Search Results - "DEBINSKI, W"

Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor by Wykosky, J, Palma, E, Gibo, D M, Ringler, S, Turner, C P, Debinski, W

“…The ephrinA1 ligand exerts antioncogenic effects in tumor cells through activation and downregulation of the EphA2 receptor and has been described as a…”
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Characterization of Ablation Thresholds for 3D-Cultured Patient-Derived Glioma Stem Cells in Response to High-Frequency Irreversible Electroporation by Ivey, J. W., Wasson, E. M., Alinezhadbalalami, N., Kanitkar, A., Debinski, W., Sheng, Z., Davalos, R. V., Verbridge, S. S.

“…High-frequency irreversible electroporation (H-FIRE) is a technique that uses pulsed electric fields that have been shown to ablate malignant cells. In order…”
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Hybrid mathematical model of glioma progression by Tanaka, M. L., Debinski, W., Puri, I. K.

“…Objectives:  Gliomas are an important form of brain cancer, with high mortality rate. Mathematical models are often used to understand and predict their…”
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Genomic Predictors of Imaging Response and Survival in Glioblastoma by Soike, M, McTyre, E, Holmes, J.A, Paulsson, A.K, Miller, L, Lesser, G.J, Strowd, R.E, Johnson, A, Lo, H.W, Laxton, A.W, Tatter, S.B, Debinski, W, Chan, M.D

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Genomic Predictors of Infield and Marginal Failure for Glioblastoma Treated With Concurrent Radiation Therapy and Temozolomide: A Step Towards Personalized Radiation Fields? by Holmes, J.A, Paulsson, A, Peiffer, A.M, Miller, L.D, Xu, J, Hinson, W.H, Lesser, G.J, Tatter, S.B, Debinski, W, Chan, M.D

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Does Delay of Start of Radiation Affect Clinical Outcomes of Glioblastoma by Randolph, D.M, Peiffer, A.M, Paulsson, A.K, Hinson, W, Laxton, A.W, Tatter, S.B, Debinski, W, Chan, M.D

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FUNCTIONAL PRESENCE OF M2 MACROPHAGE MARKERS IN GBM TUMOR CELLS by Debinski, W., Rodriguez, A., Gibo, D., Tatter, S. B., Mott, R., Lively, M., Miller, L., Seals, D. F.

“…BACKGROUND: Tumor associated macrophages (TAMS) have been suggested to be key players in the tumor microenvironment. The M2 activation phenotype is believed to…”
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Molecular expression analysis of restrictive receptor for interleukin 13, a brain tumor-associated cancer/testis antigen by Debinski, W, Gibo, D M

“…The vast majority of patients with high-grade gliomas (HGG) over-express interleukin 4 (IL4)-independent binding sites for IL13 in situ. In addition, mutated…”
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Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15 by Obiri, N I, Debinski, W, Leonard, W J, Puri, R K

“…Interleukin 13 (IL-13) shares many biological properties with IL-4, and although the receptor for IL-4 (IL-4R) has been characterized, the expression and…”
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Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin by DEBINSKI, W, OBIRI, N. I, POWERS, S. K, PASTAN, I, PURI, R. K

“…Recently, we have demonstrated that a spectrum of human adenocarcinoma cell lines express binding sites for interleukin 13 (IL-13). These cells are killed by a…”
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P06.02 A multivalent protein for immune checkpoint inhibition at the tumor site by Debinski, W., Rodriguez, A.

“…Monoclonal antibodies targeting programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4, CTLA-4 on T cells have demonstrated efficacy in…”
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VEGF-D is an X-linked/AP-1 regulated putative onco-angiogen in human glioblastoma multiforme by Debinski, W, Slagle-Webb, B, Achen, M G, Stacker, S A, Tulchinsky, E, Gillespie, G Y, Gibo, D M

“…Glioblastoma multiforme (GBM) is a hypervascularized and locally infiltrating brain tumor of astroglial origin with a very poor prognosis. An X-linked c-fos…”
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Characterization and Distribution of Ferritin Binding Sites in the Adult Mouse Brain by Hulet, S. W., Hess, E. J., Debinski, W., Arosio, P., Bruce, K., Powers, S., Connor, J. R.

“…: Studies on iron uptake into the brain have traditionally focused on transport by transferrin. However, transferrin receptors are not found in all brain…”
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Expression of a restrictive receptor for interleukin 13 is associated with glial transformation by DEBINSKI, Waldemar, SLAGLE, Becky, GIBO, Denise M, POWERS, Stephen K, GILLESPIE, G. Y

“…We have previously documented that the vast majority of high-grade gliomas over-express binding sites for interleukin 13 (IL13) in situ. We now extend this…”
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Receptor for interleukin 13 is abundantly and specifically over-expressed in patients with glioblastoma multiforme by Debinski, W, Gibo, D M, Slagle, B, Powers, S K, Gillespie, G Y

“…We have recently documented that the vast majority of patients with glioblastoma multiforme (GBM) over-express a receptor (R) for interleukin 13 (IL13) in…”
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Targeting of Interleukin-13 Receptor on Human Renal Cell Carcinoma Cells by a Recombinant Chimeric Protein Composed of Interleukin-13 and a Truncated Form of Pseudomonas Exotoxin A (PE38QQR) by Puri, Raj K., Leland, Pamela, Obiri, Nicholas I., Husain, S.Rafat, Kreitman, Robert J., Haas, Gabriel P., Pastan, Ira, Debinski, Waldemar

“…We have previously shown that human renal cell carcinoma (RCC) cells express large numbers of interleukin-13 receptors (IL-13R), a newly described hemopoietic…”
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Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein by HUSAIN, S. R, OBIRI, N. I, GILL, P, ZHENG, T, PASTAN, I, DEBINSKI, W, PURI, R. K

“…AIDS-associated Kaposi's sarcoma (AIDS-KS), the most common malignant complication of human immunodeficiency virus infection, is characterized by neoplastic…”
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Interleukin 13 inhibits growth of human renal cell carcinoma cells independently of the p140 interleukin 4 receptor chain by OBIRI, N. I, RAFAT HUSAIN, S, DEBINSKI, W, PURI, R. K

“…Interleukin-13 (IL-13) is a cytokine produced primarily by activated T lymphocytes. It exerts a variety of effects on different cell types, including…”
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A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin by DEBINSKI, W, PURI, R. K, KREITMAN, R. J, PASTAN, I

“…A chimeric toxin has been constructed by fusion of a gene encoding human interleukin 4 (hIL4) to a gene encoding a mutant form of Pseudomonas exotoxin A (PE)…”
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Clinical Outcomes in High Risk WHO Grade II Glioma Patients Treated with Upfront TMZ-Based Chemoradiotherapy by Zarabi, H., Wicks, R., Strowd, R., Russell, G., Banderage, D., Mott, R.T., Laxton, A., Tatter, S.B., White, J., Lo, H.W., Whitlow, C., Debinski, W., Chan, M.D., Lesser, G.J., Cramer, C.K.

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