Search Results - "DEBOUVERIE, Marc"

Age-period-cohort analysis of the incidence of multiple sclerosis over twenty years in Lorraine, France by Gbaguidi, Brigitte, Guillemin, Francis, Soudant, Marc, Debouverie, Marc, Mathey, Guillaume, Epstein, Jonathan

“…Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. An increase in MS incidence over time is reported in several regions of…”
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Observatoire Français de la Sclérose en Plaques (OFSEP): A unique multimodal nationwide MS registry in France by Vukusic, Sandra, Casey, Romain, Rollot, Fabien, Brochet, Bruno, Pelletier, Jean, Laplaud, David-Axel, De Sèze, Jérôme, Cotton, François, Moreau, Thibault, Stankoff, Bruno, Fontaine, Bertrand, Guillemin, Francis, Debouverie, Marc, Clanet, Michel

“…The care of multiple sclerosis (MS) in France is based on two complementary interlinked networks: MS expert centers in university hospitals and regional…”
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Performance of administrative databases for identifying individuals with multiple sclerosis by Ducatel, Pauline, Debouverie, Marc, Soudant, Marc, Guillemin, Francis, Mathey, Guillaume, Epstein, Jonathan

“…Administrative databases are an alternative to disease registries as a research tool to study multiple sclerosis. However, they are not initially designed to…”
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Long-term analysis of patients with benign multiple sclerosis: new insights about the disability course by Mathey, Guillaume, Pisché, Guillaume, Soudant, Marc, Pittion-Vouyovitch, Sophie, Guillemin, Francis, Debouverie, Marc, Epstein, Jonathan

“…Objective To describe the course of disability in patients with benign multiple sclerosis—i.e., with an expanded disability status scale score < 3 10 years…”
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Cumulative effects of therapies on disability in relapsing multiple sclerosis by Rollot, Fabien, Casey, Romain, Leray, Emmanuelle, Debouverie, Marc, Edan, Gilles, Wiertlewski, Sandrine, Vukusic, Sandra, Laplaud, David-Axel

“…Background: Long-term effectiveness of treatment remains a key question in multiple sclerosis (MS) and the cumulative effects of past treatment have not been…”
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Item reduction based on rigorous methodological guidelines is necessary to maintain validity when shortening composite measurement scales by Goetz, Christophe, Coste, Joël, Lemetayer, Fabienne, Rat, Anne-Christine, Montel, Sébastien, Recchia, Sophie, Debouverie, Marc, Pouchot, Jacques, Spitz, Elisabeth, Guillemin, Francis

“…Abstract Objective To review current practice and update guidelines for the methodology of shortening composite measurement scales (CMSs). Study Design and…”
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Comparative effectiveness of dimethyl fumarate in multiple sclerosis by Bosco‐Lévy, Pauline, Debouverie, Marc, Brochet, Bruno, Guillemin, Francis, Louapre, Céline, Maillart, Elisabeth, Heinzlef, Olivier, Lignot, Séverine, Diez, Pauline, Abouelfath, Abdelilah, Lassalle, Régis, Blin, Patrick, Droz‐Perroteau, Cécile

“…Aims To assess the effectiveness of dimethyl fumarate (DMF) on annual rate of relapse subject to treatment (ARRt) and disability progression in multiple…”
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Mass Cytometry Identifies Expansion of T-bet + B Cells and CD206 + Monocytes in Early Multiple Sclerosis by Couloume, Laura, Ferrant, Juliette, Le Gallou, Simon, Mandon, Marion, Jean, Rachel, Bescher, Nadège, Zephir, Helene, Edan, Gilles, Thouvenot, Eric, Ruet, Aurelie, Debouverie, Marc, Tarte, Karin, Amé, Patricia, Roussel, Mikael, Michel, Laure

“…Multiple sclerosis (MS) is an immune-driven demyelinating disease of the central nervous system. Immune cell features are particularly promising as predictive…”
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Generational changes in multiple sclerosis phenotype in North African immigrants in France: A population-based observational study by Nardin, Clotilde, Latarche, Clotilde, Soudant, Marc, Dahan, Camille, Michaud, Maud, Pittion-Vouyovitch, Sophie, Guillemin, Francis, Debouverie, Marc, Mathey, Guillaume

“…The incidence of multiple sclerosis (MS) changes from generation to generation in ethnically different immigrants compared with native-born people. We aimed to…”
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Quantitative and qualitative normative dataset for intraepidermal nerve fibers using skin biopsy by Collongues, Nicolas, Samama, Brigitte, Schmidt-Mutter, Catherine, Chamard-Witkowski, Ludivine, Debouverie, Marc, Chanson, Jean-Baptiste, Antal, Maria-Cristina, Benardais, Karelle, de Seze, Jérôme, Velten, Michel, Boehm, Nelly

“…Skin biopsy is the most relevant tool to diagnose small-fiber neuropathy. A well-documented normal dataset for intraepidermal nerve fiber in the distal leg is…”
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Excess Mortality in Patients with Multiple Sclerosis Starts at 20 Years from Clinical Onset: Data from a Large-Scale French Observational Study by Leray, Emmanuelle, Vukusic, Sandra, Debouverie, Marc, Clanet, Michel, Brochet, Bruno, de Sèze, Jérôme, Zéphir, Hélène, Defer, Gilles, Lebrun-Frenay, Christine, Moreau, Thibault, Clavelou, Pierre, Pelletier, Jean, Berger, Eric, Cabre, Philippe, Camdessanché, Jean-Philippe, Kalson-Ray, Shoshannah, Confavreux, Christian, Edan, Gilles

“…Recent studies in multiple sclerosis (MS) showed longer survival times from clinical onset than older hospital-based series. However estimated median time…”
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BEST-MS: A prospective head-to-head comparative study of natalizumab and fingolimod in active relapsing MS by Cohen, Mikael, Mondot, Lydiane, Bucciarelli, Florence, Pignolet, Béatrice, Laplaud, David-Axel, Wiertlewski, Sandrine, Brochet, Bruno, Ruet, Aurélie, Defer, Gilles, Derache, Nathalie, Vermersch, Patrick, Zephir, Hélène, Debouverie, Marc, Mathey, Guillaume, Berger, Eric, Cappé, Chrystelle, Labauge, Pierre, Carra, Clarisse, De Seze, Jérôme, Bigaut, Kevin, Brassat, David, Lebrun-Frenay, Christine

“…Background: There are few head-to-head studies to compare highly active treatments in multiple sclerosis (MS) Objective: The aim of this study was to compare…”
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Oral nomegestrol acetate and transdermal 17-beta-estradiol for preventing post-partum relapses in multiple sclerosis: The POPARTMUS study by Vukusic, Sandra, Ionescu, Iuliana, Cornu, Catherine, Bossard, Nadine, Durand-Dubief, Françoise, Cotton, François, Durelli, Luca, Marignier, Romain, Gignoux, Laurence, Laplaud, David-Axel, Moreau, Thibault, Clavelou, Pierre, De Seze, Jérôme, Debouverie, Marc, Brassat, David, Pelletier, Jean, Lebrun-Frenay, Christine, Le Page, Emmanuelle, Castelnovo, Giovanni, Berger, Eric, Hautecoeur, Patrick, Heinzlef, Olivier, Trojano, Maria, Patti, Francesco, Baulieu, Etienne-Emile, Remontet, Laurent, El-Etr, Martine

“…Background: Sex steroids could explain the course of multiple sclerosis (MS) in pregnancy. Objective: To compare the annualized relapse rate (ARR) 12 weeks…”
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Efficacy of rituximab in refractory RRMS by Durozard, Pierre, Maarouf, Adil, Boutiere, Clémence, Ruet, Aurelie, Brochet, Bruno, Vukusic, Sandra, Carra-Dalliere, Clarisse, Labauge, Pierre, Mathey, Guillaume, Debouverie, Marc, Papeix, Caroline, Maillart, Elisabeth, Lubetzki, Catherine, Bensa, Caroline, Gout, Olivier, Giannesini, Claire, Stankoff, Bruno, Ciron, Jonathan, Brassat, David, Pelletier, Jean, Rico Lamy, Audrey, Audoin, Bertrand

“…Objective: To investigate the efficacy of rituximab as rescue therapy in patients with relapsing-remitting multiple sclerosis (RRMS) and persistent disease…”
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MD1003 (High-Dose Pharmaceutical-Grade Biotin) for the Treatment of Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study by Tourbah, Ayman, Gout, Olivier, Vighetto, Alain, Deburghgraeve, Véronique, Pelletier, Jean, Papeix, Caroline, Lebrun-Frenay, Christine, Labauge, Pierre, Brassat, David, Toosy, Ahmed, Laplaud, David-Axel, Outteryck, Olivier, Moreau, Thibault, Debouverie, Marc, Clavelou, Pierre, Heinzlef, Olivier, De Sèze, Jérôme, Defer, Gilles, Sedel, Frédéric, Arndt, Carl

“…Background Chronic visual loss is a disabling feature in patients with multiple sclerosis (MS). It was recently shown that MD1003 (high-dose…”
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Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction by Richard, Sébastien, Lapierre, Vanessa, Girerd, Nicolas, Bonnerot, Mathieu, Burkhard, Pierre R., Lagerstedt, Linnéa, Bracard, Serge, Debouverie, Marc, Turck, Natacha, Sanchez, Jean-Charles

“…Accurately determining time-of-onset of cerebral infarction is important to clearly identify patients who could benefit from reperfusion therapies. We assessed…”
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Intra-database validation of case-identifying algorithms using reconstituted electronic health records from healthcare claims data by Thurin, Nicolas H, Bosco-Levy, Pauline, Blin, Patrick, Rouyer, Magali, Jové, Jérémy, Lamarque, Stéphanie, Lignot, Séverine, Lassalle, Régis, Abouelfath, Abdelilah, Bignon, Emmanuelle, Diez, Pauline, Gross-Goupil, Marine, Soulié, Michel, Roumiguié, Mathieu, Le Moulec, Sylvestre, Debouverie, Marc, Brochet, Bruno, Guillemin, Francis, Louapre, Céline, Maillart, Elisabeth, Heinzlef, Olivier, Moore, Nicholas, Droz-Perroteau, Cécile

“…Diagnosis performances of case-identifying algorithms developed in healthcare database are usually assessed by comparing identified cases with an external data…”
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Geographical Heterogeneity of Multiple Sclerosis Prevalence in France by Pivot, Diane, Debouverie, Marc, Grzebyk, Michel, Brassat, David, Clanet, Michel, Clavelou, Pierre, Confavreux, Christian, Edan, Gilles, Leray, Emmanuelle, Moreau, Thibault, Vukusic, Sandra, Hédelin, Guy, Guillemin, Francis

“…Geographical variation in the prevalence of multiple sclerosis (MS) is controversial. Heterogeneity is important to acknowledge to adapt the provision of care…”
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Double-Blind Controlled Randomized Trial of Cyclophosphamide versus Methylprednisolone in Secondary Progressive Multiple Sclerosis by Brochet, Bruno, Deloire, Mathilde S A, Perez, Paul, Loock, Timothé, Baschet, Louise, Debouverie, Marc, Pittion, Sophie, Ouallet, Jean-Christophe, Clavelou, Pierre, de Sèze, Jérôme, Collongues, Nicolas, Vermersch, Patrick, Zéphir, Hélène, Castelnovo, Giovanni, Labauge, Pierre, Lebrun, Christine, Cohen, Mikael, Ruet, Aurélie

“…Therapeutic options are limited in secondary progressive multiple sclerosis (SPMS). Open-label studies suggested efficacy of monthly IV cyclophosphamide (CPM)…”
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The TOTEM RRMS (Testosterone Treatment on neuroprotection and Myelin Repair in Relapsing Remitting Multiple Sclerosis) trial: study protocol for a randomized, double-blind, placebo-controlled trial by Metzger-Peter, Katline, Kremer, Laurent Daniel, Edan, Gilles, Loureiro De Sousa, Paulo, Lamy, Julien, Bagnard, Dominique, Mensah-Nyagan, Ayikoe-Guy, Tricard, Thibault, Mathey, Guillaume, Debouverie, Marc, Berger, Eric, Kerbrat, Anne, Meyer, Nicolas, De Seze, Jérôme, Collongues, Nicolas

“…Central nervous system damage in multiple sclerosis (MS) is responsible for serious deficiencies. Current therapies are focused on the treatment of…”
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