Search Results - "DE WATER, Thomas R"

Electrode array-eluted dexamethasone protects against electrode insertion trauma induced hearing and hair cell losses, damage to neural elements, increases in impedance and fibrosis: A dose response study by Bas, Esperanza, Bohorquez, Jorge, Goncalves, Stefania, Perez, Enrique, Dinh, Christine T., Garnham, Carolyn, Hessler, Roland, Eshraghi, Adrien A., Van De Water, Thomas R.

“…We evaluated the effects of dexamethasone base (DXMb) containing electrode arrays in a guinea pig model of cochlear implantation to determine if eluted DXMb…”
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TGF β‐1 and WNT Signaling Pathways Collaboration Associated with Cochlear Implantation Trauma‐Induced Fibrosis by Bas, Esperanza, Anwar, Mir R., Van De Water, Thomas R.

“…ABSTRACT The crosstalk between TGF‐β1 and WNT pathways has been proven to regulate aspects of the development and tissue homeostasis processes. Recently, it…”
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A Regenerative Medicine Approach to the Treatment of Hearing, Balance, and Olfactory Disorders: What Is in the Future for Otolaryngology? by Van De Water, Thomas R.

“…ABSTRACT Regenerative medicine is being applied to many fields of medicine and is now starting to be considered and developed for application to treat hearing,…”
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Historical Aspects of Gene Therapy and Stem Cell Therapy in the Treatment of Hearing and Balance Disorder by Van De Water, Thomas R.

“…ABSTRACT This review presents many but not all the major historical events that have led to our current understanding of gene and stem cell therapies for the…”
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A Novel Organ of Corti Explant Model for the Study of Cochlear Implantation Trauma by Bas, Esperanza, Gupta, Chhavi, Van De Water, Thomas R.

“…This study presents a novel in vitro model of electrode insertion trauma‐induced hair cell (HC) damage and loss and its application for testing the efficacy of…”
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Recent Advancements in the Regeneration of Auditory Hair Cells and Hearing Restoration by Mittal, Rahul, Nguyen, Desiree, Patel, Amit P, Debs, Luca H, Mittal, Jeenu, Yan, Denise, Eshraghi, Adrien A, Van De Water, Thomas R, Liu, Xue Z

“…Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and…”
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Molecular mechanisms involved in cochlear implantation trauma and the protection of hearing and auditory sensory cells by inhibition of c-jun-N-terminal kinase signaling by Eshraghi, Adrien A., Gupta, Chhavi, Van De Water, Thomas R., Bohorquez, Jorge E., Garnham, Carolyn, Bas, Esperanza, Talamo, Victoria Maria

“…Objectives/Hypothesis: To investigate the molecular mechanisms involved in electrode insertion trauma (EIT) and to test the otoprotective effect of locally…”
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Spiral ganglion cells and macrophages initiate neuro-inflammation and scarring following cochlear implantation by Bas, Esperanza, Goncalves, Stefania, Adams, Michelle, Dinh, Christine T, Bas, Jose M, Van De Water, Thomas R, Eshraghi, Adrien A

“…Conservation of a patient's residual hearing and prevention of fibrous tissue/new bone formation around an electrode array are some of the major challenges in…”
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Ultrastructural Characterization of Stem Cell‐Derived Replacement Vestibular Hair Cells Within Ototoxin‐Damaged Rat Utricle Explants by Werner, Mimmi, Van De Water, Thomas R., Stenlund, Hans, Berggren, Diana

“…ABSTRACT The auditory apparatus of the inner ear does not show turnover of sensory hair cells (HCs) in adult mammals; in contrast, there are many observations…”
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Mechanisms of programmed cell death signaling in hair cells and support cells post-electrode insertion trauma by Eshraghi, Adrien A, Lang, Dustin M, Roell, Jonathan, Van De Water, Thomas R, Garnham, Carolyn, Rodrigues, Helio, Guardiola, Mateo, Gupta, Chhavi, Mittal, Jeenu

“…AbstractConclusion: Programmed cell death (PCD) initially starts in the support cells (SCs) after electrode insertion trauma (EIT), followed by PCD in hair…”
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Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma by Dinh, Christine T, Goncalves, Stefania, Bas, Esperanza, Van De Water, Thomas R, Zine, Azel

“…Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the…”
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Isolation and Characterization of Mammalian Otic Progenitor Cells that Can Differentiate into Both Sensory Epithelial and Neuronal Cell Lineages by Kojima, Ken, Nishida, Akiko T., Tashiro, Kei, Hirota, Kiichi, Nishio, Takeshi, Murata, Miyahiko, Kato, Nobuo, Kawaguchi, Saburo, Zine, Azel, Ito, Juichi, Water, Thomas R.

“…ABSTRACT The mammalian inner ear mediates hearing and balance and during development generates both cochleo‐vestibular ganglion neurons and sensory epithelial…”
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Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals by Wang, Jing, Ruel, Jérôme, Ladrech, Sabine, Bonny, Christophe, van de Water, Thomas R, Puel, Jean-Luc

“…We tested and characterized the therapeutic value of round window membrane-delivered (RWM) d-JNKI-1 peptide (Bonny et al., 2001) against sound trauma-induced…”
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Local dexamethasone therapy conserves hearing in an animal model of electrode insertion trauma-induced hearing loss by Eshraghi, Adrien A, Adil, Eelam, He, Jiao, Graves, Reid, Balkany, Thomas J, Van De Water, Thomas R

“…The progressive loss of hearing that develops after electrode insertion trauma (EIT) can be attenuated by local dexamethasone (DXM) therapy. Hearing loss (HL)…”
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Comparison of packing material in an animal model of middle ear trauma by Perez, Enrique, MD, Hachem, Ralph Abi, MD, Carlton, Daniel, MD, Bueno, Isabel, MD, Vernon, Stephen, MD, Van De Water, Thomas R., PhD, Angeli, Simon I., MD

“…Abstract Purpose To compare the performance of absorbable gelatin sponge (AGS) with polyurethane foam (PUF) as middle ear packing material after mucosal…”
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Dexamethasone Base Conserves Hearing from Electrode Trauma-Induced Hearing Loss by Vivero, Richard J., Joseph, Debbie E., Angeli, Simon, He, Jiao, Chen, Shibing, Eshraghi, Adrien A., Balkany, Thomas J., Van De Water, Thomas R.

“…Objective/Hypothesis: Local treatment of the cochlea after electrode insertion trauma with dexamethasone base conserves hearing against trauma‐induced loss…”
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Laminin-coated electrodes improve cochlear implant function and post-insertion neuronal survival by Bas, Esperanza, Anwar, Mir R., Goncalves, Stefania, Dinh, Christine T., Bracho, Olena R., Chiossone, Juan A., Van De Water, Thomas R.

“…The benefits of Cochlear implant (CI) technology depend among other factors on the proximity of the electrode array to the spiral ganglion neurons. Laminin, a…”
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Pattern of hearing loss in a rat model of cochlear implantation trauma by Eshraghi, Adrien A, Polak, Marek, He, Jiao, Telischi, Fred F, Balkany, Thomas J, Van De Water, Thomas R

“…Trauma caused by cochlear implant electrode insertion is attributable to the combination of direct physical trauma and the delayed cell death of oxidative…”
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D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma by Eshraghi, Adrien A, He, Jiao, Mou, Cai Hong, Polak, Marek, Zine, Azel, Bonny, Christophe, Balkany, Thomas J, Van De Water, Thomas R

“…1) Hearing loss caused by electrode insertion trauma has both acute and delayed components; and 2) the delayed component of trauma-initiated hearing loss can…”
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Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity by Eshraghi, Adrien A., Wang, Jing, Adil, Eelam, He, Jiao, Zine, Azel, Bublik, Michael, Bonny, Christophe, Puel, Jean-Luc, Balkany, Thomas J., Van De Water, Thomas R.

“…Neomycin ototoxicity and electrode insertion trauma both involve activation of the mitogen activated protein kinase (MAPK)/c-Jun-N-terminal kinase (JNK) cell…”
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