Search Results - "DELMOTTE, Philippe"

Inflammation-Induced Protein Unfolding in Airway Smooth Muscle Triggers a Homeostatic Response in Mitochondria by Dasgupta, Debanjali, Delmotte, Philippe, Sieck, Gary C

“…The effects of airway inflammation on airway smooth muscle (ASM) are mediated by pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFα). In this…”
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Chemical Chaperone 4-PBA Mitigates Tumor Necrosis Factor Alpha-Induced Endoplasmic Reticulum Stress in Human Airway Smooth Muscle by Delmotte, Philippe, Yap, Jane Q, Dasgupta, Debanjali, Sieck, Gary C

“…Airway inflammation and pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFα) underlie the pathophysiology of respiratory diseases, including…”
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Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle by Aravamudan, Bharathi, Kiel, Alexander, Freeman, Michelle, Delmotte, Philippe, Thompson, Michael, Vassallo, Robert, Sieck, Gary C, Pabelick, Christina M, Prakash, Y S

“…The balance between mitochondrial fission and fusion is crucial for mitochondria to perform its normal cellular functions. We hypothesized that cigarette smoke…”
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Endoplasmic Reticulum Stress and Mitochondrial Function in Airway Smooth Muscle by Delmotte, Philippe, Sieck, Gary C

“…Inflammatory airway diseases such as asthma affect more than 300 million people world-wide. Inflammation triggers pathophysiology via such as tumor necrosis…”
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Dynamic cytosolic Ca 2+ and force responses to muscarinic stimulation in airway smooth muscle by Han, Young-Soo, Delmotte, Philippe F, Arteaga, Grace M, Sieck, Gary C

“…During agonist stimulation of airway smooth muscle (ASM), agonists such as ACh induce a transient increase in cytosolic Ca concentration ([Ca ] ), which leads…”
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Molecular Mechanisms Underlying TNFα-Induced Mitochondrial Biogenesis in Human Airway Smooth Muscle by Dasgupta, Debanjali, Mahadev Bhat, Sanjana, Price, Alexis L, Delmotte, Philippe, Sieck, Gary C

“…Proinflammatory cytokines such as TNFα mediate airway inflammation. Previously, we showed that TNFα increases mitochondrial biogenesis in human ASM (hASM)…”
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Effects of TNFα on Dynamic Cytosolic Ca2 + and Force Responses to Muscarinic Stimulation in Airway Smooth Muscle by Han, Young-Soo, Delmotte, Philippe, Sieck, Gary C.

“…Previously, we reported that in airway smooth muscle (ASM), the cytosolic Ca 2+ ([Ca 2+ ] cyt ) and force response induced by acetyl choline (ACh) are…”
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Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle by Sathish, Venkatachalem, Delmotte, Philippe F, Thompson, Michael A, Pabelick, Christina M, Sieck, Gary C, Prakash, Y S

“…Enhanced airway contractility following inflammation by cytokines such as tumor necrosis factor alpha (TNFα) or interleukin-13 (IL-13) involves increased…”
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Cell-Based Measurement of Mitochondrial Function in Human Airway Smooth Muscle Cells by Mahadev Bhat, Sanjana, Yap, Jane Q, Ramirez-Ramirez, Oscar A, Delmotte, Philippe, Sieck, Gary C

“…Cellular mitochondrial function can be assessed using high-resolution respirometry that measures the O consumption rate (OCR) across a number of cells…”
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Ciliary Beat Frequency Is Maintained at a Maximal Rate in the Small Airways of Mouse Lung Slices by Delmotte, Philippe, Sanderson, Michael J

“…Ciliary beat frequency (CBF) is a key factor in the defense of the airways, and ATP can stimulate CBF by increasing intracellular calcium concentration…”
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Bioresorbable Magnesium-Based Stent: Real-World Clinical Experience and Feasibility of Follow-Up by Coronary Computed Tomography: A New Window to Look at New Scaffolds by Ghafari, Chadi, Brassart, Nicolas, Delmotte, Philippe, Brunner, Philippe, Dghoughi, Sarah, Carlier, Stéphane

“…(1) Background: The diagnostic accuracy of coronary computed tomography angiography (CCTA) for coronary artery disease (CAD) has greatly improved so CCTA…”
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High Fidelity Pressure Wires Provide Accurate Validation of Non-Invasive Central Blood Pressure and Pulse Wave Velocity Measurements by Scalia, Alessandro, Ghafari, Chadi, Navarre, Wivine, Delmotte, Philippe, Phillips, Rob, Carlier, Stéphane

“…Central blood pressure (cBP) is known to be a better predictor of the damage caused by hypertension in comparison with peripheral blood pressure. During…”
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Mechanisms underlying TNFα‐induced enhancement of force generation in airway smooth muscle by Sieck, Gary C., Dogan, Murat, Young‐Soo, Han, Osorio Valencia, Sara, Delmotte, Philippe

“…Airway diseases such as asthma are triggered by inflammation and mediated by proinflammatory cytokines such as tumor necrosis factor alpha (TNFα). Our goal was…”
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Inflammation alters regional mitochondrial Ca²+ in human airway smooth muscle cells by Delmotte, Philippe, Yang, Binxia, Thompson, Michael A, Pabelick, Christina M, Prakash, Y S, Sieck, Gary C

“…Regulation of cytosolic Ca(2+) concentration ([Ca(2+)](cyt)) in airway smooth muscle (ASM) is a key aspect of airway contractility and can be modulated by…”
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Cytoskeletal remodeling slows cross‐bridge cycling and ATP hydrolysis rates in airway smooth muscle by Delmotte, Philippe, Han, Young‐soo, Sieck, Gary C.

“…During isometric activation of airway smooth muscle (ASM), cross‐bridge cycling and ATP hydrolysis rates decline across time even though isometric force is…”
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Effects of Formoterol on Contraction and Ca2+ Signaling of Mouse Airway Smooth Muscle Cells by Delmotte, Philippe, Sanderson, Michael J

“…Formoterol, a long-acting beta(2)-receptor agonist, is used to relieve bronchial constriction. However, formoterol is often a racemic formulation, and contains…”
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COVID-19 Outbreak in a Hemodialysis Center: A Retrospective Monocentric Case Series by Mazzoleni, Lionel, Ghafari, Chadi, Mestrez, Fabienne, Sava, Roxana, Bivoleanu, Elena, Delmotte, Philippe, Laurent, France, Roland, Thomas, Rossi, Camelia, Carlier, Stéphane

“…Background: The rapid worldwide spread of COVID-19 has posed a serious threat to patients treated with kidney replacement therapy (KRT). Moreover, the impact…”
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Human airway contraction and formoterol-induced relaxation is determined by Ca2+ oscillations and Ca2+ sensitivity by Ressmeyer, Anna-Rebekka, Bai, Yan, Delmotte, Philippe, Uy, Karl F, Thistlethwaite, Patricia, Fraire, Armando, Sato, Osamu, Ikebe, Mitsuo, Sanderson, Michael J

“…The etiology of airway hyperresponsiveness associated with asthma requires an understanding of the regulatory mechanisms mediating human airway smooth muscle…”
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Recognition of Lewis x Derivatives Present on Mucins by Flagellar Components of Pseudomonas aeruginosa by SCHARFMAN, Andree, ARORA, Shiwani K, DELMOTTE, Philippe, VAN BRUSSEL, Edwige, MAZURIER, Joel, RAMPHAL, Reuben, ROUSSEL, Philippe

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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TNF alpha induces mitophagy in human airway smooth muscle cells by Mahadev Bhat, Sanjana, Ramirez Ramirez, Oscar, Delmotte, Philippe, Sieck, Gary

“…Abstract only Mitophagy is a regulated multistep process of selective removal of dysfunctional/damaged mitochondria by autophagy and is critical for the…”
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