Search Results - "DEKKER, Niek"

Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography by Heath, Nikki, Grant, Lois, De Oliveira, Taiana Maia, Rowlinson, Rachel, Osteikoetxea, Xabier, Dekker, Niek, Overman, Ross

“…Extracellular vesicles (EVs) have important roles in physiology, pathology, and more recently have been identified as efficient carriers of therapeutic…”
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Molecular tuning of farnesoid X receptor partial agonism by Merk, Daniel, Sreeramulu, Sridhar, Kudlinzki, Denis, Saxena, Krishna, Linhard, Verena, Gande, Santosh L., Hiller, Fabian, Lamers, Christina, Nilsson, Ewa, Aagaard, Anna, Wissler, Lisa, Dekker, Niek, Bamberg, Krister, Schubert-Zsilavecz, Manfred, Schwalbe, Harald

“…The bile acid-sensing transcription factor farnesoid X receptor (FXR) regulates multiple metabolic processes. Modulation of FXR is desired to overcome several…”
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Chemogenetics defines a short-chain fatty acid receptor gut-brain axis by Barki, Natasja, Bolognini, Daniele, Börjesson, Ulf, Jenkins, Laura, Riddell, John, Hughes, David I, Ulven, Trond, Hudson, Brian D, Ulven, Elisabeth Rexen, Dekker, Niek, Tobin, Andrew B, Milligan, Graeme

“…Volatile small molecules, including the short-chain fatty acids (SCFAs), acetate and propionate, released by the gut microbiota from the catabolism of…”
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Quantification of protein cargo loading into engineered extracellular vesicles at single‐vesicle and single‐molecule resolution by Silva, Andreia M., Lázaro‐Ibáñez, Elisa, Gunnarsson, Anders, Dhande, Aditya, Daaboul, George, Peacock, Ben, Osteikoetxea, Xabier, Salmond, Nikki, Friis, Kristina Pagh, Shatnyeva, Olga, Dekker, Niek

“…Extracellular Vesicles (EVs) have been intensively explored for therapeutic delivery of proteins. However, methods to quantify cargo proteins loaded into…”
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Thermofluor-based high-throughput stability optimization of proteins for structural studies by Ericsson, Ulrika B., Hallberg, B. Martin, DeTitta, George T., Dekker, Niek, Nordlund, Pär

“…Production of proteins well suited for structural studies is inherently difficult and time-consuming. Protein sample homogeneity, stability, and solubility are…”
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A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias by Bolognini, Daniele, Moss, Catherine E., Nilsson, Karolina, Petersson, Annika U., Donnelly, Iona, Sergeev, Eugenia, König, Gabriele M., Kostenis, Evi, Kurowska-Stolarska, Mariola, Miller, Ashley, Dekker, Niek, Tobin, Andrew B., Milligan, Graeme

“…The short chain fatty acid receptor FFA2 is able to stimulate signaling via both Gi- and Gq/G11-promoted pathways. These pathways are believed to control…”
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Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis by Tejedor, Sandra, Buigues, Marc, González-King, Hernán, Silva, Andreia M, García, Nahuel Aquiles, Dekker, Niek, Sepúlveda, Pilar

“…Myocardial fibrosis is a pathological hallmark of cardiac dysfunction. Oncostatin M (OSM) is a pleiotropic cytokine that can promote fibrosis in different…”
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Engineered Cas9 extracellular vesicles as a novel gene editing tool by Osteikoetxea, Xabier, Silva, Andreia, Lázaro‐Ibáñez, Elisa, Salmond, Nikki, Shatnyeva, Olga, Stein, Josia, Schick, Jan, Wren, Stephen, Lindgren, Julia, Firth, Mike, Madsen, Alexandra, Mayr, Lorenz M., Overman, Ross, Davies, Rick, Dekker, Niek

“…Extracellular vesicles (EVs) have shown promise as biological delivery vehicles, but therapeutic applications require efficient cargo loading. Here, we…”
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In vivo phage display identifies novel peptides for cardiac targeting by Ivanova, Alena, Kohl, Franziska, González-King Garibotti, Hernán, Chalupska, Renata, Cvjetkovic, Aleksander, Firth, Mike, Jennbacken, Karin, Martinsson, Sofia, Silva, Andreia M., Viken, Ida, Wang, Qing-Dong, Wiseman, John, Dekker, Niek

“…Heart failure remains a leading cause of mortality. Therapeutic intervention for heart failure would benefit from targeted delivery to the damaged heart…”
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Molecular architecture of potassium chloride co-transporter KCC2 by Agez, Morgane, Schultz, Patrick, Medina, Igor, Baker, David J., Burnham, Matthew P., Cardarelli, Ross A., Conway, Leslie C., Garnier, Kelly, Geschwindner, Stefan, Gunnarsson, Anders, McCall, Eileen J., Frechard, Alexandre, Audebert, Stéphane, Deeb, Tarek Z., Moss, Stephen J., Brandon, Nicholas J., Wang, Qi, Dekker, Niek, Jawhari, Anass

“…KCC2 is a neuron specific K + -Cl − co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases…”
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Human pancreatic islet-derived extracellular vesicles modulate insulin expression in 3D-differentiating iPSC clusters by Ribeiro, Diana, Andersson, Eva-Marie, Heath, Nikki, Persson-Kry, Anette, Collins, Richard, Hicks, Ryan, Dekker, Niek, Forslöw, Anna

“…It has been suggested that extracellular vesicles (EVs) can mediate crosstalk between hormones and metabolites within pancreatic tissue. However, the possible…”
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Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice by Bartesaghi, Stefano, Wallenius, Kristina, Hovdal, Daniel, Liljeblad, Mathias, Wallin, Simonetta, Dekker, Niek, Barlind, Louise, Davies, Nigel, Seeliger, Frank, Winzell, Maria Sörhede, Patel, Sima, Theisen, Matt, Brito, Luis, Bergenhem, Nils, Andersson, Shalini, Peng, Xiao-Rong

“…Fibroblast growth factor 21 (FGF21) is a promising therapeutic agent for treatment of type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH). We show…”
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Creating Designer Engineered Extracellular Vesicles for Diverse Ligand Display, Target Recognition, and Controlled Protein Loading and Delivery by Ivanova, Alena, Badertscher, Lukas, O'Driscoll, Gwen, Bergman, Joakim, Gordon, Euan, Gunnarsson, Anders, Johansson, Camilla, Munson, Michael J., Spinelli, Cristiana, Torstensson, Sara, Vilén, Liisa, Voirel, Andrei, Wiseman, John, Rak, Janusz, Dekker, Niek, Lázaro‐Ibáñez, Elisa

“…Efficient and targeted delivery of therapeutic agents remains a bottleneck in modern medicine. Here, biochemical engineering approaches to advance the…”
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Outer‐membrane phospholipase A: known structure, unknown biological function by Dekker, Niek

“…Outer‐membrane phospholipase A (OMPLA) is one of the few enzymes present in the outer membrane of Gram‐negative bacteria. The enzymatic activity of OMPLA is…”
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Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition by Kennedy, Amanda J., Sundström, Linda, Geschwindner, Stefan, Poon, Eunice K. Y., Jiang, Yuhong, Chen, Rongfeng, Cooke, Rob, Johnstone, Shawn, Madin, Andrew, Lim, Junxian, Liu, Qingqi, Lohman, Rink-Jan, Nordqvist, Anneli, Fridén-Saxin, Maria, Yang, Wenzhen, Brown, Dean G., Fairlie, David P., Dekker, Niek

“…Protease-activated receptor-2 (PAR2) has been implicated in multiple pathophysiologies but drug discovery is challenging due to low small molecule tractability…”
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Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease by Giordanetto, Fabrizio, Pettersen, Daniel, Starke, Ingemar, Nordberg, Peter, Dahlström, Mikael, Knerr, Laurent, Selmi, Nidhal, Rosengren, Birgitta, Larsson, Lars-Olof, Sandmark, Jenny, Castaldo, Marie, Dekker, Niek, Karlsson, Ulla, Hurt-Camejo, Eva

“…Expedited structure-based optimization of the initial fragment hit 1 led to the design of (R)-7 (AZD2716) a novel, potent secreted phospholipase A2 (sPLA2)…”
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Head‐to‐head comparison of relevant cell sources of small extracellular vesicles for cardiac repair: Superiority of embryonic stem cells by González‐King, Hernán, Rodrigues, Patricia G., Albery, Tamsin, Tangruksa, Benyapa, Gurrapu, Ramya, Silva, Andreia M., Musa, Gentian, Kardasz, Dominika, Liu, Kai, Kull, Bengt, Åvall, Karin, Rydén‐Markinhuhta, Katarina, Incitti, Tania, Sharma, Nitin, Graneli, Cecilia, Valadi, Hadi, Petkevicius, Kasparas, Carracedo, Miguel, Tejedor, Sandra, Ivanova, Alena, Heydarkhan‐Hagvall, Sepideh, Menasché, Phillipe, Synnergren, Jane, Dekker, Niek, Wang, Qing‐Dong, Jennbacken, Karin

“…Small extracellular vesicles (sEV) derived from various cell sources have been demonstrated to enhance cardiac function in preclinical models of myocardial…”
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Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site by Vandeputte-Rutten, Lucy, Kramer, R.Arjen, Kroon, Jan, Dekker, Niek, Egmond, Maarten R., Gros, Piet

“…OmpT from Escherichia coli belongs to a family of highly homologous outer membrane proteases, known as omptins, which are implicated in the virulence of…”
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TRPV1 signaling: mechanistic understanding and therapeutic potential by Xia, Rong, Samad, Tarek A, Btesh, Joan, Jiang, Lin-Hua, Kays, Ibrahim, Stjernborg, Louise, Dekker, Niek

“…Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel gated by noxious heat, vanilloids and extracellular protons. TRPV1 is acting…”
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Substrate Specificity of the Integral Membrane Protease OmpT Determined by Spatially Addressed Peptide Libraries by Dekker, Niek, Cox, Ruud C, Kramer, R. Arjen, Egmond, Maarten R

“…Escherichia coli outer membrane protease T (OmpT) is an endopeptidase that specifically cleaves between two consecutive basic residues. In this study we have…”
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