Search Results - "DE VOS VAN STEENWIJK, Peggy J"

M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells by Heusinkveld, Moniek, de Vos van Steenwijk, Peggy J, Goedemans, Renske, Ramwadhdoebe, Tamara H, Gorter, Arko, Welters, Marij J P, van Hall, Thorbald, van der Burg, Sjoerd H

“…Monocytes attracted by tumor-induced chronic inflammation differentiate to APCs, the type of which depends on cues in the local tumor milieu. In this work, we…”
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Optimising follow-up strategy based on cytology and human papillomavirus after fertility-sparing surgery for early stage cervical cancer: a nationwide, population-based, retrospective cohort study by Schuurman, Teska N, Schaafsma, Mirte, To, Kaylee H, Verhoef, Viola M J, Sikorska, Karolina, Siebers, Albert G, Wenzel, Hans H B, Bleeker, Maaike C G, Roes, Eva Maria, Zweemer, Ronald P, de Vos van Steenwijk, Peggy J, Yigit, Refika, Beltman, Jogchum J, Zusterzeel, Petra L M, Lok, Christianne A R, Bekkers, Ruud L M, Mom, Constantijne H, van Trommel, Nienke E

“…The optimal follow-up strategy to detect recurrence after fertility-sparing surgery for early stage cervical cancer is unknown. Tailored surveillance based on…”
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A pre‐existing coordinated inflammatory microenvironment is associated with complete response of vulvar high‐grade squamous intraepithelial lesions to different forms of immunotherapy by Abdulrahman, Ziena, Miranda, Noel F. C. C., Hellebrekers, Bart W. J., Vos van Steenwijk, Peggy J., Esch, Edith M. G., Burg, Sjoerd H., Poelgeest, Mariette I. E.

“…Immunotherapy of vulvar high‐grade squamous intraepithelial lesion (vHSIL) is investigated as an alternative for surgery, because of high comorbidity and risk…”
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Pre-existing inflammatory immune microenvironment predicts the clinical response of vulvar high-grade squamous intraepithelial lesions to therapeutic HPV16 vaccination by Abdulrahman, Ziena, de Miranda, Noel, van Esch, Edith M G, de Vos van Steenwijk, Peggy J, Nijman, Hans W, J. P. Welters, Marij, van Poelgeest, Mariette I E, van der Burg, Sjoerd H

“…BackgroundVulvar high-grade squamous intraepithelial lesion (vHSIL) is predominantly induced by high-risk human papilloma virus type 16 (HPV16). In two…”
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Vulvar cancer subclassification by HPV and p53 status results in three clinically distinct subtypes by Kortekaas, Kim E., Bastiaannet, Esther, van Doorn, Helena C., de Vos van Steenwijk, Peggy J., Ewing-Graham, Patricia C., Creutzberg, Carien L., Akdeniz, Kadir, Nooij, Linda S., van der Burg, Sjoerd H., Bosse, Tjalling, van Poelgeest, Mariette I.E.

“…There is great need for better risk stratification in vulvar squamous cell carcinoma (VSCC). Our aim was to define the prognostic significance of stratifying…”
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Immune-based biomarker accurately predicts response to imiquimod immunotherapy in cervical high-grade squamous intraepithelial lesions by Abdulrahman, Ziena, Hendriks, Natasja, J Kruse, Arnold, Somarakis, Antonios, J M van de Sande, Anna, J van Beekhuizen, Heleen, M J Piek, Jurgen, de Miranda, Noel F C C, Kooreman, Loes F S, F M Slangen, Brigitte, van der Burg, Sjoerd H, de Vos van Steenwijk, Peggy J, van Esch, Edith M G

“…BackgroundThe complete response rate of cervical high-grade squamous intraepithelial lesion (cHSIL) patients to imiquimod immunotherapy is approximately 60%…”
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The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival by Santegoets, Saskia J, van Ham, Vanessa J, Ehsan, Ilina, Charoentong, Pornpimol, Duurland, Chantal L, van Unen, Vincent, Höllt, Thomas, van der Velden, Lilly-Ann, van Egmond, Sylvia L, Kortekaas, Kim E, de Vos van Steenwijk, Peggy J, van Poelgeest, Mariëtte I E, Welters, Marij J P, van der Burg, Sjoerd H

“…The tumor immune microenvironment determines clinical outcome. Whether the original tissue in which a primary tumor develops influences this microenvironment…”
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Topical imiquimod treatment of residual or recurrent cervical intraepithelial neoplasia lesions (TOPIC-2): A randomised controlled trial by van de Sande, Anna J M, van Baars, Romy, Koeneman, Margot M, Gerestein, Cornelis G, Kruse, Arnold-Jan, van Esch, Edith M G, de Vos van Steenwijk, Peggy J, Muntinga, Caroline L P, Willemsen, Sten P, van Doorn, Helena C, van Kemenade, Folkert J, van Beekhuizen, Helene J

“…To investigate the efficacy of imiquimod in women with residual or recurrent cervical intraepithelial neoplasia (rrCIN), compared with large loop excision of…”
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Surgery followed by Persistence of High-Grade Squamous Intraepithelial Lesions Is Associated with the Induction of a Dysfunctional HPV16-Specific T-Cell Response by DE VOS VAN STEENWIJK, Peggy J, PIERSMA, Sytse J, WELTERS, Marij J. P, VAN DER HULST, Jeanette M, FLEUREN, Gertjan, HELLEBREKERS, Bart W. J, KENTER, Gemma G, VAN DER BURG, Sjoerd H

“…Purpose: To characterize HPV16 E6- and E7-specific T-cell immunity in patients with high-grade squamous intraepithelial lesions (HSIL). Experimental Design:…”
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The immune microenvironment in vulvar (pre)cancer: review of literature and implications for immunotherapy by Abdulrahman, Ziena, Kortekaas, Kim E, De Vos Van Steenwijk, Peggy J, Van Der Burg, Sjoerd H, Van Poelgeest, Mariette Ie

“…Vulvar squamous cell carcinoma (VSCC) develops via two different pathways: TP53 mutations in a background of lichen sclerosus or a persistent infection with…”
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How the Gut Microbiome Links to Menopause and Obesity, with Possible Implications for Endometrial Cancer Development by Schreurs, Malou P. H., de Vos van Steenwijk, Peggy J., Romano, Andrea, Dieleman, Sabine, Werner, Henrica M. J.

“…Background: Interest is growing in the dynamic role of gut microbiome disturbances in human health and disease. No direct evidence is yet available to link gut…”
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Importance of the Immune Microenvironment in the Spontaneous Regression of Cervical Squamous Intraepithelial Lesions (cSIL) and Implications for Immunotherapy by Muntinga, Caroline L P, de Vos van Steenwijk, Peggy J, Bekkers, Ruud L M, van Esch, Edith M G

“…Cervical high-grade squamous intraepithelial lesions (cHSILs) develop as a result of a persistent high-risk human papilloma virus (hrHPV) infection. The…”
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A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions by de Vos van Steenwijk, Peggy J., Ramwadhdoebe, Tamara H., Löwik, Margriet J. G., van der Minne, Caroline E., Berends-van der Meer, Dorien M. A., Fathers, Lorraine M., Valentijn, A. Rob P. M., Oostendorp, Jaap, Fleuren, Gert Jan, Hellebrekers, Bart W. J., Welters, Marij J. P., van Poelgeest, Mariette I., Melief, Cornelis J. M., Kenter, Gemma G., van der Burg, Sjoerd H.

“…The aim of this study was to investigate the capacity of an HPV16 E6/E7 synthetic overlapping long-peptide vaccine to stimulate the HPV16-specific T-cell…”
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Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions by Speetjens, Frank M, Welters, Marij J P, Slingerland, Marije, van Poelgeest, Mariette I E, de Vos van Steenwijk, Peggy J, Roozen, Inge, Boekestijn, Sanne, Loof, Nikki M, Zom, Gijs G, Valentijn, A Rob P M, Krebber, Willem-Jan, Meeuwenoord, Nico J, Janssen, Catharina A H, Melief, Cornelis J M, van der Marel, Gijs A, Filippov, Dmitri V, van der Burg, Sjoerd H, Gelderblom, Hans, Ossendorp, Ferry

“…BackgroundAmplivant is a molecularly optimized Toll-like receptor 2 ligand that can be covalently conjugated to tumor peptide antigens. In preclinical models,…”
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The long-term immune response after HPV16 peptide vaccination in women with low-grade pre-malignant disorders of the uterine cervix: a placebo-controlled phase II study by de Vos van Steenwijk, Peggy J., van Poelgeest, Mariette I. E., Ramwadhdoebe, Tamara H., Löwik, Margriet J. G., Berends-van der Meer, Dorien M. A., van der Minne, Caroline E., Loof, Nikki M., Stynenbosch, Linda F. M., Fathers, Lorraine M., Valentijn, A. Rob P. M., Oostendorp, Jaap, Osse, Elisabeth M., Fleuren, Gert Jan, Nooij, Linda, Kagie, Marjolein J., Hellebrekers, Bart W. J., Melief, Cornelis J. M., Welters, Marij J. P., van der Burg, Sjoerd H., Kenter, Gemma G.

“…The capacity of a low-dose HPV16 synthetic long-peptide vaccine (HPV16-SLP) to induce an HPV16-specific T-cell response as well as to establish long-term…”
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An Unexpectedly Large Polyclonal Repertoire of HPV-Specific T Cells Is Poised for Action in Patients with Cervical Cancer by DE VOS VAN STEENWIJK, Peggy J, HEUSINKVELD, Moniek, RAMWADHDOEBE, Tamara H, LÖWIK, Margriet J, VAN DER HULST, Jeanette M, GOEDEMANS, Renske, PIERSMA, Sytse J, KENTER, Gemma G, VAN DER BURG, Sjoerd H

“…The diversity and extent of the local tumor-specific T-cell response in a given individual is largely unknown. We have performed an in-depth study of the local…”
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Incisional hernia after repair of wound dehiscence: incidence and risk factors by van't, Riet Martijne T, De Vos Van Steenwijk, Peggy J, Bonjer, H Jaap, Steyerberg, Ewout W, Jeekel, Johannes

“…The true incidence of incisional hernia after wound dehiscence repair remains unclear because thorough long-term follow-up studies are not available. Medical…”
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Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses by Welters, Marij J. P., Kenter, Gemma G., de Vos van Steenwijk, Peggy J., Löwik, Margriet J. G., der Meer, Dorien M. A. Berends-van, Essahsah, Farah, Stynenbosch, Linda F. M., Vloon, Annelies P. G., Ramwadhdoebe, Tamara H., Piersma, Sytse J., van der Hulst, Jeanette M., Valentijn, A. Rob P. M., Fathers, Lorraine M., Drijfhout, Jan W., Franken, Kees L. M. C., Oostendorp, Jaap, Fleuren, Gert Jan, Melief, Cornelis J. M., van der Burg, Sjoerd H., van Rood, Johannes J.

“…One half of a group of 20 patients with human papillomavirus type 16 (HPV16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression…”
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Topical Imiquimod Treatment of High-grade Cervical Intraepithelial Neoplasia (TOPIC-3): A Nonrandomized Multicenter Study by Hendriks, Natasja, Koeneman, Margot M., van de Sande, Anna J.M., Penders, Charlotte G.J., Piek, Jurgen M.J., Kooreman, Loes F.S., van Kuijk, Sander M.J., Hoosemans, Linde, Sep, Simone J.S., de Vos Van Steenwijk, Peggy J., van Beekhuizen, Heleen J., Slangen, Brigitte F.M., Nijman, Hans W., Kruitwagen, Roy F.P.M., Kruse, Arnold-Jan

“…Topical imiquimod could be an alternative, noninvasive, treatment modality for high-grade cervical intraepithelial neoplasia (CIN). However, evidence is…”
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Prevention of adhesion to prosthetic mesh: Comparison of different barriers using an incisional hernia model by VAN'T RIET, Martijne, DE VOS VAN STEENWIJK, Peggy J, BONTHUIS, Fred, MARQUET, Richard L, STEYERBERG, Ewout W, JEEKEL, Johannes, BONJER, H. Jaap

“…To assess whether use of antiadhesive liquids or coatings could prevent adhesion formation to prosthetic mesh. Incisional hernia repair frequently involves the…”
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