Search Results - "DEIULIIS, Jeffrey A"

Long-Term Dipeptidyl-Peptidase 4 Inhibition Reduces Atherosclerosis and Inflammation via Effects on Monocyte Recruitment and Chemotaxis by SHAH, Zubair, KAMPFRATH, Thomas, QINGHUA SUN, MIHAI, Georgeta, MAISEYEU, Andrei, RAJAGOPALAN, Sanjay, DEIULIIS, Jeffrey A, JIXIN ZHONG, PINEDA, Colleen, ZHEKANG YING, XIAOHUA XU, BO LU, MOFFATT-BRUCE, Susan, DURAIRAJ, Rekha

“…Dipeptidyl-peptidase 4 (DPP-4) inhibitors are increasingly used to accomplish glycemic targets in patients with type II diabetes mellitus. Because DPP-4 is…”
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The Role of the Mineralocorticoid Receptor in Inflammation: Focus on Kidney and Vasculature by Belden, Zachary, Deiuliis, Jeffrey A, Dobre, Mirela, Rajagopalan, Sanjay

“…The remarkable success of clinical trials in mineralocorticoid receptor (MR) inhibition in heart failure has driven research on the physiological and…”
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Ambient Air Pollution Exaggerates Adipose Inflammation and Insulin Resistance in a Mouse Model of Diet-Induced Obesity by QINGHUA SUN, PEIBIN YUE, BROOK, Robert D, MOFFATT-BRUCE, Susan D, LUNG CHI CHEN, RAJAGOPALAN, Sanjay, DEIULIIS, Jeffrey A, LUMENG, Carey N, KAMPFRATH, Thomas, MIKOLAJ, Michael B, YING CAI, OSTROWSKI, Michael C, BO LU, PARTHASARATHY, Sampath

“…There is a strong link between urbanization and type 2 diabetes mellitus. Although a multitude of mechanisms have been proposed, there are no studies…”
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Visceral Adipose MicroRNA 223 Is Upregulated in Human and Murine Obesity and Modulates the Inflammatory Phenotype of Macrophages by Deiuliis, Jeffrey A, Syed, Rafay, Duggineni, Dheeraj, Rutsky, Jessica, Rengasamy, Palanivel, Zhang, Jie, Huang, Kun, Needleman, Bradley, Mikami, Dean, Perry, Kyle, Hazey, Jeffrey, Rajagopalan, Sanjay

“…Obesity in humans and mice is typified by an activated macrophage phenotype in the visceral adipose tissue (VAT) leading to increased macrophage-mediated…”
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Exposure to Air Pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics by Palanivel, Rengasamy, Vinayachandran, Vinesh, Biswal, Shyam, Deiuliis, Jeffrey A., Padmanabhan, Roshan, Park, Bongsoo, Gangwar, Roopesh Singh, Durieux, Jared C., Ebreo Cara, Elaine Ann, Das, Lopa, Bevan, Graham, Fayad, Zahi A., Tawakol, Ahmed, Jain, Mukesh K., Rao, Sujata, Rajagopalan, Sanjay

“…Particulate matter ≤2.5μm (PM2.5) air pollution is a leading environmental risk factor contributing disproportionately to the global burden of non-communicable…”
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Noncoding RNAs in Cardiovascular Disease: Pathological Relevance and Emerging Role as Biomarkers and Therapeutics by Gangwar, Roopesh S, Rajagopalan, Sanjay, Natarajan, Rama, Deiuliis, Jeffrey A

“…Abstract Noncoding RNAs (ncRNA) include a diverse range of functional RNA species—microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) being most studied in…”
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Effect of co-exposure to nickel and particulate matter on insulin resistance and mitochondrial dysfunction in a mouse model by Xu, Xiaohua, Rao, Xiaoquan, Wang, Tse-Yao, Jiang, Silis Y, Ying, Zhekang, Liu, Cuiqing, Wang, Aixia, Zhong, Mianhua, Deiuliis, Jeffrey A, Maiseyeu, Andrei, Rajagopalan, Sanjay, Lippmann, Morton, Chen, Lung-Chi, Sun, Qinghua

“…It has been well recognized that toxicity of fine ambient air particulate matter (PM(2.5)) may depend on its chemical constituents, including components such…”
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Hybrid nanoparticles improve targeting to inflammatory macrophages through phagocytic signals by Bagalkot, Vaishali, Badgeley, Marcus A., Kampfrath, Thomas, Deiuliis, Jeffrey A., Rajagopalan, Sanjay, Maiseyeu, Andrei

“…Macrophages are innate immune cells with great phenotypic plasticity, which allows them to regulate an array of physiological processes such as host defense,…”
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MicroRNA 223 Enhances ABCA1 Protein Stability and Supports Efflux in Cholesterol-Burdened Macrophages by Syed, Rafay, Rengasamy, Palanivel, Rajagopalan, Sanjay, Deiuliis, Jeffrey A., Maiseyeu, Andrei

“…Macrophages are present in all vertebrates as part of the innate immune system, which protects from pathogens and scavenges sterol rich, cellular debris and…”
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“Eat me” imaging and therapy by Bagalkot, Vaishali, Deiuliis, Jeffrey A., Rajagopalan, Sanjay, Maiseyeu, Andrei

“…Clearance of apoptotic debris is a vital role of the innate immune system. Drawing upon principles of apoptotic clearance, convenient delivery vehicles…”
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Novel Long Noncoding RNA, Macrophage Inflammation-Suppressing Transcript (MIST), Regulates Macrophage Activation During Obesity by Stapleton, Kenneth, Das, Sadhan, Reddy, Marpadga A., Leung, Amy, Amaram, Vishnu, Lanting, Linda, Chen, Zhuo, Zhang, Lingxiao, Palanivel, Rengasamy, Deiuliis, Jeffrey A., Natarajan, Rama

“…OBJECTIVE:Systemic low-grade inflammation associated with obesity and metabolic syndrome is a strong risk factor for the development of diabetes mellitus and…”
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Metabolic effects of air pollution exposure and reversibility by Rajagopalan, Sanjay, Park, Bongsoo, Palanivel, Rengasamy, Vinayachandran, Vinesh, Deiuliis, Jeffrey A, Gangwar, Roopesh Singh, Das, Lopa, Yin, Jinhu, Choi, Youngshim, Al-Kindi, Sadeer, Jain, Mukesh K, Hansen, Kasper D, Biswal, Shyam

“…Air pollution involving particulate matter smaller than 2.5 μm in size (PM2.5) is the world's leading environmental risk factor contributing to mortality…”
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Chronic Fine Particulate Matter Exposure Induces Systemic Vascular Dysfunction via NADPH Oxidase and TLR4 Pathways by Kampfrath, Thomas, Maiseyeu, Andrei, Ying, Zhekang, Shah, Zubair, Deiuliis, Jeffrey A, Xu, Xiaohua, Kherada, Nisharahmed, Brook, Robert D, Reddy, Kongara M, Padture, Nitin P, Parthasarathy, Sampath, Chen, Lung Chi, Moffatt-Bruce, Susan, Sun, Qinghua, Morawietz, Henning, Rajagopalan, Sanjay

“…RATIONALE:Chronic exposure to ambient air-borne particulate matter of <2.5 μm (PM2.5) increases cardiovascular risk. The mechanisms by which inhaled ambient…”
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CITED2 Restrains Proinflammatory Macrophage Activation and Response by Kim, Gun-Dong, Das, Riku, Rao, Xiaoquan, Zhong, Jixin, Deiuliis, Jeffrey A., Ramirez-Bergeron, Diana L., Rajagopalan, Sanjay, Mahabeleshwar, Ganapati H.

“…Macrophages are strategically distributed in mammalian tissues and play an essential role in priming the immune response. However, macrophages need to…”
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Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome by Gao, Shupei, Li, Wenjuan, Huang, Zhiwen, Deiuliis, Jeffrey A., Braunstein, Zachary, Liu, Xinxin, Li, Xinlu, Kosari, Mohammadreza, Chen, Jun, Min, Xinwen, Yang, Handong, Gong, Quan, Liu, Zheng, Wei, Yingying, Zhang, Ziyang, Dong, Lingli, Zhong, Jixin

“…Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by severe inflammation and pulmonary dysfunction. Despite advancements…”
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T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance by JIXIN ZHONG, XIAOQUAN RAO, DEIULIIS, Jeffrey A, SATOSKAR, Abhay R, RAJAGOPALAN, Sanjay, BRAUNSTEIN, Zachary, TAYLOR, Anne, NARULA, Vimal, HAZEY, Jeffrey, MIKAMI, Dean, NEEDLEMAN, Bradley, RUTSKY, Jessica, QINGHUA SUN

“…A key pathophysiologic role for activated T-cells in mediating adipose inflammation and insulin resistance (IR) has been recently postulated. However,…”
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Pulmonary T cell activation in response to chronic particulate air pollution by Deiuliis, Jeffrey A, Kampfrath, Thomas, Zhong, Jixin, Oghumu, Steve, Maiseyeu, Andrei, Chen, Lung Chi, Sun, Qinghua, Satoskar, Abhay R, Rajagopalan, Sanjay

“…The purpose of this study was to investigate the effects of chronically inhaled particulate matter <2.5 μm (PM(2.5)) on inflammatory cell populations in the…”
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CXCR3 modulates obesity‐induced visceral adipose inflammation and systemic insulin resistance by Deiuliis, Jeffrey A., Oghumu, Steve, Duggineni, Dheeraj, Zhong, Jixin, Rutsky, Jessica, Banerjee, Ambar, Needleman, Bradley, Mikami, Dean, Narula, Vimal, Hazey, Jeffrey, Satoskar, Abhay R., Rajagopalan, Sanjay

“…Objective Chemokine (C‐X‐C motif) receptor 3 (CXCR3) is a chemokine receptor involved in the regulation of immune cell trafficking and activation. Increased…”
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Monocyte DPP4 Expression in Human Atherosclerosis Is Associated With Obesity and Dyslipidemia by Rao, Xiaoquan, Deiuliis, Jeffrey A, Mihai, Georgeta, Varghese, Juliet, Xia, Chang, Frieman, Matthew B, Sztalryd, Carole, Sun, Xiao Jian, Quon, Michael J, Taylor, Simeon I, Rajagopalan, Sanjay, Zhong, Jixin

“…Studies including ours indicate that systemic inhibition of dipeptidyl peptidase 4 (DPP4), an ubiquitously expressed peptidase, by pharmaceutical inhibitors…”
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In Vivo Targeting of Inflammation-Associated Myeloid-Related Protein 8/14 Via Gadolinium Immunonanoparticles by Maiseyeu, Andrei, Badgeley, Marcus A, Kampfrath, Thomas, Mihai, Georgeta, Deiuliis, Jeffrey A, Liu, Cuiqing, Sun, Qinghua, Parthasarathy, Sampath, Simon, Daniel I, Croce, Kevin, Rajagopalan, Sanjay

“…OBJECTIVE—Myeloid-related protein (Mrp) 8/14 complex (is a highly expressed extracellularly secreted protein, implicated in atherosclerosis. In this study, we…”
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