Search Results - "DEANS, Julie"

MS4A4A: a novel cell surface marker for M2 macrophages and plasma cells by Sanyal, Ratna, Polyak, Maria J, Zuccolo, Jonathan, Puri, Mandip, Deng, Lili, Roberts, Luc, Zuba, Ania, Storek, Jan, Luider, Joanne M, Sundberg, Ellen M, Mansoor, Adnan, Baigorri, Eva, Chu, Michael P, Belch, Andrew R, Pilarski, Linda M, Deans, Julie P

“…MS4A4A is a member of the membrane‐spanning, four domain family, subfamily A (MS4A) that includes CD20 (MS4A1), FcRβ (MS4A2) and Htm4 (MS4A3). Like the first…”
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CD20 Homo-oligomers Physically Associate with the B Cell Antigen Receptor: DISSOCIATION UPON RECEPTOR ENGAGEMENT AND RECRUITMENT OF PHOSPHOPROTEINS AND CALMODULIN-BINDING PROTEINS by Polyak, Maria J, Li, Haidong, Shariat, Neda, Deans, Julie P

“…B cell antigen receptor (BCR) signaling initiates sustained cellular calcium influx necessary for the development, differentiation, and activation of B…”
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Phylogenetic analysis of the MS4A and TMEM176 gene families by Zuccolo, Jonathan, Bau, Jeremy, Childs, Sarah J, Goss, Greg G, Sensen, Christoph W, Deans, Julie P

“…The MS4A gene family in humans includes CD20 (MS4A1), FcRbeta (MS4A2), Htm4 (MS4A3), and at least 13 other syntenic genes encoding membrane proteins, most…”
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Acquirement of Rituximab Resistance in Lymphoma Cell Lines Is Associated with Both Global CD20 Gene and Protein Down-Regulation Regulated at the Pretranscriptional and Posttranscriptional Levels by CZUCZMAN, Myron S, OLEJNICZAK, Scott, GOWDA, Aruna, KOTOWSKI, Adam, BINDER, Arvinder, KAUR, Harman, KNIGHT, Joy, STAROSTIK, Petr, DEANS, Julie, HERNANDEZ-LLIZALITURRI, Francisco J

“…Acquirement of resistance to rituximab has been observed in lymphoma patients. To define mechanisms associated with rituximab resistance, we developed various…”
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Reduced T-dependent humoral immunity in CD20-deficient mice by Morsy, Deyaa El Deen, Sanyal, Ratna, Zaiss, Anne K, Deo, Rucha, Muruve, Dan A, Deans, Julie P

“…CD20 is a tetraspanning membrane protein expressed on B lymphocytes. CD20 deficiency in both mice and humans has recently been shown to have deleterious…”
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Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure by Polyak, Maria J., Deans, Julie P.

“…In vivo ablation of malignant B cells can be achieved using antibodies directed against the CD20 antigen. Fine specificity differences among CD20 monoclonal…”
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Determination of apparent calcium affinity for endogenously expressed human sarco(endo)plasmic reticulum calcium-ATPase isoform SERCA3 by Chandrasekera, P Charukeshi, Kargacin, Margaret E, Deans, Julie P, Lytton, Jonathan

“…The sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs) play a crucial role in regulating free cytosolic Ca(2+) concentration in diverse cell types. It has…”
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Store-operated Cation Entry Mediated by CD20 in Membrane Rafts by Li, Haidong, Ayer, Linda M., Lytton, Jonathan, Deans, Julie P.

“…B cell activation requires sustained elevation of cytoplasmic free calcium, achieved by influx through store-operated calcium (SOC) channels. The molecular…”
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Expression of MS4A and TMEM176 Genes in Human B Lymphocytes by Zuccolo, Jonathan, Deng, Lili, Unruh, Tammy L, Sanyal, Ratna, Bau, Jeremy A, Storek, Jan, Demetrick, Douglas J, Luider, Joanne M, Auer-Grzesiak, Iwona A, Mansoor, Adnan, Deans, Julie P

“…The MS4A gene family in humans includes CD20 and at least 15 other genes. CD20 exists as homo-oligomers in the plasma membrane, however different MS4A proteins…”
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CD20‐mediated apoptosis: signalling through lipid rafts by Deans, Julie P., Li, Haidong, Polyak, Maria J.

“…Summary CD20 is an effective target for therapeutic B‐cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity…”
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FMC7 is an epitope of CD20 by Deans, Julie P., Polyak, Maria J.

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Efficient isolation of highly purified tonsil B lymphocytes using RosetteSep with allogeneic human red blood cells by Zuccolo, Jonathan, Unruh, Tammy L, Deans, Julie P

“…Human tonsils are a rich source of B lymphocytes exhibiting a variety of phenotypes and activation states. Existing methods of purification are time consuming…”
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Quantification of CD20 mRNA and protein levels in chronic lymphocytic leukemia suggests a post-transcriptional defect by Sarro, Shannon M, Unruh, Tammy L, Zuccolo, Jonathan, Sanyal, Ratna, Luider, Joanne M, Auer-Grzesiak, Iwona A, Mansoor, Adnan, Deans, Julie P

“…Abstract Chronic lymphocytic leukemia is less effectively treated than other B cell malignancies with the anti-CD20 agent, rituximab, presumably due, at least…”
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Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor by Mutch, Cathlin M., Sanyal, Ratna, Unruh, Tammy L., Grigoriou, Lana, Zhu, Minghua, Zhang, Weiguo, Deans, Julie P.

“…Linker for activation of B cell (LAB)/non-T cell activation linker (NTAL) and phosphoprotein associated with glycophospholipid-enriched membrane microdomain…”
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Colocalization of the B Cell Receptor and CD20 Followed by Activation-Dependent Dissociation in Distinct Lipid Rafts by Petrie, Ryan J, Deans, Julie P

“…The B cell Ag receptor (BCR) and CD20, a putative calcium channel, inducibly associate with cholesterol-dependent membrane microdomains known as lipid rafts. A…”
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Transient Translocation of the B Cell Receptor and Src Homology 2 Domain-Containing Inositol Phosphatase to Lipid Rafts: Evidence Toward a Role in Calcium Regulation by Petrie, Ryan J, Schnetkamp, Paul P. M, Patel, Kamala D, Awasthi-Kalia, Manjula, Deans, Julie P

“…Membrane microdomains (lipid rafts) are enriched in selected signaling molecules and may compartmentalize receptor-mediated signals. Here, we report that in…”
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Cholesterol depletion inhibits src family kinase‐dependent calcium mobilization and apoptosis induced by rituximab crosslinking by Unruh, Tammy L., Li, Haidong, Mutch, Cathlin M., Shariat, Neda, Grigoriou, Lana, Sanyal, Ratna, Brown, Christopher B., Deans, Julie P.

“…Summary The monoclonal antibody (mAb) rituximab produces objective clinical responses in patients with B‐cell non‐Hodgkin's lymphoma and antibody‐based…”
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The CD20 calcium channel is localized to microvilli and constitutively associated with membrane rafts: antibody binding increases the affinity of the association through an epitope-dependent cross-linking-independent mechanism by Li, Haidong, Ayer, Linda M, Polyak, Maria J, Mutch, Cathlin M, Petrie, Ryan J, Gauthier, Laura, Shariat, Neda, Hendzel, Michael J, Shaw, Andrew R, Patel, Kamala D, Deans, Julie P

“…CD20 is a B cell-specific membrane protein that functions in store-operated calcium entry and serves as a useful target for antibody-mediated therapeutic…”
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Therapeutic (High) Doses of Rituximab Activate Calcium Mobilization and Inhibit B-cell Growth via an Unusual Mechanism Triggered Independently of Both CD20 and Fcγ Receptors by UNRUH, Tammy L, ZUCCOLO, Jonathan, BEERS, Stephen A, KANEVETS, Uliana, YAN SHI, DEANS, Julie P

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Identification of a Cytoplasmic Region of CD20 Required for Its Redistribution to a Detergent-Insoluble Membrane Compartment by Polyak, Maria J, Tailor, Sweta H, Deans, Julie P

“…CD20 is a B lymphocyte integral membrane protein with signal-transducing properties. Abs directed toward extracellular CD20 epitopes activate nonreceptor…”
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