Search Results - "DE WIT, Harm"

Deficiencies of the T and natural killer cell system in major depressive disorder by Grosse, Laura, Hoogenboezem, Thomas, Ambrée, Oliver, Bellingrath, Silja, Jörgens, Silke, de Wit, Harm J, Wijkhuijs, Annemarie M, Arolt, Volker, Drexhage, Hemmo A

“…Highlights • Lymphocyte subsets were analyzed in major depressive disorder (MDD) patients. • NK cells, Th-2 cells, and Th-17 cells were reduced in MDD…”
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Inflammatory cytokines influence measures of white matter integrity in Bipolar Disorder by Benedetti, Francesco, Poletti, Sara, Hoogenboezem, Thomas A, Mazza, Elena, Ambrée, Oliver, de Wit, Harm, Wijkhuijs, Annemarie J.M, Locatelli, Clara, Bollettini, Irene, Colombo, Cristina, Arolt, Volker, Drexhage, Hemmo A

“…Abstract Background Bipolar disorder (BD) is associated with elevated biomarkers of cell-mediated immune activation and inflammation and with signs of…”
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Deficiencies of the T and natural killer cell system in major depressive disorder: T regulatory cell defects are associated with inflammatory monocyte activation by Grosse, Laura, Hoogenboezem, Thomas, Ambrée, Oliver, Bellingrath, Silja, Jörgens, Silke, de Wit, Harm J, Wijkhuijs, Annemarie M, Arolt, Volker, Drexhage, Hemmo A

“…In a previous study, we found an up-regulated inflammatory monocyte gene expression profile in major depressive disorder (MDD) patients aged ⩾ 28 years and a…”
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Th17 cells correlate positively to the structural and functional integrity of the brain in bipolar depression and healthy controls by Poletti, Sara, de Wit, Harm, Mazza, Elena, Wijkhuijs, Annemarie J.M, Locatelli, Clara, Aggio, Veronica, Colombo, Cristina, Benedetti, Francesco, Drexhage, Hemmo A

“…Highlights • Frequency of Th17 correlated to higher coherence of white matter microstructure. • Frequency of T regulatory cells correlated to a reduced…”
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Decreased serum level of miR-146a as sign of chronic inflammation in type 2 diabetic patients by Baldeón R, Lucy, Weigelt, Karin, de Wit, Harm, Ozcan, Behiye, van Oudenaren, Adri, Sempértegui, Fernando, Sijbrands, Eric, Grosse, Laura, Freire, Wilma, Drexhage, Hemmo A, Leenen, Pieter J M

“…There is increasing evidence that chronic inflammation is an important determinant in insulin resistance and in the pathogenesis of type 2 diabetes (T2D)…”
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TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model by Castro Eiro, Melisa D, Hioki, Kou, Li, Ling, Wilmsen, Merel E P, Kiernan, Caoimhe H, Brouwers-Haspels, Inge, van Meurs, Marjan, Zhao, Manzhi, de Wit, Harm, Grashof, Dwin G B, van de Werken, Harmen J G, Mueller, Yvonne M, Schliehe, Christopher, Temizoz, Burcu, Kobiyama, Kouji, Ishii, Ken J, Katsikis, Peter D

“…Immune checkpoint blockade (ICB) immunotherapies have emerged as promising strategies for the treatment of cancer; however, there remains a need to improve…”
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An imbalance in the production of IL-1β and IL-6 by monocytes of bipolar patients: restoration by lithium treatment by Knijff, Esther M, Nadine Breunis, M, Kupka, Ralph W, De Wit, Harm J, Ruwhof, Cindy, Akkerhuis, Grard W, Nolen, Willem A, Drexhage, Hemmo A

“…Objectives:  To study the ex vivo interleukin (IL)‐1β and IL‐6 production of monocytes in bipolar disorder (BD) patients in the absence/presence of lithium…”
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Type 2 Diabetes Monocyte MicroRNA and mRNA Expression: Dyslipidemia Associates with Increased Differentiation-Related Genes but Not Inflammatory Activation by Baldeón R, Lucy, Weigelt, Karin, de Wit, Harm, Ozcan, Behiye, van Oudenaren, Adri, Sempértegui, Fernando, Sijbrands, Eric, Grosse, Laura, van Zonneveld, Anton-Jan, Drexhage, Hemmo A, Leenen, Pieter J M

“…To study the expression pattern of microRNAs and mRNAs related to inflammation in T2D monocytes. A microRNA finding study on monocytes of T2D patients and…”
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TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors by Weigelt, Karin, Carvalho, Livia A, Drexhage, Roos C, Wijkhuijs, Annemarie, Wit, Harm de, van Beveren, Nico J.M, Birkenhäger, Tom K, Bergink, Veerle, Drexhage, Hemmo A

“…Highlight ► TREM-1 gene expression is significantly up-regulated in monocytes of patients with severe psychiatric disorders and TREM-1 is a novel target gene…”
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Stem Cell Factor (SCF) is a putative biomarker of antidepressant response by Benedetti, Francesco, Poletti, Sara, Hoogenboezem, Thomas A., Locatelli, Clara, Ambrée, Oliver, de Wit, Harm, Wijkhuijs, Annemarie J. M., Mazza, Elena, Bulgarelli, Chiara, Vai, Benedetta, Colombo, Cristina, Smeraldi, Enrico, Arolt, Volker, Drexhage, Hemmo A.

“…Growth factors involved in neurogenesis and neuroplasticity could play a role in biological processes that drive depression recovery. Combined total sleep…”
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Targeted multiomics in childhood-onset SLE reveal distinct biological phenotypes associated with disease activity: results from an explorative study by Wahadat, Mohamed Javad, van Tilburg, Sander J, Mueller, Yvonne M, de Wit, Harm, Van Helden-Meeuwsen, Cornelia G, Langerak, Anton W, Gruijters, Marike J, Mubarak, Amani, Verkaaik, Marleen, Katsikis, Peter D, Versnel, Marjan A, Kamphuis, Sylvia

“…ObjectiveTo combine targeted transcriptomic and proteomic data in an unsupervised hierarchical clustering method to stratify patients with childhood-onset SLE…”
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An Inflammatory Gene-Expression Fingerprint in Monocytes of Autoimmune Thyroid Disease Patients by van der Heul-Nieuwenhuijsen, Leonie, Padmos, Roos C, Drexhage, Roosmarijn C, de Wit, Harm, Berghout, Arie, Drexhage, Hemmo A

“…Context: In monocytes of patients with autoimmune diabetes, we recently identified a gene expression fingerprint of two partly overlapping gene clusters, a…”
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Distinct Monocyte Gene-Expression Profiles in Autoimmune Diabetes by PADMOS, Roos C, SCHLOOT, Nanette C, DREXHAGE, Roos C, MENART, Barbara, LESLIE, R. David, DREXHAGE, Hemmo A, BEYAN, Huriya, RUWHOF, Cindy, STAAL, Frank J. T, DE RIDDER, Dick, AANSTOOT, Henk-Jan, LAM-TSE, Wai Kwan, DE WIT, Harm, DE HERDER, Christian

“…Distinct Monocyte Gene-Expression Profiles in Autoimmune Diabetes Roos C. Padmos 1 , Nanette C. Schloot 2 , Huriya Beyan 3 , Cindy Ruwhof 1 , Frank J.T. Staal…”
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A relative resistance of T cells to dexamethasone in bipolar disorder by Knijff, Esther M, Breunis, M Nadine, Van Geest, Marielle C, Kupka, Ralph W, Ruwhof, Cindy, De Wit, Harm J, Nolen, Willem A, Drexhage, Hemmo A

“…Objective:  A relative resistance of immune cells to steroids has been established in patients with major depression (MD). In this study, we investigated the…”
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Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome by Beumer, Wouter, Drexhage, Roosmarijn C, De Wit, Harm, Versnel, Marjan A, Drexhage, Hemmo A, Cohen, Dan

“…Summary At present there are strong indications of a shared vulnerability factor for schizophrenia (SZ), diabetes and the metabolic syndrome (metS). In this…”
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Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder by Benedetti, Francesco, Poletti, Sara, Hoogenboezem, Thomas A, Locatelli, Clara, de Wit, Harm, Wijkhuijs, Annemarie J M, Colombo, Cristina, Drexhage, Hemmo A

“…The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity,…”
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Monocyte mitochondrial dysfunction, inflammaging, and inflammatory pyroptosis in major depression by Simon, Maria S., Schiweck, Carmen, Arteaga-Henríquez, Gara, Poletti, Sara, Haarman, Bartholomeus C.M., Dik, Wim A., Schwarz, Markus, Vrieze, Elske, Mikova, Olya, Joergens, Silke, Musil, Richard, Claes, Stephan, Baune, Bernhard T., Leboyer, Marion, Benedetti, Francesco, Furlan, Roberto, Berghmans, Raf, de Wit, Harm, Wijkhuijs, Annemarie, Arolt, Volker, Müller, Norbert, Drexhage, Hemmo A.

“…The macrophage theory of depression states that macrophages play an important role in Major Depressive Disorder (MDD). MDD patients (N = 140) and healthy…”
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Markers of neuroinflammation influence measures of cortical thickness in bipolar depression by Poletti, Sara, Leone, Giovanni, Hoogenboezem, Thomas A., Ghiglino, Davide, Vai, Benedetta, de Wit, Harm, Wijkhuijs, Annemarie J.M., Locatelli, Clara, Colombo, Cristina, Drexhage, Hemmo A., Benedetti, Francesco

“…•Serum levels of ICAM-1, CCL4, sDC25 correlated with lower cortical thickness.•Serum levels of TNF-α, IL-8, and CCL2 correlated with a higher cortical…”
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Monocyte-Derived Dendritic Cells in Bipolar Disorder by Knijff, Esther M., Ruwhof, Cindy, de Wit, Harm J., Kupka, Ralph W., Vonk, Ronald, Akkerhuis, Grard W., Nolen, Willem A., Drexhage, Hemmo A.

“…Dendritic cells (DC) are key regulators of the immune system, which is compromised in patients with bipolar disorder. We sought to study monocyte-derived DC in…”
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Immune System Dysregulation in First-Onset Postpartum Psychosis by Bergink, Veerle, Burgerhout, Karin M, Weigelt, Karin, Pop, Victor J, de Wit, Harm, Drexhage, Roos C, Kushner, Steven A, Drexhage, Hemmo A

“…Background Accumulating evidence suggests that dysregulation of the immune system represents an important vulnerability factor for mood disorders. Postpartum…”
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