Search Results - "DEMİRAYAK, Şeref"

In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells by Yurttas, Leyla, Demirayak, Seref, Ilgin, Sinem, Atli, Oezlem

“…The graphical and numeral illustrate of necrotic, late apoptotic, viable and early apoptotic cells (%) induced by compounds 5, 7 and cisplatin. [Display…”
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Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors by Sahin, Zafer, Biltekin, Sevde Nur, Yurttaş, Leyla, Berk, Barkin, Küçükkılınç, Tuba Tüylü, Demirayak, Şeref

“…•Microwave synthesis step for benzofurane ring closure.•Close and remarkable one digit micromolar acetylcholinesterase inhibitor activity compared to…”
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Synthesis of some 5,6-diaryl-1,2,4-triazine derivatives and investigation of their cyclooxygenase (COX) inhibitory activity by Ertaş, Merve, Biltekin, Sevde Nur, Berk, Barkın, Yurttaş, Leyla, Demirayak, Şeref

“…Within this study, 20 2-[(5,6-diaryl-1,2,4-triazin-3-yl)thio]-N-(benzo/thiazol-2-yl)acetamide derivatives (4a-4t) were synthesized and COX inhibitory…”
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Synthesis and in vitro antitumor activities of novel thioamide substituted piperazinyl‐1,2,4‐triazines by Sahin, Zafer, Biltekin, Sevde Nur, Ozansoy, Mehmet, Hemiş, Bervis, Ozansoy, Muzaffer Beyza, Yurttaş, Leyla, Berk, Barkin, Demirayak, Şeref

“…Triazines are in great interest for their potential to mimic nucleoside analog compounds. Three different isomers exist including 1,2,3‐triazine,…”
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Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition by Sahin, Zafer, Biltekin, Sevde Nur, Yurttas, Leyla, Berk, Barkin, Özhan, Yağmur, Sipahi, Hande, Gao, Zhan-Guo, Jacobson, Kenneth A., Demirayak, Şeref

“…Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated…”
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Synthesis and antitumor activity evaluation of new 2-(4-aminophenyl)benzothiazole derivatives bearing different heterocyclic rings by Yurttaş, Leyla, Tay, Funda, Demirayak, Şeref

“…Twenty-five new N-[4-(benzothiazole-2-yl)phenyl]acetamide derivatives bearing different heterocyclic ring systems were synthesized using…”
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Discovery of novel potent human chondrosarcoma (SW1353) inhibitors: 4-(2/3/4-pyridyl)thiazole 2-acetamide derivatives by Coşkun, Göknil Pelin, Sahin, Zafer, Erdoğan, Ömer, Çevik, Özge, Biltekin, Sevde Nur, Yurttas, Leyla, Berk, Barkin, Ülgen, Mert, Demirayak, Şeref

“…•24 novel thiazole derivatives were synthesized.•Chondrosarcoma inhibitors are discovered.•Apoptotic pathways are monitorized.•Tyrosine kinases could be the…”
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Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs by Şahİn, Zafer, Bİltekİn, Sevde Nur, YurttaŞ, Leyla, Demİrayak, Şeref

“…Marine compound dendrodoine was first obtained from tunicate species ( ). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found…”
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Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation by Sahin, Zafer, Özhan, Yağmur, Sipahi, Hande, Biltekin, Sevde Nur, Yurttaş, Leyla, Berk, Barkin, Demirayak, Şeref

“…Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties…”
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Synthesis, antimicrobial activity and modeling studies of thiazoles bearing pyridyl and triazolyl scaffolds by Funda Tay, Naime, Berk, Barkın, Duran, Murat, Kayagil, İsmail, Yurttaş, Leyla, Biltekin Kaleli, Sevde Nur, Yamaç, Mustafa, Karaduman, Ayşe Betül, Demirayak, Şeref

“…In this study, novel 4-(5-((2/3/4-substituted benzyl)thio)-4-(4-substituted phenyl)-4 -1,2,4-triazol-3-yl)-2-(pyridin-3/4-yl)thiazoles were synthesized…”
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Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives by Tay, Naime Funda, Duran, Murat, Kayagil, İsmail, Yurttaş, Leyla, Göger, Gamze, Göger, Fatih, Demirci, Fatih, Demirayak, Şeref

“…Abstract In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives…”
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Design and synthesis of new donepezil analogs derived from arylpiperazine scaffold as acetylcholinesterase inhibitors by Sahin, Zafer, Biltekin, Sevde Nur, Bülbül, Emre Fatih, Yurttas, Leyla, Berk, Barkin, Demirayak, Şeref

“…Newly synthesized 4-substituted phenyl-2-(4-substituted phenylpiperazine-1-yl)thiazole derivatives (4a-v) were evaluated in terms of their acetylcholinesterase…”
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Novel thiazole‐piperazine derivatives as potential cholinesterase inhibitors by Demirayak, Şeref, Şahin, Zafer, Ertaş, Merve, Bülbül, Emre Fatih, Bender, Ceysu, Biltekin, Sevde Nur, Berk, Barkin, Sağlık, Begüm Nurpelin, Levent, Serkan, Yurttaş, Leyla

“…Dementia is a cognitive disorder mostly associated with Alzheimer's disease (AD) in addition to being seen in many other diseases of the central nervous system…”
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Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines by Yurttas, Leyla, Demirayak, Seref, Ciftci, Gulsen Akalın

“…Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited…”
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Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles by Şahin, Zafer, Koçoğlu Kalkan, Melike, Berk, Barkın, Yurttaş, Leyla, Bender, Ceysu, Biltekin Kaleli, Sevde Nur, Demirayak, Şeref

“…Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements…”
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Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives by Yurttaş, Leyla, Duran, Murat, Demirayak, Şeref, Gençer, Hülya Karaca, Tunalı, Yağmur

“…In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl)ethanone derivatives were synthesized and investigated for their…”
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Synthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N-(thiazole-2-yl)acetamide derivatives and their anticancer activities by Duran, Murat, Demirayak, Şeref

“…In this work, 2-(4,5-dimethyl-1-(phenylamino)-1 H -imidazol-2-ylthio)- N -(thiazol-2-yl) acetamide derivatives were synthesized by reacting…”
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Potent ribonucleotide reductase inhibitors: Thiazole‐containing thiosemicarbazone derivatives by Ertas, Merve, Sahin, Zafer, Bulbul, Emre F., Bender, Ceysu, Biltekin, Sevde N., Berk, Barkin, Yurttas, Leyla, Nalbur, Aysu M., Celik, Hayati, Demirayak, Şeref

“…The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal…”
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Thiazole‐substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors by Sahin, Zafer, Ertas, Merve, Bender, Ceysu, Bülbül, Emre F., Berk, Barkin, Biltekin, Sevde N., Yurttaş, Leyla, Demirayak, Şeref

“…Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE)…”
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Synthesis, characterization and antibacterial evaluation of new pyridyl-thiazole hybrids of sulfonamides by Şahin,Zafer, Biltekin,Sevde Nur, Yurttaş,Leyla, Demirayak,Şeref

“…Background and Aims: Sulfonamide drugs are a very old and noted group of small molecules, and are still one of the most important antimicrobial compounds. In…”
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