HEREDITARY ANGIOEDEMA: DENTAL MANAGEMENT OF 9 PATIENTS FROM BRAZIL

To describe the dental management and oral health status of 9 patients with hereditary angioedema (HAE). Demographic data, type and severity of HAE, long and short-term prophylaxis, and number of occurrences of angioedema after dental procedures were retrieved from the files of patients submitted to...

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Published in:	Oral surgery, oral medicine, oral pathology and oral radiology Vol. 129; no. 1; p. e157
Main Authors:	LIMA, BERNARDO CORREIA, BARBOSA, FABIOLLA SOARES, DE SAN THIAGO RAGON, CLÁUDIA, FERRARI, ALESSANDRA OLIVEIRA, VALLE, SOLANGE OLIVEIRA RODRIGUES, TORRES, SANDRA REGINA, AGOSTINI, MICHELLE
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-01-2020
Online Access:	Get full text
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Summary:	To describe the dental management and oral health status of 9 patients with hereditary angioedema (HAE). Demographic data, type and severity of HAE, long and short-term prophylaxis, and number of occurrences of angioedema after dental procedures were retrieved from the files of patients submitted to dental procedures in a university hospital from Brazil from 2012 to 2017. Number of teeth and presence of bone loss were evaluated by panoramic radiographs. Nine patients were enrolled into the study, all in use of long-term prophylaxis, most with attenuated androgens (AAs); most patients (78%) were women, with C1-inibitor (INH)-HAE type I and mean age of 47 years. The mean number of present teeth was 23, and 5 patients (58%) showed signs of periodontal disease. Forty-three dental procedures were performed, the most common being tooth extractions, dental restorations, and supragingival removal of calculus. Six patients (67%) were submitted to dental procedures without modification of long-term prophylaxis, whereas an increased dose of AAs or C1-INH concentrate was administrated before the dental procedures in 3 patients (33%), especially in those undergoing dental extractions. Angioedema attacks were not observed. This is the first large series on dental management of Brazilian patients with HAE.
ISSN:	2212-4403 2212-4411
DOI:	10.1016/j.oooo.2019.06.673