Search Results - "DENYS, A"

Translation inhibition and stress granules in the antiviral immune response by McCormick, Craig, Khaperskyy, Denys A.

“…Key Points Stress granules form when cells sense stress and rapidly arrest protein synthesis. Double-stranded RNA-activated protein kinase (PKR) is the main…”
Get full text

Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation by Dolliver, Stacia M, Kleer, Mariel, Bui-Marinos, Maxwell P, Ying, Shan, Corcoran, Jennifer A, Khaperskyy, Denys A

“…Stress granules (SGs) are cytoplasmic condensates that often form as part of the cellular antiviral response. Despite the growing interest in understanding the…”
Get full text

A systematic review of vitamin D status in populations worldwide by Hilger, Jennifer, Friedel, Angelika, Herr, Raphael, Rausch, Tamara, Roos, Franz, Wahl, Denys A., Pierroz, Dominique D., Weber, Peter, Hoffmann, Kristina

“…Vitamin D deficiency is associated with osteoporosis and is thought to increase the risk of cancer and CVD. Despite these numerous potential health effects,…”
Get full text

Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein by Khaperskyy, Denys A, Schmaling, Summer, Larkins-Ford, Jonah, McCormick, Craig, Gaglia, Marta M

“…Influenza A viruses (IAVs) inhibit host gene expression by a process known as host shutoff. Host shutoff limits host innate immune responses and may also…”
Get full text

Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins by Khaperskyy, Denys A, McCormick, Craig

“…Like all viruses, influenza viruses (IAVs) use host translation machinery to decode viral mRNAs. IAVs ensure efficient translation of viral mRNAs through host…”
Get full text

Influenza a virus host shutoff disables antiviral stress-induced translation arrest by Khaperskyy, Denys A, Emara, Mohamed M, Johnston, Benjamin P, Anderson, Paul, Hatchette, Todd F, McCormick, Craig

“…Influenza A virus (IAV) polymerase complexes function in the nucleus of infected cells, generating mRNAs that bear 5' caps and poly(A) tails, and which are…”
Get full text

UV damage induces G3BP1-dependent stress granule formation that is not driven by mTOR inhibition-mediated translation arrest by Ying, Shan, Khaperskyy, Denys A

“…Translation arrest is a part of the cellular stress response that decreases energy consumption and enables rapid reprioritisation of gene expression. Often…”
Get full text

Influenza A virus inhibits cytoplasmic stress granule formation by Khaperskyy, Denys A., Hatchette, Todd F., McCormick, Craig

“…An important component of the mammalian stress response is the reprogramming of translation. A variety of stresses trigger abrupt polysome disassembly and the…”
Get full text

Parallel Evaluation of the MALDI Sepsityper and Verigene BC-GN Assays for Rapid Identification of Gram-Negative Bacilli from Positive Blood Cultures by Arroyo, Miguel A, Denys, Gerald A

“…Rapid identification of microorganisms from positive blood cultures has improved clinical management and antimicrobial stewardship. The advent of…”
Get full text

The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression by Gaucherand, Lea, Porter, Brittany K., Levene, Rachel E., Price, Emma L., Schmaling, Summer K., Rycroft, Chris H., Kevorkian, Yuzo, McCormick, Craig, Khaperskyy, Denys A., Gaglia, Marta M.

“…Many viruses shut off host gene expression to inhibit antiviral responses. Viral proteins and host proteins required for viral replication are typically spared…”
Get full text

Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells by Dolliver, Stacia M, Galbraith, Caleb, Khaperskyy, Denys A

“…Viruses evolve many strategies to ensure the efficient synthesis of their proteins. One such strategy is the inhibition of the integrated stress response-the…”
Get full text

Influenza A virus NS1 effector domain is required for PA-X-mediated host shutoff in infected cells by Bougon, Juliette, Kadijk, Eileigh, Gallot-Lavallee, Lucie, Curtis, Bruce A, Landers, Matthew, Archibald, John M, Khaperskyy, Denys A

“…Many viruses inhibit general host gene expression to limit innate immune responses and gain preferential access to the cellular translational apparatus for…”
Get full text

Fine-tuning a blunt tool: Regulation of viral host shutoff RNases by Daly, Raecliffe, Khaperskyy, Denys A, Gaglia, Marta Maria

“…The evolutionary arms race between host and pathogen has resulted in the ability of many human viruses to alter the host gene expression profile during…”
Get full text

Preparation of Chitosan with Different Characteristics and Its Application for Biofilms Production by Moura, Jaqueline M, Farias, Bruna S, Rodrigues, Denys A. S, Moura, Catarina M, Dotto, Guilherme L, Pinto, Luiz A. A

“…In this research, different chitosan samples were obtained and were applied to produce biopolymeric films, aiming to obtain environmentally friendly materials…”
Get full text

Thiopurines activate an antiviral unfolded protein response that blocks influenza A virus glycoprotein accumulation by Slaine, Patrick D, Kleer, Mariel, Duguay, Brett A, Pringle, Eric S, Kadijk, Eileigh, Ying, Shan, Balgi, Aruna, Roberge, Michel, McCormick, Craig, Khaperskyy, Denys A

“…Influenza A viruses (IAVs) utilize host shutoff mechanisms to limit antiviral gene expression and redirect translation machinery to the synthesis of viral…”
Get full text

Stress Granule-Inducing Eukaryotic Translation Initiation Factor 4A Inhibitors Block Influenza A Virus Replication by Slaine, Patrick D, Kleer, Mariel, Smith, Nathan K, Khaperskyy, Denys A, McCormick, Craig

“…Eukaryotic translation initiation factor 4A (eIF4A) is a helicase that facilitates assembly of the translation preinitiation complex by unwinding structured…”
Get full text

UV damage induces G3BP1-dependent stress granule formation that is not driven by mTOR inhibition-mediated translation arrest by Ying, Shan, Khaperskyy, Denys A

Get full text

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions by Pringle, Eric S, Duguay, Brett A, Bui-Marinos, Maxwell P, Mulloy, Rory P, Landreth, Shelby L, Desireddy, Krishna Swaroop, Dolliver, Stacia M, Ying, Shan, Caddell, Taylor, Tooley, Trinity H, Slaine, Patrick D, Bearne, Stephen L, Falzarano, Darryl, Corcoran, Jennifer A, Khaperskyy, Denys A, McCormick, Craig

“…There is an outstanding need for broadly acting antiviral drugs to combat emerging viral diseases. Here, we report that thiopurines inhibit the replication of…”
Get full text

Metal-Free C–H Difluoromethylation of Imidazoles with the Ruppert–Prakash Reagent by Kvasha, Denys A., Deviatkin, Andrii, Poturai, Andrii S., Nosik, Pavel S., Kyrylchuk, Andrii A., Suikov, Sergiy, Rozhenko, Alexander B., Volochnyuk, Dmitriy M., Grygorenko, Oleksandr O.

“…The reaction of trimethyl­(trifluoromethyl)­silane–tetrabutylammonium difluorotriphenylsilicate (CF3SiMe3–TBAT) with a series of imidazoles gives products of…”
Get full text

Effects of deep brain stimulation on cognitive functioning in treatment-resistant depression: a systematic review and meta-analysis by Runia, N., Mol, G. J. J., Hillenius, T., Hassanzadeh, Z., Denys, D. A. J. P., Bergfeld, I. O.

“…Deep brain stimulation (DBS) is a promising intervention for treatment-resistant depression (TRD). Effects on cognitive functioning are unclear since they have…”
Get full text