Search Results - "DE SOUZA, S. J"

Evolution of transcriptional enhancers and animal diversity by Rubinstein, Marcelo, de Souza, Flávio S. J.

“…Deciphering the genetic bases that drive animal diversity is one of the major challenges of modern biology. Although four decades ago it was proposed that…”
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Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons by Franchini, Lucía F, López-Leal, Rodrigo, Nasif, Sofía, Beati, Paula, Gelman, Diego M, Low, Malcolm J, de Souza, Flávio J. S, Rubinstein, Marcelo

“…The proopiomelanocortin gene (POMC) is expressed in a group of neurons present in the arcuate nucleus of the hypothalamus. Neuron-specific POMC expression in…”
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Sequencing of small RNAs of the fern Pleopeltis minima (Polypodiaceae) offers insight into the evolution of the microrna repertoire in land plants by Berruezo, Florencia, de Souza, Flávio S J, Picca, Pablo I, Nemirovsky, Sergio I, Martínez Tosar, Leandro, Rivero, Mercedes, Mentaberry, Alejandro N, Zelada, Alicia M

“…MicroRNAs (miRNAs) are short, single stranded RNA molecules that regulate the stability and translation of messenger RNAs in diverse eukaryotic groups. Several…”
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Exaptation of transposable elements into novel cis-regulatory elements: is the evidence always strong? by de Souza, Flávio S J, Franchini, Lucía F, Rubinstein, Marcelo

“…Transposable elements (TEs) are mobile genetic sequences that can jump around the genome from one location to another, behaving as genomic parasites. TEs have…”
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Bioinformatics construction of the human cell surfaceome by da Cunha, J.P.C, Galante, P.A.F, de Souza, J.E, de Souza, R.F, Carvalho, P.M, Ohara, D.T, Moura, R.P, Oba-Shinja, S.M, Marie, S.K.N, Silva, W.A. Jr, Perez, R.O, Stransky, B, Pieprzyk, M, Moore, J, Caballero, O, Gama-Rodrigues, J, Habr-Gama, A, Kuo, W.P, Simpson, A.J, Camargo, A.A, Old, Lloyd J, de Souza, S.J

“…Cell surface proteins are excellent targets for diagnostic and therapeutic interventions. By using bioinformatics tools, we generated a catalog of 3,702…”
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The estrogen receptor α colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2 by de Souza, Flávio S.J., Nasif, Sofia, López-Leal, Rodrigo, Levi, Diego H., Low, Malcolm J., Rubinsten, Marcelo

“…The gene encoding the prohormone proopiomelanocortin (POMC) is mainly expressed in two regions in vertebrates, namely corticotrophs and melanotrophs in the…”
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Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood by Nasif, Sofia, de Souza, Flavio S. J., González, Laura E., Yamashita, Miho, Orquera, Daniela P., Low, Malcolm J., Rubinstein, Marcelo

“…Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons located in the mediobasal…”
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Transcriptional Regulation of Pituitary POMC Is Conserved at the Vertebrate Extremes Despite Great Promoter Sequence Divergence by Bumaschny, Viviana F, de Souza, Flávio S. J, López Leal, Rodrigo A, Santangelo, Andrea M, Baetscher, Manfred, Levi, Diego H, Low, Malcolm J, Rubinstein, Marcelo

“…The stress response involves complex physiological mechanisms that maximize behavioral efficacy during attack or defense and is highly conserved in all…”
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Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene by Santangelo, Andrea M, de Souza, Flávio S J, Franchini, Lucía F, Bumaschny, Viviana F, Low, Malcolm J, Rubinstein, Marcelo

“…The proopiomelanocortin gene (POMC) is expressed in the pituitary gland and the ventral hypothalamus of all jawed vertebrates, producing several bioactive…”
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Biogenesis of circular RNAs and their role in cellular and molecular phenotypes of neurological disorders by Guerra, BS, Lima, J, Araujo, BHS, Torres, LB, Santos, JCC, Machado, DJS, Cunha, EBB, Serrato, JA, de Souza, JS, Martins, JV, Scalabrin, EE, Herai, RH

“…Circular RNA (circRNA) is an unusual class of RNA-like structures composed by exonic and/or intronic sequences that are regulated by the backsplicing mechanism…”
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A Transgenic Marker for Newly Born Granule Cells in Dentate Gyrus by Overstreet, Linda S, Hentges, Shane T, Bumaschny, Viviana F, de Souza, Flavio S. J, Smart, James L, Santangelo, Andrea M, Low, Malcolm J, Westbrook, Gary L, Rubinstein, Marcelo

“…Neurogenesis in the dentate gyrus continues into adulthood, yet little is known about the function of newly born neurons or how they integrate into an existing…”
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Enhancer turnover and conserved regulatory function in vertebrate evolution by Domené, Sabina, Bumaschny, Viviana F., de Souza, Flávio S. J., Franchini, Lucía F., Nasif, Sofía, Low, Malcolm J., Rubinstein, Marcelo

“…Mutations in regulatory regions including enhancers are an important source of variation and innovation during evolution. Enhancers can evolve by changes in…”
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Conserved roles of Rax/rx3 genes in hypothalamus and pituitary development by De Souza, Flávio S J, Placzek, Marysia

“…( ) genes encode paired-type homeodomain-containing transcription factors present in virtually all metazoan groups. In vertebrates, studies in fish, amphibian,…”
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Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold by Lam, Daniel D, de Souza, Flavio S J, Nasif, Sofia, Yamashita, Miho, López-Leal, Rodrigo, Otero-Corchon, Veronica, Meece, Kana, Sampath, Harini, Mercer, Aaron J, Wardlaw, Sharon L, Rubinstein, Marcelo, Low, Malcolm J

“…Cell-specific expression of many genes is conveyed by multiple enhancers, with each individual enhancer controlling a particular expression domain. In…”
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Subfunctionalization of expression and peptide domains following the ancient duplication of the proopiomelanocortin gene in teleost fishes by de Souza, Flávio S J, Bumaschny, Viviana F, Low, Malcolm J, Rubinstein, Marcelo

“…The proopiomelanocortin gene (POMC) encodes several bioactive peptides, including adrenocorticotropin hormone, alpha-, beta-, and gamma-melanocyte-stimulating…”
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A mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight by Rojo, Daniela, Hael, Clara E, Soria, Agustina, de Souza, Flávio S J, Low, Malcolm J, Franchini, Lucía F, Rubinstein, Marcelo

“…Food intake and energy balance are tightly regulated by a group of hypothalamic arcuate neurons expressing the proopiomelanocortin ( gene. In mammals,…”
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The first evidence of hepatitis A virus subgenotype IIIA in the Eastern Brazilian Amazon, 1982–1983 by Moreira, Luiz V. L., Malheiros, Andreza P., Barbosa, Kemere M. V., Freitas, Pedro E. B., Silva, Andrea L., Cruz, Ana C. R., Nunes, Heloisa M., Chagas, André A. C., Souza, Alex J. S.

“…Hepatitis A virus (HAV) is a major causative agent of acute hepatitis worldwide. Although discovered in 1973, due to limitations of applicable serological…”
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Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors by Brinkmeier, Michelle L, Bando, Hironori, Camarano, Adriana C, Fujio, Shingo, Yoshimoto, Koji, de Souza, Flávio Sj, Camper, Sally A

“…The transcription factor ISL1 is expressed in pituitary gland stem cells and the thyrotrope and gonadotrope lineages. Pituitary-specific Isl1 deletion causes…”
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Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic Footprinting by de Souza, Flávio S. J., Santangelo, Andrea M., Bumaschny, Viviana, Avale, María Elena, Smart, James L., Low, Malcolm J., Rubinstein, Marcelo

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Obesity-programmed mice are rescued by early genetic intervention by Bumaschny, Viviana F, Yamashita, Miho, Casas-Cordero, Rodrigo, Otero-Corchón, Verónica, de Souza, Flávio S J, Rubinstein, Marcelo, Low, Malcolm J

“…Obesity is a chronic metabolic disorder affecting half a billion people worldwide. Major difficulties in managing obesity are the cessation of continued weight…”
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