Search Results - "DELACOURTE, ANDRÉ"

Revising the definition of Alzheimer's disease: a new lexicon by Dubois, Bruno, Prof, Feldman, Howard H, Prof, Jacova, Claudia, PhD, Cummings, Jeffrey L, MD, DeKosky, Steven T, Prof, Barberger-Gateau, Pascale, MD, Delacourte, André, PhD, Frisoni, Giovanni, Prof, Fox, Nick C, Prof, Galasko, Douglas, Prof, Gauthier, Serge, Prof, Hampel, Harald, Prof, Jicha, Gregory A, MD, Meguro, Kenichi, MD, O'Brien, John, DM, Pasquier, Florence, Prof, Robert, Philippe, Prof, Rossor, Martin, Prof, Salloway, Steven, Prof, Sarazin, Marie, MD, de Souza, Leonardo C, MD, Stern, Yaakov, Prof, Visser, Pieter J, MD, Scheltens, Philip, Prof

“…Summary Alzheimer's disease (AD) is classically defined as a dual clinicopathological entity. The recent advances in use of reliable biomarkers of AD that…”
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Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression by Hébert, Sébastien S, Horré, Katrien, Nicolaï, Laura, Papadopoulou, Aikaterini S, Mandemakers, Wim, Silahtaroglu, Asli N, Kauppinen, Sakari, Delacourte, André, De Strooper, Bart

“…Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known about the molecular mechanisms…”
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MicroRNA regulation of Alzheimer's Amyloid precursor protein expression by Hébert, Sébastien S, Horré, Katrien, Nicolaï, Laura, Bergmans, Bruno, Papadopoulou, Aikaterini S, Delacourte, André, De Strooper, Bart

“…Abstract Gene dosage effects of Amyloid precursor protein ( APP ) can cause familial AD. Recent evidence suggest that microRNA (miRNA) pathways, implicated in…”
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Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria by Dubois, Bruno, MD, Feldman, Howard H, MD, Jacova, Claudia, PhD, DeKosky, Steven T, MD, Barberger-Gateau, Pascale, MD, Cummings, Jeffrey, MD, Delacourte, André, PhD, Galasko, Douglas, MD, Gauthier, Serge, MD, Jicha, Gregory, MD, Meguro, Kenichi, MD, O'Brien, John, MD, Pasquier, Florence, MD, Robert, Philippe, MD, Rossor, Martin, MD, Salloway, Steven, MD, Stern, Yaakov, PhD, Visser, Pieter J, MD, Scheltens, Philip, MD

“…Summary The NINCDS–ADRDA and the DSM-IV-TR criteria for Alzheimer's disease (AD) are the prevailing diagnostic standards in research; however, they have now…”
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Orphan G Protein-Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons by Thathiah, Amantha, Spittaels, Kurt, Hoffmann, Marcel, Staes, Mik, Cohen, Adrian, Horré, Katrién, Vanbrabant, Mieke, Coun, Frea, Baekelandt, Veerle, Delacourte, André, Fischer, David F, Pollet, Dirk, De Strooper, Bart, Merchiers, Pascal

“…Deposition of the amyloid-β peptide is a pathological hallmark of Alzheimer's disease. A high-throughput functional genomics screen identified G…”
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Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease by Hudry, Eloise, Van Dam, Debby, Kulik, Wim, De Deyn, Peter P, Stet, Femke S, Ahouansou, Ornella, Benraiss, Abdellatif, Delacourte, André, Bougnères, Pierre, Aubourg, Patrick, Cartier, Nathalie

“…The development of Alzheimer's disease (AD) is closely connected with cholesterol metabolism. Cholesterol increases the production and deposition of amyloid-β…”
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Biochemistry of Tau in Alzheimer's disease and related neurological disorders by Sergeant, Nicolas, Bretteville, Alexis, Hamdane, Malika, Caillet-Boudin, Marie-Laure, Grognet, Pierre, Bombois, Stephanie, Blum, David, Delacourte, André, Pasquier, Florence, Vanmechelen, Eugeen, Schraen-Maschke, Susanna, Buée, Luc

“…Microtubule-associated Tau proteins belong to a family of factors that polymerize tubulin dimers and stabilize microtubules. Tau is strongly expressed in…”
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Alkalizing Drugs Induce Accumulation of Amyloid Precursor Protein By-products in Luminal Vesicles of Multivesicular Bodies by Vingtdeux, Valérie, Hamdane, Malika, Loyens, Anne, Gelé, Patrick, Drobeck, Hervé, Bégard, Séverine, Galas, Marie-Christine, Delacourte, André, Beauvillain, Jean-Claude, Buée, Luc, Sergeant, Nicolas

“…Amyloid precursor protein (APP) metabolism is central to the pathogenesis of Alzheimer disease. We showed recently that the amyloid intracellular domain…”
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Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease by Kashani, Alireza, Lepicard, Ève, Poirel, Odile, Videau, Catherine, David, Jean Philippe, Fallet-Bianco, Catherine, Simon, Axelle, Delacourte, André, Giros, Bruno, Epelbaum, Jacques, Betancur, Catalina, El Mestikawy, Salah

“…Abstract Several lines of evidence suggest that the glutamatergic system is severely impaired in Alzheimer disease (AD). Here, we assessed the status of…”
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Comparative Biochemistry of Tau in Progressive Supranuclear Palsy, Corticobasal Degeneration, FTDP-17 and Pick's Disease by Buée, Luc, Delacourte, André

“…Neurodegenerative disorders referred to as tauopathies have cellular hyperphosphorylated tau protein aggregates in the absence of amyloid deposits. Comparative…”
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Neurosteroid Quantification in Human Brain Regions: Comparison between Alzheimer’s and Nondemented Patients by Weill-Engerer, Sébastien, David, Jean-Philippe, Sazdovitch, Véronique, Liere, Philippe, Eychenne, Bernard, Pianos, Antoine, Schumacher, Michael, Delacourte, André, Baulieu, Etienne-Emile, Akwa, Yvette

“…Some neurosteroids have been shown to display beneficial effects on neuroprotection in rodents. To investigate the physiopathological significance of…”
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Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity by Ma, Huifang, Lesné, Sylvain, Kotilinek, Linda, Steidl-Nichols, Jill V, Sherman, Mathew, Younkin, Linda, Younkin, Steven, Forster, Colleen, Sergeant, Nicolas, Delacourte, André, Vassar, Robert, Citron, Martin, Kofuji, Paulo, Boland, Linda M, Ashe, Karen H

“…The amyloid precursor protein (APP) undergoes sequential cleavages to generate various polypeptides, including the amyloid-β protein (Aβ), which forms amyloid…”
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p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death by Hamdane, Malika, Bretteville, Alexis, Sambo, Anne-Véronique, Schindowski, Katharina, Bégard, Séverine, Delacourte, André, Bertrand, Philippe, Buée, Luc

“…In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to…”
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Chloroquine and Chloroquinoline Derivatives as Models for the Design of Modulators of Amyloid Peptide Precursor Metabolism by Melnyk, Patricia, Vingtdeux, Valérie, Burlet, Stéphane, Eddarkaoui, Sabiha, Grosjean, Marie-Eve, Larchanché, Paul-Emmanuel, Hochart, Guillaume, Sergheraert, Christian, Estrella, Cecilia, Barrier, Mathieu, Poix, Virginie, Plancq, Pauline, Lannoo, Cécile, Hamdane, Malika, Delacourte, André, Verwaerde, Philippe, Buée, Luc, Sergeant, Nicolas

“…The amyloid precursor protein (APP) plays a central role in Alzheimer’s disease (AD). Preventing deregulated APP processing by inhibiting amyloidogenic…”
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Tau pathology and neurodegeneration: an obvious but misunderstood link by Delacourte, André

“…Most dementing disorders result from a degenerating process named tauopathy. Alzheimer disease is the most frequent one, but only one among the large spectrum…”
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Intracellular pH regulates amyloid precursor protein intracellular domain accumulation by Vingtdeux, Valérie, Hamdane, Malika, Bégard, Séverine, Loyens, Anne, Delacourte, André, Beauvillain, Jean-Claude, Buée, Luc, Marambaud, Philippe, Sergeant, Nicolas

“…Abstract The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a…”
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Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in β-amyloid deposits in the cerebral cortex of vitamin A deprived rats by Husson, Marianne, Enderlin, Valérie, Delacourte, André, Ghenimi, Nadirah, Alfos, Serge, Pallet, Véronique, Higueret, Paul

“…Recent data have revealed that disruption of vitamin A signaling observed in Alzheimer's disease (AD) leads to a deposition of β-amyloid (Aβ). The aim of this…”
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Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms by Cacquevel, Mathias, Launay, Séverine, Castel, Hervé, Benchenane, Karim, Chéenne, Simon, Buée, Luc, Moons, Lieve, Delacourte, André, Carmeliet, Peter, Vivien, Denis

“…Abstract Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder in the ageing population. It is characterized by the cerebral…”
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Tauopathies: recent insights into old diseases by Delacourte, Andre

“…Neurofibrillary tangles are brain lesions that have been discovered at the beginning of the 20th century, using histological silver staining. Tangles are…”
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Dysregulation of human brain microtubule-associated tau mRNA maturation in myotonic dystrophy type 1 by SERGEANT, Nicolas, SABLONNIERE, Bernard, SCHRAEN-MASCHKE, Suzanna, GHESTEM, Antoine, MAURAGE, Claude-Alain, WATTEZ, Annick, VERMERSCH, Patrick, DELACOURTE, André

“…Intraneuronal aggregates of hyperphosphorylated tau proteins, referred to as pathological tau, are found in brain areas of demented patients affected by…”
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