Search Results - "DE SOUZA, Elen Mello"

TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease by Ferreira, Roberto Rodrigues, Abreu, Rayane da Silva, Vilar-Pereira, Glaucia, Degrave, Wim, Meuser-Batista, Marcelo, Ferreira, Nilma Valéria Caldeira, da Cruz Moreira, Otacílio, da Silva Gomes, Natália Lins, Mello de Souza, Elen, Ramos, Isalira P, Bailly, Sabine, Feige, Jean-Jacques, Lannes-Vieira, Joseli, de Araújo-Jorge, Tania C, Waghabi, Mariana Caldas

“…TGF-β involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The TGF-β signaling pathway is activated in the cardiac tissue of chronic…”
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CRISPR/Cas-9 vector system: targets UL-39 and inhibits Simplexvirus humanalpha1 (HSV-1) replication in vitro by Jéssica Vasques Raposo, Luciana Rodrigues Carvalho Barros, Lauana Ribas Torres, Rafaela Barbosa da Silva Pinto, Amanda de Oliveira Lopes, Elen Mello de Souza, Martin Hernan Bonamino, Vanessa Salete de Paula

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Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies by XIAOHUA ZHU, QIANG LIU, STEPHENS, Chad E, BANERJEE, Moloy, FARAHAT, Abdelbasset A, MUNDE, Manoj, DAVID WILSON, W, BOYKIN, David W, ZHUO WANG, Michael, WERBOVETZ, Karl A, SIHYUNG YANG, PARMAN, Toufan, GREEN, Carol E, MIRSALIS, Jon C, DE NAZARE CORREIA SOEIRO, Maria, DE SOUZA, Elen Mello, DA SILVA, Cristiane França, DA GAMA JAEN BATISTA, Denise

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Suppression of TGF‐β/Smad2 signaling by GW788388 enhances DENV‐2 clearance in macrophages by Teixeira, Gabrielly Sbano, Andrade, Audrien Alves, Torres, Lauana Ribas, Couto‐Lima, Dinair, Moreira, Otacilio C., Abreu, Rayane, Waghabi, Mariana Caldas, de Souza, Elen Mello

“…Dengue fever, caused by the dengue virus (DENV‐1, −2, −3, and −4), affects millions of people in the tropical and subtropical regions worldwide. Severe dengue…”
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Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease by Waghabi, Mariana Caldas, Ferreira, Roberto Rodrigues, Abreu, Rayane da Silva, Degrave, Wim, de Souza, Elen Mello, Bailly, Sabine, Feige, Jean-Jacques, de Araújo-Jorge, Tania C

“…Transforming growth factor beta (TGF-β) is deeply involved on the pathogenesis of Chagas disease. Our group has been investigating the participation of this…”
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Increased angiogenesis parallels cardiac tissue remodelling in experimental acute Trypanosoma cruzi infection by Nisimura, Lindice Mitie, Ferreira, Roberto Rodrigues, Coelho, Laura Lacerda, Souza, Elen Mello de, Gonzaga, Beatriz Matheus, Ferrão, Patrícia Mello, Waghabi, Mariana Caldas, Mesquita, Liliane Batista de, Pereira, Mirian Claudia de Souza, Moreira, Otacilio da Cruz, Lannes-Vieira, Joseli, Garzoni, Luciana Ribeiro

“…Angiogenesis has been implicated in tissue injury in several noninfectious diseases, but its role in Chagas disease (CD) physiopathology is unclear. The…”
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In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi by DE NAZARE CORREIA SOEIRO, Maria, DE SOUZA, Elen Mello, BRITTO, Constança, KWANGHO KIM, SULIKOWSKI, Gary, HARGROVE, Tatiana Y, WATERMAN, Michael R, LEPESHEVA, Galina I, DA SILVA, Cristiane França, DA GAMA JAEN BATISTA, Denise, BATISTA, Marcos Meuser, PAVAO, Beatriz Philot, ARAUJO, Julianna Siciliano, AIUB, Claudia Alessandra Fortes, DA SILVA, Patricia Bernardino, LIONEL, Jessica

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Structural investigation of C6/36 and Vero cell cultures infected with a Brazilian Zika virus by Barreto-Vieira, Debora Ferreira, Jácome, Fernanda Cunha, da Silva, Marcos Alexandre Nunes, Caldas, Gabriela Cardoso, de Filippis, Ana Maria Bispo, de Sequeira, Patrícia Carvalho, de Souza, Elen Mello, Andrade, Audrien Alves, Manso, Pedro Paulo de Abreu, Trindade, Gisela Freitas, Lima, Sheila Maria Barbosa, Barth, Ortrud Monika

“…Zika virus (ZIKV) is a member of the flavivirus genus, and its genome is approximately 10.8 kilobases of positive-strand RNA enclosed in a capsid and…”
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In Chagas disease, transforming growth factor beta neutralization reduces Trypanosoma cruzi infection and improves cardiac performance by Ferreira, Roberto Rodrigues, de Souza, Elen Mello, Vilar-Pereira, Glaucia, Degrave, Wim M S, Abreu, Rayane da Silva, Meuser-Batista, Marcelo, Ferreira, Nilma Valéria Caldeira, Ledbeter, Steve, Barker, Robert H, Bailly, Sabine, Feige, Jean-Jacques, Lannes-Vieira, Joseli, de Araújo-Jorge, Tania C, Waghabi, Mariana Caldas

“…Chronic Chagasic cardiomyopathy (CCC), a progressive inflammatory and fibrosing disease, is the most prominent clinical form of Chagas disease, a neglected…”
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Trypanosoma cruzi: Activity of heterocyclic cationic molecules in vitro by Pacheco, Michele Gabriele de Oliveira, Silva, Cristiane França da, Souza, Elen Mello de, Batista, Marcos Meuser, Silva, Patrícia Bernardino da, Kumar, Arvind, Stephens, Chad E., Boykin, David W., Soeiro, Maria de Nazaré C.

“…Chagas disease remains a serious public health problem in several Latin American countries. New chemotherapy is urgently needed since current drugs are limited…”
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Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells by de Souza, Audrien Alves Andrade, Torres, Lauana Ribas, Capobianco, Lyana Rodrigues Pinto Lima, de Paula, Vanessa Salete, Cascabulho, Cynthia Machado, Salomão, Kelly, Bonecini-Almeida, Maria da Gloria, Ferreira, Maria de Lourdes Garcia, Boechat, Nubia, Pinheiro, Luiz Carlos da Silva, de Souza, Elen Mello

“…Despite the severe morbidity caused by Zika fever, its specific treatment is still a challenge for public health. Several research groups have investigated the…”
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Activities of Psilostachyin A and Cynaropicrin against Trypanosoma cruzi In Vitro and In Vivo by DA SILVA, Cristiane França, DA GAMA JAEN BATISTA, Denise, ZIMMERMANN, Stefanie, HAMBURGER, Matthias, BRUN, Reto, SCHÜHLY, Wolfgang, DE NAZARE CORREIA SOEIRO, Maria, DE ARAUJO, Julianna Siciliano, BATISTA, Marcos Meuser, LIONEL, Jessica, DE SOUZA, Elen Mello, HAMMER, Erica Ripoll, DA SILVA, Patricia Bernardino, DE MIERI, Maria, ADAMS, Michael

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In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection by da Silva, Cristiane França, Batista, Denise da Gama Jaen, Oliveira, Gabriel Melo, de Souza, Elen Mello, Hammer, Erica Ripoll, da Silva, Patricia Bernardino, Daliry, Anissa, Araujo, Julianna Siciliano, Britto, Constança, Rodrigues, Ana Carolina Mondaine, Liu, Zongying, Farahat, Abdelbasset A, Kumar, Arvind, Boykin, David W, Soeiro, Maria de Nazaré Correia

“…Chagas disease is caused by infection with the intracellular protozoan parasite Trypanosoma cruzi. At present, nifurtimox and benznidazole, both compounds…”
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Acute Chagas disease induces cerebral microvasculopathy in mice by Nisimura, Lindice Mitie, Estato, Vanessa, de Souza, Elen Mello, Reis, Patricia A, Lessa, Marcos Adriano, Castro-Faria-Neto, Hugo Caire, Pereira, Mirian Claudia de Souza, Tibiriçá, Eduardo, Garzoni, Luciana Ribeiro

“…Cardiomyopathy is the main clinical form of Chagas disease (CD); however, cerebral manifestations, such as meningoencephalitis, ischemic stroke and cognitive…”
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In Vitro and In Vivo Studies of the Trypanocidal Activity of a Diarylthiophene Diamidine against Trypanosoma cruzi by DA SILVA, Cristiane Franca, BATISTA, Marcos Meuser, JAEN BATISTA, Denise Da Gama, DE SOUZA, Elen Mello, DA SILVA, Patricia Bernardino, DE OLIVEIRA, Gabriel Melo, MEUSER, Andrea Souza, SHAREEF, Abdur-Rafay, BOYKIN, David W, SOEIRO, Maria De Nazare C

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In Vitro Measurement of Enzymatic Markers as a Tool to Detect Mouse Cardiomyocytes Injury by Souza, Elen Mello de, Henriques-Pons, Andrea, Bailly, Christian, Lansiaux, Amelie, Araújo-Jorge, Tânia Cremonine, Soeiro, Maria de Nazaré Correia

“…Primary cultures of cardiomyocytes represent a useful model for analyzing cardiac cell biology as well as pathogenesis of several cardiovascular disorders. Our…”
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Activity of “reversed” diamidines against Trypanosoma cruzi “ in vitro” by Silva, C.F., Batista, Marcos Meuser, Mota, Renata Alves, de Souza, Elen Mello, Stephens, Chad E., Som, Phanneth, Boykin, David Wilson, Soeiro, Maria de Nazaré C.

“…Chagas’ disease is an important parasitic illness caused by the flagellated protozoan Trypanosoma cruzi. The disease affects nearly 17 million individuals in…”
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ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection by Torres, Lauana Ribas, Capobianco, Lyana Rodrigues Pinto Lima, de Souza, Audrien Alves Andrade, de Almeida Ribeiro, Camilla Rodrigues, Cascabulho, Cynthia, Garzoni, Luciana Ribeiro, Portari, Elyzabeth Avvad, Gardel, Marcelo Aranha, Meuser-Batista, Marcelo, de Paula, Vanessa Salete, de Souza, Elen Mello

“…During the Zika fever outbreak in Brazil in 2015–2016, only some babies from infected mothers had teratogenic effects, suggesting that cofactors may influence…”
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TGF-[beta] inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease by Ferreira, Roberto Rodrigues, Abreu, Rayane da Silva, Vilar-Pereira, Glaucia, Degrave, Wim, Meuser-Batista, Marcelo, Ferreira, Nilma Valéria Caldeira, da Cruz Moreira, Otacílio, da Silva Gomes, Natália Lins, Mello de Souza, Elen, Ramos, Isalira P, Bailly, Sabine, Feige, Jean-Jacques, Lannes-Vieira, Joseli, de Araújo-Jorge, Tania C, Waghabi, Mariana Caldas

“…TGF-[beta] involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The TGF-[beta] signaling pathway is activated in the cardiac tissue of…”
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Proteins involved on TGF-β pathway are up-regulated during the acute phase of experimental Chagas disease by Ferreira, Roberto Rodrigues, de Souza, Elen Mello, de Oliveira, Fabiane Loiola, Ferrão, Patrícia Mello, Gomes, Leonardo Henrique Ferreira, Mendonça-Lima, Leila, Meuser-Batista, Marcelo, Bailly, Sabine, Feige, Jean Jacques, de Araujo-Jorge, Tania Cremonini, Waghabi, Mariana Caldas

“…Abstract Studies developed by our group in the last years have shown the involvement of TGF-β in acute and chronic Chagas heart disease, with elevated plasma…”
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