Search Results - "DE PAEPE, Peter"
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Combined oropharyngeal/nasal swab is equivalent to nasopharyngeal sampling for SARS-CoV-2 diagnostic PCR
Published in BMC microbiology (22-01-2021)“…Early 2020, a COVID-19 epidemic became a public health emergency of international concern. To address this pandemic broad testing with an easy, comfortable and…”
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Characteristics and costs in adults with acute poisoning admitted to the emergency department of a university hospital in Belgium
Published in PloS one (04-10-2019)“…The aims of this study were to assess the characteristics of all acute poisoning admissions among adult emergency department (ED) patients, to identify factors…”
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Pharmacokinetics of fluoroquinolones in critical care patients: A bio-analytical HPLC method for the simultaneous quantification of ofloxacin, ciprofloxacin and moxifloxacin in human plasma
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01-04-2009)“…A high-performance liquid chromatographic (HPLC) method with fluorescence detection was developed and validated for the simultaneous quantification of…”
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Augmented renal clearance implies a need for increased amoxicillin-clavulanic acid dosing in critically ill children
Published in Antimicrobial agents and chemotherapy (01-11-2015)“…There is little data available to guide amoxicillin-clavulanic acid dosing in critically ill children. The primary objective of this study was to investigate…”
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Dose optimization of piperacillin/tazobactam in critically ill children
Published in Journal of antimicrobial chemotherapy (01-07-2017)“…To characterize the population pharmacokinetics of piperacillin and tazobactam in critically ill infants and children, in order to develop an evidence-based…”
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Vancomycin dosing and therapeutic drug monitoring practices: guidelines versus real-life
Published in International journal of clinical pharmacy (01-10-2021)“…Background Correct dosing and therapeutic drug monitoring (TDM) practices are essential when aiming for optimal vancomycin treatment. Objective To assess…”
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Recognition of a disulfiram ethanol reaction in the emergency department is not always straightforward
Published in PloS one (03-12-2020)“…Disulfiram is an adjunct in the treatment of alcohol use disorders, but case reports indicate that disulfiram ethanol reactions are not always recognized in…”
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Possible Pathogenic Mechanism of Propofol Infusion Syndrome Involves Coenzyme Q
Published in Anesthesiology (Philadelphia) (01-02-2015)“…BACKGROUND:Propofol is a short-acting intravenous anesthetic agent. In rare conditions, a life-threatening complication known as propofol infusion syndrome can…”
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Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model
Published in Frontiers in pharmacology (26-01-2021)“…Augmented renal clearance (ARC) observed in the critically ill pediatric population has received an increased attention over the last years due to its major…”
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9 Tissue penetration of piperacillin-tazobactam in critically ill children – a microdialysis study
Published in BMJ paediatrics open (01-08-2024)“…IntroductionCritical illness may affect many pharmacokinetic (PK) processes. Research in adults suggests an impaired tissue penetration of beta-lactam…”
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A multicentric, randomized, controlled clinical trial to study the impact of bedside model-informed precision dosing of vancomycin in critically ill children-BENEFICIAL trial
Published in Current controlled trials in cardiovascular medicine (10-10-2024)“…Vancomycin is a commonly prescribed antibiotic to treat serious Gram-positive infections in children. The efficacy of vancomycin is known to be directly…”
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Conventional Pig as Animal Model for Human Renal Drug Excretion Processes: Unravelling the Porcine Renal Function by Use of a Cocktail of Exogenous Markers
Published in Frontiers in pharmacology (12-06-2020)“…Over recent years, pigs have been promoted as potential animal model due to their anatomical and physiological similarities with humans. However, information…”
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Medically unexplained physical symptoms in patients visiting the emergency department: an international multicentre retrospective study
Published in European journal of emergency medicine (01-08-2019)“…OBJECTIVEThe objective of this study was to assess the incidence and characteristics of patients presenting with physical symptoms that remain medically…”
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The Development of a Juvenile Porcine Augmented Renal Clearance Model Through Continuous Infusion of Lipopolysaccharides: An Exploratory Study
Published in Frontiers in veterinary science (29-04-2021)“…Augmented renal clearance (ARC) as observed in the critically ill (pediatric) population can have a major impact on the pharmacokinetics and posology of…”
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AUGMENTED RENAL CLEARANCE IMPLIES A NEED FOR INCREASED AMOXICILLIN-CLAVULANATE DOSING IN CRITICALLY ILL CHILDREN
Published in Archives of disease in childhood (01-01-2016)“…Background Amoxicillin/clavulanate is commonly used to treat community-acquired infections on the pediatric intensive care unit. Few data are available to…”
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Acute Chlorophenylpiperazine Overdose: A Case Report and Review of the Literature
Published in Therapeutic drug monitoring (01-06-2008)“…This case report describes an acute overdose in a female patient with the serotonin mixed agonist-antagonist m-chlorophenylpiperazine (mCPP), a new synthetic…”
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Biomarkers in patients admitted to the emergency department after exposure to acrylonitrile in a major railway incident involving bulk chemical material
Published in International journal of hygiene and environmental health (01-03-2017)“…A railway incident with victims of exposure to the cyanogenic substance acrylonitrile (ACN). We retrospectively (i)built an inventory of the clinical…”
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Out of hours care: a profile analysis of patients attending the emergency department and the general practitioner on call
Published in BMC family practice (15-11-2010)“…Overuse of emergency departments (ED) is of concern in Western society and it is often referred to as 'inappropriate' use. This phenomenon may compromise…”
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Disorders of Consciousness Induced by Intoxication
Published in Neurologic clinics (01-02-2012)“…The prognosis of patients with altered consciousness is mainly determined by early diagnosis and appropriate therapeutic interventions and by the type of…”
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Enhancing hospital emergency response based on the experience of COVID-19
Published in Acta clinica belgica (English ed. Online) (11-08-2024)“…The COVID-19 pandemic required a significant response from global healthcare systems. In Belgium, the crisis began in March 2020, prompting quick action in…”
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