Search Results - "DERRY, J. M. J"
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ABC Triblock Copolymer Worms: Synthesis, Characterization, and Evaluation as Pickering Emulsifiers for Millimeter-Sized Droplets
Published in Macromolecules (25-10-2016)“…Polymerization-induced self-assembly (PISA) is used to prepare linear poly(glycerol monomethacrylate)–poly(2-hydroxypropyl methacrylate)–poly(benzyl…”
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Altered gene expression in slc4a11−/− mouse cornea highlights SLC4A11 roles
Published in Scientific reports (22-10-2021)“…SLC4A11 is a H + /NH 3 /water transport protein, of corneal endothelial cells. SLC4A11 mutations cause congenital hereditary endothelial dystrophy and some…”
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3
Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
Published in Science translational medicine (14-06-2017)“…A potentially useful approach for drug discovery is to connect gene expression profiles of disease-affected tissues ("disease signatures") to drug signatures,…”
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Developing predictive molecular maps of human disease through community-based modeling
Published in Nature genetics (01-02-2012)“…Synapse provides various functionalities: the management of datasets, analysis code and models in user-created projects; the ability to publish these resources…”
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Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross
Published in PloS one (14-12-2010)“…To identify the genes and pathways that underlie cardiovascular and metabolic phenotypes we performed an integrated analysis of a mouse C57BL/6JxA/J F2 (B6AF2)…”
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Vermicious thermo-responsive Pickering emulsifiers
Published in Chemical science (Cambridge) (01-07-2015)“…Thermo-responsive vermicious (or worm-like) diblock copolymer nanoparticles prepared directly in -dodecane polymerisation-induced self-assembly (PISA) were…”
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Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution
Published in Chemical science (Cambridge) (14-02-2018)“…A series of pH-responsive all-methacrylic ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles RAFT seeded emulsion…”
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Heterotelechelic homopolymers mimicking high χ - ultralow N block copolymers with sub-2 nm domain size
Published in Chemical science (Cambridge) (06-04-2022)“…Three fluorinated, hydrophobic initiators have been utilised for the synthesis of low molecular mass fluoro-poly(acrylic acid) heterotelechelic homopolymers to…”
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The Wiskott-Aldrich Syndrome and X-Linked Congenital Thrombocytopenia Are Caused by Mutations of the Same Gene
Published in Blood (15-11-1995)“…The Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder characterized by thrombocytopenia, small platelets, eczema, recurrent infections, and…”
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Expression of four alternative dystrophin transcripts in brain regions regulated by different promoters
Published in Human molecular genetics (01-10-1992)“…Cognitive impairment occurs in one-third of patients with Duchenne muscular dystrophy, a lethal X-linked, recessive disease caused by mutations in the…”
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Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
Published in Nature communications (06-06-2017)“…Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not…”
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Polymer and Soft Matter Research at Diamond Light Source
Published in Synchrotron radiation news (04-03-2023)Get full text
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WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia
Published in Human molecular genetics (01-07-1995)“…The WASP gene has been recently cloned from Xp11.23 and shown to be mutated in three patients with the Wiskott-Aldrich syndrome (WAS). We have developed a…”
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Expression of human Wiskott-Aldrich syndrome protein in patients' cells leads to partial correction of a phenotypic abnormality of cell surface glycoproteins
Published in Gene therapy (01-02-2000)“…The Wiskott-Aldrich syndrome (WAS) is an uncommon X-linked recessive disease characterized by thrombocytopenia, eczema and immunodeficiency. The biochemical…”
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Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage
Published in Gut (01-06-2002)“…Background and aims: Persistent inflammation observed in inflammatory bowel disease may be the consequence of an increased or aberrant immune response to…”
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Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination
Published in Blood (01-10-2006)“…Ectodermal dysplasia with immune deficiency (EDI) is caused by alterations in NEMO (nuclear factor [NF]–κB essential modulator). Most genetic mutations are…”
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Integrative genomics and drug development
Published in Pharmacogenomics (01-02-2009)“…The pharmaceutical industry faces unprecedented pressures based largely on the inability to bring sufficient new medicines to market. The high failure rate of…”
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Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Published in Clinical cancer research (15-09-2023)“…Cancer drug development is currently limited by a paradigm of preclinical evaluation that does not adequately recapitulate the complexity of the intact human…”
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Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment
Published in Frontiers in pharmacology (2024)“…Drug development is systemically inefficient. Research and development costs for novel therapeutics average hundreds of millions to billions of dollars, with…”
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Differential expression of DMD transcripts as a novel prognostic biomarker in histologically diverse mesotheliomas
Published in Translational lung cancer research (29-04-2024)Get full text
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