Search Results - "DENCE, Carmen S"

Sex and Type 2 Diabetes: Obesity-Independent Effects on Left Ventricular Substrate Metabolism and Relaxation in Humans by Peterson, Linda R., Saeed, Ibrahim M., McGill, Janet B., Herrero, Pilar, Schechtman, Kenneth B., Gunawardena, Ratnasiri, Recklein, Carol L., Coggan, Andrew R., DeMoss, Amanda J., Dence, Carmen S., Gropler, Robert J.

“…Patients with type 2 diabetes (T2DM), particularly women, are at risk for heart failure. Myocardial substrate metabolism derangements contribute to cardiac…”
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Positron tomographic assessment of androgen receptors in prostatic carcinoma by Dehdashti, Farrokh, Picus, Joel, Michalski, Jeff M, Dence, Carmen S, Siegel, Barry A, Katzenellenbogen, John A, Welch, Michael J

“…The purpose of this study was to evaluate the feasibility of androgen receptor (AR) imaging with 16beta-[18F]fluoro-5alpha-dihydrotestosterone (FDHT) by…”
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Optimization of the preparation of fluorine-18-labeled steroid receptor ligands 16alpha-[18F]fluoroestradiol (FES), [18F]fluoro furanyl norprogesterone (FFNP), and 16beta-[18F]fluoro-5alpha-dihydrotestosterone (FDHT) as radiopharmaceuticals by Zhou, Dong, Lin, Mai, Yasui, Norio, Al-Qahtani, Mohammed H., Dence, Carmen S., Schwarz, Sally, Katzenellenbogen, John A.

“…Fluorine‐18‐labeled steroid receptor tracers, 16α‐[18F]fluoroestradiol (FES), [18F]fluoro furanyl norprogesterone (FFNP), and…”
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Blood-to-Brain Glucose Transport, Cerebral Glucose Metabolism, and Cerebral Blood Flow Are Not Increased After Hypoglycemia by SEGEL, Scott A, FANELLI, Carmine G, DENCE, Carmen S, MARKHAM, Joanne, VIDEEN, Tom O, PARAMORE, Deanna S, POWERS, William J, CRYER, Philip E

“…Blood-to-Brain Glucose Transport, Cerebral Glucose Metabolism, and Cerebral Blood Flow Are Not Increased After Hypoglycemia Scott A. Segel 1 3 4 , Carmine G…”
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Synthesis and in vivo evaluation of [ 11C]PJ34, a potential radiotracer for imaging the role of PARP-1 in necrosis by Tu, Zhude, Chu, Wenhua, Zhang, Jun, Dence, Carmen S., Welch, Michael J., Mach, Robert H.

“…Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme of eukaryotic cells that has been implicated in response to DNA injury. PARP-1 detects…”
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Longitudinal noninvasive imaging of progesterone receptor as a predictive biomarker of tumor responsiveness to estrogen deprivation therapy by Chan, Szeman Ruby, Fowler, Amy M, Allen, Julie A, Zhou, Dong, Dence, Carmen S, Sharp, Terry L, Fettig, Nicole M, Dehdashti, Farrokh, Katzenellenbogen, John A

“…To investigate whether longitudinal functional PET imaging of mammary tumors using the radiopharmaceuticals [(18)F]FDG (to measure glucose uptake), [(18)F]FES…”
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Small-animal PET of steroid hormone receptors predicts tumor response to endocrine therapy using a preclinical model of breast cancer by Fowler, Amy M, Chan, Szeman Ruby, Sharp, Terry L, Fettig, Nicole M, Zhou, Dong, Dence, Carmen S, Carlson, Kathryn E, Jeyakumar, M, Katzenellenbogen, John A, Schreiber, Robert D, Welch, Michael J

“…Estrogen receptor-α (ERα) and progesterone receptor (PR) are expressed in most human breast cancers and are important predictive factors for directing therapy…”
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New approach to fully automated synthesis of sodium [ 18F]fluoroacetate — a simple and fast method using a commercial synthesizer by Sun, Li-Quan, Mori, Tetsuya, Dence, Carmen S., Ponde, Datta E., Welch, Michael J., Furukawa, Takako, Yonekura, Yoshiharu, Fujibayashi, Yasuhisa

“…A simple, rapid and fully automated preparation of sodium [ 18F]fluoroacetate has been developed by taking advantage of the similarities between the reaction…”
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Autoradiographic and small-animal PET comparisons between (18)F-FMISO, (18)F-FDG, (18)F-FLT and the hypoxic selective (64)Cu-ATSM in a rodent model of cancer by Dence, Carmen S, Ponde, Datta E, Welch, Michael J, Lewis, Jason S

“…Copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone), or Cu-ATSM, a hypoxia imaging agent, has been shown to be predictive of response to traditional cancer…”
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Utilizing electrostatic interactions to facilitate F-18 radiolabeling of poly(amido)amine (PAMAM) dendrimers by Zhou, Dong, Kim, Sung Hoon, Carroll, Vincent M, Dence, Carmen S, Katzenellenbogen, John A

“…The development of methods for the facile conjugation and radiolabeling of poly(amido)amine (PAMAM) dendrimers would be of great benefit in evaluating…”
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Development of [F-18]Fluorine-Substituted Tanaproget as a Progesterone Receptor Imaging Agent for Positron Emission Tomography by Lee, Jae Hak, Zhou, Hai-bing, Dence, Carmen S, Carlson, Kathryn E, Welch, Michael J, Katzenellenbogen, John A

“…The level of progesterone receptors (PRs) in breast tumors can be used to guide the selection of endocrine therapies for breast cancer patients. To this end,…”
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Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans by Fagan, Anne M., Mintun, Mark A., Mach, Robert H., Lee, Sang-Yoon, Dence, Carmen S., Shah, Aarti R., LaRossa, Gina N., Spinner, Michael L., Klunk, William E., Mathis, Chester A., DeKosky, Steven T., Morris, John C., Holtzman, David M.

“…Objectives Amyloid‐β42 (Aβ42) appears central to Alzheimer's disease (AD) pathogenesis and is a major component of amyloid plaques. Mean cerebrospinal fluid…”
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Potentiation of abnormalities in myocardial metabolism with the development of diabetes in women with obesity and insulin resistance by McGill, Janet B., Peterson, Linda R., Herrero, Pilar, Saeed, Ibrahim M., Recklein, Carol, Coggan, Andrew R., DeMoss, Amanda J., Schechtman, Kenneth B., Dence, Carmen S., Gropler, Robert J.

“…Because studies in animal models of type-2 diabetes mellitus (DM) show that excessive myocardial fatty acid (FA) metabolism (at the expense of glucose…”
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Synthesis of an Estrogen Receptor β-Selective Radioligand:  5-[18F]Fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and Comparison of in Vivo Distribution with 16α-[18F]Fluoro-17β-estradiol by Yoo, Jeongsoo, Dence, Carmen S, Sharp, Terry L, Katzenellenbogen, John A, Welch, Michael J

“…Estrogen receptor β (ERβ), a less active ER subtype that appears to have a restraining effect on the more active ERα, could be a factor that determines the…”
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Synthesis and Evaluation of 15-(4-(2-[18F]Fluoroethoxy)phenyl)pentadecanoic Acid: A Potential PET Tracer for Studying Myocardial Fatty Acid Metabolism by Tu, Zhude, Li, Shihong, Sharp, Terry L., Herrero, Pilar, Dence, Carmen S., Gropler, Robert J., Mach, Robert H.

“…15-(4-(2-[18F]fluoroethoxy)phenyl)pentadecanoic acid ([18F]7) was synthesized as a PET probe for assessing myocardial fatty acid metabolism. The radiosynthesis…”
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Synthesis and biological evaluation of two agents for imaging estrogen receptor β by positron emission tomography: challenges in PET imaging of a low abundance target by Lee, Jae Hak, Peters, Olaf, Lehmann, Lutz, Dence, Carmen S, Sharp, Terry L, Carlson, Kathryn E, Zhou, Dong, Jeyakumar, M, Welch, Michael J, Katzenellenbogen, John A

“…Abstract Introduction Independent measurement of the levels of both the estrogen receptors, ERα and ERβ, in breast cancer could improve prediction of benefit…”
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64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry by Zeng, Dexing, Lee, Nam S, Liu, Yongjian, Zhou, Dong, Dence, Carmen S, Wooley, Karen L, Katzenellenbogen, John A, Welch, Michael J

“…A novel strategy based on metal-free “click” chemistry was developed for the copper-64 radiolabeling of the core in shell-cross-linked nanoparticles (SCK-NPs)…”
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Synthesis and Biological Evaluation of [18F]Bicalutamide, 4-[76Br]Bromobicalutamide, and 4-[76Br]Bromo-thiobicalutamide as Non-Steroidal Androgens for Prostate Cancer Imaging by Parent, Ephraim E, Dence, Carmen S, Jenks, Carl, Sharp, Terry L, Welch, Michael J, Katzenellenbogen, John A

“…Androgen receptors (AR) are overexpressed in most primary and metastatic prostate cancers. To develop a nonsteroidal AR-mediated imaging agent, we synthesized…”
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Highly efficient click labeling using 2-[18F]fluoroethyl azide and synthesis of an 18FN-hydroxysuccinimide ester as conjugation agent by Zhou, Dong, Chu, Wenhua, Dence, Carmen S., Mach, Robert H., Welch, Michael J.

“…Click labeling using 2-[18F]fluoroethyl azide has been proven to be promising methods of radiolabeling small molecules and peptides, some of which are…”
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PET detection of the impact of dobutamine on myocardial glucose metabolism in women with type 1 diabetes mellitus by Herrero, Pilar, McGill, Janet, Lesniak, Donna S., Dence, Carmen S., Scott, Shalonda W., Kisrieva-Ware, Zulfia, Gropler, Robert J.

“…Background . Our objective was to determine, in the hearts of women with type 1 diabetes mellitus (T1DM), whether the fate of extracted glucose is altered and,…”
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