ravi A, Oates, Andrew C, Jülicher, Frank

“…We present a general theory of noisy genetic oscillators with externally regulated production rate and multiplicative noise. The observables that characterize…”
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Increased Ribozyme Activity in Crowded Solutions by Desai, Ravi, Kilburn, Duncan, Lee, Hui-Ting, Woodson, Sarah A.

“…Noncoding RNAs must function in the crowded environment of the cell. Previous small-angle x-ray scattering experiments showed that molecular crowders stabilize…”
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Impact of cost on prescribing diabetes medications for older adults with type 2 diabetes in the outpatient setting by Lussier, Mia E., Desai, Ravi J., Wright, Eric A., Gionfriddo, Michael R.

“…Newer diabetes medications have cardiorenal benefits beyond blood sugar lowering that make them a preferred treatment option in many patients. Despite this,…”
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A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells by Ferrell, Nicholas, Desai, Ravi R., Fleischman, Aaron J., Roy, Shuvo, Humes, H. David, Fissell, William H.

“…We have developed a bilayer microfluidic system with integrated transepithelial electrical resistance (TEER) measurement electrodes to evaluate kidney…”
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