Search Results - "DEAN, DAVID D"

Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies by Block, Travis J, Marinkovic, Milos, Tran, Olivia N, Gonzalez, Aaron O, Marshall, Amanda, Dean, David D, Chen, Xiao-Dong

“…Degenerative diseases are a major public health concern for the aging population and mesenchymal stem cells (MSCs) have great potential for treating many of…”
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Culture on a native bone marrow‐derived extracellular matrix restores the pancreatic islet basement membrane, preserves islet function, and attenuates islet immunogenicity by Wang, Hanzhou, Li, Shengxian, Dai, Qiuxia, Gonzalez, Aaron, Tran, Olivia N., Sun, Haiyan, DeFronzo, Ralph A., Dean, David D., Yeh, Chih‐Ko, Chen, Xiao‐Dong

“…Islet transplantation in man is limited by multiple factors including islet availability, islet cell damage caused by collagenase during isolation, maintenance…”
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Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration by Marinkovic, Milos, Tran, Olivia N., Wang, Hanzhou, Abdul-Azees, Parveez, Dean, David D., Chen, Xiao-Dong, Yeh, Chih-Ko

“…Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical manifestation that has the potential to cause severe oral and/or…”
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Native extracellular matrix preserves mesenchymal stem cell "stemness" and differentiation potential under serum-free culture conditions by Rakian, Rubie, Block, Travis J, Johnson, Shannan M, Marinkovic, Milos, Wu, Junjie, Dai, Qiuxia, Dean, David D, Chen, Xiao-Dong

“…Bone marrow-derived mesenchymal stem cells (BM-MSCs) for clinical use should not be grown in media containing fetal bovine serum (FBS), because of…”
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Organ-specific extracellular matrix directs trans-differentiation of mesenchymal stem cells and formation of salivary gland-like organoids in vivo by Tran, Olivia N, Wang, Hanzhou, Li, Shengxian, Malakhov, Andrey, Sun, Yuyang, Abdul Azees, Parveez A, Gonzalez, Aaron O, Cao, Brian, Marinkovic, Milos, Singh, Brij B, Dean, David D, Yeh, Chih-Ko, Chen, Xiao-Dong

“…Current treatments for salivary gland (SG) hypofunction are palliative and do not address the underlying cause or progression of the disease. SG-derived stem…”
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Native extracellular matrix, synthesized ex vivo by bone marrow or adipose stromal cells, faithfully directs mesenchymal stem cell differentiation by Marinkovic, Milos, Tran, Olivia N., Block, Travis J., Rakian, Rubie, Gonzalez, Aaron O., Dean, David D., Yeh, Chih-Ko, Chen, Xiao-Dong

“…Mesenchymal stem cells (MSCs) are highly responsive to cues in the microenvironment (niche) that must be recapitulated ex vivo to study their authentic…”
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Umbilical cord blood-derived non-hematopoietic stem cells retrieved and expanded on bone marrow-derived extracellular matrix display pluripotent characteristics by Wu, Junjie, Sun, Yun, Block, Travis J, Marinkovic, Milos, Zhang, Zhi-Liang, Chen, Richard, Yin, Yixia, Song, Juquan, Dean, David D, Lu, Zhongding, Chen, Xiao-Dong

“…Umbilical cord blood (UCB) not only contains hematopoietic stem cells (HSCs), but also non-hematopoietic stem cells (NHSCs) that are able to differentiate into…”
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Age-related effect on the concentration of collagen crosslinks in human osteonal and interstitial bone tissue by Nyman, Jeffry S., Roy, Anuradha, Acuna, Rae L., Gayle, Heather J., Reyes, Michael J., Tyler, Jerrod H., Dean, David D., Wang, Xiaodu

“…Collagen crosslinks are important to the quality of bone and may be contributors to the age-related increase in bone fracture. This study was performed to…”
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Percutaneous injection of Augment Injectable Bone Graft (rhPDGF-BB and β-tricalcium phosphate [β-TCP]/bovine Type I collagen matrix) increases vertebral bone mineral density in geriatric female baboons by Perrien, Daniel S., PhD, Young, Conan S., PhD, Alvarez-Urena, Pedro P., MS, Dean, David D., PhD, Lynch, Samuel E., DMD, DSc, Hollinger, Jeffrey O., DDS, PhD

“…Abstract Background context Recombinant human platelet-derived growth factor-BB (rhPDGF-BB) homodimer is a chemotactic, mitogenic, and angiogenic factor…”
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Ceramic and PMMA particles differentially affect osteoblast phenotype by Lohmann, Christoph H, Dean, David D, Köster, Georg, Casasola, David, Buchhorn, Gottfried H, Fink, Ulrich, Schwartz, Zvi, Boyan, Barbara D

“…There is increasing evidence that wear debris particles present in periprosthetic tissues have direct effects on osteoblasts. The nature of the cell response…”
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Secretion of salivary statherin is compromised in uncontrolled diabetic patients by Izumi, Masahiro, Zhang, Bin-Xian, Dean, David D, Lin, Alan L, Saunders, Michèle J, Hazuda, Helen P, Yeh, Chih-Ko

“…Statherin is an important salivary protein for maintaining oral health. The purpose of the current study was to determine if differences in statherin levels…”
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Nitric Oxide Donors Selectively Reduce the Expression of Matrix Metalloproteinases-8 and -9 by Human Diabetic Skin Fibroblasts by Burrow, Jamey W., M.D., M.S, Koch, Joey A., B.S, Chuang, Hui-Hsiu, B.S, Zhong, Weinan, Dean, David D., Ph.D, Sylvia, Victor L., Ph.D

“…Background Chronic, nonhealing skin wounds are a common ailment in uncontrolled diabetes and are associated with significant morbidity. The nonhealing diabetic…”
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One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior by Marinkovic, Milos, Block, Travis J., Rakian, Rubie, Li, Qihong, Wang, Exing, Reilly, Matthew A., Dean, David D., Chen, Xiao-Dong

“…For more than 100years, cells and tissues have been studied in vitro using glass and plastic surfaces. Over the last 10–20years, a great body of research has…”
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Activation of Latent Transforming Growth Factor β1 by Stromelysin 1 in Extracts of Growth Plate Chondrocyte‐Derived Matrix Vesicles by Maeda, Shingo, Dean, David D., Gay, Isabel, Schwartz, Zvi, Boyan, Barbara D.

“…Previous studies have shown that matrix vesicles isolated from cultures of costochondral growth zone chondrocytes and treated with 1α,25‐dihydroxyvitamin D3…”
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Matrix-bound Cyr61/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging by Marinkovic, Milos, Dai, Qiuxia, Gonzalez, Aaron O., Tran, Olivia N., Block, Travis J., Harris, Stephen E., Salmon, Adam B., Yeh, Chih-Ko, Dean, David D., Chen, Xiao-Dong

“…•A novel in vitro model was used to study ECM components which are responsible for the properties of the stem cell niche.•ECMs produced by stromal cells from…”
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In vivo hydroxyapatite scaffold performance in infected bone defects by Pearson, Joseph J., Gerken, Nicholas, Bae, Chunsik, Lee, Kyu‐Bok, Satsangi, Arpan, McBride, Sean, Appleford, Mark R., Dean, David D., Hollinger, Jeffrey O., Ong, Joo L., Guda, Teja

“…Critically sized bone defects are often compounded by infectious complications. The standard of care consists of bone autografts with systemic antibiotics…”
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Rapid-prototyped PLGA/β-TCP/hydroxyapatite nanocomposite scaffolds in a rabbit femoral defect model by Kim, Jinku, McBride, Sean, Tellis, Brandi, Alvarez-Urena, Pedro, Song, Young-Hye, Dean, David D, Sylvia, Victor L, Elgendy, Hoda, Ong, Joo, Hollinger, Jeffrey O

“…Bone tissue engineering scaffolds composed of poly(d,l-lactide:glycolide) (DL-PLGA) and β-tricalcium phosphate (β-TCP) nanocomposites were prepared and…”
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Extracellular matrix turnover in salivary gland disorders and regenerative therapies: Obstacles and opportunities by Marinkovic, Milos, Tran, Olivia N., Wang, Hanzhou, Abdul-Azees, Parveez, Dean, David D., Chen, Xiao-Dong, Yeh, Chih-Ko

“…Salivary gland (SG) extracellular matrix (ECM) has a major influence on tissue development, homeostasis, and tissue regeneration after injury. During aging,…”
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Changes in oral health during aging in a novel non-human primate model by Abdul-Azees, Parveez Ahamed, Wang, Hanzhou, Chun, Yong-Hee P., Pizzini, Jason, Dean, David D., Reveles, Kelly R., Marinkovic, Milos, Chen, Xiao-Dong, Salmon, Adam B., Yeh, Chih-Ko

“…Oral health plays a significant role in the quality of life and overall well-being of the aging population. However, age-related changes in oral health are not…”
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Silk fibroin scaffolds promote formation of the ex vivo niche for salivary gland epithelial cell growth, matrix formation, and retention of differentiated function by Zhang, Bin-Xian, Zhang, Zhi-Liang, Lin, Alan L, Wang, Hanzhou, Pilia, Marcello, Ong, Joo L, Dean, David D, Chen, Xiao-Dong, Yeh, Chih-Ko

“…Salivary gland hypofunction often results from a number of causes, including the use of various medications, radiation for head and neck tumors, autoimmune…”
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