Search Results - "DEL POZO, A"

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis by Goetz, Jacky G., Minguet, Susana, Navarro-Lérida, Inmaculada, Lazcano, Juan José, Samaniego, Rafael, Calvo, Enrique, Tello, Marta, Osteso-Ibáñez, Teresa, Pellinen, Teijo, Echarri, Asier, Cerezo, Ana, Klein-Szanto, Andres J.P., Garcia, Ricardo, Keely, Patricia J., Sánchez-Mateos, Paloma, Cukierman, Edna, Del Pozo, Miguel A.

“…Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is driven by intercellular adhesions, cell contractility, and forces…”
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Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells by Thottacherry, Joseph Jose, Kosmalska, Anita Joanna, Kumar, Amit, Vishen, Amit Singh, Elosegui-Artola, Alberto, Pradhan, Susav, Sharma, Sumit, Singh, Parvinder P., Guadamillas, Marta C., Chaudhary, Natasha, Vishwakarma, Ram, Trepat, Xavier, del Pozo, Miguel A., Parton, Robert G., Rao, Madan, Pullarkat, Pramod, Roca-Cusachs, Pere, Mayor, Satyajit

“…Plasma membrane tension regulates many key cellular processes. It is modulated by, and can modulate, membrane trafficking. However, the cellular pathway(s)…”
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Caveolae - mechanosensitive membrane invaginations linked to actin filaments by Echarri, Asier, Del Pozo, Miguel A

“…An essential property of the plasma membrane of mammalian cells is its plasticity, which is required for sensing and transmitting of signals, and for…”
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Tox_(R)CNN: Deep learning-based nuclei profiling tool for drug toxicity screening by Jimenez-Carretero, Daniel, Abrishami, Vahid, Fernández-de-Manuel, Laura, Palacios, Irene, Quílez-Álvarez, Antonio, Díez-Sánchez, Alberto, Del Pozo, Miguel A, Montoya, María C

“…Toxicity is an important factor in failed drug development, and its efficient identification and prediction is a major challenge in drug discovery. We have…”
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A novel Carcinoembryonic Antigen (CEA)-Targeted Trimeric Immunotoxin shows significantly enhanced Antitumor Activity in Human Colorectal Cancer Xenografts by Lázaro-Gorines, R., Ruiz-de-la-Herrán, J., Navarro, R., Sanz, L., Álvarez-Vallina, L., Martínez-del-Pozo, A., Gavilanes, J. G., Lacadena, J.

“…Immunotoxins are chimeric molecules, which combine antibody specificity to recognize and bind with high-affinity tumor-associated antigens (TAA) with the…”
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Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion by Navarro-Lérida, Inmaculada, Pellinen, Teijo, Sanchez, Susana A., Guadamillas, Marta C., Wang, Yinhai, Mirtti, Tuomas, Calvo, Enrique, Del Pozo, Miguel A.

“…Nuclear membrane microdomains are proposed to act as platforms for regulation of nuclear function, but little is known about the mechanisms controlling their…”
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Structural recovery of the retina in a retinoschisin-deficient mouse after gene replacement therapy by solid lipid nanoparticles by Apaolaza, P.S, del Pozo-Rodríguez, A, Solinís, M.A, Rodríguez, J.M, Friedrich, U, Torrecilla, J, Weber, B.H.F, Rodríguez-Gascón, A

“…Abstract X-linked juvenile retinoschisis (XLRS) is a retinal degenerative disorder caused by mutations in the RS1 gene encoding a protein termed retinoschisin…”
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Overcoming anoikis--pathways to anchorage-independent growth in cancer by Guadamillas, Marta C, Cerezo, Ana, Del Pozo, Miguel A

“…Anoikis (or cell-detachment-induced apoptosis) is a self-defense strategy that organisms use to eliminate 'misplaced' cells, i.e. cells that are in an…”
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Caveolae couple mechanical stress to integrin recycling and activation by Lolo, Fidel-Nicolás, Pavón, Dácil María, Grande, Araceli, Elósegui Artola, Alberto, Segatori, Valeria Inés, Sánchez, Sara, Trepat, Xavier, Roca-Cusachs, Pere, Del Pozo, Miguel A

“…Cells are subjected to multiple mechanical inputs throughout their lives. Their ability to detect these environmental cues is called mechanosensing, a process…”
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Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization by del Pozo, Miguel A, Balasubramanian, Nagaraj, Alderson, Nazilla B, Kiosses, William B, Grande-García, Araceli, Anderson, Richard G. W, Schwartz, Martin A

“…Growth of normal cells is anchorage dependent because signalling through multiple pathways including Erk, phosphatidylinositol-3-OH kinase (PI(3)K) and Rac…”
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Short- and long-term stability study of lyophilized solid lipid nanoparticles for gene therapy by del Pozo-Rodríguez, A., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Most studies in gene therapy are focused on developing more efficient non-viral vectors, ignoring their stability, even though physically and chemically stable…”
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Integrins Regulate Rac Targeting by Internalization of Membrane Domains by del Pozo, Miguel A., Alderson, Nazilla B., Kiosses, William B., Chiang, Hui-Hsien, Richard G. W. Anderson, Schwartz, Martin A.

“…Translocation of the small GTP-binding protein Rac1 to the cell plasma membrane is essential for activating downstream effectors and requires integrin-mediated…”
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Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation by Castro-Castro, Antonio, Muriel, Olivia, Del Pozo, Miguel A, Bustelo, Xosé R

“…The Rac1 GTPase plays key roles in cytoskeletal organization, cell motility and a variety of physiological and disease-linked responses. Wild type Rac1…”
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A deep learning-based tool for the automated detection and analysis of caveolae in transmission electron microscopy images by Aboy-Pardal, María C.M., Jimenez-Carretero, Daniel, Terrés-Domínguez, Sara, Pavón, Dácil M., Sotodosos-Alonso, Laura, Jiménez-Jiménez, Víctor, Sánchez-Cabo, Fátima, Pozo, Miguel A. Del

“…[Display omitted] Caveolae are nanoscopic and mechanosensitive invaginations of the plasma membrane, essential for adipocyte biology. Transmission electron…”
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Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK by del Pozo, Miguel A, Price, Leo S, Alderson, Nazilla B, Ren, Xiang-Dong, Schwartz, Martin Alexander

“…The small GTPase Rac regulates cytoskeletal organization, cell cycle progression, gene expression and oncogenic transformation, processes that depend upon both…”
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Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP by García-García, María, Sánchez-Perales, Sara, Jarabo, Patricia, Calvo, Enrique, Huyton, Trevor, Fu, Liran, Ng, Sheung Chun, Sotodosos-Alonso, Laura, Vázquez, Jesús, Casas-Tintó, Sergio, Görlich, Dirk, Echarri, Asier, Del Pozo, Miguel A.

“…Mechanical forces regulate multiple essential pathways in the cell. The nuclear translocation of mechanoresponsive transcriptional regulators is an essential…”
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A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors by del Pozo-Rodríguez, A., Pujals, S., Delgado, D., Solinís, M.A., Gascón, A.R., Giralt, E., Pedraz, J.L.

“…The aim of this work was to improve the transfection efficacy of solid lipid nanoparticle (SLN)-based non-viral vectors into ARPE-19 cells through the addition…”
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Solid lipid nanoparticles for retinal gene therapy: Transfection and intracellular trafficking in RPE cells by del Pozo-Rodríguez, A., Delgado, D., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Retinal pigment epithelial (RPE) cells are usually employed to study DNA systems for diseases related to problems in the retina. Solid lipid nanoparticles…”
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Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP by Moreno-Vicente, Roberto, Pavón, Dácil María, Martín-Padura, Inés, Català-Montoro, Mauro, Díez-Sánchez, Alberto, Quílez-Álvarez, Antonio, López, Juan Antonio, Sánchez-Álvarez, Miguel, Vázquez, Jesús, Strippoli, Raffaele, del Pozo, Miguel A.

“…The transcriptional regulator YAP orchestrates many cellular functions, including tissue homeostasis, organ growth control, and tumorigenesis. Mechanical…”
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Caveolae Internalization Regulates Integrin-Dependent Signaling Pathways by Echarri, Asier, Pozo, Miguel A. Del

“…Integrin-mediated adhesion regulates trafficking of cholesterol-enriched membrane microdomains (CEMM). Upon cell detachment from the extracellular matrix…”
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