Search Results - "DE SOUSA E MELO, Felipe"

Targeting Wnt Signaling in Colon Cancer Stem Cells by MELO, Felipe De Sousa E, VERMEULEN, Louis, RICHEL, Dick, MEDEMA, Jan Paul

“…The identification of cancer stem cell (CSC) populations in virtually all tumor types has widespread clinical consequences. CSCs are suggested to be the only…”
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The consensus molecular subtypes of colorectal cancer by Guinney, Justin, Dienstmann, Rodrigo, Wang, Xin, de Reyniès, Aurélien, Schlicker, Andreas, Soneson, Charlotte, Marisa, Laetitia, Roepman, Paul, Nyamundanda, Gift, Angelino, Paolo, Bot, Brian M, Morris, Jeffrey S, Simon, Iris M, Gerster, Sarah, Fessler, Evelyn, De Sousa E Melo, Felipe, Missiaglia, Edoardo, Ramay, Hena, Barras, David, Homicsko, Krisztian, Maru, Dipen, Manyam, Ganiraju C, Broom, Bradley, Boige, Valerie, Perez-Villamil, Beatriz, Laderas, Ted, Salazar, Ramon, Gray, Joe W, Hanahan, Douglas, Tabernero, Josep, Bernards, Rene, Friend, Stephen H, Laurent-Puig, Pierre, Medema, Jan Paul, Sadanandam, Anguraj, Wessels, Lodewyk, Delorenzi, Mauro, Kopetz, Scott, Vermeulen, Louis, Tejpar, Sabine

“…An international consortium of colorectal cancer researchers undertakes a large-scale data sharing project to achieve a consensus molecular classification of…”
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Cancer heterogeneity-a multifaceted view by Melo, Felipe De Sousa E, Vermeulen, Louis, Fessler, Evelyn, Medema, Jan Paul

“…Cancers of various organs have been categorized into distinct subtypes after increasingly sophisticated taxonomies. Additionally, within a seemingly…”
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Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry by Trinh, Anne, Trumpi, Kari, De Sousa E Melo, Felipe, Wang, Xin, de Jong, Joan H, Fessler, Evelyn, Kuppen, Peter J K, Reimers, Marlies S, Swets, Marloes, Koopman, Miriam, Nagtegaal, Iris D, Jansen, Marnix, Hooijer, Gerrit K J, Offerhaus, George J A, Kranenburg, Onno, Punt, Cornelis J, Medema, Jan Paul, Markowetz, Florian, Vermeulen, Louis

“…Recent transcriptomic analyses have identified four distinct molecular subtypes of colorectal cancer with evident clinical relevance. However, the requirement…”
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Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients by de Sousa E Melo, Felipe, Colak, Selcuk, Buikhuisen, Joyce, Koster, Jan, Cameron, Kate, de Jong, Joan H., Tuynman, Jurriaan B., Prasetyanti, Pramudita R., Fessler, Evelyn, van den Bergh, Saskia P., Rodermond, Hans, Dekker, Evelien, van der Loos, Chris M., Pals, Steven T., van de Vijver, Marc J., Versteeg, Rogier, Richel, Dick J., Vermeulen, Louis, Medema, Jan Paul

“…Gene signatures derived from cancer stem cells (CSCs) predict tumor recurrence for many forms of cancer. Here, we derived a gene signature for colorectal CSCs…”
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Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon by Prasetyanti, Pramudita Ramadhina, Zimberlin, Cheryl Doreen, Bots, Michael, Vermeulen, Louis, Melo, Felipe De Sousa E, Medema, Jan Paul

“…Colon cancer stem cells are shown to be the self-renewing cells within a tumor that give rise to all lineages of more differentiated tumor cells. In this…”
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The developing cancer stem-cell model: clinical challenges and opportunities by Vermeulen, Louis, Dr, de Sousa e Melo, Felipe, MSc, Richel, Dick J, Prof, Medema, Jan Paul, Prof

“…Summary During the past decade, a stem-cell-like subset of cancer cells has been identified in many malignancies. These cells, referred to as cancer stem cells…”
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Antibody targeting of E3 ubiquitin ligases for receptor degradation by Marei, Hadir, Tsai, Wen-Ting K., Kee, Yee-Seir, Ruiz, Karen, He, Jieyan, Cox, Chris, Sun, Tao, Penikalapati, Sai, Dwivedi, Pankaj, Choi, Meena, Kan, David, Saenz-Lopez, Pablo, Dorighi, Kristel, Zhang, Pamela, Kschonsak, Yvonne T., Kljavin, Noelyn, Amin, Dhara, Kim, Ingrid, Mancini, Andrew G., Nguyen, Thao, Wang, Chunling, Janezic, Eric, Doan, Alexander, Mai, Elaine, Xi, Hongkang, Gu, Chen, Heinlein, Melanie, Biehs, Brian, Wu, Jia, Lehoux, Isabelle, Harris, Seth, Comps-Agrar, Laetitia, Seshasayee, Dhaya, de Sauvage, Frederic J., Grimmer, Matthew, Li, Jing, Agard, Nicholas J., de Sousa e Melo, Felipe

“…Most current therapies that target plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. However, typical mammalian…”
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Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function by Storm, Elaine E., Durinck, Steffen, de Sousa e Melo, Felipe, Tremayne, Jarrod, Kljavin, Noelyn, Tan, Christine, Ye, Xiaofen, Chiu, Cecilia, Pham, Thinh, Hongo, Jo-Anne, Bainbridge, Travis, Firestein, Ron, Blackwood, Elizabeth, Metcalfe, Ciara, Stawiski, Eric W., Yauch, Robert L., Wu, Yan, de Sauvage, Frederic J.

“…Antibody-mediated inhibition of R-spondin-3 in colorectal tumours decreases tumour growth and promotes differentiation—these effects are associated with a…”
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Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions by De Sousa E Melo, Felipe, Wang, Xin, Jansen, Marnix, Fessler, Evelyn, Trinh, Anne, de Rooij, Laura P M H, de Jong, Joan H, de Boer, Onno J, van Leersum, Ronald, Bijlsma, Maarten F, Rodermond, Hans, van der Heijden, Maartje, van Noesel, Carel J M, Tuynman, Jurriaan B, Dekker, Evelien, Markowetz, Florian, Medema, Jan Paul, Vermeulen, Louis

“…Analysis of gene-expression profiles led to the identification of three molecularly distinct subtypes of colon cancer. One of these subtypes is new, and its…”
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OTULIN limits cell death and inflammation by deubiquitinating LUBAC by Heger, Klaus, Wickliffe, Katherine E., Ndoja, Ada, Zhang, Juan, Murthy, Aditya, Dugger, Debra L., Maltzman, Allie, de Sousa e Melo, Felipe, Hung, Jeffrey, Zeng, Yi, Verschueren, Erik, Kirkpatrick, Donald S., Vucic, Domagoj, Lee, Wyne P., Roose-Girma, Merone, Newman, Robert J., Warming, Søren, Hsiao, Yi-Chun, Kőműves, László G., Webster, Joshua D., Newton, Kim, Dixit, Vishva M.

“…OTULIN (OTU deubiquitinase with linear linkage specificity) removes linear polyubiquitin from proteins that have been modified by LUBAC (linear ubiquitin chain…”
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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment by Merz, Christian, Medema, Jan Paul, Rodermond, Hans, Borovski, Tijana, Sprick, Martin R, Richel, Dick J, de Jong, Joan H, Todaro, Matilde, Cameron, Kate, De Sousa E Melo, Felipe, van der Heijden, Maartje, Vermeulen, Louis, Tuynman, Jurriaan B, Kemper, Kristel, Stassi, Giorgio

“…Cancer stem cell activity may not merely be an intrinsic characteristic of a subset of cancer cells and could be regulated by environmental cues. High Wnt…”
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Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer by Lenos, Kristiaan J., Miedema, Daniël M., Lodestijn, Sophie C., Nijman, Lisanne E., van den Bosch, Tom, Romero Ros, Xavier, Lourenço, Filipe C., Lecca, Maria C., van der Heijden, Maartje, van Neerven, Sanne M., van Oort, Anita, Leveille, Nicolas, Adam, Ronja S., de Sousa E Melo, Felipe, Otten, Joy, Veerman, Patrick, Hypolite, Guillaume, Koens, Lianne, Lyons, Scott K., Stassi, Giorgio, Winton, Douglas J., Medema, Jan Paul, Morrissey, Edward, Bijlsma, Maarten F., Vermeulen, Louis

“…Solid malignancies have been speculated to depend on cancer stem cells (CSCs) for expansion and relapse after therapy. Here we report on quantitative analyses…”
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Cancer stem cell dynamics in tumor progression and metastasis: Is the microenvironment to blame? by Fessler, Evelyn, Dijkgraaf, Feline E, De Sousa E Melo, Felipe, Medema, Jan Paul

“…Highlights ► Like normal tissues, cancerous tissues are organized hierarchically. ► The hierarchy in cancer is more dynamic with the possibility of reversion…”
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TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype by Fessler, Evelyn, Drost, Jarno, van Hooff, Sander R, Linnekamp, Janneke F, Wang, Xin, Jansen, Marnix, De Sousa E Melo, Felipe, Prasetyanti, Pramudita R, IJspeert, Joep EG, Franitza, Marek, Nürnberg, Peter, van Noesel, Carel JM, Dekker, Evelien, Vermeulen, Louis, Clevers, Hans, Medema, Jan Paul

“…The heterogeneous nature of colorectal cancer (CRC) complicates prognosis and is suggested to be a determining factor in the efficacy of adjuvant therapy for…”
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Wnt Signaling in Cancer Stem Cell Biology by de Sousa E Melo, Felipe, Vermeulen, Louis

“…Aberrant regulation of Wnt signaling is a common theme seen across many tumor types. Decades of research have unraveled the epigenetic and genetic alterations…”
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Cellular Plasticity in Intestinal Homeostasis and Disease by de Sousa e Melo, Felipe, de Sauvage, Frederic J.

“…The intestinal epithelium is one the fastest renewing tissues in mammals and is endowed with extensive adaptability. The more traditional view of a…”
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Cancer Stem Cell Niche: The Place to Be by BOROVSKI, Tijana, DE SOUSA E MELO, Felipe, VERMEULEN, Louis, MEDEMA, Jan Paul

“…Tumors are being increasingly perceived as abnormal organs that, in many respects, recapitulate the outgrowth and differentiation patterns of normal tissues…”
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'Mini-colons' shed light on cancer progression by Riggi, Nicolò, e Melo, Felipe de Sousa

“…To investigate the effect of frequently occurring mutations associated with colorectal cancer, the authors built such mini-colons out of mouse intestinal…”
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A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer by de Sousa e Melo, Felipe, Kurtova, Antonina V., Harnoss, Jonathan M., Kljavin, Noelyn, Hoeck, Joerg D., Hung, Jeffrey, Anderson, Jeffrey Eastham, Storm, Elaine E., Modrusan, Zora, Koeppen, Hartmut, Dijkgraaf, Gerrit J. P., Piskol, Robert, de Sauvage, Frederic J.

“…Cancer stem cells (CSCs) have been hypothesized to represent the driving force behind tumour progression and metastasis, making them attractive cancer targets…”
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