Search Results - "DELCANALE, Maurizio"

Novel Class of Benzoic Acid Ester Derivatives as Potent PDE4 Inhibitors for Inhaled Administration in the Treatment of Respiratory Diseases by Armani, Elisabetta, Amari, Gabriele, Rizzi, Andrea, Fanti, Renato De, Ghidini, Eleonora, Capaldi, Carmelida, Carzaniga, Laura, Caruso, Paola, Guala, Matilde, Peretto, Ilaria, La Porta, Elena, Bolzoni, Pier T, Facchinetti, Fabrizio, Carnini, Chiara, Moretto, Nadia, Patacchini, Riccardo, Bassani, Franco, Cenacchi, Valentina, Volta, Roberta, Amadei, Francesco, Capacchi, Silvia, Delcanale, Maurizio, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Villetti, Gino

“…The first steps in the selection process of a new anti-inflammatory drug for the inhaled treatment of asthma and chronic obstructive pulmonary disease are…”
Get full text

Pharmacological actions of a novel, potent, tissue-selective benzopyran estrogen by Galbiati, Elisabetta, Caruso, Paola Lorenza, Amari, Gabriele, Armani, Elisabetta, Ghirardi, Silvia, Delcanale, Maurizio, Civelli, Maurizio

“…We have identified a new benzopyran derivative, 3-(4-methoxy) phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]-2H-1-benzopyran-7-ol hydrochloride (CHF…”
Get more information

Effects of 3-phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]- 2H-1-benzopyran-7-ol (CHF 4056), a novel nonsteroidal estrogen agonist/antagonist, on reproductive and nonreproductive tissue by Galbiati, Elisabetta, Caruso, Paola Lorenza, Amari, Gabriele, Armani, Elisabetta, Ghirardi, Silvia, Delcanale, Maurizio, Civelli, Maurizio

“…We have discovered a new, nonsteroidal, estrogen agonist/antagonist, 3-phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl] methyl]-2H-1-benzopyran-7-ol (CHF 4056)…”
Get more information

Optimization of M3 Antagonist–PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD by Rizzi, Andrea, Amari, Gabriele, Pivetti, Fausto, Delcanale, Maurizio, Amadei, Francesco, Pappani, Alice, Fornasari, Luca, Villetti, Gino, Marchini, Gessica, Pisano, Anna Rita, Pitozzi, Vanessa, Pittelli, Maria Gloria, Trevisani, Marcello, Salvadori, Michela, Cenacchi, Valentina, Fioni, Alessandro, Puccini, Paola, Civelli, Maurizio, Patacchini, Riccardo, Baker-Glenn, Charles, Van de Poël, Hervé, Blackaby, Wesley, Nash, Kevin, Armani, Elisabetta

“…Aiming at the inhaled treatment of pulmonary diseases, the optimization process of the previously reported MAPI compound 92a is herein described. The project…”
Get full text

Discovery of a Potent, Selective, and Orally Bioavailable Tool Compound for Probing the Role of Lysophosphatidic Acid Type 2 Receptor Antagonists in Fibrotic Disorders by Armani, Elisabetta, Rizzi, Andrea, Iotti, Nicolò, Saccani, Francesca, Di Lascia, Maria Rosaria, Tigli, Laura, Pappani, Alice, Marchini, Gessica, Murgo, Annalisa, Capelli, Anna Maria, Delcanale, Maurizio, Puccini, Paola, Villetti, Gino, Civelli, Maurizio, Beato, Claudia, Giuliani, Marta, Mundi, Claudia, Murarolli, Francesca, Pagano, Mafalda, Raveglia, Luca F., Remelli, Rosaria, Amari, Gabriele

“…Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease characterized by lung fibrosis leading to an irreversible decline of lung function…”
Get full text

Optimization of M 3 Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD by Rizzi, Andrea, Amari, Gabriele, Pivetti, Fausto, Delcanale, Maurizio, Amadei, Francesco, Pappani, Alice, Fornasari, Luca, Villetti, Gino, Marchini, Gessica, Pisano, Anna Rita, Pitozzi, Vanessa, Pittelli, Maria Gloria, Trevisani, Marcello, Salvadori, Michela, Cenacchi, Valentina, Fioni, Alessandro, Puccini, Paola, Civelli, Maurizio, Patacchini, Riccardo, Baker-Glenn, Charles, Van de Poël, Hervé, Blackaby, Wesley, Nash, Kevin, Armani, Elisabetta

“…Aiming at the inhaled treatment of pulmonary diseases, the optimization process of the previously reported MAPI compound is herein described. The project was…”
Get full text

Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β 2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD) by Rancati, Fabio, Linney, Ian D, Rizzi, Andrea, Delcanale, Maurizio, Knight, Chris K, Schmidt, Wolfgang, Pastore, Fiorella, Riccardi, Benedetta, Mileo, Valentina, Carnini, Chiara, Cesari, Nicola, Blackaby, Wesley P, Patacchini, Riccardo, Carzaniga, Laura

“…The targeting of both the muscarinic and β-adrenergic pathways is a well validated therapeutic approach for the treatment of chronic obstructive pulmonary…”
Get full text

Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD) by Rancati, Fabio, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Knight, Chris K., Schmidt, Wolfgang, Pastore, Fiorella, Riccardi, Benedetta, Mileo, Valentina, Carnini, Chiara, Cesari, Nicola, Blackaby, Wesley P., Patacchini, Riccardo, Carzaniga, Laura

“…[Display omitted] The targeting of both the muscarinic and β-adrenergic pathways is a well validated therapeutic approach for the treatment of chronic…”
Get full text

Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases by Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio

“…The development of molecules embedding two distinct pharmacophores acting as muscarinic antagonists and β2 agonists (MABAs) promises to be an excellent…”
Get full text

Discovery of M 3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease by Armani, Elisabetta, Rizzi, Andrea, Capaldi, Carmelida, De Fanti, Renato, Delcanale, Maurizio, Villetti, Gino, Marchini, Gessica, Pisano, Anna Rita, Pitozzi, Vanessa, Pittelli, Maria Gloria, Trevisani, Marcello, Salvadori, Michela, Cenacchi, Valentina, Puccini, Paola, Amadei, Francesco, Pappani, Alice, Civelli, Maurizio, Patacchini, Riccardo, Baker-Glenn, Charles A.G., Van de Poël, Hervé, Blackaby, Wesley P., Nash, Kevin, Amari, Gabriele

Get full text

CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration by Moretto, Nadia, Caruso, Paola, Bosco, Raffaella, Marchini, Gessica, Pastore, Fiorella, Armani, Elisabetta, Amari, Gabriele, Rizzi, Andrea, Ghidini, Eleonora, De Fanti, Renato, Capaldi, Carmelida, Carzaniga, Laura, Hirsch, Emilio, Buccellati, Carola, Sala, Angelo, Carnini, Chiara, Patacchini, Riccardo, Delcanale, Maurizio, Civelli, Maurizio, Villetti, Gino, Facchinetti, Fabrizio

“…This study examined the pharmacologic characterization of CHF6001…”
Get more information

Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β 2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases by Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio

Get full text

Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases by Armani, Elisabetta, Capaldi, Carmelida, Bagnacani, Valentina, Saccani, Francesca, Aquino, Giancarlo, Puccini, Paola, Facchinetti, Fabrizio, Martucci, Cataldo, Moretto, Nadia, Villetti, Gino, Patacchini, Riccardo, Civelli, Maurizio, Hurley, Chris, Jennings, Andrew, Alcaraz, Lilian, Bloomfield, Dawn, Briggs, Michael, Daly, Stephen, Panchal, Terry, Russell, Vince, Wicks, Sharon, Finch, Harry, Fitzgerald, Mary, Fox, Craig, Delcanale, Maurizio

“…The identification of novel inhaled p38α/β mitogen-activated protein kinases (MAPK) (MAPK14/11) inhibitors suitable for the treatment of pulmonary inflammatory…”
Get full text

Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease by Armani, Elisabetta, Rizzi, Andrea, Capaldi, Carmelida, De Fanti, Renato, Delcanale, Maurizio, Villetti, Gino, Marchini, Gessica, Pisano, Anna Rita, Pitozzi, Vanessa, Pittelli, Maria Gloria, Trevisani, Marcello, Salvadori, Michela, Cenacchi, Valentina, Puccini, Paola, Amadei, Francesco, Pappani, Alice, Civelli, Maurizio, Patacchini, Riccardo, Baker-Glenn, Charles A.G, Van de Poël, Hervé, Blackaby, Wesley P, Nash, Kevin, Amari, Gabriele

“…In this paper, we report the discovery of dual M3 antagonist-PDE4 inhibitor (MAPI) compounds for the inhaled treatment of pulmonary diseases. The…”
Get full text

Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases by Carzaniga, Laura, Amari, Gabriele, Rizzi, Andrea, Capaldi, Carmelida, De Fanti, Renato, Ghidini, Eleonora, Villetti, Gino, Carnini, Chiara, Moretto, Nadia, Facchinetti, Fabrizio, Caruso, Paola, Marchini, Gessica, Battipaglia, Loredana, Patacchini, Riccardo, Cenacchi, Valentina, Volta, Roberta, Amadei, Francesco, Pappani, Alice, Capacchi, Silvia, Bagnacani, Valentina, Delcanale, Maurizio, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Armani, Elisabetta

“…Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of inflammatory disease, and its pharmacological inhibition has been…”
Get full text

Erythroid differentiation ability of butyric acid analogues: Identification of basal chemical structures of new inducers of foetal haemoglobin by Bianchi, Nicoletta, Chiarabelli, Cristiano, Zuccato, Cristina, Lampronti, Ilaria, Borgatti, Monica, Amari, Gabriele, Delcanale, Maurizio, Chiavilli, Francesco, Prus, Eugenia, Fibach, Eitan, Gambari, Roberto

“…Several investigations have demonstrated a mild clinical status in patients with β-globin disorders and congenital high persistence of foetal haemoglobin. This…”
Get full text

Solution- and solid-state structures of the (-)-n-heptylcarbamate of geneseroline and its hydrochloride salt by Redenti, E, Delcanale, M, Amari, G, Ventura, P, Bacchi, A, Pelizzi, G

“…The solid state structures of the (-)-n-heptylcarbamate of geneseroline and its hydrochloride salt were determined by single crystal X-ray diffraction…”
Get more information

Structural Determinants of Torpedo californica Acetylcholinesterase Inhibition by the Novel and Orally Active Carbamate Based Anti-Alzheimer Drug Ganstigmine (CHF-2819) by BARTOLUCCI, Cecilia, SIOTTO, Mariacristina, GHIDINI, Eleonora, AMARI, Gabriele, BOLZONI, Pier Tonino, RACCHI, Marco, VILLETTI, Gino, DELCANALE, Maurizio, LAMBA, Doriano

“…Ganstigmine is an orally active, geneserine derived, carbamate-based acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease. The…”
Get full text

Functionalized pyrazoles and pyrazolo[3,4- d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity by Biagini, Pierfrancesco, Biancalani, Claudio, Graziano, Alessia, Cesari, Nicoletta, Giovannoni, Maria Paola, Cilibrizzi, Agostino, Piaz, Vittorio Dal, Vergelli, Claudia, Crocetti, Letizia, Delcanale, Maurizio, Armani, Elisabetta, Rizzi, Andrea, Puccini, Paola, Gallo, Paola Maria, Spinabelli, Daniele, Caruso, Paola

“…A series of pyrazoles and pyrazolo[3,4- d]pyridazinones were synthesized and evaluated for their PDE4 inhibitory activity. All the pyrazoles were found devoid…”
Get full text

Discovery of Diaryl Imidazolidin-2-one Derivatives, a Novel Class of Muscarinic M3 Selective Antagonists (Part 1) by Peretto, Ilaria, Forlani, Roberto, Fossati, Claudia, Giardina, Giuseppe A. M, Giardini, Alessandra, Guala, Matilde, La Porta, Elena, Petrillo, Paola, Radaelli, Stefano, Radice, Luigi, Raveglia, Luca F, Santoro, Enza, Scudellaro, Roberta, Scarpitta, Francesca, Bigogno, Chiara, Misiano, Paola, Dondio, Giulio M, Rizzi, Andrea, Armani, Elisabetta, Amari, Gabriele, Civelli, Maurizio, Villetti, Gino, Patacchini, Riccardo, Bergamaschi, Marco, Delcanale, Maurizio, Salcedo, Carolina, Fernández, Andrés G, Imbimbo, Bruno P

“…Pharmacophore-based structural identification, synthesis, and structure−activity relationships of a new class of muscarinic M3 receptor antagonists, the diaryl…”
Get full text