Search Results - "DEAN BEFUS, A"

Mast cell mediators: their differential release and the secretory pathways involved by Moon, Tae Chul, Befus, A Dean, Kulka, Marianna

“…Mast cells (MC) are widely distributed throughout the body and are common at mucosal surfaces, a major host-environment interface. MC are functionally and…”
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Exertional intolerance and dyspnea with preserved lung function: an emerging long COVID phenotype? by Lam, Grace Y, Befus, A. Dean, Damant, Ronald W, Ferrara, Giovanni, Fuhr, Desi P, Stickland, Michael K, Varughese, Rhea A, Wong, Eric Y, Smith, Maeve P

“…The COVID-19 pandemic has resulted in significant acute morbidity and mortality worldwide. There is now a growing recognition of the longer-term sequelae of…”
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The Complexity of Sesquiterpene Chemistry Dictates Its Pleiotropic Biologic Effects on Inflammation by Arizmendi, Narcy, Alam, Syed Benazir, Azyat, Khalid, Makeiff, Darren, Befus, A Dean, Kulka, Marianna

“…Sesquiterpenes (SQs) are volatile compounds made by plants, insects, and marine organisms. SQ have a large range of biological properties and are potent…”
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Identification and characterization of calcium binding protein, spermatid-associated 1 (CABS1)# in selected human tissues and fluids by Reyes-Serratos, Eduardo, Ramielle L Santos, Joy, Puttagunta, Lakshmi, Lewis, Stephen J, Watanabe, Mechiko, Gonshor, Aron, Buck, Robert, Befus, A Dean, Marcet-Palacios, Marcelo

“…Calcium binding protein, spermatid associated 1 (CABS1) is a protein most widely studied in spermatogenesis. However, mRNA for CABS1 has been found in numerous…”
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CD4 and CD8: an inside-out coreceptor model for innate immune cells by Gibbings, Derrick, Befus, A. Dean

“…CD4 and CD8 enhancement of FcR‐like signaling is discussed as a potential role when expressed by innate immune cells. CD8 and CD4 are expressed by several cell…”
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Expression of DP2 (CRTh2), a prostaglandin D₂ receptor, in human mast cells by Moon, Tae Chul, Campos-Alberto, Eduardo, Yoshimura, Tsuyoshi, Bredo, Graeme, Rieger, Aja M, Puttagunta, Lakshmi, Barreda, Daniel R, Befus, A Dean, Cameron, Lisa

“…PGD₂ has long been implicated in allergic diseases. Recent cloning of a second PGD₂ receptor, DP2 (also known as CRTh2), led to a greater understanding of the…”
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Microenvironmental regulation of inducible nitric oxide synthase expression and nitric oxide production in mouse bone marrow-derived mast cells by Moon, Tae Chul, Yoshimura, Tsuyoshi, Parsons, Thomas, Befus, A. Dean

“…Mast cell progenitors that develop in SCF+IL‐4 can be induced to express NOS2 after receiving appropriate signals such as IFNγ, and subsequently produce NO. In…”
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Posttraumatic elbow contractures: targeting neuroinflammatory fibrogenic mechanisms by Monument, Michael J., Hart, David A., Salo, Paul T., Hildebrand, Kevin A., Dean Befus, A.

“…Posttraumatic elbow stiffness remains a common and challenging clinical problem. In the setting of a congruent articular surface, the joint capsule is regarded…”
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Developments in asthma incidence and prevalence in Alberta between 1995 and 2015 by Bosonea, Ana-Maria, Sharpe, Heather, Wang, Ting, Bakal, Jeffrey A, Befus, A Dean, Svenson, Lawrence W, Vliagoftis, Harissios

“…Asthma is a chronic respiratory disease characterized by reversible bronchoconstriction and airway inflammation. According to Statistics Canada in 2014, 8.1%…”
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The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures by Monument, Michael J., Hart, David A., Befus, A. Dean, Salo, Paul T., Zhang, Mei, Hildebrand, Kevin A.

“…Objectives Using a rabbit model of post-traumatic joint contractures, we investigated whether treatment with a mast cell stabilizer after joint injury would…”
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Rapidly changing perspectives about mast cells at mucosal surfaces by Vliagoftis, Harissios, Befus, A. Dean

“…Mast cells (MCs) are major effector cells of immunoglobulin E (IgE)‐mediated allergic inflammation. However, it has become increasingly clear that they also…”
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Measurement of nitric oxide in mast cells with the fluorescent indicator DAF-FM diacetate by St Laurent, Chris D, Moon, Tae Chul, Befus, A Dean

“…The production of nitric oxide in mast cells has been difficult to measure due to the low amounts made by mast cells, as well as limitations in the specificity…”
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Expression of nitric oxide synthases in leukocytes in nasal polyps by Yoshimura, Tsuyoshi, MD, Moon, Tae Chul, PhD, St. Laurent, Chris D., BSc, Puttagunta, Lakshmi, MD, Chung, Kerri, MD, Wright, Erin, MD, Yoshikawa, Mamoru, MD, Moriyama, Hiroshi, MD, Befus, A. Dean, PhD

“…Abstract Background Nitric oxide (NO) has various roles in airway physiology and pathophysiology. Monitoring exhaled NO levels is increasingly common to…”
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Opposing Effects of Short- and Long-term Stress on Airway Inflammation by Forsythe, Paul, Ebeling, Cory, Gordon, John R, Befus, A. Dean, Vliagoftis, Harissios

“…Between 20% and 35% of subjects with asthma experience asthma exacerbations during periods of stress. The biological mechanisms underlying these exacerbations…”
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Inhibition of Allergic Inflammation in the Airways Using Aerosolized Antisense to Syk Kinase by Stenton, Grant R, Ulanova, Marina, Dery, Rene E, Merani, Shaheed, Kim, Moo-Kyung, Gilchrist, Mark, Puttagunta, Lakshmi, Musat-Marcu, Sorin, James, Deborah, Schreiber, Alan D, Befus, A. Dean

“…Activation of the protein tyrosine kinase Syk is an early event that follows cross-linking of Fc gamma R and Fc epsilon R, leading to the release of…”
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A method to study protein biomarkers in saliva using an automated capillary nano-immunoassay platform (Wes™) by Reyes-Serratos, Eduardo, Marcet-Palacios, Marcelo, Rosenfield, David, Ritz, Thomas, Befus, A. Dean

“…Traditional immunoprobing techniques like Western blot continue to play a crucial role in the discovery and validation of biomarkers. This technique suffers…”
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A children's asthma education program: Roaring Adventures of Puff (RAP), improves quality of life by McGhan, Shawna L, Wong, Eric, Sharpe, Heather M, Hessel, Patrick A, Mandhane, Puish, Boechler, Vivki L, Majaesic, Carina, Befus, A Dean

“…It is postulated that children with asthma who receive an interactive, comprehensive education program would improve their quality of life, asthma management…”
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Nitric oxide and cyclic GMP increase the expression of matrix metalloproteinase-9 in vascular smooth muscle by Marcet-Palacios, Marcelo, Graham, Kathryn, Cass, Carol, Befus, A Dean, Mayers, Irvin, Radomski, Marek W

“…Interactions and possible cross talk between inducible nitricoxide synthase (iNOS), cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9), were…”
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Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein by Mathison, Ronald D, Davison, Joseph S, Befus, A Dean, Gingerich, Daniel A

“…The limitations of steroidal and non steroidal anti-inflammatory drugs have prompted investigation into other biologically based therapeutics, and…”
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The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma by Subbarao, Padmaja, Anand, Sonia S, Becker, Allan B, Befus, A Dean, Brauer, Michael, Brook, Jeffrey R, Denburg, Judah A, HayGlass, Kent T, Kobor, Michael S, Kollmann, Tobias R, Kozyrskyj, Anita L, Lou, W Y Wendy, Mandhane, Piushkumar J, Miller, Gregory E, Moraes, Theo J, Pare, Peter D, Scott, James A, Takaro, Tim K, Turvey, Stuart E, Duncan, Joanne M, Lefebvre, Diana L, Sears, Malcolm R

“…The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We…”
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