Search Results - "DEROANNE, Christophe"

The Dual Function of RhoGDI2 in Immunity and Cancer by Tripathi, Mudrika, Colige, Alain, Deroanne, Christophe F

“…RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of small GTPases. It is highly expressed in hematopoietic cells but is…”
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Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression by Brohée, Laura, Peulen, Olivier, Nusgens, Betty, Castronovo, Vincent, Thiry, Marc, Colige, Alain C., Deroanne, Christophe F.

“…Propranolol, a widely used non-selective beta-adrenergic receptor blocker, was recently shown to display anticancer properties. Its potential to synergize with…”
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Acidosis-induced regulation of adipocyte G0S2 promotes crosstalk between adipocytes and breast cancer cells as well as tumor progression by Cremer, Julie, Brohée, Laura, Dupont, Laura, Lefevre, Camille, Peiffer, Raphaël, Saarinen, Alicia M., Peulen, Olivier, Bindels, Laure, Liu, Jun, Colige, Alain, Deroanne, Christophe F.

“…Bidirectional interactions between cancer cells and their microenvironment govern tumor progression. Among the stromal cells in this microenvironment,…”
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Lipin-1, a Versatile Regulator of Lipid Homeostasis, Is a Potential Target for Fighting Cancer by Brohée, Laura, Crémer, Julie, Colige, Alain, Deroanne, Christophe

“…The rewiring of lipid metabolism is a major adaptation observed in cancer, and it is generally associated with the increased aggressiveness of cancer cells…”
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Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment by Brohée, Laura, Demine, Stéphane, Willems, Jérome, Arnould, Thierry, Colige, Alain C, Deroanne, Christophe F

“…Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual…”
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MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells by Sabatel, Céline, Malvaux, Ludovic, Bovy, Nicolas, Deroanne, Christophe, Lambert, Vincent, Gonzalez, Maria-Luz Alvarez, Colige, Alain, Rakic, Jean-Marie, Noël, Agnès, Martial, Joseph A, Struman, Ingrid

“…MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that regulate gene expression at post-transcriptional level. The recent discovery of the…”
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RhoGTPases as Key Players in Mammalian Cell Adaptation to Microgravity by Guignandon, Alain, Vico, Laurence, Deroanne, Christophe, Louis, Fiona, Nusgens, Betty

“…A growing number of studies are revealing that cells reorganize their cytoskeleton when exposed to conditions of microgravity. Most, if not all, of the…”
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Development of a Chitosan Nanofibrillar Scaffold for Skin Repair and Regeneration by Tchemtchoua, Victor T, Atanasova, Ganka, Aqil, Abdel, Filée, Patrice, Garbacki, Nancy, Vanhooteghem, Olivier, Deroanne, Christophe, Noël, Agnès, Jérome, Christine, Nusgens, Betty, Poumay, Yves, Colige, Alain

“…The final goal of the present study was the development of a 3-D chitosan dressing that would shorten the healing time of skin wounds by stimulating migration,…”
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Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents by Mineur, Pierre, Colige, Alain C, Deroanne, Christophe.F, Dubail, Johanne, Kesteloot, Frédéric, Habraken, Yvette, Noël, Agnès, Vöö, Stefan, Waltenberger, Johannes, Lapière, Charles M, Nusgens, Betty V, Lambert, Charles A

“…Ultraviolet B and genotoxic drugs induce the expression of a vascular endothelial growth factor A (VEGF-A) splice variant (VEGF111) encoded by exons 1-4 and 8…”
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MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets by Garbacki, Nancy, Di Valentin, Emmanuel, Huynh-Thu, Vân Anh, Geurts, Pierre, Irrthum, Alexandre, Crahay, Céline, Arnould, Thierry, Deroanne, Christophe, Piette, Jacques, Cataldo, Didier, Colige, Alain

“…miRNAs are now recognized as key regulator elements in gene expression. Although they have been associated with a number of human diseases, their implication…”
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A Novel Physiological Glycosaminoglycan-Deficient Splice Variant of Neuropilin-1 Is Anti-Tumorigenic In Vitro and In Vivo by Hendricks, Céline, Dubail, Johanne, Brohée, Laura, Delforge, Yves, Colige, Alain, Deroanne, Christophe

“…Neuropilin-1 (NRP1) is a transmembrane protein acting as a co-receptor for several growth factors and interacting with other proteins such as integrins and…”
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Histone Deacetylase 7 Silencing Alters Endothelial Cell Migration, a Key Step in Angiogenesis by Mottet, Denis, Bellahcène, Akeila, Pirotte, Sophie, Waltregny, David, Deroanne, Christophe, Lamour, Virginie, Lidereau, Rosette, Castronovo, Vincent

“…Global inhibition of class I and II histone deacetylases (HDACs) impairs angiogenesis. Herein, we have undertaken the identification of the specific HDAC(s)…”
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uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis by Durré, Tania, Morfoisse, Florent, Erpicum, Charlotte, Ebroin, Marie, Blacher, Silvia, García-Caballero, Melissa, Deroanne, Christophe, Louis, Thomas, Balsat, Cédric, Van de Velde, Maureen, Kaijalainen, Seppo, Kridelka, Frédéric, Engelholm, Lars, Struman, Ingrid, Alitalo, Kari, Behrendt, Niels, Paupert, Jenny, Noel, Agnès

“…The development of new lymphatic vessels occurs in many cancerous and inflammatory diseases through the binding of VEGF-C to its receptors, VEGFR-2 and…”
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ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis by Dupont, Laura, Joannes, Loïc, Morfoisse, Florent, Blacher, Silvia, Monseur, Christine, Deroanne, Christophe F, Noël, Agnès, Colige, Alain Cma

“…The capacity of ADAMTS3 to cleave pro-VEGFC into active VEGFC able to bind its receptors and to stimulate lymphangiogenesis has been clearly established during…”
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Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4‐MMP) in breast cancer cells by Truong, Alice, Yip, Cassandre, Paye, Alexandra, Blacher, Silvia, Munaut, Carine, Deroanne, Christophe, Noel, Agnès, Sounni, Nor Eddine

“…Membrane type 4 matrix metalloproteinase (MT4‐MMP) [matrix metalloproteinase (MMP) 17] is a GPI‐anchored membrane‐type MMP expressed on the cell surface of…”
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Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling by DEROANNE, Christophe F, BONJEAN, Karine, CASTRONOVO, Vincent, SERVOTTE, Sandrine, DEVY, Laetitia, COLIGE, Alain, CLAUSSE, Nathalie, BLACHER, Sylvia, VERDIN, Eric, FOIDART, Jean-Michel, NUSGENS, Betty V

“…Angiogenesis is a complex biological process involving the coordinated modulation of many genes. Histone deacetylases (HDAC) are a growing family of enzymes…”
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Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: An approach of vascular development chronology in psoriasis by Henno, Audrey, Blacher, Silvia, Lambert, Charles A, Deroanne, Christophe, Noël, Agnès, Lapière, Charles, de la Brassinne, Michel, Nusgens, Betty V, Colige, Alain

“…Abstract Background Dysregulation of angiogenesis and lymphangiogenesis could participate in psoriasis pathogenesis. Analysis of nascent psoriasis lesions…”
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In vivo N-Terminomics Highlights Novel Functions of ADAMTS2 and ADAMTS14 in Skin Collagen Matrix Building by Leduc, Cédric, Dupont, Laura, Joannes, Loïc, Monseur, Christine, Baiwir, Dominique, Mazzucchelli, Gabriel, Deroanne, Christophe, Colige, Alain, Bekhouche, Mourad

“…A disintegrin and metalloproteinase with thrombospondin type I motif (ADAMTS)2 and ADAMTS14 were originally known for their ability to cleave the…”
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Microgravity triggers ferroptosis and accelerates senescence in the MG-63 cell model of osteoblastic cells by Garbacki, Nancy, Willems, Jérôme, Neutelings, Thibaut, Lambert, Charles, Deroanne, Christophe, Adrian, Astrid, Franz, Markus, Maurer, Matthias, De Gieter, Philippe, Nusgens, Betty, Colige, Alain

“…In space, cells sustain strong modifications of their mechanical environment. Mechanosensitive molecules at the cell membrane regulate mechanotransduction…”
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RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis by Giang Ho, T T, Stultiens, Audrey, Dubail, Johanne, Lapière, Charles M, Nusgens, Betty V, Colige, Alain C, Deroanne, Christophe F

“…RhoGTPases are key signaling molecules regulating main cellular functions such as migration, proliferation, survival, and gene expression through interactions…”
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