Search Results - "DENT, Paul"

Investigational CHK1 inhibitors in early phase clinical trials for the treatment of cancer by Dent, Paul

“…: Checkpoint kinase 1 (CHK1) inhibitors have been in development for two decades. The initial CHK1 inhibitor staurosporine analog, UCN01, entered clinical…”
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Bile acids as regulatory molecules by Hylemon, Phillip B., Zhou, Huiping, Pandak, William M., Ren, Shunlin, Gil, Gregorio, Dent, Paul

“…In the past, bile acids were considered to be just detergent molecules derived from cholesterol in the liver. They were known to be important for the…”
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Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation by SHUANG CHEN, YUN DAI, HARADA, Hisashi, DENT, Paul, GRANT, Steven

“…The Bcl-2 antagonist ABT-737 targets Bcl-2/Bcl-xL but not Mcl-1, which may confer resistance to this novel agent. Here, we show that Mcl-1 down-regulation by…”
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Multi-Objective Design and Optimization of Hardware-Friendly Grid-Based Sparse MIMO Arrays by Tanyer, Suleyman Gokhun, Dent, Paul, Ali, Murtaza, Davis, Curtis, Rajagopal, Senthilkumar, Driessen, Peter F.

“…A comprehensive design framework is proposed for optimizing sparse MIMO (multiple-input, multiple-output) arrays to enhance multi-target detection. The…”
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Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes by Studer, Elaine, Zhou, Xiqiao, Zhao, Renping, Wang, Yun, Takabe, Kazuaki, Nagahashi, Masayuki, Pandak, William M., Dent, Paul, Spiegel, Sarah, Shi, Ruihua, Xu, Weiren, Liu, Xuyuan, Bohdan, Pat, Zhang, Luyong, Zhou, Huiping, Hylemon, Phillip B.

“…Bile acids have been shown to be important regulatory molecules for cells in the liver and gastrointestinal tract. They can activate various cell signaling…”
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Targeting the Bcl-2 family for cancer therapy by Thomas, Shibu, Quinn, Bridget A, Das, Swadesh K, Dash, Rupesh, Emdad, Luni, Dasgupta, Santanu, Wang, Xiang-Yang, Dent, Paul, Reed, John C, Pellecchia, Maurizio, Sarkar, Devanand, Fisher, Paul B

“…Programmed cell death is well-orchestrated process regulated by multiple pro-apoptotic and anti-apoptotic genes, particularly those of the Bcl-2 gene family…”
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The Bruton tyrosine kinase (BTK) inhibitor PCI‐32765 synergistically increases proteasome inhibitor activity in diffuse large‐B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib by Dasmahapatra, Girija, Patel, Hiral, Dent, Paul, Fisher, Richard I., Friedberg, Jonathan, Grant, Steven

“…Summary Interactions between the Bruton tyrosine kinase (BTK) inhibitor PCI‐32765 and the proteasome inhibitor (bortezomib) were examined in diffuse large‐B…”
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Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance by IHLE, Nathan T, LEMOS, Robert, WIPF, Peter, YACOUB, Adly, MITCHELL, Clint, SIWAK, Doris, MILLS, Gordon B, DENT, Paul, KIRKPATRICK, D. Lynn, POWIS, Garth

“…The novel phosphatidylinositol-3-kinase (PI3K) inhibitor PX-866 was tested against 13 experimental human tumor xenografts derived from cell lines of various…”
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Validation of Teleconference-based Goniometry for Measuring Elbow Joint Range of Motion by Dent, Jr, Paul A, Wilke, Benjamin, Terkonda, Sarvram, Luther, Ian, Shi, Glenn G

“…Background  Range of motion (ROM) is a critical component of a physician's evaluation for many consultations. The purpose of this study was to evaluate if…”
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The Kinase Inhibitor Sorafenib Induces Cell Death through a Process Involving Induction of Endoplasmic Reticulum Stress by Rahmani, Mohamed, Davis, Eric Maynard, Crabtree, Timothy Ryan, Habibi, Joseph Reza, Nguyen, Tri K., Dent, Paul, Grant, Steven

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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GZ17-6.02 and Doxorubicin Interact to Kill Sarcoma Cells via Autophagy and Death Receptor Signaling by Booth, Laurence, West, Cameron, Hoff, Daniel Von, Dent, Paul

“…GZ17-6.02 (602) is presently under phase I clinical evaluation (NCT03775525). We defined the mechanisms by which it interacted with a standard of care…”
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OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies by Booth, Laurence, Roberts, Jane L., Tavallai, Mehrad, Nourbakhsh, Aida, Chuckalovcak, John, Carter, Jori, Poklepovic, Andrew, Dent, Paul

“…We examined the interaction between OSU‐03012 (also called AR‐12) with phosphodiesterase 5 (PDE5) inhibitors to determine the role of the chaperone…”
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Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction by Das, Anindita, Durrant, David, Mitchell, Clint, Mayton, Eric, Hoke, Nicholas N., Salloum, Fadi N., Park, Margaret A., Qureshi, Ian, Lee, Ray, Dent, Paul, Kukreja, Rakesh C., Weissbach, Herbert

“…We have shown that the potent phosphodiesterase-5 (PDE-5) inhibitor sildenafil (Viagra) induces a powerful effect on reduction of infarct size following…”
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GZ17-6.02 kills prostate cancer cells in vitro and in vivo by Booth, Laurence, Roberts, Jane L., West, Cameron, Dent, Paul

“…GZ17-6.02 is undergoing clinical evaluation in solid tumors and lymphoma. We defined the biology of GZ17-6.02 in prostate cancer cells and determined whether…”
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Blockade of Histone Deacetylase Inhibitor-Induced RelA/p65 Acetylation and NF-κB Activation Potentiates Apoptosis in Leukemia Cells through a Process Mediated by Oxidative Damage, XIAP Downregulation, and c-Jun N-Terminal Kinase 1 Activation by Dai, Yun, Rahmani, Mohamed, Dent, Paul, Grant, Steven

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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GZ17-6.02 and Pemetrexed Interact to Kill Osimertinib-Resistant NSCLC Cells That Express Mutant ERBB1 Proteins by Booth, Laurence, West, Cameron, Moore, Robert P., Von Hoff, Daniel, Dent, Paul

“…We determined the molecular mechanisms by which the novel therapeutic GZ17-6.02 killed non-small cell lung cancer (NSCLC) cells. Erlotinib, afatinib, and…”
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Apoptosis Induced by the Kinase Inhibitor BAY 43-9006 in Human Leukemia Cells Involves Down-regulation of Mcl-1 through Inhibition of Translation by Rahmani, Mohamed, Davis, Eric Maynard, Bauer, Cheryl, Dent, Paul, Grant, Steven

“…BAY 43-9006 is a kinase inhibitor that induces apoptosis in a variety of tumor cells. Here we report that treatment with BAY 43-9006 results in marked…”
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The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo by Dasmahapatra, Girija, Lembersky, Dmitry, Kramer, Lora, Fisher, Richard I., Friedberg, Jonathan, Dent, Paul, Grant, Steven

“…Interactions between histone deacetylase inhibitors (HDACIs) and the novel proteasome inhibitor carfilzomib (CFZ) were investigated in GC- and activated…”
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Corrigendum: GZ17-6.02 and Doxorubicin Interact to Kill Sarcoma Cells via Autophagy and Death Receptor Signaling by Booth, Laurence, West, Cameron, Von Hoff, Daniel, Dent, Paul

“…[This corrects the article DOI: 10.3389/fonc.2020.01331.]…”
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Axitinib and HDAC Inhibitors Interact to Kill Sarcoma Cells by Roberts, Jane L., Booth, Laurence, Poklepovic, Andrew, Dent, Paul

“…We have extended our analyses of HDAC inhibitor biology in sarcoma. The multi-kinase inhibitor axitinib interacted with multiple HDAC inhibitors to kill…”
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