Search Results - "DEKOSKY, Steven T"

Alzheimer's disease: The right drug, the right time by Golde, Todd E, DeKosky, Steven T, Galasko, Douglas

“…Lessons from failed clinical trials can improve the development of Alzheimer's disease–modifying therapies Alzheimer's disease (AD) is an age-associated…”
Get full text

Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers by DeKosky, Steven T., Blennow, Kaj, Ikonomovic, Milos D., Gandy, Sam

“…Traumatic brain injury (TBI) can occur as a single severe cranial impact or as repetitive concussions, and commonly affects professional athletes in contact…”
Get full text

Revising the definition of Alzheimer's disease: a new lexicon by Dubois, Bruno, Prof, Feldman, Howard H, Prof, Jacova, Claudia, PhD, Cummings, Jeffrey L, MD, DeKosky, Steven T, Prof, Barberger-Gateau, Pascale, MD, Delacourte, André, PhD, Frisoni, Giovanni, Prof, Fox, Nick C, Prof, Galasko, Douglas, Prof, Gauthier, Serge, Prof, Hampel, Harald, Prof, Jicha, Gregory A, MD, Meguro, Kenichi, MD, O'Brien, John, DM, Pasquier, Florence, Prof, Robert, Philippe, Prof, Rossor, Martin, Prof, Salloway, Steven, Prof, Sarazin, Marie, MD, de Souza, Leonardo C, MD, Stern, Yaakov, Prof, Visser, Pieter J, MD, Scheltens, Philip, Prof

“…Summary Alzheimer's disease (AD) is classically defined as a dual clinicopathological entity. The recent advances in use of reliable biomarkers of AD that…”
Get full text

Traumatic Brain Injury — Football, Warfare, and Long-Term Effects by DeKosky, Steven T, Ikonomovic, Milos D, Gandy, Sam

“…In late July, the National Football League introduced a new poster to be hung in league locker rooms, warning players of possible long-term health effects of…”
Get full text

Toward the Treatment and Prevention of Alzheimer's Disease: Rational Strategies and Recent Progress by Gandy, Sam, DeKosky, Steven T

“…Alzheimer's disease (AD) is the major cause of late-life brain failure. In the past 25 years, autosomal dominant forms of AD were found to be primariy…”
Get full text

The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease by Colom-Cadena, Martí, Spires-Jones, Tara, Zetterberg, Henrik, Blennow, Kaj, Caggiano, Anthony, DeKosky, Steven T, Fillit, Howard, Harrison, John E, Schneider, Lon S, Scheltens, Phillip, de Haan, Willem, Grundman, Michael, van Dyck, Christopher H, Izzo, Nicholas J, Catalano, Susan M

“…Synapse damage and loss are fundamental to the pathophysiology of Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is…”
Get full text

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease by Albert, Marilyn S, DeKosky, Steven T, Dickson, Dennis, Dubois, Bruno, Feldman, Howard H, Fox, Nick C, Gamst, Anthony, Holtzman, David M, Jagust, William J, Petersen, Ronald C, Snyder, Peter J, Carrillo, Maria C, Thies, Bill, Phelps, Creighton H

“…Abstract The National Institute on Aging and the Alzheimer’s Association charged a workgroup with the task of developing criteria for the symptomatic…”
Get full text

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria by Dubois, Bruno, MD, Feldman, Howard H, MD, Jacova, Claudia, PhD, DeKosky, Steven T, MD, Barberger-Gateau, Pascale, MD, Cummings, Jeffrey, MD, Delacourte, André, PhD, Galasko, Douglas, MD, Gauthier, Serge, MD, Jicha, Gregory, MD, Meguro, Kenichi, MD, O'Brien, John, MD, Pasquier, Florence, MD, Robert, Philippe, MD, Rossor, Martin, MD, Salloway, Steven, MD, Stern, Yaakov, PhD, Visser, Pieter J, MD, Scheltens, Philip, MD

“…Summary The NINCDS–ADRDA and the DSM-IV-TR criteria for Alzheimer's disease (AD) are the prevailing diagnostic standards in research; however, they have now…”
Get full text

The Long and the Short of Benzodiazepines and Sleep Medications: Short-Term Benefits, Long-Term Harms? by DeKosky, Steven T., Williamson, John B.

Get full text

Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients by DeKosky, Steven T, Kochanek, Patrick M, Valadka, Alex B, Clark, Robert S B, Chou, Sherry H-Y, Au, Alicia K, Horvat, Christopher, Jha, Ruchira M, Mannix, Rebekah, Wisniewski, Stephen R, Wintermark, Max, Rowell, Susan E, Welch, Robert D, Lewis, Lawrence, House, Stacey, Tanzi, Rudolph E, Smith, Darci R, Vittor, Amy Y, Denslow, Nancy D, Davis, Michael D, Glushakova, Olena Y, Hayes, Ronald L

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple organs of coronavirus disease 2019 (COVID-19) patients, including the…”
Get more information

Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease by Reiman, Eric M, Chen, Kewei, Liu, Xiaofen, Bandy, Daniel, Yu, Meixiang, Lee, Wendy, Ayutyanont, Napatkamon, Keppler, Jennifer, Reeder, Stephanie A, Langbaum, Jessica B.S, Alexander, Gene E, Klunk, William E, Mathis, Chester A, Price, Julie C, Aizenstein, Howard J, DeKosky, Steven T, Caselli, Richard J

“…Fibrillar amyloid-beta (Aβ) is found in the brains of many cognitively normal older people. Whether or not this reflects a predisposition to Alzheimer's…”
Get full text

Mild cognitive impairment: pathology and mechanisms by Mufson, Elliott J., Binder, Lester, Counts, Scott E., DeKosky, Steven T., deToledo-Morrell, Leyla, Ginsberg, Stephen D., Ikonomovic, Milos D., Perez, Sylvia E., Scheff, Stephen W.

“…Mild cognitive impairment (MCI) is rapidly becoming one of the most common clinical manifestations affecting the elderly. The pathologic and molecular…”
Get full text

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease by Ikonomovic, Milos D., Klunk, William E., Abrahamson, Eric E., Mathis, Chester A., Price, Julie C., Tsopelas, Nicholas D., Lopresti, Brian J., Ziolko, Scott, Bi, Wenzhu, Paljug, William R., Debnath, Manik L., Hope, Caroline E., Isanski, Barbara A., Hamilton, Ronald L., DeKosky, Steven T.

“…The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds with high affinity to β-pleated sheet aggregates of the amyloid-β (Aβ)…”
Get full text

Looking Backward to Move Forward: Early Detection of Neurodegenerative Disorders by DeKosky, Steven T., Marek, Kenneth

“…Early detection of neurodegenerative disorders would provide clues to the underlying pathobiology of these diseases and would enable more effective diagnosis…”
Get full text

Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification by Izzo, Nicholas J., Yuede, Carla M., LaBarbera, Kelsie M., Limegrover, Colleen S., Rehak, Courtney, Yurko, Raymond, Waybright, Lora, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Hamby, Mary E., Williams, Claire, Sadlek, Kelsey, Edwards, Hannah M., Davis, Charles S., Grundman, Michael, Schneider, Lon S., DeKosky, Steven T., Chelsky, Daniel, Pike, Ian, Henstridge, Christopher, Blennow, Kaj, Zetterberg, Henrik, LeVine, Harry, Spires‐Jones, Tara L., Cirrito, John R., Catalano, Susan M.

“…Introduction Amyloid beta (Aβ) oligomers are one of the most toxic structural forms of the Aβ protein and are hypothesized to cause synaptotoxicity and memory…”
Get full text

Amyloid imaging in mild cognitive impairment subtypes by Wolk, David A., Price, Julie C., Saxton, Judy A., Snitz, Beth E., James, Jeffrey A., Lopez, Oscar L., Aizenstein, Howard J., Cohen, Ann D., Weissfeld, Lisa A., Mathis, Chester A., Klunk, William E., DeKosky, Steven T.

“…Objective We utilized the amyloid imaging ligand Pittsburgh Compound B (PiB) to determine the presence of Alzheimer's disease (AD) pathology in different mild…”
Get full text

Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literature by Walker, Ariel, Chapin, Ben, Abisambra, Jose, DeKosky, Steven T

“…The initiation, anatomic pattern, and extent of tau spread in traumatic brain injury (TBI), and the mechanism by which TBI leads to long-term tau pathology,…”
Get full text

Chronic traumatic encephalopathy in a National Football League player by Omalu, Bennet I, DeKosky, Steven T, Minster, Ryan L, Kamboh, M Ilyas, Hamilton, Ronald L, Wecht, Cyril H

“…We present the results of the autopsy of a retired professional football player that revealed neuropathological changes consistent with long-term repetitive…”
Get full text

Imaging of amyloid burden and distribution in cerebral amyloid angiopathy by Johnson, Keith A., Gregas, Matt, Becker, John A., Kinnecom, Catherine, Salat, David H., Moran, Erin K., Smith, Erin E., Rosand, Jonathan, Rentz, Dorene M., Klunk, William E., Mathis, Chester A., Price, Julie C., DeKosky, Steven T., Fischman, Alan J., Greenberg, Steven M.

“…Objective Cerebrovascular deposition of β‐amyloid (cerebral amyloid angiopathy [CAA]) is a major cause of hemorrhagic stroke and a likely contributor to…”
Get full text

Prevalence and trend of central nervous system-active medication polypharmacy among US commercially insured adults with vs without early-onset dementia: a multi-year cross-sectional study by Wei, Yu-Jung Jenny, Shrestha, Nistha, Chiang, ChienWei, DeKosky, Steven T

“…Limited data exist on the prevalence and trend of central nervous system (CNS)-active medication polypharmacy among adults with early-onset dementia (EOD) and…”
Get full text