Search Results - "DEAN, Reginald L"
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Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat
Published in Neuropharmacology (01-03-2019)“…Approximately two-thirds of major depressive disorder (MDD) patients do not respond adequately to current therapies. BUP/SAM (ALKS 5461), a combination of…”
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Pharmaceutical treatment for cognitive deficits in Alzheimer’s disease and other neurodegenerative conditions: exploring new territory using traditional tools and established maps
Published in Psychopharmacology (2009)“…Rationale Over 30 years ago, we began to develop a nonhuman primate model to study cognitive deficits of age-related neurodegenerative diseases and their…”
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The Role of Leukocytes Following Cerebral Ischemia: Pathogenic Variable or Bystander Reaction to Emerging Infarct?
Published in Experimental Neurology (01-01-2002)“…Data accumulated over the last 10 years have led to the popular hypothesis that neutrophils and other inflammatory cells play a prominent role in the…”
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Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data?
Published in Neuroscience and biobehavioral reviews (01-01-2020)“…•The opioid system has a key role in modulating neural systems dysregulated in MDD.•Opioids have effects on reward processing and emotional regulation in…”
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Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates
Published in Journal of psychopharmacology (Oxford) (01-10-2019)“…Background: Olanzapine, regarded as one of the most efficacious antipsychotic medications for the treatment of schizophrenia, is associated with a high risk of…”
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Investigation of the reinforcing potential of samidorphan and naltrexone by fixed and progressive ratio intravenous self-administration testing in heroin-maintained rats
Published in Journal of psychopharmacology (Oxford) (01-03-2019)“…Background: Samidorphan is a novel μ-opioid antagonist with low intrinsic activity at κ- and δ-opioid receptors. Aims: Because samidorphan is central nervous…”
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Antidepressant-like effects of 3-carboxamido seco-nalmefene (3CS-nalmefene), a novel opioid receptor modulator, in a rat IFN-α-induced depression model
Published in Brain, behavior, and immunity (01-01-2018)“…•IFN-α treatment induced depressive-like and cognitive deficits in the rat.•IFN-α increased IL-6, IL-1β and corticosterone, and decreased neurogenesis and…”
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Samidorphan, an opioid receptor antagonist, attenuates drug-induced increases in extracellular dopamine concentrations and drug self-administration in male Wistar rats
Published in Pharmacology, biochemistry and behavior (01-05-2021)“…Opioid receptors modulate neurochemical and behavioral responses to drugs of abuse in nonclinical models. Samidorphan (SAM) is a new molecular entity that…”
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Prodrugs of Pioglitazone for Extended-Release (XR) Injectable Formulations
Published in Molecular pharmaceutics (06-10-2014)“…N-Acyloxymethyl derivatives of pioglitazone (PIO) have been prepared and characterized as model candidates for extended-release injectable formulations. All…”
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The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Published in Science (American Association for the Advancement of Science) (30-07-1982)“…Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically…”
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Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats
Published in Pharmacology, biochemistry and behavior (01-01-2012)“…Naltrexone is a μ-opioid receptor antagonist that has been extensively studied for its ability to block the rewarding effects of ethanol. Opioid receptors are…”
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Effects of Extended-Release Injectable Naltrexone on Self-Injurious Behavior in Rhesus Macaques (Macaca mulatta)
Published in Comparative medicine (01-06-2012)“…Self-injurious behavior (SIB) is a spontaneous behavior that threatens the health and wellbeing of multiple species. In humans, the opioid antagonist…”
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Naltrexone decreases D-amphetamine and ethanol self-administration in rhesus monkeys
Published in Behavioural pharmacology (01-02-2011)“…Amphetamines are the second most highly abused illicit drugs worldwide, yet there is no pharmacological treatment for amphetamine abuse and dependence…”
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Overriding the blockade of antinociceptive actions of opioids in rats treated with extended-release naltrexone
Published in Pharmacology, biochemistry and behavior (01-06-2008)“…A monthly extended-release formulation of the opioid antagonist naltrexone (XR-NTX) is approved for treatment of alcohol dependence. There is little research…”
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Vivitrex , an Injectable, Extended-Release Formulation of Naltrexone, Provides Pharmacokinetic and Pharmacodynamic Evidence of Efficacy for 1 Month in Rats
Published in Neuropsychopharmacology (01-11-2003)“…While oral naltrexone is effective in treating alcohol and opiate dependencies, poor patient adherence and widely fluctuating plasma levels limit its efficacy…”
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The development of the bradykinin agonist labradimil as a means to increase the permeability of the blood-brain barrier from concept to clinical evaluation
Published in Clinical pharmacokinetics (2001)“…Labradimil (Cereport; also formerly referred to as RMP-7) is a 9-amino-acid peptide designed for selectivity for the bradykinin B2 receptor and a longer plasma…”
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Route of administration affects the ability of naltrexone to reduce amphetamine-potentiated brain stimulation reward in rats
Published in Addiction biology (01-10-2009)“…Opioid receptor antagonism has been shown to attenuate behavioral and neurochemical effects of amphetamine in humans and rodents. The effects of acute (oral or…”
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Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage
Published in Journal of cerebral blood flow and metabolism (01-07-1994)“…Experiments were conducted to determine whether a potent, reversible calpain inhibitor could reduce the cortical ischemic brain damage associated with focal…”
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Time-related neuronal changes following middle cerebral artery occlusion: implications for therapeutic intervention and the role of calpain
Published in Journal of cerebral blood flow and metabolism (01-11-1995)“…Changes in neocortex and striatum were characterized over time following focal ischemia to the brain. Rats were subjected to permanent middle cerebral artery…”
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