Search Results - "DEPOORTERE, I."

Chronobesity: role of the circadian system in the obesity epidemic by Laermans, J, Depoortere, I

“…Although obesity is considered to result from an imbalance between energy uptake and energy expenditure, the strategy of dietary changes and physical exercise…”
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Chemoreceptors in the Gut by Steensels, S, Depoortere, I

“…The gastrointestinal tract represents the largest interface between the human body and the external environment. It must continuously monitor and discriminate…”
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The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity by Avau, B., Depoortere, I.

“…The bitter taste receptor (TAS2R)‐family of G‐protein‐coupled receptors has been identified on the tongue as detectors of bitter taste over a decade ago. In…”
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Review article: the role of gastric motility in the control of food intake by Janssen, P., Vanden Berghe, P., Verschueren, S., Lehmann, A., Depoortere, I., Tack, J.

“…Aliment Pharmacol Ther 2011; 33: 880–894 Summary Background  From a classical point of view, gastric motility acts to clear the stomach between meals, whereas…”
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Motilin-induced gastric contractions signal hunger in man by Tack, J, Deloose, E, Ang, D, Scarpellini, E, Vanuytsel, T, Van Oudenhove, L, Depoortere, I

“…Hunger is controlled by the brain, which receives input from signals of the GI tract (GIT). During fasting, GIT displays a cyclical motor pattern, the…”
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Role of the clock gene Bmal1 and the gastric ghrelin-secreting cell in the circadian regulation of the ghrelin-GOAT system by Laermans, J., Vancleef, L., Tack, J., Depoortere, I.

“…As adequate food intake is crucial to survival, organisms have evolved endogenous circadian clocks to generate optimal temporal patterns of food-related…”
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Abdominal vagus nerve stimulation as a new therapeutic approach to prevent postoperative ileus by Stakenborg, N., Wolthuis, A. M., Gomez‐Pinilla, P. J., Farro, G., Di Giovangiulio, M., Bosmans, G., Labeeuw, E., Verhaegen, M., Depoortere, I., D'Hoore, A., Matteoli, G., Boeckxstaens, G. E.

“…Background Electrical stimulation of the cervical vagus nerve (VNS) prevents postoperative ileus (POI) in mice. As this approach requires an additional…”
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Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in healthy female volunteers by Deloose, E., Corsetti, M., Oudenhove, L., Depoortere, I., Tack, J.

“…Background Intragastric administration of the bitter tastant denatonium benzoate inhibits the increase of motilin plasma levels and antral contractility. While…”
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Ghrelin signaling in the gut, its physiological properties, and therapeutic potential by Avau, B., Carbone, F., Tack, J., Depoortere, I.

“…Background Ghrelin, an orexigenic hormone secreted from the stomach, was soon after its discovery hypothesized to be a prokinetic agent, due to its homology to…”
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Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man by Deloose, E., Vos, R., Corsetti, M., Depoortere, I., Tack, J.

“…Background Fluctuations in motilin plasma levels have been implicated in the control of the migrating motor complex (MMC). A plasma peak of motilin is present…”
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Influence of ghrelin on gastric emptying and meal‐related symptoms in idiopathic gastroparesis by TACK, J., DEPOORTERE, I., BISSCHOPS, R., VERBEKE, K., JANSSENS, J., PEETERS, T.

“…Summary Background : Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor, is released from the stomach. Animal studies suggest that…”
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Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces by Farré, R, van Malenstein, H, De Vos, R, Geboes, K, Depoortere, I, Vanden Berghe, P, Fornari, F, Blondeau, K, Mertens, V, Tack, J, Sifrim, D

“…Severe duodeno-gastro-oesophageal reflux (DGOR) is a risk factor for oesophagitis and Barrett's oesophagus. Patients with non-erosive reflux disease (NERD)…”
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Higher plasma motilin levels in obese patients decrease after Roux-en-Y gastric bypass surgery and regulate hunger by Deloose, E, Janssen, P, Lannoo, M, Van der Schueren, B, Depoortere, I, Tack, J

“…Motilin-induced phase III contractions of the migrating motor complex (MMC) signal hunger in healthy volunteers. The current aim was to study the role of…”
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Influence of ghrelin on interdigestive gastrointestinal motility in humans by Tack, J, Depoortere, I, Bisschops, R, Delporte, C, Coulie, B, Meulemans, A, Janssens, J, Peeters, T

“…Background: Recent studies in animals have shown that ghrelin stimulates upper gastrointestinal motility through the vagus and enteric nervous system. The aim…”
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Chemosensory signalling pathways involved in sensing of amino acids by the ghrelin cell by Vancleef, L., Van Den Broeck, T., Thijs, T., Steensels, S., Briand, L., Tack, J., Depoortere, I.

“…Taste receptors on enteroendocrine cells sense nutrients and transmit signals that control gut hormone release. This study aimed to investigate the amino acid…”
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Neurotransmitters involved in fast excitatory neurotransmission directly activate enteric glial cells by Boesmans, W., Cirillo, C., Van den Abbeel, V., Van den Haute, C., Depoortere, I., Tack, J., Vanden Berghe, P.

“…Background  The intimate association between glial cells and neurons within the enteric nervous system has confounded careful examination of the direct…”
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Smooth muscle and neural dysfunction contribute to different phases of murine postoperative ileus by Farro, G., Gomez‐Pinilla, P. J., Di Giovangiulio, M., Stakenborg, N., Auteri, M., Thijs, T., Depoortere, I., Matteoli, G., Boeckxstaens, G. E.

“…Background Postoperative ileus (POI) is characterized by a transient inhibition of gastrointestinal (GI) motility after abdominal surgery mediated by the…”
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Review: Chemosensing of nutrients and non-nutrients in the human and porcine gastrointestinal tract by Roura, E., Depoortere, I., Navarro, M.

“…The gastrointestinal tract (GIT) is an interface between the external and internal milieus that requires continuous monitoring for nutrients or pathogens and…”
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Role of the AMP-activated protein kinase (AMPK) signaling pathway in the orexigenic effects of endogenous ghrelin by Verhulst, P.J., Janssen, S., Tack, J., Depoortere, I.

“…Ghrelin, released from the stomach, stimulates food intake through activation of the ghrelin receptor (GHS-R) located on neuropeptide Y (NPY)/agouti-related…”
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Effect of peripheral obestatin on gastric emptying and intestinal contractility in rodents by De Smet, B., Thijs, T., Peeters, T. L., Depoortere, I.

“…Obestatin has recently been discovered in the rat stomach. It is encoded by the ghrelin gene and has been claimed to be a functional opponent of ghrelin and to…”
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