Search Results - "DE SILVA, T. Michael"

Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke by Hu, Xiaoming, De Silva, T Michael, Chen, Jun, Faraci, Frank M

“…The consequences of cerebrovascular disease are among the leading health issues worldwide. Large and small cerebral vessel disease can trigger stroke and…”
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Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin by Niego, Be'eri, Lee, Natasha, Larsson, Pia, De Silva, T Michael, Au, Amanda E-Ling, McCutcheon, Fiona, Medcalf, Robert L

“…Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced…”
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Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke by De Silva, T Michael, Brait, Vanessa H, Drummond, Grant R, Sobey, Christopher G, Miller, Alyson A

“…Post-ischemic oxidative stress and vasomotor dysfunction in cerebral arteries may increase the likelihood of cognitive impairment and secondary stroke…”
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The Vascular Consequences of Metabolic Syndrome: Rodent Models, Endothelial Dysfunction, and Current Therapies by Tran, Vivian, De Silva, T Michael, Sobey, Christopher G, Lim, Kyungjoon, Drummond, Grant R, Vinh, Antony, Jelinic, Maria

“…Metabolic syndrome is characterized by visceral obesity, dyslipidemia, hyperglycemia and hypertension, and affects over one billion people. Independently, the…”
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Vitamin D Deficiency and the Risk of Cerebrovascular Disease by Kim, Hyun Ah, Perrelli, Andrea, Ragni, Alberto, Retta, Francesca, De Silva, T Michael, Sobey, Christopher G, Retta, Saverio Francesco

“…Vitamin D deficiency has been clearly linked to major chronic diseases associated with oxidative stress, inflammation, and aging, including cardiovascular and…”
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Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress by Dinh, Quynh Nhu, Drummond, Grant R, Kemp-Harper, Barbara K, Diep, Henry, De Silva, T Michael, Kim, Hyun Ah, Vinh, Antony, Robertson, Avril A B, Cooper, Matthew A, Mansell, Ashley, Chrissobolis, Sophocles, Sobey, Christopher G

“…Aging is commonly associated with chronic low-grade inflammation and hypertension but it is unknown whether a cause-effect relationship exists between them. We…”
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Human amnion epithelial cell therapy reduces hypertension-induced vascular stiffening and cognitive impairment by Dinh, Quynh Nhu, Lo, Cecilia, Zhang, David Wong, Tran, Vivian, Gibson-Hughes, Tayla, Sheriff, Ashleigh, Diep, Henry, Kim, Hyun Ah, Zhang, Shenpeng R., Barreto-Arce, Liz J., Jelinic, Maria, Vinh, Antony, Arumugam, Thiruma V., Chan, Siow Teng, Lim, Rebecca, Drummond, Grant R., Sobey, Christopher G., De Silva, T. Michael

“…Vascular inflammation and fibrosis are hallmarks of hypertension and contribute to the development of cardiovascular disease and cognitive impairment. However,…”
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Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment by Rajeev, Vismitha, Chai, Yuek Ling, Poh, Luting, Selvaraji, Sharmelee, Fann, David Y, Jo, Dong-Gyu, De Silva, T Michael, Drummond, Grant R, Sobey, Christopher G, Arumugam, Thiruma V, Chen, Christopher P, Lai, Mitchell K P

“…Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related to cerebrovascular diseases. Although the loss of blood flow to…”
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Genetic Interference With Peroxisome Proliferator–Activated Receptor γ in Smooth Muscle Enhances Myogenic Tone in the Cerebrovasculature via A Rho Kinase–Dependent Mechanism by De Silva, T Michael, Ketsawatsomkron, Pimonrat, Pelham, Christopher, Sigmund, Curt D, Faraci, Frank M

“…Myogenic responses by resistance vessels are a key component of autoregulation in brain, thus playing a crucial role in regulating cerebral blood flow and…”
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Heterogeneous Impact of ROCK2 on Carotid and Cerebrovascular Function by De Silva, T Michael, Kinzenbaw, Dale A, Modrick, Mary L, Reinhardt, Lindsey D, Faraci, Frank M

“…Rho kinase (ROCK) has been implicated in physiological and pathophysiological processes, including regulation of vascular function. ROCK signaling is thought…”
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Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment by Rajeev, Vismitha, Fann, David Y., Dinh, Quynh Nhu, Kim, Hyun Ah, De Silva, T. Michael, Jo, Dong-Gyu, Drummond, Grant R., Sobey, Christopher G., Lai, Mitchell K.P., Chen, Christopher Li-Hsian, Arumugam, Thiruma V.

“…Background - Chronic cerebral hypoperfusion (CCH) is an important pathophysiological mechanism of vascular cognitive impairment (VCI). The heterogeneous…”
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Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity by Miller, Alyson A., Maxwell, Kate F., Chrissobolis, Sophocles, Bullen, Michelle L., Ku, Jacqueline M., Michael De Silva, T., Selemidis, Stavros, Hooker, Elizabeth U., Drummond, Grant R., Sobey, Christopher G., Kemp-Harper, Barbara K.

“…Nox2 oxidase activity underlies the oxidative stress and vascular dysfunction associated with several vascular-related diseases. We have reported that nitric…”
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Contributions of Aging to Cerebral Small Vessel Disease by De Silva, T. Michael, Faraci, Frank M

“…Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow…”
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NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2 by Miller, Alyson A, Drummond, Grant R, De Silva, T Michael, Mast, Anja E, Hickey, Haruyo, Williams, John P, Broughton, Brad R S, Sobey, Christopher G

“…We previously reported that NADPH oxidase activity is greater in intracranial cerebral versus systemic arteries of the rat. Here, we first tested whether NADPH…”
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Microvascular Dysfunction and Cognitive Impairment by De Silva, T. Michael, Faraci, Frank M.

“…The impact of vascular risk factors on cognitive function has garnered much interest in recent years. The appropriate distribution of oxygen, glucose, and…”
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Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a by Chassagnon, Irène R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D., King, Glenn F.

“…Stroke is the second-leading cause of death worldwide, yet there are no drugs available to protect the brain from stroke-induced neuronal injury. Acid-sensing…”
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Cerebral Small Vessel Disease: Targeting Oxidative Stress as a Novel Therapeutic Strategy? by De Silva, T Michael, Miller, Alyson A

“…Cerebral small vessel disease (SVD) is a major contributor to stroke, and a leading cause of cognitive impairment and dementia. Despite the devastating effects…”
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Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment by Rajeev, Vismitha, Fann, David Y, Dinh, Quynh Nhu, Kim, Hyun Ah, De Silva, T Michael, Lai, Mitchell K P, Chen, Christopher Li-Hsian, Drummond, Grant R, Sobey, Christopher G, Arumugam, Thiruma V

“…The prevalence of cerebrovascular disease increases with age, placing the elderly at a greater lifetime risk for dementia. Vascular cognitive impairment (VCI)…”
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The opposing roles of NO and oxidative stress in cardiovascular disease by Ritchie, Rebecca H., Drummond, Grant R., Sobey, Christopher G., De Silva, T. Michael, Kemp-Harper, Barbara K.

“…[Display omitted] Nitric oxide (NO) plays a pivotal role in the maintenance of cardiovascular homeostasis. A reduction in the bioavailability of endogenous NO,…”
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Ischemic stroke and infection: A brief update on mechanisms and potential therapies by Ghelani, Drishti P., Kim, Hyun Ah, Zhang, Shenpeng R., Drummond, Grant R., Sobey, Christopher G., De Silva, T. Michael

“…[Display omitted] Ischemic stroke triggers a multifaceted inflammatory response in the brain that contributes to secondary brain injury and infarct expansion…”
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