Search Results - "DE SOMER, Lien"

ADA2 Deficiency Mimicking Idiopathic Multicentric Castleman Disease by Van Nieuwenhove, Erika, Humblet-Baron, Stephanie, Van Eyck, Lien, De Somer, Lien, Dooley, James, Tousseyn, Thomas, Hershfield, Michael, Liston, Adrian, Wouters, Carine

“…Multicentric Castleman disease (MCD) is a rare entity that, unlike unicentric Castleman disease, involves generalized polyclonal lymphoproliferation, systemic…”
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Synovial Fluid Neutrophils From Patients With Juvenile Idiopathic Arthritis Display a Hyperactivated Phenotype by Metzemaekers, Mieke, Malengier‐Devlies, Bert, Yu, Karen, Vandendriessche, Sofie, Yserbyt, Jonas, Matthys, Patrick, De Somer, Lien, Wouters, Carine, Proost, Paul

“…Objective Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. The predominant subtypes, oligoarticular and polyarticular…”
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Mepolizumab in childhood onset steroid dependent eosinophilic granulomatosis with polyangiitis by Awouters, Marijke, De Somer, Lien, Wouters, Carine, Proesmans, Marijke, Boon, Mieke

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Fast and furious: The neutrophil and its armamentarium in health and disease by Metzemaekers, Mieke, Malengier‐Devlies, Bert, Gouwy, Mieke, De Somer, Lien, Cunha, Fernando de Queiroz, Opdenakker, Ghislain, Proost, Paul

“…Neutrophils are powerful effector cells leading the first wave of acute host‐protective responses. These innate leukocytes are endowed with oxidative and…”
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Inflammatory Gene Expression Profile and Defective Interferon‐γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients by Put, Karen, Vandenhaute, Jessica, Avau, Anneleen, van Nieuwenhuijze, Annemarie, Brisse, Ellen, Dierckx, Tim, Rutgeerts, Omer, Garcia‐Perez, Josselyn E., Toelen, Jaan, Waer, Mark, Leclercq, Georges, Goris, An, Van Weyenbergh, Johan, Liston, Adrian, De Somer, Lien, Wouters, Carine H., Matthys, Patrick

“…Objective Systemic juvenile idiopathic arthritis (JIA) is an immunoinflammatory disease characterized by arthritis and systemic manifestations. The role of…”
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Pathobiologic Mechanisms of Neurodegeneration in Osteopetrosis Derived From Structural and Functional Analysis of 14 ClC‐7 Mutants by Di Zanni, Eleonora, Palagano, Eleonora, Lagostena, Laura, Strina, Dario, Rehman, Asma, Abinun, Mario, De Somer, Lien, Martire, Baldassarre, Brown, Justin, Kariminejad, Ariana, Balasubramaniam, Shanti, Baynam, Gareth, Gurrieri, Fiorella, Pisanti, Maria A, De Maggio, Ilaria, Abboud, Miguel R, Chiesa, Robert, Burren, Christine P, Villa, Anna, Sobacchi, Cristina, Picollo, Alessandra

“…ABSTRACT ClC‐7 is a chloride‐proton antiporter of the CLC protein family. In complex with its accessory protein Ostm‐1, ClC‐7 localizes to lysosomes and to the…”
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Two Cases Presenting With Unilateral Adduction Deficit Associated With Human Adenosine Deaminase 2 Deficiency by Veryser, Eline, Meyts, Isabelle, Casteels, Ingele, Demaerel, Philippe, De Somer, Lien, Cassiman, Catherine

“…Deficiency of human adenosine deaminase 2 (DADA2) is an auto-inflammatory inborn error of immunity caused by biallelic deleterious mutations in the gene…”
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Intrinsic Defects in B Cell Development and Differentiation, T Cell Exhaustion and Altered Unconventional T Cell Generation Characterize Human Adenosine Deaminase Type 2 Deficiency by Yap, Jin Yan, Moens, Leen, Lin, Ming-Wei, Kane, Alisa, Kelleher, Anthony, Toong, Catherine, Wu, Kathy H.C., Sewell, William A., Phan, Tri Giang, Hollway, Georgina E., Enthoven, Karen, Gray, Paul E., Casas-Martin, Jose, Wouters, Carine, De Somer, Lien, Hershfield, Michael, Bucciol, Giorgia, Delafontaine, Selket, Ma, Cindy S., Tangye, Stuart G., Meyts, Isabelle

“…Purpose Deficiency of adenosine deaminase type 2 (ADA2) (DADA2) is a rare inborn error of immunity caused by deleterious biallelic mutations in ADA2 . Clinical…”
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Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis by Imbrechts, Maya, Avau, Anneleen, Vandenhaute, Jessica, Malengier-Devlies, Bert, Put, Karen, Mitera, Tania, Berghmans, Nele, Burton, Oliver, Junius, Steffie, Liston, Adrian, de Somer, Lien, Wouters, Carine, Matthys, Patrick

“…Systemic juvenile idiopathic arthritis (sJIA) is a childhood-onset immune disorder of unknown cause. One of the concepts is that the disease results from an…”
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Dry synovitis, a rare entity distinct from juvenile idiopathic arthritis by De Somer, Lien, Bader-Meunier, Brigitte, Breton, Sylvain, Brachi, Sara, Wouters, Carine, Zulian, Francesco

“…Dry synovitis (DS) is a rare entity as only a few cases have been reported to date. We describe the clinical features, radiological manifestations and course…”
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Novel method to quantify peptidylarginine deiminase activity shows distinct citrullination patterns in rheumatoid and juvenile idiopathic arthritis by Yu, Karen, Dillemans, Luna, Gouwy, Mieke, Bessa, Helena, Metzemaekers, Mieke, Martens, Erik, Matthys, Patrick, Bossuyt, Xavier, Verschueren, Patrick, Wouters, Carine, De Somer, Lien, Proost, Paul

“…Peptidylarginine deiminases (PADs) mediate citrullination, an irreversible posttranslational modification that converts arginine to citrulline residues in…”
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Warts and DADA2: a Mere Coincidence? by Arts, Katrijn, Bergerson, Jenna R. E., Ombrello, Amanda K., Similuk, Morgan, Oler, Andrew J., Agharahimi, Anahita, Mace, Emily M., Hershfield, Mike, Wouters, Carine, De Somer, Lien, Morren, Marie-Anne, Diego, Rebeca Perez-de, Moens, Leen, Freeman, Alexandra F., Meyts, Isabelle

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Phenotypical and Functional Characterization of Neutrophils in Two Pyrin-Associated Auto-inflammatory Diseases by Malengier-Devlies, Bert, Metzemaekers, Mieke, Gouwy, Mieke, Van Nieuwenhove, Erika, Betrains, Albrecht, Cockx, Maaike, Vanbrabant, Lotte, Pörtner, Noëmie, Vercauteren, Jurgen, De Somer, Lien, Struyf, Sofie, Vanderschueren, Steven, De Langhe, Ellen, Proost, Paul, Matthys, Patrick, Wouters, Carine

“…Purpose Familial Mediterranean Fever (FMF) and Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis (PAAND) are clinically distinct autoinflammatory…”
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From ELISA to Immunosorbent Tandem Mass Spectrometry Proteoform Analysis: The Example of CXCL8/Interleukin-8 by Metzemaekers, Mieke, Abouelasrar Salama, Sara, Vandooren, Jennifer, Mortier, Anneleen, Janssens, Rik, Vandendriessche, Sofie, Ganseman, Eva, Martens, Erik, Gouwy, Mieke, Neerinckx, Barbara, Verschueren, Patrick, De Somer, Lien, Wouters, Carine, Struyf, Sofie, Opdenakker, Ghislain, Van Damme, Jo, Proost, Paul

“…With ELISAs one detects the ensemble of immunoreactive molecules in biological samples. For biomolecules undergoing proteolysis for activation, potentiation or…”
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Chronic nonbacterial osteomyelitis in children: a multicentre Belgian cohort of 30 children by Kaut, Sara, Van den Wyngaert, Ine, Christiaens, Davy, Wouters, Carine, Noppe, Nathalie, Herregods, Nele, Dehoorne, Joke, De Somer, Lien

“…To evaluate clinical characteristics, imaging findings, therapeutic approach and outcome of paediatric patients with Chronic Non-Bacterial Osteomyelitis (CNO)…”
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Spondyloenchondrodysplasia Due to Mutations in ACP5: A Comprehensive Survey by Briggs, Tracy A., Rice, Gillian I., Adib, Navid, Ades, Lesley, Barete, Stephane, Baskar, Kannan, Baudouin, Veronique, Cebeci, Ayse N., Clapuyt, Philippe, Coman, David, De Somer, Lien, Finezilber, Yael, Frydman, Moshe, Guven, Ayla, Heritier, Sébastien, Karall, Daniela, Kulkarni, Muralidhar L., Lebon, Pierre, Levitt, David, Le Merrer, Martine, Linglart, Agnes, Livingston, John H., Navarro, Vincent, Okenfuss, Ericka, Puel, Anne, Revencu, Nicole, Scholl-Bürgi, Sabine, Vivarelli, Marina, Wouters, Carine, Bader-Meunier, Brigitte, Crow, Yanick J.

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Granulomatous skin lesions complicating Varicella infection in a patient with Rothmund-Thomson syndrome and immune deficiency: case report by De Somer, Lien, Wouters, Carine, Morren, Marie-Anne, De Vos, Rita, Van Den Oord, Joost, Devriendt, Koenraad, Meyts, Isabelle

“…Rothmund-Thomson syndrome (RTS)(OMIM 268400) is a rare autosomal recessive genodermatosis characterized by poikiloderma, small stature, skeletal and dental…”
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Recipient lymphocyte infusion in MHC-matched bone marrow chimeras induces a limited lymphohematopoietic host-versus-graft reactivity but a significant antileukemic effect mediated by CD8+ T cells and natural killer cells by DE SOMER, Lien, SPRANGERS, Ben, FEVERY, Sabine, RUTGEERTS, Omer, LENAERTS, Caroline, BOON, Louis, WAER, Mark, BILLIAU, An D

“…Challenge of MHC-mismatched murine bone marrow chimeras with recipient-type lymphocytes (recipient lymphocyte infusion) produces antileukemic responses in…”
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A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment by Dillemans, Luna, De Somer, Lien, Neerinckx, Barbara, Proost, Paul

“…Chemokines are pivotal players in instigation and perpetuation of synovitis through leukocytes egress from the blood circulation into the inflamed…”
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Reversible Hypothalamic Obesity in a Girl with Suprasellar Tuberculoma by Rochtus, Anne, Lagae, Lieven, Jansen, Katrien, De Somer, Lien, Vermeulen, François, de Zegher, Francis

“…Suprasellar tuberculoma are extremely rare in children and most of those patients present with headache, vomiting, visual disturbances, and hypofunction of the…”
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