Search Results - "DEPPONG, Christine M"

Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation by Dodson, Lindzy F., Boomer, Jonathan S., Deppong, Christine M., Shah, Dulari D., Sim, Julia, Bricker, Traci L., Russell, John H., Green, Jonathan M.

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CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-β by Deppong, Christine M, Bricker, Traci L, Rannals, Brandy D, Van Rooijen, Nico, Hsieh, Chyi-Song, Green, Jonathan M

“…The CD28 costimulatory receptor is a critical regulator of T cell function, making it an attractive therapeutic target for the treatment of immune-mediated…”
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CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors by Lio, Chan-Wang J, Dodson, Lindzy F, Deppong, Christine M, Hsieh, Chyi-Song, Green, Jonathan M

“…The T cell costimulatory molecule CD28 plays an important role in the thymic generation of Foxp3(+) regulatory T cells (Tregs) essential for the maintenance of…”
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Cutting edge: A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression by Boomer, Jonathan S, Deppong, Christine M, Shah, Dulari D, Bricker, Traci L, Green, Jonathan M

“…CD28 is a critical regulator of T cell function, augmenting proliferation, cytokine secretion, and cell survival. Our previous work using knockin mice…”
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A Randomized Controlled Trial to Evaluate Inhibition of T-Cell Costimulation in Allergen-induced Airway Inflammation by PARULEKAR, Amit D, BOOMER, Jonathan S, PATTERSON, Brenda M, YIN-DECLUE, Huiqing, DEPPONG, Christine M, WILSON, Brad S, JARJOUR, Nizar N, CASTRO, Mario, GREEN, Jonathan M

“…T lymphocytes are important in the pathogenesis of allergic asthma. Costimulation through CD28 is critical for optimal activation of T cells, and inhibition of…”
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Airway epithelial cells suppress T cell proliferation by an IFNγ/STAT1/TGFβ-dependent mechanism by Deppong, Christine M, Xu, Jian, Brody, Steven L, Green, Jonathan M

“…Organ-specific regulation of immune responses relies on the exchange of information between nonimmune and immune cells. In a primary culture model of the lung…”
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CTLA4-Ig inhibits allergic airway inflammation by a novel CD28-independent, nitric oxide synthase-dependent mechanism by Deppong, Christine M, Parulekar, Amit, Boomer, Jonathan S, Bricker, Traci L, Green, Jonathan M

“…The T-cell response to antigen depends on coordinate signaling between costimulatory and inhibitory receptors. The altered function of either may underlie the…”
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Experimental advances in understanding allergic airway inflammation by Deppong, Christine M, Green, Jonathan M

“…Asthma is largely an inflammatory disease, with the development of T cell mediated inflammation in the lung following exposure to allergen or other…”
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A detailed phenotypic analysis of immune cell populations in the bronchoalveolar lavage fluid of atopic asthmatics after segmental allergen challenge by Boomer, Jonathan S, Parulekar, Amit D, Patterson, Brenda M, Yin-Declue, Huiqing, Deppong, Christine M, Crockford, Seth, Jarjour, Nizar N, Castro, Mario, Green, Jonathan M

“…Atopic asthma is characterized by intermittent exacerbations triggered by exposure to allergen. Exacerbations are characterized by an acute inflammatory…”
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A double mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-Xl expression1 by Boomer, Jonathan S., Deppong, Christine M., Shah, Dulari D., Bricker, Traci L., Green, Jonathan M.

“…CD28 is a critical regulator of T cell function, augmenting proliferation, cytokine secretion and cell survival. Our previous work using knockin mice…”
Get full text

CTLA4Ig inhibits effector T cells through regulatory T cells and TGFβ1 by Deppong, Christine M., Bricker, Traci L., Rannals, Brandy D., Van Rooijen, Nico, Hsieh, Chyi-Song, Green, Jonathan M.

“…The CD28 costimulatory receptor is a critical regulator of T cell function making it an attractive therapeutic target for the treatment of immune mediated…”
Get full text

CD28 facilitates the generation of Foxp3− cytokine responsive regulatory T cell precursors1 by Lio, Chan-Wang J., Dodson, Lindzy F., Deppong, Christine M., Hsieh, Chyi-Song, Green, Jonathan M.

“…The T cell co-stimulatory molecule CD28 plays an important role in the thymic generation of Foxp3 + regulatory T (Treg) cells essential for the maintenance of…”
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