Search Results - "DELABESSE, Eric"

Intensified Therapy of Acute Lymphoblastic Leukemia in Adults: Report of the Randomized GRAALL-2005 Clinical Trial by Huguet, Françoise, Chevret, Sylvie, Leguay, Thibaut, Thomas, Xavier, Boissel, Nicolas, Escoffre-Barbe, Martine, Chevallier, Patrice, Hunault, Mathilde, Vey, Norbert, Bonmati, Caroline, Lepretre, Stéphane, Marolleau, Jean-Pierre, Pabst, Thomas, Rousselot, Philippe, Buzyn, Agnès, Cahn, Jean-Yves, Lhéritier, Véronique, Béné, Marie C, Asnafi, Vahid, Delabesse, Eric, Macintyre, Elizabeth, Chalandon, Yves, Ifrah, Norbert, Dombret, Hervé

“…Purpose To evaluate randomly the role of hyperfractionated cyclophosphamide (hyper-C) dose intensification in adults with newly diagnosed Philadelphia…”
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Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells by Larrue, Clément, Saland, Estelle, Boutzen, Héléna, Vergez, François, David, Marion, Joffre, Carine, Hospital, Marie-Anne, Tamburini, Jérôme, Delabesse, Eric, Manenti, Stéphane, Sarry, Jean Emmanuel, Récher, Christian

“…Internal tandem duplication of the Fms-like tyrosine kinase-3 receptor (FLT3) internal tandem duplication (ITD) is found in 30% of acute myeloid leukemia (AML)…”
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Pediatric-Inspired Therapy in Adults With Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia: The GRAALL-2003 Study by HUGUET, Francoise, LEGUAY, Thibaut, VERNANT, Jean-Paul, LAFAGE-POCHITALOFF, Marina, CHASSEVENT, Agnès, LHERITIER, Véronique, MACINTYRE, Elizabeth, BENE, Marie-Christine, IFRAH, Norbert, DOMBRET, Hervé, RAFFOUX, Emmanuel, THOMAS, Xavier, BELDJORD, Kheira, DELABESSE, Eric, CHEVALLIER, Patrice, BUZYN, Agnes, DELANNOY, André, CHALANDON, Yves

“…Retrospective comparisons have suggested that adolescents or teenagers with acute lymphoblastic leukemia (ALL) benefit from pediatric rather than adult…”
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Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers by Fagnan, Alexandre, Bagger, Frederik Otzen, Piqué-Borràs, Maria-Riera, Ignacimouttou, Cathy, Caulier, Alexis, Lopez, Cécile K., Robert, Elie, Uzan, Benjamin, Gelsi-Boyer, Véronique, Aid, Zakia, Thirant, Cécile, Moll, Ute, Tauchmann, Samantha, Kurtovic-Kozaric, Amina, Maciejewski, Jaroslaw, Dierks, Christine, Spinelli, Orietta, Salmoiraghi, Silvia, Pabst, Thomas, Shimoda, Kazuya, Deleuze, Virginie, Lapillonne, Hélène, Sweeney, Connor, De Mas, Véronique, Leite, Betty, Kadri, Zahra, Malinge, Sébastien, de Botton, Stéphane, Micol, Jean-Baptiste, Kile, Benjamin, Carmichael, Catherine L., Iacobucci, Ilaria, Mullighan, Charles G., Carroll, Martin, Valent, Peter, Bernard, Olivier A., Delabesse, Eric, Vyas, Paresh, Birnbaum, Daniel, Anguita, Eduardo, Garçon, Loïc, Soler, Eric, Schwaller, Juerg, Mercher, Thomas

“…Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells…”
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Dexamethasone in hyperleukocytic acute myeloid leukemia by Bertoli, Sarah, Picard, Muriel, Bérard, Emilie, Griessinger, Emmanuel, Larrue, Clément, Mouchel, Pierre Luc, Vergez, François, Tavitian, Suzanne, Yon, Edwige, Ruiz, Jean, Delabesse, Eric, Luquet, Isabelle, Linares, Laetitia Karine, Saland, Estelle, Carroll, Martin, Danet-Desnoyers, Gwenn, Sarry, Audrey, Huguet, Françoise, Sarry, Jean Emmanuel, Récher, Christian

“…Patients with acute myeloid leukemia and a high white blood cell count are at increased risk of early death and relapse. Because mediators of inflammation…”
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Somatic genetic alterations predict hematological progression in GATA2 deficiency by Largeaud, Laetitia, Collin, Matthew, Monselet, Nils, Vergez, Francois, Fregona, Vincent, Larcher, Lise, Hirsch, Pierre, Duployez, Nicolas, Bidet, Audrey, Luquet, Isabelle, Bustamante, Jacinta, Dufrechou, Stephanie, Prade, Nais, Nolla, Marie, Hamelle, Camille, Tavitian, Suzanne, Habib, Christophe, Meynier, Mateo, Bellanne-Chantelot, Christine, Donadieu, Jean, De Fontbrune, Flore Sicre, Fieschi, Claire, Ferster, Alina, Delhommeau, Francois, Delabesse, Eric, Pasquet, Marlene

“…Germline GATA2 mutations predispose to myeloid malignancies resulting from the progressive acquisition of additional somatic mutations. Here we describe…”
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CHK1 as a therapeutic target to bypass chemoresistance in AML by David, Laure, Fernandez-Vidal, Anne, Bertoli, Sarah, Grgurevic, Srdana, Lepage, Benoît, Deshaies, Dominique, Prade, Naïs, Cartel, Maëlle, Larrue, Clément, Sarry, Jean-Emmanuel, Delabesse, Eric, Cazaux, Christophe, Didier, Christine, Récher, Christian, Manenti, Stéphane, Hoffmann, Jean-Sébastien

“…The nucleoside analog cytarabine, an inhibitor of DNA replication fork progression that results in DNA damage, is currently used in the treatment of acute…”
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High tumor burden before blinatumomab has a negative impact on the outcome of adult patients with B-cell precursor acute lymphoblastic leukemia. A real-world study by the GRAALL by Cabannes-Hamy, Aurelie, Brissot, Eolia, Leguay, Thibaut, Huguet, Francoise, Chevallier, Patrice, Hunault, Mathilde, Escoffre-Barbe, Martine, Cluzeau, Thomas, Balsat, Marie, Nguyen, Stephanie, Pasquier, Florence, Alexis, Magda, Lheritier, Veronique, Pastoret, Cedric, Delabesse, Eric, Clappier, Emmanuelle, Dombret, Herve, Boissel, Nicolas

“…Blinatumomab is a bispecific T-cell engager approved for B-cell precursor acute lymphoblastic leukemia (B-ALL) with persistent minimal residual disease (MRD)…”
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Long non-coding RNA expression profile in cytogenetically normal acute myeloid leukemia identifies a distinct signature and a new biomarker in NPM1-mutated patients by De Clara, Etienne, Gourvest, Morgane, Ma, Hanjing, Vergez, François, Tosolini, Marie, Dejean, Sébastien, Demur, Cécile, Delabesse, Eric, Recher, Christian, Touriol, Christian, Martelli, Maria Paola, Falini, Brunangelo, Brousset, Pierre, Bousquet, Marina

“…Long non-coding RNAs are defined as transcripts larger than 200 nucleotides but without protein-coding potential. There is growing evidence of the important…”
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TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs) by Kosmider, Olivier, Gelsi-Boyer, Véronique, Cheok, Meyling, Grabar, Sophie, Della-Valle, Véronique, Picard, Françoise, Viguié, Franck, Quesnel, Bruno, Beyne-Rauzy, Odile, Solary, Eric, Vey, Norbert, Hunault-Berger, Mathilde, Fenaux, Pierre, Mansat-De Mas, Véronique, Delabesse, Eric, Guardiola, Philippe, Lacombe, Catherine, Vainchenker, William, Preudhomme, Claude, Dreyfus, François, Bernard, Olivier A., Birnbaum, Daniel, Fontenay, Michaëla

“…Oncogenic pathways underlying in the development of myelodysplastic syndromes (MDS) remain poorly characterized, but mutations of the ten-eleven translocation…”
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Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors by Göttgens, Berthold, Nastos, Aristotelis, Kinston, Sarah, Piltz, Sandie, Delabesse, Eric C.M., Stanley, Maureen, Sanchez, Maria-Jose, Ciau-Uitz, Aldo, Patient, Roger, Green, Anthony R.

“…Stem cells are a central feature of metazoan biology. Haematopoietic stem cells (HSCs) represent the best‐characterized example of this phenomenon, but the…”
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Impact of TP53 mutations in acute myeloid leukemia patients treated with azacitidine by Bories, Pierre, Prade, Naïs, Lagarde, Stéphanie, Cabarrou, Bastien, Largeaud, Laetitia, Plenecassagnes, Julien, Luquet, Isabelle, De Mas, Véronique, Filleron, Thomas, Cassou, Manon, Sarry, Audrey, Fornecker, Luc-Matthieu, Simand, Célestine, Bertoli, Sarah, Recher, Christian, Delabesse, Eric, Bertolini, Francesco

“…Hypomethylating agents are a classical frontline low-intensity therapy for older patients with acute myeloid leukemia. Recently, TP53 gene mutations have been…”
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PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice by Jamrog, Laura, Chemin, Guillaume, Fregona, Vincent, Coster, Lucie, Pasquet, Marlène, Oudinet, Chloé, Rouquié, Nelly, Prade, Naïs, Lagarde, Stéphanie, Cresson, Charlotte, Hébrard, Sylvie, Huu, Ngoc Sa Nguyen, Bousquet, Marina, Quelen, Cathy, Brousset, Pierre, Mancini, Stéphane J. C., Delabesse, Eric, Khamlichi, Ahmed Amine, Gerby, Bastien, Broccardo, Cyril

“…PAX5 is a well-known haploinsufficient tumor suppressor gene in human B-cell precursor acute lymphoblastic leukemia (B-ALL) and is involved in various…”
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Imatinib with intensive chemotherapy in AML with t(9;22)(q34.1;q11.2)/BCR::ABL1. A DATAML registry study by Gondran, Camille, Dumas, Pierre-Yves, Bérard, Emilie, Bidet, Audrey, Delabesse, Eric, Tavitian, Suzanne, Leguay, Thibaut, Huguet, Françoise, Borel, Cécile, Forcade, Edouard, Vergez, François, Vial, Jean-Philippe, Rieu, Jean Baptiste, Lechevalier, Nicolas, Luquet, Isabelle, Canali, Alban, Klein, Emilie, Sarry, Audrey, de Grande, Anne-Charlotte, Pigneux, Arnaud, Récher, Christian, Largeaud, Laetitia, Bertoli, Sarah

“…Acute myeloid leukemia (AML) with t(9;22) (q34.1; q11.2)/ BCR::ABL1 , a distinct entity within the group of AML with defining genetic abnormalities, belong to…”
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Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia by Vergez, François, Largeaud, Laetitia, Bertoli, Sarah, Nicolau, Marie-Laure, Rieu, Jean-Baptiste, Vergnolle, Inès, Saland, Estelle, Sarry, Audrey, Tavitian, Suzanne, Huguet, Françoise, Picard, Muriel, Vial, Jean-Philippe, Lechevalier, Nicolas, Bidet, Audrey, Dumas, Pierre-Yves, Pigneux, Arnaud, Luquet, Isabelle, Mansat-De Mas, Véronique, Delabesse, Eric, Carroll, Martin, Danet-Desnoyers, Gwenn, Sarry, Jean-Emmanuel, Récher, Christian

“…Classifications of acute myeloid leukemia (AML) patients rely on morphologic, cytogenetic, and molecular features. Here we have established a novel flow…”
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TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia by Pérez, Cristina, Martínez-Calle, Nicolas, Martín-Subero, José Ignacio, Segura, Victor, Delabesse, Eric, Fernandez-Mercado, Marta, Garate, Leire, Alvarez, Sara, Rifon, José, Varea, Sara, Boultwood, Jacqueline, Wainscoat, James S, Cruz Cigudosa, Juan, Calasanz, María José, Cross, Nicholas C P, Prósper, Felipe, Agirre, Xabier

“…Chronic myelomonocytic leukemia (CMML) has recently been associated with a high incidence of diverse mutations in genes such as TET2 or EZH2 that are…”
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Impact of obesity in favorable‐risk AML patients receiving intensive chemotherapy by Tavitian, Suzanne, Denis, Amélia, Vergez, François, Berard, Emilie, Sarry, Audrey, Huynh, Anne, Delabesse, Eric, Luquet, Isabelle, Huguet, Françoise, Récher, Christian, Bertoli, Sarah

“…We assessed the influence of obesity on the characteristics and prognosis of acute myeloid leukemia (AML). Indeed, safety of intensive chemotherapy and outcome…”
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Anthracycline dose intensification improves molecular response and outcome of patients treated for core binding factor acute myeloid leukemia by Prebet, Thomas, Bertoli, Sarah, Delaunay, Jacques, Pigneux, Arnaud, Delabesse, Eric, Mozziconacci, Marie Joelle, Bidet, Audrey, Recher, Christian, Vey, Norbert

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LOSS OF HSC STEMNESS IDENTITY IS ASSOCIATED WITH EXHAUSTION AND HYPORESPONSIVENESS IN GATA2 DEFICIENCY SYNDROME by Largeaud, Laëtitia, Fregona, Vincent, Jamrog, Laura, Hamelle, Camille, Dufrechou, Stephanie, Prade, Naïs, Sellam, Esmaa, Enfedaque, Pauline, Bayet, Manon, Hebrard, Sylvie, Didier, Christine, Delabesse, Eric, Gerby, Bastien, Pasquet, Marlène, Broccardo, Cyril

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Genomic landscape of hyperleukocytic acute myeloid leukemia by Largeaud, Laetitia, Bertoli, Sarah, Bérard, Emilie, Tavitian, Suzanne, Picard, Muriel, Dufrechou, Stéphanie, Prade, Naïs, Vergez, François, Rieu, Jean Baptiste, Luquet, Isabelle, Sarry, Audrey, Huguet, Françoise, Ruiz, Jean, De Mas, Véronique, Delabesse, Eric, Récher, Christian

“…Approximately 20% of patients with acute myeloid leukemia (AML) present at diagnosis with hyperleukocytosis, which is commonly defined as a white blood cell…”
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