Search Results - "DEPOORTERE, Ronan"

The selective 5-HT1A receptor agonist NLX-112 displays anxiolytic-like activity in mice by Powell, William H., Annett, Lucy E., Depoortere, Ronan, Newman-Tancredi, Adrian, Iravani, Mahmoud M.

“…Anxiety is amongst the commonest neuropsychiatric disorders, and there is a large body of evidence to suggest that abnormalities in serotonergic function are…”
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Discriminative stimulus properties of the 5-HT1A receptor biased agonists NLX-101 and F13714, in rats trained to discriminate 8-OH-DPAT from saline by Broadbear, Jillian H., Depoortere, Ronan Y., Vacy, Kristina, Ralph, David, Tunstall, Brendan J., Newman-Tancredi, Adrian

“…NLX-101 and F13714 are selective, full efficacy, biased agonists of the serotonin (5-HT1A) receptor. NLX-101 preferentially activates cortical postsynaptic…”
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Multimodal imaging study of the 5-HT1A receptor biased agonist, NLX-112, in a model of L-DOPA-induced dyskinesia by Chaib, Sarah, Vidal, Benjamin, Bouillot, Caroline, Depoortere, Ronan, Newman-Tancredi, Adrian, Zimmer, Luc, Levigoureux, Elise

“…[Display omitted] •Hemiparkinsonian (HPK) rats show a specific L-DOPA-induced brain metabolic pattern.•NLX-112 attenuated or reversed the cerebral effects of…”
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Dissecting the contribution of 5-HT1A auto- and heteroreceptors in sucrose overconsumption in mice by Beecher, Kate, Wang, Joshua, Chehrehasa, Fatemeh, Depoortere, Ronan, Varney, Mark A., Newman-Tancredi, Adrian, Bartlett, Selena E., Belmer, Arnauld

“…The rise in obesity prevalence has been linked to overconsumption of high-sugar containing food and beverages. Recent evidence suggests that chronic sucrose…”
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Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders by Newman-Tancredi, Adrian, Depoortère, Ronan Y., Kleven, Mark S., Kołaczkowski, Marcin, Zimmer, Luc

“…Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted rapidly increasing interest as a means to improve discovery of more…”
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Pharmacodynamic, pharmacokinetic and rat brain receptor occupancy profile of NLX-112, a highly selective 5-HT1A receptor biased agonist by Depoortère, Ronan Y., McCreary, Andrew C., Vidal, Benjamin, Varney, Mark A., Zimmer, Luc, Newman-Tancredi, Adrian

“…NLX-112 (i.e., F13640, befiradol) exhibits nanomolar affinity, exceptional selectivity and full agonist efficacy at serotonin 5-HT1A receptors. NLX-112 shows…”
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The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models by Papp, Mariusz, Gruca, Piotr, Lason, Magdalena, Litwa, Ewa, Newman-Tancredi, Adrian, Depoortère, Ronan

“…Objectives NLX-101 and NLX-204 are highly selective serotonin 5-HT 1A ‘biased’ agonists, displaying potent and efficacious antidepressant-like activity upon…”
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The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, like ketamine, elicit rapid-acting antidepressant activity in the rat chronic mild stress model via cortical mechanisms by Papp, Mariusz, Gruca, Piotr, Litwa, Ewa, Lason, Magdalena, Newman-Tancredi, Adrian, Depoortère, Ronan

“…Background: The highly selective 5-HT1A serotonin receptor “biased” agonists NLX-101 and NLX-204 display, like ketamine, potent and efficacious rapid-acting…”
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Serotonin 5‑HT1A Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model by Depoortère, Ronan, Bardin, Laurent, Varney, Mark A, Newman-Tancredi, Adrian

“…When placed in an unfamiliar and brightly lit open-field, two adult male rats that have not previously interacted display a low level of social interaction…”
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The 5-HT1A receptor biased agonist, NLX-204, shows rapid-acting antidepressant-like properties and neurochemical changes in two mouse models of depression by Głuch-Lutwin, Monika, Sałaciak, Kinga, Pytka, Karolina, Gawalska, Alicja, Jamrozik, Marek, Śniecikowska, Joanna, Kołaczkowski, Marcin, Depoortère, Ronan Y., Newman-Tancredi, Adrian

“…Activation of cortical serotonin 5-HT1A receptors may be a promising strategy to achieve rapid-acting antidepressant (RAAD) activity. NLX-204 is a selective…”
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Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in mice by Bruins Slot, Liesbeth A, Bardin, Laurent, Auclair, Agnès L, Depoortere, Ronan, Newman-Tancredi, Adrian

“…Antipsychotics constitute efficacious augmenting agents in the treatment of anxiety disorders, including refractory obsessive-compulsive disorder. We examined…”
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Cortical 5-hydroxytryptamine 1A receptor biased agonist, NLX-101, displays rapid-acting antidepressant-like properties in the rat chronic mild stress model by Depoortère, Ronan, Papp, Mariusz, Gruca, Piotr, Lason-Tyburkiewicz, Magdalena, Niemczyk, Monika, Varney, Mark A, Newman-Tancredi, Adrian

“…Background: NLX-101 (also known as F15599) is a highly selective and efficacious ‘biased’ agonist at cortical 5-hydroxytryptamine 1A (5-HT1A) heteroreceptors…”
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Fentanyl dose-sparing in polyarthritic rats requires full agonism at 5-HT 1A receptors: Comparison between NLX-112, (±)8-OH-DPAT, and buspirone by Depoortere, Ronan, Bardin, Laurent, Newman-Tancredi, Adrian

“…NLX-112 (a.k.a. F13640, befiradol) is a highly selective and fully efficacious agonist at 5-hydroxytryptamine (5-HT ) receptors. It has been shown to be…”
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NLX-101, a cortical 5-HT1A receptor biased agonist, reverses scopolamine-induced deficit in the delayed non-matching to position model of cognition by Depoortere, Ronan Yves, Auclair, Agnès Laure, Newman-Tancredi, Adrian

“…•The delayed non-matching to position (DNMTP) is a model of memory/cognition.•The muscarinic antagonist, scopolamine, produces cognitive deficits in the…”
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F15599, a preferential post-synaptic 5-HT1A receptor agonist: Activity in models of cognition in comparison with reference 5-HT1A receptor agonists by Depoortère, Ronan, Auclair, Agnès L, Bardin, Laurent, Colpaert, Francis C, Vacher, Bernard, Newman-Tancredi, Adrian

“…Abstract We assessed the activity of F15599, a selective and high efficacy 5-HT1A agonist that preferentially activates post- versus pre-synaptic receptors, in…”
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Neural serotonergic circuits for controlling long-term voluntary alcohol consumption in mice by Belmer, Arnauld, Depoortere, Ronan, Beecher, Kate, Newman-Tancredi, Adrian, Bartlett, Selena E.

“…Alcohol-use-disorders are chronic relapsing illnesses, often co-morbid with anxiety. We have previously shown using the “drinking-in-the-dark” model in mice…”
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Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain by Berrocoso, Esther, Mico, Juan-Antonio, Vitton, Olivier, Ladure, Philippe, Newman-Tancredi, Adrian, Depoortère, Ronan, Bardin, Laurent

“…Milnacipran, a serotonin/norepinephrine reuptake inhibitor (SNRI), has shown efficacy against several chronic pain conditions, including fibromyalgia. Here, we…”
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The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity by Auclair, Agnès L., Cathala, Adeline, Sarrazin, Frédéric, Depoortère, Ronan, Piazza, Pier Vincenzo, Newman‐Tancredi, Adrian, Spampinato, Umberto

“…J. Neurochem. (2010) 114, 1323–1332. The function of the serotonin2B receptor (5‐HT2BR) in the mammalian brain is poorly characterized, especially with regard…”
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Haloperidol-induced catalepsy is absent in dopamine D2, but maintained in dopamine D3 receptor knock-out mice by BOULAY, D, DEPOORTERE, R, OBLIN, A, SANGER, D. J, SCHOEMAKER, H, PERRAULT, G

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F15599, a highly selective post-synaptic 5-HT1A receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity by Assié, Marie-Bernadette, Bardin, Laurent, Auclair, Agnès L., Carilla-Durand, Elisabeth, Depoortère, Ronan, Koek, Wouter, Kleven, Mark S., Colpaert, Francis, Vacher, Bernard, Newman-Tancredi, Adrian

“…F15599 is a novel agonist with high selectivity and efficacy at serotonin 5-HT1A receptors (5-HT1ARs). In signal transduction, electrophysiological and…”
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