Search Results - "DEPIL, Stephane"

Human Endogenous Retroviruses (HERVs): Shaping the Innate Immune Response in Cancers by Alcazer, Vincent, Bonaventura, Paola, Depil, Stephane

“…Human Endogenous Retroviruses (HERVs) are accounting for 8% of the human genome. These sequences are remnants from ancient germline infections by exogenous…”
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Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity by Sung, Pei-Ju, Rama, Nicolas, Imbach, Jeromine, Fiore, Stephany, Ducarouge, Benjamin, Neves, David, Chen, Huei-Wen, Bernard, David, Yang, Pan-Chyr, Bernet, Agnès, Depil, Stephane, Mehlen, Patrick

“…Netrin-1 is upregulated in a large fraction of human neoplasms. In multiple animal models, interference with netrin-1 is associated with inhibition of tumor…”
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Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality by Sachdeva, Mohit, Busser, Brian W., Temburni, Sonal, Jahangiri, Billal, Gautron, Anne-Sophie, Maréchal, Alan, Juillerat, Alexandre, Williams, Alan, Depil, Stéphane, Duchateau, Philippe, Poirot, Laurent, Valton, Julien

“…Endowing chimeric antigen receptor (CAR) T cells with additional potent functionalities holds strong potential for improving their antitumor activity. However,…”
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Radiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors by Laurent, Pierre-Antoine, Morel, Daphne, Meziani, Lydia, Depil, Stephane, Deutsch, Eric

“…Chimeric antigen receptor (CAR)-T cells have demonstrated significant improvements in the treatment of refractory B-cell malignancies that previously showed…”
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Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade by Shekarian, Tala, Sivado, Eva, Jallas, Anne-Catherine, Depil, Stéphane, Kielbassa, Janice, Janoueix-Lerosey, Isabelle, Hutter, Gregor, Goutagny, Nadège, Bergeron, Christophe, Viari, Alain, Valsesia-Wittmann, Sandrine, Caux, Christophe, Marabelle, Aurélien

“…Although immune checkpoint-targeted therapies are currently revolutionizing cancer care, only a minority of patients develop durable objective responses to…”
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TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer by Maire, Virginie, Baldeyron, Céline, Richardson, Marion, Tesson, Bruno, Vincent-Salomon, Anne, Gravier, Eléonore, Marty-Prouvost, Bérengère, De Koning, Leanne, Rigaill, Guillem, Dumont, Aurélie, Gentien, David, Barillot, Emmanuel, Roman-Roman, Sergio, Depil, Stéphane, Cruzalegui, Francisco, Pierré, Alain, Tucker, Gordon C, Dubois, Thierry

“…Triple-negative breast cancer (TNBC) represents a subgroup of breast cancers (BC) associated with the most aggressive clinical behavior. No targeted therapy is…”
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Polo-like Kinase 1: A Potential Therapeutic Option in Combination with Conventional Chemotherapy for the Management of Patients with Triple-Negative Breast Cancer by MAIRE, Virginie, NEMATI, Fariba, GENTIEN, David, DUMONT, Aurélie, BARILLOT, Emmanuel, MARANGONI, Elisabetta, DECAUDIN, Didier, ROMAN-ROMAN, Sergio, PIERRE, Alain, CRUZALEGUI, Francisco, DEPIL, Stéphane, TUCKER, Gordon C, RICHARDSON, Marion, DUBOIS, Thierry, VINCENT-SALOMON, Anne, TESSON, Bruno, RIGAILL, Guillem, GRAVIER, Eléonore, MARTY-PROUVOST, Bérengère, DE KONING, Leanne, LANG, Guillaume

“…Breast cancers are composed of molecularly distinct subtypes with different clinical outcomes and responses to therapy. To discover potential therapeutic…”
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The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression by SALVADOR, Marion A, WICINSKI, Julien, COLLETTE, Yves, BIRNBAUM, Daniel, CHARAFE-JAUFFRET, Emmanuelle, GINESTIER, Christophe, CABAUD, Olivier, TOIRON, Yves, FINETTI, Pascal, JOSSELIN, Emmanuelle, LELIEVRE, Hélène, KRAUS-BERTHIER, Laurence, DEPIL, Stéphane, BERTUCCI, François

“…Cancer stem cells (CSC) are the tumorigenic cell population that has been shown to sustain tumor growth and to resist conventional therapies. The purpose of…”
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Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor by Ducarouge, Benjamin, Redavid, Anna-Rita, Victoor, Camille, Chira, Ruxanda, Fonseca, Aurélien, Hervieu, Maëva, Bergé, Roméo, Lengrand, Justine, Vieugué, Pauline, Neves, David, Goddard, Isabelle, Richaud, Mathieu, Laval, Pierre-Alexandre, Rama, Nicolas, Goldschneider, David, Paradisi, Andrea, Gourdin, Nicolas, Chabaud, Sylvie, Treilleux, Isabelle, Gadot, Nicolas, Ray-Coquard, Isabelle, Depil, Stéphane, Decaudin, Didier, Némati, Fariba, Marangoni, Elisabetta, Mery-Lamarche, Eliane, Génestie, Catherine, Tabone-Eglinger, Séverine, Devouassoux-Shisheboran, Mojgan, Moore, Kathryn J., Gibert, Benjamin, Mehlen, Patrick, Bernet, Agnes

“…Drug resistance and cancer relapse represent significant therapeutic challenges after chemotherapy or immunotherapy, and a major limiting factor for long-term…”
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Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy by Bonaventura, Paola, Alcazer, Vincent, Mutez, Virginie, Tonon, Laurie, Martin, Juliette, Chuvin, Nicolas, Michel, Emilie, Boulos, Rasha E, Estornes, Yann, Valladeau-Guilemond, Jenny, Viari, Alain, Wang, Qing, Caux, Christophe, Depil, Stéphane

“…Human endogenous retroviruses (HERVs) represent 8% of the human genome. HERV products may represent tumor antigens relevant for cancer immunotherapy. We…”
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Activation of IFN/STAT1 signalling predicts response to chemotherapy in oestrogen receptor-negative breast cancer by Legrier, Marie-Emmanuelle, Bièche, Ivan, Gaston, Julie, Beurdeley, Arnaud, Yvonnet, Vanessa, Déas, Olivier, Thuleau, Aurélie, Château-Joubert, Sophie, Servely, Jean-Luc, Vacher, Sophie, Lassalle, Myriam, Depil, Stéphane, C Tucker, Gordon, Fontaine, Jean-Jacques, Poupon, Marie-France, Roman-Roman, Sergio, Judde, Jean-Gabriel, Decaudin, Didier, Cairo, Stefano, Marangoni, Elisabetta

“…Background: Oestrogen receptor-negative (ER−) breast cancer is intrinsically sensitive to chemotherapy. However, tumour response is often incomplete, and…”
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HERVs characterize normal and leukemia stem cells and represent a source of shared epitopes for cancer immunotherapy by Alcazer, Vincent, Bonaventura, Paola, Tonon, Laurie, Michel, Emilie, Mutez, Virginie, Fabres, Clémentine, Chuvin, Nicolas, Boulos, Rasha, Estornes, Yann, Maguer‐Satta, Véronique, Geistlich, Kevin, Viari, Alain, Metzeler, Klaus H., Hiddemann, Wolfgang, Batch, Aarif M. N., Herold, Tobias, Caux, Christophe, Depil, Stéphane

“…Human endogenous retroviruses (HERVs) represent 8% of the human genome. The expression of HERVs and their immune impact have not been extensively studied in…”
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Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers by Grandin, Mélodie, Meier, Markus, Delcros, Jean Guy, Nikodemus, Denise, Reuten, Raphael, Patel, Trushar R., Goldschneider, David, Orriss, George, Krahn, Natalie, Boussouar, Amina, Abes, Riad, Dean, Yann, Neves, David, Bernet, Agnes, Depil, Stephane, Schneiders, Fiona, Poole, Kate, Dante, Robert, Koch, Manuel, Mehlen, Patrick, Stetefeld, Jörg

“…Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of…”
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Treatment of nasopharyngeal carcinoma cells with the histone-deacetylase inhibitor abexinostat: cooperative effects with cis-platin and radiotherapy on patient-derived xenografts by Gressette, Mélanie, Vérillaud, Benjamin, Jimenez-Pailhès, Anne-Sophie, Lelièvre, Hélène, Lo, Kwok-Wai, Ferrand, François-Régis, Gattolliat, Charles-Henry, Jacquet-Bescond, Anne, Kraus-Berthier, Laurence, Depil, Stéphane, Busson, Pierre

“…EBV-related nasopharyngeal carcinomas (NPCs) still raise serious therapeutic problems. The therapeutic potential of the histone-deacetylase (HDAC) inhibitor…”
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Phase 1 study of the oral histone deacetylase inhibitor abexinostat in patients with Hodgkin lymphoma, non-Hodgkin lymphoma, or chronic lymphocytic leukaemia by Morschhauser, Franck, Terriou, Louis, Coiffier, Bertrand, Bachy, Emmanuel, Varga, Andrea, Kloos, Ioana, Lelièvre, Hélène, Sarry, Anne-Laure, Depil, Stéphane, Ribrag, Vincent

“…Summary Background We determined the safety, pharmacokinetics, pharmacodynamics, and antitumour activity of abexinostat in B-cell lymphoma or chronic…”
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Epstein–Barr virus infection induces an increase of T regulatory type 1 cells in Hodgkin lymphoma patients by Morales, Olivier, Mrizak, Dhafer, François, Violaine, Mustapha, Rami, Miroux, Céline, Depil, Stéphane, Decouvelaere, Anne‐Valérie, Lionne‐Huyghe, Pauline, Auriault, Claude, Launoit, Yvan, Pancré, Véronique, Delhem, Nadira

“…Summary Epstein–Barr Virus (EBV) is present in the neoplastic cells of around 20–30% of patients with Hodgkin Lymphoma (HL). Although, an immunosuppressive…”
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S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab by Burbridge, Mike F, Bossard, Céline J, Saunier, Carine, Fejes, Imre, Bruno, Alain, Léonce, Stéphane, Ferry, Gilles, Da Violante, Georges, Bouzom, François, Cattan, Valérie, Jacquet-Bescond, Anne, Comoglio, Paolo M, Lockhart, Brian P, Boutin, Jean A, Cordi, Alex, Ortuno, Jean-Claude, Pierré, Alain, Hickman, John A, Cruzalegui, Francisco H, Depil, Stéphane

“…Aberrant activity of the receptor tyrosine kinases MET, AXL, and FGFR1/2/3 has been associated with tumor progression in a wide variety of human malignancies,…”
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Pharmacokinetic/pharmacodynamic modelling-based optimisation of administration schedule for the histone deacetylase inhibitor abexinostat (S78454/PCI-24781) in phase I by Fouliard, Sylvain, Robert, Renata, Jacquet-Bescond, Anne, du Rieu, Quentin Chalret, Balasubramanian, Sriram, Loury, David, Loriot, Yohann, Hollebecque, Antoine, Kloos, Ioana, Soria, Jean-Charles, Chenel, Marylore, Depil, Stéphane

“…Abstract Abexinostat, an oral pan-histone deacetylase inhibitor (HDACi), was evaluated in patients with advanced solid tumours in two single agent phase I…”
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Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia by Trad, Rim, Warda, Walid, Alcazer, Vincent, Neto da Rocha, Mathieu, Berceanu, Ana, Nicod, Clémentine, Haderbache, Rafik, Roussel, Xavier, Desbrosses, Yohan, Daguindau, Etienne, Renosi, Florain, Roumier, Christophe, Bouquet, Lucie, Biichle, Sabeha, Guiot, Melanie, Seffar, Evan, Caillot, Denis, Depil, Stephane, Robinet, Eric, Salma, Yahya, Deconinck, Eric, Deschamps, Marina, Ferrand, Christophe

“…BackgroundAcute myeloid leukemia (AML) remains a very difficult disease to cure due to the persistence of leukemic stem cells (LSCs), which are resistant to…”
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Histone deacetylase inhibitor abexinostat affects chromatin organization and gene transcription in normal B cells and in mantle cell lymphoma by Markozashvili, Diana, Pichugin, Andrei, Barat, Ana, Camara-Clayette, Valerie, Vasilyeva, Natalia V., Lelièvre, Hélène, Kraus-Berthier, Laurence, Depil, Stéphane, Ribrag, Vincent, Vassetzky, Yegor

“…Mantle cell lymphoma (MCL) is a rare lymphoma caused by the t(11:14) juxtaposing the cyclin D1 (CCND1) locus on chromosome 11 and the immunoglobulin heavy…”
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