Search Results - "DEGLI ESPOSTI, A"

Tissue‐resident memory NK cells: Homing in on local effectors and regulators by Schuster, Iona S., Andoniou, Christopher E., Degli‐Esposti, Mariapia A.

“…Summary Natural killer (NK) cells are the prototype innate effector lymphocyte population that plays an important role in controlling viral infections and…”
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TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity by Schuster, Iona S., Wikstrom, Matthew E., Brizard, Geraldine, Coudert, Jerome D., Estcourt, Marie J., Manzur, Mitali, O’Reilly, Lorraine A., Smyth, Mark J., Trapani, Joseph A., Hill, Geoffrey R., Andoniou, Christopher E., Degli-Esposti, Mariapia A.

“…Natural killer (NK) cells have been reported to control adaptive immune responses that occur in lymphoid organs at the early stages of immune challenge…”
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Modulation of innate and adaptive immunity by cytomegaloviruses by Berry, Richard, Watson, Gabrielle M., Jonjic, Stipan, Degli-Esposti, Mariapia A., Rossjohn, Jamie

“…The coordinated activities of innate and adaptive immunity are critical for effective protection against viruses. To counter this, some viruses have evolved…”
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ILC1 Confer Early Host Protection at Initial Sites of Viral Infection by Weizman, Orr-El, Adams, Nicholas M., Schuster, Iona S., Krishna, Chirag, Pritykin, Yuri, Lau, Colleen, Degli-Esposti, Mariapia A., Leslie, Christina S., Sun, Joseph C., O’Sullivan, Timothy E.

“…Infection is restrained by the concerted activation of tissue-resident and circulating immune cells. Whether tissue-resident lymphocytes confer early antiviral…”
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Peripheral natural killer cell maturation depends on the transcription factor Aiolos by Holmes, Melissa L, Huntington, Nicholas D, Thong, Rebecca PL, Brady, Jason, Hayakawa, Yoshihiro, Andoniou, Christopher E, Fleming, Peter, Shi, Wei, Smyth, Gordon K, Degli-Esposti, Mariapia A, Belz, Gabrielle T, Kallies, Axel, Carotta, Sebastian, Smyth, Mark J, Nutt, Stephen L

“…Natural killer (NK) cells are an innate lymphoid cell lineage characterized by their capacity to provide rapid effector functions, including cytokine…”
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A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment by Young, Arabella, Ngiow, Shin Foong, Gao, Yulong, Patch, Ann-Marie, Barkauskas, Deborah S, Messaoudene, Meriem, Lin, Gene, Coudert, Jerome D, Stannard, Kimberley A, Zitvogel, Laurence, Degli-Esposti, Mariapia A, Vivier, Eric, Waddell, Nicola, Linden, Joel, Huntington, Nicholas D, Souza-Fonseca-Guimaraes, Fernando, Smyth, Mark J

“…Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of cytotoxic lymphocytes and impairs antitumor immune responses. Here,…”
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MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota by Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce R., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A., Hill, Geoffrey R.

“…Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantation…”
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High Chlamydia Burden Promotes Tumor Necrosis Factor–Dependent Reactive Arthritis in SKG Mice by Baillet, Athan C., Rehaume, Linda M., Benham, Helen, O'Meara, Connor P., Armitage, Charles W., Ruscher, Roland, Brizard, Geraldine, Harvie, Marina C. G., Velasco, Jared, Hansbro, Phillip M., Forrester, John V., Degli‐Esposti, Mariapia A., Beagley, Kenneth W., Thomas, Ranjeny

“…Objective Chlamydia trachomatis is a sexually transmitted obligate intracellular pathogen that causes inflammatory reactive arthritis, spondylitis,…”
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Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity by Degli-Esposti, Mariapia A, Andoniou, Christopher E, van Dommelen, Serani L H, Voigt, Valentina, Andrews, Daniel M, Brizard, Geraldine, Asselin-Paturel, Carine, Delale, Thomas, Stacey, Katryn J, Trinchieri, Giorgio

“…Dendritic cells (DCs) regulate various aspects of innate immunity, including natural killer (NK) cell function. Here we define the mechanisms involved in DC-NK…”
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Functional interactions between dendritic cells and NK cells during viral infection by Degli-Esposti, Mariapia A, Andrews, Daniel M, Scalzo, Anthony A, Yokoyama, Wayne M, Smyth, Mark J

“…Ly49H(+)NK1.1(+) natural killer (NK) cells are essential for the control of murine cytomegalovirus (MCMV) during the acute stage of infection. This cell subset…”
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NK cells require IL-28R for optimal in vivo activity by Souza-Fonseca-Guimaraes, Fernando, Young, Arabella, Mittal, Deepak, Martinet, Ludovic, Bruedigam, Claudia, Takeda, Kazuyoshi, Andoniou, Christopher E., Degli-Esposti, Mariapia A., Hill, Geoffrey R., Smyth, Mark J.

“…Natural killer (NK) cells are naturally circulating innate lymphoid cells that protect against tumor initiation and metastasis and contribute to…”
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Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation by Martins, Jose Paulo, Andoniou, Christopher E, Fleming, Peter, Kuns, Rachel D, Schuster, Iona S, Voigt, Valentina, Daly, Sheridan, Varelias, Antiopi, Tey, Siok-Keen, Degli-Esposti, Mariapia A, Hill, Geoffrey R

“…Cytomegalovirus infection is a frequent and life-threatening complication that significantly limits positive transplantation outcomes. We developed preclinical…”
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Natural killer cells in viral infection: more than just killers by Andoniou, Christopher E., Andrews, Daniel M., Degli-Esposti, Mariapia A.

“…Innate immunity was believed originally to serve simply as the first‐line defense against infection and malignancy, with adaptive immunity imposing specificity…”
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MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication by Fleming, Peter, Kvansakul, Marc, Voigt, Valentina, Kile, Benjamin T, Kluck, Ruth M, Huang, David C S, Degli-Esposti, Mariapia A, Andoniou, Christopher E

“…Successful replication and transmission of large DNA viruses such as the cytomegaloviruses (CMV) family of viruses depends on the ability to interfere with…”
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TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL by Walczak, Henning, Degli-Esposti, Mariapia A., Johnson, Richard S., Smolak, Pam J., Waugh, Jennifer Y., Boiani, Norman, Timour, Martin S., Gerhart, Mary J., Schooley, Kenneth A., Smith, Craig A., Goodwin, Raymond G., Rauch, Charles T.

“…TRAIL is a member of the tumor necrosis factor (TNF) family of cytokines and induces apoptosis in a wide variety of cells. Based on homology searching of a…”
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DOT1L maintains NK cell phenotype and function for optimal tumor control by Sudholz, Harrison, Schuster, Iona S., Foroutan, Momeneh, Sng, Xavier, Andoniou, Christopher E., Doan, Anh, Camilleri, Tania, Shen, Zihan, Zaph, Colby, Degli-Esposti, Mariapia A., Huntington, Nicholas D., Scheer, Sebastian

“…Histone methyltransferases (HMTs) are crucial in gene regulation and function, yet their role in natural killer (NK) cell biology within the tumor…”
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Murine Cytomegalovirus m157 Mutation and Variation Leads to Immune Evasion of Natural Killer Cells by Voigt, Valentina, Forbes, Catherine A., Tonkin, Joanne N., Degli-Esposti, Mariapia A., Hamish R. C. Smith, Yokoyama, Wayne M., Scalzo, Anthony A.

“…Effective natural killer (NK) cell recognition of murine cytomegalovirus (MCMV)-infected cells depends on binding of the Ly49H NK cell activation receptor to…”
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CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation by Tze, Lina E, Horikawa, Keisuke, Domaschenz, Heather, Howard, Debbie R, Roots, Carla M, Rigby, Robert J, Way, David A, Ohmura-Hoshino, Mari, Ishido, Satoshi, Andoniou, Christopher E, Degli-Esposti, Mariapia A, Goodnow, Christopher C

“…Effective vaccine adjuvants must induce expression of major histocompatibility (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells…”
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Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial by Rakoczy, Elizabeth P, Prof, Lai, Chooi-May, PhD, Magno, Aaron L, PhD, Wikstrom, Matthew E, PhD, French, Martyn A, Prof, Pierce, Cora M, RN, Schwartz, Steven D, Prof, Blumenkranz, Mark S, Prof, Chalberg, Thomas W, PhD, Degli-Esposti, Mariapia A, Prof, Constable, Ian J, Prof

“…Summary Background Neovascular, or wet, age-related macular degeneration causes central vision loss and represents a major health problem in elderly people,…”
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The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s by Sheppard, Sam, Schuster, Iona S., Andoniou, Christopher E., Cocita, Clement, Adejumo, Thomas, Kung, Sam K.P., Sun, Joseph C., Degli-Esposti, Mariapia A., Guerra, Nadia

“…TRAIL is an apoptosis-inducing ligand constitutively expressed on liver-resident type 1 innate lymphoid cells (ILC1s) and a subset of natural killer (NK)…”
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